메뉴 건너뛰기




Volumn 196, Issue 3, 2008, Pages 455-464

Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FATTY ACID; GLUCOSE; INSULIN; MONOUNSATURATED FATTY ACID; OLEIC ACID; REACTIVE OXYGEN METABOLITE;

EID: 41149178575     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-07-0174     Document Type: Article
Times cited : (38)

References (46)
  • 2
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46 3-10.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 3
    • 0036230225 scopus 로고    scopus 로고
    • Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function
    • Busch AK, Cordery D, Denyer GS & Biden TJ 2002 Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function. Diabetes 51 977-987.
    • (2002) Diabetes , vol.51 , pp. 977-987
    • Busch, A.K.1    Cordery, D.2    Denyer, G.S.3    Biden, T.J.4
  • 4
    • 0033305516 scopus 로고    scopus 로고
    • Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
    • Carlsson C, Borg LA & Welsh N 1999 Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140 3422-3428.
    • (1999) Endocrinology , vol.140 , pp. 3422-3428
    • Carlsson, C.1    Borg, L.A.2    Welsh, N.3
  • 8
    • 33748752150 scopus 로고    scopus 로고
    • 5-Aminoimid, dazole-4-carboxamide-1 -beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insuhn-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes
    • Gaidhu MP, Fediuc S & Ceddia RB 2006 5-Aminoimid, dazole-4-carboxamide-1 -beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insuhn-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes. Journal of Biological Chemistry 281 25956-25964.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 25956-25964
    • Gaidhu, M.P.1    Fediuc, S.2    Ceddia, R.B.3
  • 13
    • 0036829870 scopus 로고    scopus 로고
    • Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
    • Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB & Wheeler MB 2002 Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51 3211-3219.
    • (2002) Diabetes , vol.51 , pp. 3211-3219
    • Joseph, J.W.1    Koshkin, V.2    Zhang, C.Y.3    Wang, J.4    Lowell, B.B.5    Chan, C.B.6    Wheeler, M.B.7
  • 17
    • 0036315888 scopus 로고    scopus 로고
    • Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    • Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patine G, Boggi U, Piro S, Anello M et al. 2002b Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51 1437-1442.
    • (2002) Diabetes , vol.51 , pp. 1437-1442
    • Lupi, R.1    Dotta, F.2    Marselli, L.3    Del Guerra, S.4    Masini, M.5    Santangelo, C.6    Patine, G.7    Boggi, U.8    Piro, S.9    Anello, M.10
  • 19
    • 0033042342 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats
    • Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF & Giacca A 1999 Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 48 524-530.
    • (1999) Diabetes , vol.48 , pp. 524-530
    • Mason, T.M.1    Goh, T.2    Tchipashvili, V.3    Sandhu, H.4    Gupta, N.5    Lewis, G.F.6    Giacca, A.7
  • 20
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • McGarry JD & Dobbins RL 1999 Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42 128-138.
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 21
    • 33746377553 scopus 로고    scopus 로고
    • Obesity-related derangements in metabolic regulation
    • Muoio, DM & Newgard CB 2006 Obesity-related derangements in metabolic regulation. Annual Review of Biochemistry 75 367-401.
    • (2006) Annual Review of Biochemistry , vol.75 , pp. 367-401
    • Muoio, D.M.1    Newgard, C.B.2
  • 23
    • 33846267745 scopus 로고    scopus 로고
    • Life and death decisions of the pancreatic beta-cell: The role of fatty acids
    • Newsholme P, Keane D, Welters HJ & Morgan NG 2007b Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clinical Science 112 27-42.
    • (2007) Clinical Science , vol.112 , pp. 27-42
    • Newsholme, P.1    Keane, D.2    Welters, H.J.3    Morgan, N.G.4
  • 27
    • 0034072962 scopus 로고    scopus 로고
    • Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: A direct metformin effect on pancreatic beta-cells
    • Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R & Purrello F 2000 Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells. Diabetes 49 735-740.
    • (2000) Diabetes , vol.49 , pp. 735-740
    • Patane, G.1    Piro, S.2    Rabuazzo, A.M.3    Anello, M.4    Vigneri, R.5    Purrello, F.6
  • 28
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN & Newsholme EA 1963 The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 29
    • 0025151910 scopus 로고
    • Metabolism of adipose tissue in intraabdominal depots in severely obese men and women
    • Rebuffe-Scrive M, Anderson B, Olbe L & Bjorntorp P 1990 Metabolism of adipose tissue in intraabdominal depots in severely obese men and women. Metabolism 39 1021-1025.
    • (1990) Metabolism , vol.39 , pp. 1021-1025
    • Rebuffe-Scrive, M.1    Anderson, B.2    Olbe, L.3    Bjorntorp, P.4
  • 31
    • 0842284799 scopus 로고    scopus 로고
    • Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson RP, Harmon J, Tran PO & Poitout V 2004 Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 (Suppl 1) S119-S124.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Poitout, V.4
  • 32
  • 33
    • 3042841952 scopus 로고    scopus 로고
    • How free fatty acids inhibit glucose utilization in human skeletal muscle
    • Roden M 2004 How free fatty acids inhibit glucose utilization in human skeletal muscle. News in Physiological Sciences 19 92-96.
    • (2004) News in Physiological Sciences , vol.19 , pp. 92-96
    • Roden, M.1
  • 34
    • 12144291143 scopus 로고    scopus 로고
    • A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
    • Roduit R, Nolan C, Alarcon C, Moore P Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Masse F, Massie B et al. 2004 A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes 53 1007-1019.
    • (2004) Diabetes , vol.53 , pp. 1007-1019
    • Roduit, R.1    Nolan, C.2    Alarcon, C.3    Moore, P.4    Barbeau, A.5    Delghingaro-Augusto, V.6    Przybykowski, E.7    Morin, J.8    Masse, F.9    Massie, B.10
  • 35
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson SE, Herrero L & Naaz A 2007 Obesity, inflammation, and insulin resistance. Gastroenterology 132 2169-2180.
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 36
    • 18844369302 scopus 로고    scopus 로고
    • Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options
    • Srivastava SK, Ramana KV & Bhatnagar A 2005 Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocrine Reviews 26 380-392.
    • (2005) Endocrine Reviews , vol.26 , pp. 380-392
    • Srivastava, S.K.1    Ramana, K.V.2    Bhatnagar, A.3
  • 37
    • 20944433543 scopus 로고    scopus 로고
    • The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
    • Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD & Edlund H 2005 The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metabolism 1 245-258.
    • (2005) Cell Metabolism , vol.1 , pp. 245-258
    • Steneberg, P.1    Rubins, N.2    Bartoov-Shifman, R.3    Walker, M.D.4    Edlund, H.5
  • 38
    • 22244458625 scopus 로고    scopus 로고
    • Applications of DNA microarrays in biology
    • Stoughton R.B 2005 Applications of DNA microarrays in biology. Annual Review of Biochemistry 74 53-82.
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 53-82
    • Stoughton, R.B.1
  • 39
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ & van Haeften TW 2005 Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365 1333-1346.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 41
    • 0035125917 scopus 로고    scopus 로고
    • Lipotoxicity ofbeta-cells in obesity and in other causes of fatty acid spillover
    • Unger RH & Zhou YT 2001 Lipotoxicity ofbeta-cells in obesity and in other causes of fatty acid spillover. Diabetes 50 (Suppl 1) S118-S121.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Unger, R.H.1    Zhou, Y.T.2
  • 42
    • 9144242433 scopus 로고    scopus 로고
    • Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S & Wheeler MB 2004 Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Diabetes 53 129-140.
    • Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S & Wheeler MB 2004 Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Diabetes 53 129-140.
  • 44
    • 0034751632 scopus 로고    scopus 로고
    • The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: Studies using high density oligonucleotide microarray
    • Yiao J, Gregersen S, Kruhoffer M, Pedersen SB, Orntoft TF & Hermansen K 2001 The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology 142 4777-4784.
    • (2001) Endocrinology , vol.142 , pp. 4777-4784
    • Yiao, J.1    Gregersen, S.2    Kruhoffer, M.3    Pedersen, S.B.4    Orntoft, T.F.5    Hermansen, K.6
  • 45
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig Al, Boss O, Kim YB et al. 2001 Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105 745-755.
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3    Krauss, S.4    Peroni, O.5    Grujic, D.6    Hagen, T.7    Vidal-Puig, A.8    Boss, O.9    Kim, Y.B.10
  • 46
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP & Grill V 1995 Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. Journal of Clinical Endocrinology and Metabolism 80 1584-1590.
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.