Deletion of Fas in the pancreatic β-cells leads to enhanced insulin secretion

American Journal of Physiology - Endocrinology and Metabolism

Volumn 297, Issue 6, 2009, Pages

  Choi, Diana ^a   Radziszewska, Anna ^a   Schroer, Stephanie A ^a   Liadis, Nicole ^a   Liu, Yunfeng ^b   Zhang, Yi ^b   Lam, Patrick P L ^b   Sheu, Laura ^b   Hao, Zhenyue ^c   Gaisano, Herbert Y ^b   Woo, Minna ^a,c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Apoptosis; Diabetes; Exocytosis; Islets

Indexed keywords

CELL PROTEIN; FAS ANTIGEN; FAS LIGAND; GLUCOSE; INSULIN; MUNC18 PROTEIN; STREPTOZOCIN; SYNAPTOBREVIN 2; SYNTAXIN 1A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; ELECTRIC CAPACITANCE; EXOCYTOSIS; FEMALE; FUNCTIONAL ASSESSMENT; GENE DELETION; GENE FUNCTION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; INNER CELL MASS; INSULIN RELEASE; LIPID DIET; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; DIABETES MELLITUS; EIF-2 KINASE; FAS LIGAND PROTEIN; FEMALE; FLOW CYTOMETRY; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MUNC18 PROTEINS; PATCH-CLAMP TECHNIQUES; SYNTAXIN 1; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 72249090205     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00217.2009     Document Type: Article

References (36)

1. Allison J, Strasser A. Mechanisms of beta cell death in diabetes: a minor role for CD95. Proc Natl Acad Sci USA 95: 13818-13822, 1998. (Pubitemid 28523056)
2. Apostolou I, Hao Z, Rajewsky K, von Boehmer H. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. J Exp Med 198: 1103-1106, 2003. (Pubitemid 37248625)
3. Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab 11: 375-378, 2000. (Pubitemid 30778474)
4. Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277: 11225-11232, 2002. (Pubitemid 34952885)
5. Chervonsky AV, Wang Y, Wong FS, Visintin I, Falvell RA, Janeway CA Jr, Matis LA. The role of Fas in autoimmune diabetes. Cell 89: 17-24, 1997.
6. Desbarats J, Birge RB, Mimouni-Rongy M, Weinstein DE, Palerme JS, Newell MK. Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat Cell Biol 5: 118-125, 2003. (Pubitemid 36204194)
7. Desbarats J, Newell MK. Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 6: 920-923, 2000. (Pubitemid 30644752)
8. Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M. Mechanisms of β-cell death in type 2 diabetes. Diabetes 54, Suppl 2: S108-S113, 2005.
9. Drucker DJ. Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17: 161-171, 2003. (Pubitemid 36183142)
10. Hao Z, Hampel B, Yagita H, Rajewsky K. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med 199: 1355-1365, 2004. (Pubitemid 38685727)
11. Ingrid H, Wilhelm D, Bohler T, Angel P, Debatin KM. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 16: 6200-6208, 1997. (Pubitemid 27458340)
12. Itoh N, Imagawa A, Hanafusa T, Waguri M, Yamamoto K, Iwahashi H, Moriwaki M, Nakajima H, Miyagawa J, Namba M, Makino S, Nagata S, Kono N, Matsuzawa Y. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med 186: 613-618, 1997. (Pubitemid 27360805)
13. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233-243, 1991. (Pubitemid 121001362)
14. Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Breener O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173: 2976-2984, 2004. (Pubitemid 39142002)
15. Krammer PH. CD95's deadly mission in the immune system. Nature 407: 789-795, 2000.
16. Lee HO, Ferguson TA. Biology of FasL. Cytokine Growth Factor Rev 14: 325-335, 2003.
17. Liadis N, Murakami K, Eweida M, Elford AR, Sheu L, Gaisano HY, Hakem R, Ohashi PS, Woo M. Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol Cell Biol 25: 3620-3629, 2005. (Pubitemid 40559568)
18. Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, Li X, Sheu L, Eweida M, Xu S, Gaisano HY, Hakem R, Woo M. Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. Diabetes 56: 2302-2311, 2007. (Pubitemid 47358237)
19. Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415-417, 1976.
20. Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 47: 727-732, 1998.
21. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY. Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110: 851-860, 2002. (Pubitemid 35050963)
22. Mathis D, Vence L, Benoist C. Beta-cell death during progression to diabetes. Nature 414: 792-798, 2001.
23. Muzio M, Chinnaiyan AM, Kischikel FC, O'Rouke K, Shevchendo A, Scaffidi C, Bretz JD, Zhang M, Ni J, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED- 3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827, 1996. (Pubitemid 26193033)
24. Nagata S, Goldstein P. The Fas death factor. Science 267: 1449-1456, 1995.
25. Nakayama M, Nagata M, Yasuda H, Arisawa K, Kotani R, Yamada K, Chowdhury SA, Chakrabarty S, Jin ZZ, Yagita H, Yokono K, Kasuga M. Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes. Diabetes 51: 1391-1397, 2002. (Pubitemid 34826604)
26. Norlin S, Ahlgren U, Edlund H. Nuclear factor-κB activity in β-cells is required for glucose-stimulated insulin secretion. Diabetes 54: 125-132, 2005. (Pubitemid 40105103)
27. Ohlsson H, Karlsson K, Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12: 4251-4259, 1993. (Pubitemid 23302039)
28. Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH. The CD95 receptor: apoptosis revisited. Cell 129: 447-450, 2007.
29. Peter ME, Krammer PH. The CD95 (APO-1/Fas) DISC and beyond. Cell Death Differ 10: 26-35, 2003.
30. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles of glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274: 305-315, 1999. (Pubitemid 29035064)
31. Schumann DM, Maedler K, Franklin I, Konrad D, Storling J, Boni- Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY. The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci USA 104: 2861-2866, 2007. (Pubitemid 46327970)
32. Suarez-Pinzon W, Sorensen O, Bleackley RC, Elliott JF, Rajotte RV, Rabinovitch A. Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets. Diabetes 48: 21-28, 1999. (Pubitemid 29019348)
33. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969-977, 1994. (Pubitemid 24106378)
34. Vence L, Benoist C, Mathis D. Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells. Diabetes 53: 2797-2803, 2004. (Pubitemid 39425904)
35. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314-317, 1992.
36. Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M. Muscle-specific PTEN deletion protects against insulin resistance and diabetes. Mol Cell Biol 25: 1135-1145, 2005. (Pubitemid 40165819)