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1
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0034529505
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Epidemiology of schizophrenia: The global burden of disease and disability
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Jablensky A. Epidemiology of schizophrenia: the global burden of disease and disability. Eur Arch Psychiatry Clin Neurosci 2000; 250:274-285.
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Eur Arch Psychiatry Clin Neurosci
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Jablensky, A.1
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2
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34548499635
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Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia
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A strategically designed microarray study focused on genes with definable CNS function that suggests a role for altered pro-inflammatory pathways in the CNS of patients with schizophrenia
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Arion D, Unger T, Lewis DA, et al. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 2007; 62:711-721. A strategically designed microarray study focused on genes with definable CNS function that suggests a role for altered pro-inflammatory pathways in the CNS of patients with schizophrenia.
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(2007)
Biol Psychiatry
, vol.62
, pp. 711-721
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Arion, D.1
Unger, T.2
Lewis, D.A.3
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3
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34548809845
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Inflammation, depression and dementia: Are they connected?
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Leonard BE. Inflammation, depression and dementia: are they connected? Neurochem Res 2007; 32:1749-1756.
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(2007)
Neurochem Res
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Leonard, B.E.1
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4
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34250868380
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Variations in oligodendrocyte-related gene expression across multiple cortical regions: Implications for the pathophysiology of schizophrenia
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A significant study that strongly reinforces a role for altered expression of myelin-related genes in the CNS of patients with schizophrenia
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Haroutunian V, Katsel P, Dracheva S, et al. Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia. Int J Neuropsychopharmacol 2007; 10:565-573. A significant study that strongly reinforces a role for altered expression of myelin-related genes in the CNS of patients with schizophrenia.
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(2007)
Int J Neuropsychopharmacol
, vol.10
, pp. 565-573
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Haroutunian, V.1
Katsel, P.2
Dracheva, S.3
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5
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34248145469
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Dean B, Keriakous D, Scarr E, Thomas EA. Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia. Aust NZJ Psychiatry 2007; 41:308-320. An alternate approach to profiling the human transcriptome that identified changes in cell adhesion, signal transduction, development, transcription, energy/metabolism and myelination as being altered in schizophrenia. In addition, preliminary data are presented to suggest that some changes in gene expression may only occur at specific times during the disease progression.
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Dean B, Keriakous D, Scarr E, Thomas EA. Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia. Aust NZJ Psychiatry 2007; 41:308-320. An alternate approach to profiling the human transcriptome that identified changes in cell adhesion, signal transduction, development, transcription, energy/metabolism and myelination as being altered in schizophrenia. In addition, preliminary data are presented to suggest that some changes in gene expression may only occur at specific times during the disease progression.
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6
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33846645320
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Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
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A PCR study confirming altered levels of myelin-related mRNA in the CNS of patients with schizophrenia
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McCullumsmith RE, Gupta D, Beneyto M, et al. Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia. Schizophr Res 2007; 90:15-27. A PCR study confirming altered levels of myelin-related mRNA in the CNS of patients with schizophrenia.
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(2007)
Schizophr Res
, vol.90
, pp. 15-27
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McCullumsmith, R.E.1
Gupta, D.2
Beneyto, M.3
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7
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37049025403
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Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia
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Mitkus SN, Hyde TM, Vakkalanka R, et al. Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. Schizophr Res 2008; 98:129-138.
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(2008)
Schizophr Res
, vol.98
, pp. 129-138
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Mitkus, S.N.1
Hyde, T.M.2
Vakkalanka, R.3
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8
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63049120234
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Narayan S, Head SR, Gilmartin TJ, et al. Evidence for disruption of sphingolipid metabolism in schizophrenia. J Neurosci Res 2009; 87:278-288. This article shows that differences in gene expression profiles change, in the DLPFC of patients with schizophrenia, as the disease progresses. Both studies show many more changes in gene expression early in the course of frank illness (duration < 5 years) compared with what can be detected later in the disease (duration of illness > 20 years). These data suggest that the underlying pathology of schizophrenia may change with disease progression, and this changing gene expression profile may underpin the change in symptom profile as the disease moves from an acute to chronic form.
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Narayan S, Head SR, Gilmartin TJ, et al. Evidence for disruption of sphingolipid metabolism in schizophrenia. J Neurosci Res 2009; 87:278-288. This article shows that differences in gene expression profiles change, in the DLPFC of patients with schizophrenia, as the disease progresses. Both studies show many more changes in gene expression early in the course of frank illness (duration < 5 years) compared with what can be detected later in the disease (duration of illness > 20 years). These data suggest that the underlying pathology of schizophrenia may change with disease progression, and this changing gene expression profile may underpin the change in symptom profile as the disease moves from an acute to chronic form.
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9
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53949085543
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Narayan S, Tang B, Head SR, et al. Molecular profiles of schizophrenia in the CNS at different stages of illness. Brain Res doi: 80006-8993(08)01941-0 [pii];10.1016/j.brainres.2008.08.023 [doi, Epub ahead of print, This article shows that differences in gene expression profiles change, in the DLPFC of patients with schizophrenia, as the disease progresses. Both studies show many more changes in gene expression early in the course of frank illness (duration < 5 years) compared with what can be detected later in the disease duration of illness > 20 years, These data suggest that the underlying pathology of schizophrenia may change with disease progression, and this changing gene expression profile may underpin the change in symptom profile as the disease moves from an acute to chronic form
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Narayan S, Tang B, Head SR, et al. Molecular profiles of schizophrenia in the CNS at different stages of illness. Brain Res doi: 80006-8993(08)01941-0 [pii];10.1016/j.brainres.2008.08.023 [doi] [Epub ahead of print]. This article shows that differences in gene expression profiles change, in the DLPFC of patients with schizophrenia, as the disease progresses. Both studies show many more changes in gene expression early in the course of frank illness (duration < 5 years) compared with what can be detected later in the disease (duration of illness > 20 years). These data suggest that the underlying pathology of schizophrenia may change with disease progression, and this changing gene expression profile may underpin the change in symptom profile as the disease moves from an acute to chronic form.
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10
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0032915003
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A comparative proteome analysis of hippocampal tissue from schizophrenic and Alzheimer's disease individuals
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Edgar PF, Schonberger SJ, Dean B, et al. A comparative proteome analysis of hippocampal tissue from schizophrenic and Alzheimer's disease individuals. Mol Psychiatry 1999; 4:173-178.
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Mol Psychiatry
, vol.4
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Edgar, P.F.1
Schonberger, S.J.2
Dean, B.3
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11
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38349149023
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Abnormal pathways in the genu of the corpus collosum in schizophrenia pathogenesis: A proteome study
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An informative study of the human proteome in the corpus collosum
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Sivagnanasundaram S, Cosset B, Dedova I, et al. Abnormal pathways in the genu of the corpus collosum in schizophrenia pathogenesis: a proteome study. Proteomics Clin Appli 2007; 1:1291-1305. An informative study of the human proteome in the corpus collosum.
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(2007)
Proteomics Clin Appli
, vol.1
, pp. 1291-1305
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Sivagnanasundaram, S.1
Cosset, B.2
Dedova, I.3
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12
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49949108907
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Smalla KH, Mikhaylova M, Sahin J, et al. A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Mol Psychiatry 2008; 13:878-896. A significant development in the use of two-dimensional electrophoresis in which synaptic enrichment was completed prior to electrophoresis is used to allow the study of levels of synaptic proteins in human CNS. This study highlights a number of changes in synaptic function as being potentially involved in the pathology of schizophrenia.
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Smalla KH, Mikhaylova M, Sahin J, et al. A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Mol Psychiatry 2008; 13:878-896. A significant development in the use of two-dimensional electrophoresis in which synaptic enrichment was completed prior to electrophoresis is used to allow the study of levels of synaptic proteins in human CNS. This study highlights a number of changes in synaptic function as being potentially involved in the pathology of schizophrenia.
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13
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12344327212
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Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
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Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10:40-68.
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Mol Psychiatry
, vol.10
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Harrison, P.J.1
Weinberger, D.R.2
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14
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39949084866
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Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients
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A study that begins to investigate the mechanisms by which NRG1-related pathways may be altered in the CNS of patients with schizophrenia
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Chong VZ, Thompson M, Beltaifa S, et al. Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients. Schizophr Res 2008; 100:270-280. A study that begins to investigate the mechanisms by which NRG1-related pathways may be altered in the CNS of patients with schizophrenia.
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(2008)
Schizophr Res
, vol.100
, pp. 270-280
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Chong, V.Z.1
Thompson, M.2
Beltaifa, S.3
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15
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0034702026
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Disruption of two novel genes by a translocation co-segregating with schizophrenia
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Millar JK, Wilson-Annan JC, Anderson S, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9:1415-1423.
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Millar, J.K.1
Wilson-Annan, J.C.2
Anderson, S.3
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16
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43049167463
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Leliveld SR, Bader V, Hendriks P, et al. Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci 2008; 28:3839-3845. Initial data to suggest that insoluble DISC1 may be altered in the CNS of patients with schizophrenia. Given the role of insoluble proteins in disease such as Alzheimer's, this could be a significant factor that needs considering with regards to the pathology of the schizophrenia.
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Leliveld SR, Bader V, Hendriks P, et al. Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci 2008; 28:3839-3845. Initial data to suggest that insoluble DISC1 may be altered in the CNS of patients with schizophrenia. Given the role of insoluble proteins in disease such as Alzheimer's, this could be a significant factor that needs considering with regards to the pathology of the schizophrenia.
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A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
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Kamiya A, Kubo K, Tomoda T, et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol 2005; 7:1167-1178.
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Kamiya, A.1
Kubo, K.2
Tomoda, T.3
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Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
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Mimics K, Middleton FA, Stanwood GD, et al. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 2001; 6:293-301.
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Mimics, K.1
Middleton, F.A.2
Stanwood, G.D.3
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19
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33845331085
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Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia
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Bowden NA, Scott RJ, Tooney PA. Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia. Schizophr Res 2007; 89:165-168.
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Schizophr Res
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Bowden, N.A.1
Scott, R.J.2
Tooney, P.A.3
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20
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Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia
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Gibbons A, Scarr E, McOmish CE, et al. Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia. Aust NZJ Psychiatry 2008; 42:740-745.
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Aust NZJ Psychiatry
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Gibbons, A.1
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McOmish, C.E.3
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RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
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Lipska BK, Mitkus S, Caruso M, et al. RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity. Hum Mol Genet 2006; 15:2804-2812.
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Hum Mol Genet
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Lipska, B.K.1
Mitkus, S.2
Caruso, M.3
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23
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37049006760
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Weickert CS, Rothmond DA, Hyde TM, et al. Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res 2008; 98:105-110. Recent meta-analyses suggest that there is strong evidence that DTNBP1 is a susceptibility gene for schizophrenia. Therefore, data showing alterations of the expression of this gene are important in beginning to understand how the gene may confer a predisposition for the disorder and be involved in the genesis of the symptoms of schizophrenia.
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Weickert CS, Rothmond DA, Hyde TM, et al. Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res 2008; 98:105-110. Recent meta-analyses suggest that there is strong evidence that DTNBP1 is a susceptibility gene for schizophrenia. Therefore, data showing alterations of the expression of this gene are important in beginning to understand how the gene may confer a predisposition for the disorder and be involved in the genesis of the symptoms of schizophrenia.
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58049197826
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The dystrobrevin-binding protein 1 gene: Features and networks
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Guo AY, Sun J, Riley BP, et al. The dystrobrevin-binding protein 1 gene: features and networks. Mol Psychiatry 2009; 14:18-29.
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25
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Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database
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Allen NC, Bagade S, McQueen MB, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008; 40:827-834.
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Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
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Colantuoni C, Hyde TM, Mitkus S, et al. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. Brain Struct Funct 2008; 213:255-271.
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No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter In human hippocampus
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Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia
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Severance EG, Yolken RH. Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia. Genes Brain Behav 2008; 7:37-45.
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Bray NJ. Gene expression in the etiology of schizophrenia. Schizophr Bull 2008; 34:412-418.
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Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33 (Suppl):245-254.
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Jaenisch, R.1
Bird, A.2
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32
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Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
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A seminal study highlighting the potential role of DNA methylation in the pathology of schizophrenia. DNA methylation can be regulated by environmental factors, so this type of study will inform on how genes and environment may interact to cause changes in gene expression that lead to the symptoms of schizophrenia
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Mill J, Tang T, Kaminsky Z, et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008; 82:696-711. A seminal study highlighting the potential role of DNA methylation in the pathology of schizophrenia. DNA methylation can be regulated by environmental factors, so this type of study will inform on how genes and environment may interact to cause changes in gene expression that lead to the symptoms of schizophrenia.
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Huang HS, Akbarian S. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS ONE 2007; 2:e809. A study that is the first to show data to suggest that a change in specific gene promoter methylation corresponds to an appropriate change in the level of the expression of that gene in the CNS of patients with schizophrenia.
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Huang HS, Akbarian S. GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS ONE 2007; 2:e809. A study that is the first to show data to suggest that a change in specific gene promoter methylation corresponds to an appropriate change in the level of the expression of that gene in the CNS of patients with schizophrenia.
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Selective epigenetic alteration of layer 1 GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection
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Data to suggest that levels of DNA methyltranferase, an enzyme involved in DNA methylation, are altered in cortical neurons of patients with schizophrenia
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Ruzicka WB, Zhubi A, Veldic M, et al. Selective epigenetic alteration of layer 1 GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol Psychiatry 2007; 12:385-397. Data to suggest that levels of DNA methyltranferase, an enzyme involved in DNA methylation, are altered in cortical neurons of patients with schizophrenia.
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, vol.12
, pp. 385-397
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Ruzicka, W.B.1
Zhubi, A.2
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Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia
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Hashimoto T, Arion D, Linger T, et al. Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 2008; 13:147-161.
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MicroRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
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Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
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Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
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Data that suggest that changes in glutamate release may be important in the pathology of schizophrenia
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Oni-Orisan A, Kristiansen LV, Haroutunian V, et al. Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia. Biol Psychiatry 2008; 63:766-775. Data that suggest that changes in glutamate release may be important in the pathology of schizophrenia.
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