Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 23, 2007, Pages 9667-9672

  Lytle, J Robin ^a   Yario, Therese A ^a   Steitz, Joan A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Internal ribosome entry sites; Let 7 miRNP; Method of transfection; Repression; Translation efficiency

Indexed keywords

LUCIFERASE; MESSENGER RNA; MICRORNA; PROTEIN; PROTEIN AGO2; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DNA TRANSFECTION; HELA CELL; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; REPORTER GENE; RNA BINDING; RNA TRANSLATION; STEREOCHEMISTRY; TRANSLATION INITIATION; TRANSLATION REGULATION; TRANSLATION REPRESSION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS PROTEINS; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; LUCIFERASES; MICRORNAS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; RIBONUCLEOPROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 34547441263     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703820104     Document Type: Article

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