Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways

European Respiratory Journal

Volumn 36, Issue 6, 2010, Pages 1425-1435

  Hewson, C A ^a,b   Haas, J J ^a,b   Bartlett, N W ^a,b   Message, S D ^a,b,c   Laza Stanca, V ^a,b   Kebadze, T ^a,b   Caramori, G ^e   Zhue, J ^a   Edbrooke, M R ^d   Stanciu, L A ^a,b   Kon, O M ^c   Papi, A ^e   Jefferye, P K ^a   Edwards, M R ^a,b   Johnston, S L ^a,b,c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

^e UNIVERSITY OF FERRARA   (Italy)

Author keywords

Asthma; Chronic obstructive pulmonary disease; Epidermal growth factor receptor; MUC5AC; Nuclear factor B; Rhinovirus

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 5AC; SYNAPSIN I; TRANSFORMING GROWTH FACTOR ALPHA;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; DISEASE EXACERBATION; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION; RHINOVIRUS; RHINOVIRUS INFECTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION; VIRUS INDUCTION; VIRUS LOAD;

ADULT; ASTHMA; BRONCHI; CELL LINE; EPITHELIAL CELLS; HUMANS; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUCIN 5AC; NF-KAPPA B; PICORNAVIRIDAE INFECTIONS; PROMOTER REGIONS, GENETIC; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHINOVIRUS; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR ALPHA; UP-REGULATION; VIRAL LOAD;

EID: 78049280936     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00026910     Document Type: Article

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