IL-11 expression is increased in severe asthma: Association with epithelial cells and eosinophils

Journal of Allergy and Clinical Immunology

Volumn 105, Issue 2 II, 2000, Pages 232-238

  Minshall, Eleanor ^a   Chakir, Jamila ^b   Laviolette, Michel ^b   Molet, Sophie ^a   Zhu, Zhou ^c   Olivenstein, Ron ^d   Elias, Jack A ^c   Hamid, Qutayba ^a  

^a MCGILL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Airway remodeling; Airways inflammation; Collagen deposition; IL 11; Severe asthma

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; INTERLEUKIN 11; MESSENGER RNA;

AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EOSINOPHIL; EPITHELIUM CELL; FIBROSIS; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; PRIORITY JOURNAL;

ASTHMA; BLOOD PROTEINS; COLLAGEN; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILS; EPITHELIAL CELLS; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERLEUKIN-11; LUNG; RIBONUCLEASES; RNA, MESSENGER; STAINING AND LABELING;

EID: 0033963493     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(00)90070-8     Document Type: Article

References (34)

1. Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960;13:27-33.
2. Jeffery PK. Comparative morphology of the airways in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994;150:S6-13.
3. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989;1:520-4.
4. Huang J, Olivenstein R, Taha R, Hamid QA, Ludwig M. Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med 1999;160:725-9.
5. Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB. Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989;140:1745-53.
6. James AL, Paré PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6.
7. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990;3:507-11.
8. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM Jr, et al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci USA 1990;87:7512-6.
9. Zhang XG, Gu JJ, Lu ZY, Yasukawa K, Yancopoulos GD, Turner K, et al. Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp 130. J Exp Med 1994;179:1337-42.
10. Du X, Williams DA. Interleukin-11: review of molecular, cell biology and clinical use. Blood 1997;89:3897-908.
11. Elias JA, Zheng T, Whiting NL, Trow TK, Merrill WW, Zitnik R, et al. IL-1 and transforming growth factor-β regulation of fibroblast-derived IL-11. J Immunol 1994;152:2421-9.
12. Romas E, Udagawa N, Zhou H, Tamura T, Saito M, Taga T, et al. The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. J Exp Med 1996;183:2581-91.
13. Nilsen EM, Johansen FE, Jahnsen FL, Lundin KE, Scholz T, Brandtzaeg P, et al. Cytokine profiles of cultured microvascular endothelial cells from the human intestine. Gut 1998;42:635-42.
14. Elias JA, Zheng T, Einarsson O, Landry M, Trow T, Rebert N, et al. Epithelial interleukin-11: regulation by cytokines, respiratory syncytial virus, and retinoic acid. J Biol Chem 1994;269:22261-8.
15. Einarsson O, Geba GP, Zhu Z, Landry M, Elias JA. Interleukin-11: Stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J Clin Invest 1996;97:915-24.
16. Zheng T, Nathanson MH, Elias JA. Histamine augments cytokine-stimulated IL-11 production by human lung fibroblasts. J Immunol 1994;153:4742-52.
17. Rochester CL, Ackerman SJ, Zheng T, Elias JA. Eosinophil-fibroblast interactions: granule major basic protein interacts with IL-1 and transforming growth factor-beta in the stimulation of lung fibroblast IL-6-type cytokine production. J Immunol 1996;156:4449-56.
18. Ray P, Tang W, Wang P, Homer R, Kuhn C III, Flavell RA, et al. Regulated overexpression of interleukin 11 in the lung: use to dissociate development-dependent and -independent phenotypes. J Clin Invest 1997;100:2501-11.
19. Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C III, et al. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest 1996;98:2845-53.
20. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-44.
21. Azzawi M, Bradley B, Jeffery PK, Frew AJ, Wardlaw AJ, Knowles G K, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990;142:1407-13.
22. Ying S, Durham SR, Barkans J, Matsuyama K, Jacobson M, Rak S, et al. T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis. Am J Respir Cell Mol Biol 1993;9:356-60.
23. Giaid A, Michel RP, Stewart DJ, Sheppard M, Corrin B, Hamid Q. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Lancet 1993;341:1550-4.
24. Hamid Q, Barkans J, Meng Q, Abrams JS, Kay AB, Moqbel R. Human eosinophils synthesize and secrete interleukin-6, in vitro. Blood 1992;80:1496-501.
25. Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Wakelin M, et al. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995;155:4939-47.
26. Maier R, Ganu V, Lotz M. Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J Biol Chem 1993;268:21527-32.
27. Trepicchio WL, Bozza M, Pedneault G, Dorner AJ. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J Immunol 1996;157:3627-34.
28. Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997;159:2161-8.
29. Hill GR, Cooke KR, Teshima T, Crawford JM, Keith JC Jr, Brinson YS, et al. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. J Clin Invest 1998;102:115-23.
30. Trepicchio WL, Wang L, Bozza M, Dorner AJ. IL-11 regulates macrophage effector function through the inhibition of nuclear factor-κB. J Immunol 1997;159:5661-70.
31. 1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1997;17:326-33.
32. Elias JA, Wu Y, Zheng T, Panettieri R. Cytokine- and virus-stimulated airway smooth muscle cells produce IL-11 and other IL-6-type cytokines. Am J Physiol 1997;273:L648-55.
33. Lacy P, Levi-Schaffer F, Mahmudi-Azer S, Bablitz B, Hagen SC, Velazquez J, et al. Intracellular localization of interleukin-6 in eosinophils from atopic asthmatics and effects of interferon gamma. Blood 1998;91:2508-16.
34. Marini M, Vittori E, Hollemborg J, Mattoli S. Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol 1992;89:1001-9.