Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-κB

American Journal of Respiratory Cell and Molecular Biology

Volumn 43, Issue 2, 2010, Pages 201-209

  Tacon, Claire E ^a,b   Wiehler, Shahina ^b   Holden, Neil S ^b   Newton, Robert ^b   Proud, David ^b   Leigh, Richard ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Airway epithelial cell; Airway inflammation; Airway remodeling; Human rhinovirus; Matrix metalloproteinase 9

Indexed keywords

GELATINASE B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; OLIGONUCLEOTIDE; PROTEIN P50; PROTEIN SUBUNIT; SYNAPTOTAGMIN I; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADULT; AIRWAY REMODELING; ARTICLE; BASE PAIRING; BRONCHUS MUCOSA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; EPITHELIUM CELL; FEMALE; FLUORESCENCE ANALYSIS; GEL MOBILITY SHIFT ASSAY; HELA CELL; HUMAN; HUMAN CELL; HUMAN RHINOVIRUS; HUMAN TISSUE; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; MALE; NASAL LAVAGE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOVIRUS INFECTION; UPREGULATION; ZYMOGRAPHY; BIOSYNTHESIS; BRONCHUS; ENZYMOLOGY; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; PICORNAVIRUS INFECTION; RHINOVIRUS; VIROLOGY;

HUMAN RHINOVIRUS SP.; RHINOVIRUS;

BRONCHI; EPITHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HUMANS; INFLAMMATION; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PICORNAVIRIDAE INFECTIONS; RHINOVIRUS; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 77955498224     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0216OC     Document Type: Article

References (42)

1. Proud D, Chow CW. Role of viral infections in asthma and chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2006;35:513-518. (Pubitemid 44706423)
2. Mosser AG, Vrtis R, Burchell L, Lee WM, Dick CR, Weisshaar E, Bock D, Swenson CA, Cornwell RD, Meyer KC, et al. Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues. Am J Respir Crit Care Med 2005;171:645-651. (Pubitemid 40365422)
3. Papadopoulos NG, Bates PJ, Bardin PG, Papi A, Leir SH, Fraenkel DJ, Meyer J, Lackie PM, Sanderson G, Holgate ST, et al. Rhinoviruses infect the lower airways. J Infect Dis 2000;181:1875-1884.
4. Rossmann MG. Viral cell recognition and entry. Protein Sci 1994;3:1712-1725.
5. Proud D. Upper airway viral infections. Pulm Pharmacol Ther 2008;21:468-473.
6. Leigh R, Oyelusi W, Wiehler S, Koetzler K, Zaheer RS, Newton R, Proud D. Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling. J Allergy Clin Immunol 2008;121:1238-1245.
7. Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 2002;37:375-536. (Pubitemid 36071972)
8. Mercer PF, Shute JK, Bhowmik A, Donaldson GC, Wedzicha JA, Warner JA. MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation. Respir Res 2005;6:151.
9. Lemjabbar H, Gosset P, Lamblin C, Tillie I, Hartmann D, Wallaert B, Tonnel AB, Lafuma C. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med 1999;159:1298-1307. (Pubitemid 29202571)
10. Tacon CE, Wiehler S, Proud D, Leigh R. Rhinovirus infection of the airway epithelium regulates matrix metalloproteinase production: a potential mechanism in the pathogenesis of airway remodeling. Am J Respir Crit Care Med 2008;177:A728.
11. Tacon CE, Wiehler S, Newton R, Proud D, Leigh R. Human rhinovirus increases MMP-9 expression in vitro and in vivo. Am J Respir Crit Care Med 2009;179:A5146.
12. Gern JE, Vrtis R, Kelly EA, Dick EC, Busse WW. Rhinovirus produces nonspecific activation of lymphocytes through a monocyte-dependent mechanism. J Immunol 1996;157:1605-1612. (Pubitemid 126449100)
13. Sanders SP, Siekierski ES, Porter JD, Richards SM, Proud D. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line. J Virol 1998;72:934-942. (Pubitemid 28116870)
14. Churchill L, Chilton FH, Resau JH, Bascom R, Hubbard WC, Proud D. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am Rev Respir Dis 1989;140:449-459. (Pubitemid 19218364)
15. Mosser AG, Brockman-Schneider R, Amineva S, Burchell L, Sedgwick JB, Busse WW, Gern JE. Similar frequency of rhinovirus-infectible cells in upper and lower airway epithelium. J Infect Dis 2002;185:734-743. (Pubitemid 34226201)
16. Sanders SP, Siekierski ES, Richards SM, Porter JD, Imani F, Proud D. Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo. J Allergy Clin Immunol 2001;107:235-243. (Pubitemid 32173899)
17. Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seiki M, Boyd D. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem 1996;271:10672-10680. (Pubitemid 26145802)
18. Song Y, Qian L, Song S, Chen L, Zhang Y, Yuan G, Zhang H, Xia Q, Hu M, Yu M, et al. Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene. Mol Immunol 2008;45:137-143. (Pubitemid 47331648)
19. Westermarck J, Kahari VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999;13:781-792. (Pubitemid 29220691)
20. Koetzler R, Zaheer RS, Wiehler S, Holden NS, Giembycz MA, Proud D. Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells. J Allergy Clin Immunol 2009;123:201-208.
21. Sanders SP, Proud D, Permutt S, Siekierski ES, Yachechko R, Liu MC. Role of nasal nitric oxide in the resolution of experimental rhinovirus infection. J Allergy Clin Immunol 2004;113:697-702. (Pubitemid 38530426)
22. Wang X, Lau C, Wiehler S, Pow A, Mazzulli T, Gutierrez C, Proud D, Chow CW. Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cells. J Immunol 2006;177:6859-6870. (Pubitemid 44715051)
23. Lau C, Wang X, Song L, North M, Wiehler S, Proud D, Chow CW. Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization. J Immunol 2008;180:870-880.
24. Van Wart HE, Birkedal-Hansen H. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl Acad Sci USA 1990;87:5578-5582. (Pubitemid 20260224)
25. Kim J, Sanders SP, Siekierski ES, Casolaro V, Proud D. Role of NF-kappa B in cytokine production induced from human airway epithelial cells by rhinovirus infection. J Immunol 2000;165:3384-3392.
26. Yan C, Boyd DD. Regulation of matrix metalloproteinase gene expression. J Cell Physiol 2007;211:19-26. (Pubitemid 46363892)
27. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007;408:297-315.
28. Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, Barnes PJ. Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J Pharmacol Exp Ther 2007;321:734-742. (Pubitemid 46624511)
29. Chandrasekar B, Mummidi S, Mahimainathan L, Patel DN, Bailey SR, Imam SZ, Greene WC, Valente AJ. Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB- and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. J Biol Chem 2006;281:15099-15109. (Pubitemid 43855099)
30. Ogawa K, Chen F, Kuang C, Chen Y. Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-beta is mediated by a nuclear factor-kappaB site. Biochem J 2004;381:413-422. (Pubitemid 38969685)
31. He C. Molecular mechanism of transcriptional activation of human gelatinase B by proximal promoter. Cancer Lett 1996;106:185-191. (Pubitemid 126745149)
32. Wang JH, Kwon HJ, Jang YJ. Rhinovirus upregulates matrix metalloproteinase-2, matrix metalloproteinase-9, and vascular endothelial growth factor expression in nasal polyp fibroblasts. Laryngoscope 2009;119:1834-1838.
33. Ra HJ, Parks WC. Control of matrix metalloproteinase catalytic activity. Matrix Biol 2007;26:587-596.
34. Cataldo DD, Tournoy KG, Vermaelen K, Munaut C, Foidart JM, Louis R, Noel A, Pauwels RA. Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation. Am J Pathol 2002;161:491-498. (Pubitemid 36142158)
35. Kumagai K, Ohno I, Okada S, Ohkawara Y, Suzuki K, Shinya T, Nagase H, Iwata K, Shirato K. Inhibition of matrix metalloproteinases prevents allergen-induced airway inflammation in a murine model of asthma. J Immunol 1999;162:4212-4219. (Pubitemid 29314809)
36. McMillan SJ, Kearley J, Campbell JD, Zhu XW, Larbi KY, Shipley JM, Senior RM, Nourshargh S, Lloyd CM. Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol 2004;172:2586-2594. (Pubitemid 38182410)
37. Corry DB, Kiss A, Song LZ, Song L, Xu J, Lee SH, Werb Z, Kheradmand F. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J 2004;18:995-997. (Pubitemid 39561503)
38. Castaneda FE, Walia B, Vijay-Kumar M, Patel NR, Roser S, Kolachala VL, Rojas M, Wang L, Oprea G, Garg P, et al. Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology 2005;129:1991-2008.
39. Vignola AM, Paganin F, Capieu L, Scichilone N, Bellia M, Maakel L, Bellia V, Godard P, Bousquet J, Chanez P. Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD. Eur Respir J 2004;24:910-917.
40. Malavia NK, Raub CB, Mahon SB, Brenner M, Panettieri RA Jr, George SC. Airway epithelium stimulates smooth muscle proliferation. Am J Respir Cell Mol Biol 2009;41:297-304.
41. Hu J, Van den Steen PE, Sang QX, Opdenakker G. Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov 2007;6:480-498.
42. Cundall M, Sun Y, Miranda C, Trudeau JB, Barnes S, Wenzel SE. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J Allergy Clin Immunol 2003;112:1064-1071.