Engineering a glucose-responsive human insulin-secreting cell line from islets of langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy

Journal of Biological Chemistry

Volumn 274, Issue 48, 1999, Pages 34059-34066

  MacFarlane, Wendy M ^a   Chapman, Joanna C ^b   Shepherd, Ruth M ^b   Hashmi, Molly N ^b   Kamimura, Noritaka ^b   Cosgrove, Karen E ^b   O'Brien, Rachel E ^b   Barnes, Philippa D ^b   Hart, Alan W ^a   Docherty, Hilary M ^a   Lindley, Keith J ^c   Aynsley Green, Albert ^c   James, Roger F L ^d   Docherty, Kevin ^a   Dunne, Mark J ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLUCOSE; INSULIN; POTASSIUM CHANNEL; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL LINE; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERINSULINEMIA; HYPOGLYCEMIA; INFANT DISEASE; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GENETIC ENGINEERING; GLUCOSE; HOMEODOMAIN PROTEINS; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INFANT; INSULIN; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHLORIDE; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS; TOLBUTAMIDE; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033607678     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.48.34059     Document Type: Article

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