Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 11, 2004, Pages 5535-5541

  Marchetti, Piero ^a,b   Del Guerra, Silvia ^a   Marselli, Lorella ^a   Lupi, Roberto ^a   Masini, Matilde ^a   Pollera, Maria ^a   Bugliani, Marco ^a   Boggi, Ugo ^a   Vistoli, Fabio ^a   Mosca, Franco ^a   Del Prato, Stefano ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CISANELLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CASPASE 3; CASPASE 8; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; FATTY ACID; GLUCOSE; GLUTATHIONE PEROXIDASE; INSULIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; METFORMIN; PROTEIN KINASE C BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; AGED; AMINO ACID COMPOSITION; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL GRANULE; CELL LEVEL; CELL PROTECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; APOPTOSIS; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; ISLETS OF LANGERHANS; METFORMIN; MIDDLE AGED; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 8744272467     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0150     Document Type: Article

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