IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction

Journal of Immunology

Volumn 184, Issue 9, 2010, Pages 5179-5185

  Stirnweiss, Anja ^a,b   Ksienzyk, Antje ^a   Klages, Katjana ^a   Rand, Ulfert ^a   Grashoff, Martina ^a   Hauser, Hansjörg ^a   Kröger, Andrea ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; UNCLASSIFIED DRUG; VIPERIN; VIRUS PROTEIN; VIRUS VECTOR; INTERFERON; IRF1 PROTEIN, MOUSE; PROTEIN; VIG1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIVIRAL ACTIVITY; ARTICLE; CELL PROTECTION; CYTOKINE RELEASE; FIBROBLAST; GENE INDUCTION; GENE TARGETING; GENETIC TRANSCRIPTION; INNATE IMMUNITY; MOUSE; NEWCASTLE DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; REGULATORY MECHANISM; UPREGULATION; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; VIRUS MUTANT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL STRAIN 3T3; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VESICULAR STOMATITIS; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE I; MICE; MICE, KNOCKOUT; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VESICULAR STOMATITIS; VESICULAR STOMATITIS INDIANA VIRUS; VIRUS REPLICATION;

EID: 77954472780     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902264     Document Type: Article

References (35)

1. Trinchieri, G., and A. Sher. 2007. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 7: 179-190.
2. Zhou, A., J. M. Paranjape, S. D. Der, B. R. Williams, and R. H. Silverman. 1999. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. Virology 258: 435-440.
3. Zhu, H., J. P. Cong, and T. Shenk. 1997. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc. Natl. Acad. Sci. USA 94: 13985-13990.
4. Boudinot, P., P. Massin, M. Blanco, S. Riffault, and A. Benmansour. 1999. vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. J. Virol. 73: 1846-1852.
5. Grewal, T. S., P. G. Genever, A. C. Brabbs, M. Birch, and T. M. Skerry. 2000. Best5: a novel interferon-inducible gene expressed during bone formation. FASEB J. 14: 523-531.
6. Zhou, Z., O. J. Hamming, N. Ank, S. R. Paludan, A. L. Nielsen, and R. Hartmann. 2007. Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J. Virol. 81: 7749-7758.
7. Olofsson, P. S., K. Jatta, D. Wå gsäter, S. Gredmark, U. Hedin, G. Paulsson-Berne, C. Söderberg-Nauclér, G. K. Hansson, and A. Sirsjö. 2005. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Arterioscler. Thromb. Vasc. Biol. 25: e113-e116.
8. Severa, M., E. M. Coccia, and K. A. Fitzgerald. 2006. Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J. Biol. Chem. 281: 26188-26195.
9. Boudinot, P., S. Riffault, S. Salhi, C. Carrat, C. Sedlik, N. Mahmoudi, B. Charley, and A. Benmansour. 2000. Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways. J. Gen. Virol. 81: 2675-2682.
10. Chin, K. C., and P. Cresswell. 2001. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc. Natl. Acad. Sci. USA 98: 15125-15130.
11. Wang, X., E. R. Hinson, and P. Cresswell. 2007. The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe 2: 96-105.
12. Chan, Y. L., T. H. Chang, C. L. Liao, and Y. L. Lin. 2008. The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. J. Virol. 82: 10455-10464.
13. Qiu, L. Q., P. Cresswell, and K. C. Chin. 2009. Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood 113: 3520-3529.
14. Rivieccio, M. A., H. S. Suh, Y. Zhao, M. L. Zhao, K. C. Chin, S. C. Lee, and C. F. Brosnan. 2006. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J. Immunol. 177: 4735-4741.
15. Helbig, K. J., D. T. Lau, L. Semendric, H. A. Harley, and M. R. Beard. 2005. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. . Hepatology 42: 702-710.
16. Zhang, Y., C. W. Burke, K. D. Ryman, and W. B. Klimstra. 2007. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J. Virol. 81: 11246-11255.
17. Hinson, E. R., and P. Cresswell. 2009. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J. Biol. Chem. 284: 4705-4712.
18. Haller, O., G. Kochs, and F. Weber. 2006. The interferon response circuit: induction and suppression by pathogenic viruses. Virology 344: 119-130.
19. Kröger, A., A. Dallügge, S. Kirchhoff, and H. Hauser. 2003. IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo. Oncogene 22: 1045-1056.
20. Kirchhoff, S., F. Schaper, and H. Hauser. 1993. Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes. Nucleic Acids Res. 21: 2881-2889.
21. Hennecke, M., M. Kwissa, K. Metzger, A. Oumard, A. Kröger, R. Schirmbeck, J. Reimann, and H. Hauser. 2001. Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs. Nucleic Acids Res. 29: 3327-3334.
22. Klar, M., and J. Bode. 2005. Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. Mol. Cell. Biol. 25: 10159-10170.
23. Dinter, H., and H. Hauser. 1987. Cooperative interaction of multiple DNA elements in the human interferon-beta promoter. European journal of biochemistry / FEBS 166:103-109.
24. Kröger, A., A. Stirnweiss, J. E. Pulverer, K. Klages, M. Grashoff, J. Reimann, and H. Hauser. 2007. Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1. Cancer Res. 67: 2972-2981.
25. Kröger, A., M. Köster, K. Schroeder, H. Hauser, and P. P. Mueller. 2002. Activities of IRF-1. J. Interferon Cytokine Res. 22: 5-14.
26. Pine, R., A. Canova, and C. Schindler. 1994. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. EMBO J. 13: 158-167.
27. Marcus, P. I., and M. J. Sekellick. 1985. Interferon induction by viruses. XIII. Detection and assay of interferon induction-suppressing particles. Virology 142: 411-415.
28. Stojdl, D. F., B. D. Lichty, B. R. tenOever, J. M. Paterson, A. T. Power, S. Knowles, R. Marius, J. Reynard, L. Poliquin, H. Atkins, et al. 2003. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 4: 263-275.
29. Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, T. W. Mak, et al. 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264: 1921-1924.
30. Trilling, M., V. T. Le, A. Zimmermann, H. Ludwig, K. Pfeffer, G. Sutter, G. L. Smith, and H. Hengel. 2009. Gamma interferon-induced interferon regulatory factor 1-dependent antiviral response inhibits vaccinia virus replication in mouse but not human fibroblasts. J. Virol. 83: 3684-3695.
31. Kanazawa, N., M. Kurosaki, N. Sakamoto, N. Enomoto, Y. Itsui, T. Yamashiro, Y. Tanabe, S. Maekawa, M. Nakagawa, C. H. Chen, et al. 2004. Regulation of hepatitis C virus replication by interferon regulatory factor 1. J. Virol. 78: 9713-9720.
32. Pine, R. 1992. Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection. J. Virol. 66: 4470-4478.
33. Prescott, J. B., P. R. Hall, V. S. Bondu-Hawkins, C. Ye, and B. Hjelle. 2007. Early innate immune responses to Sin Nombre hantavirus occur independently of IFN regulatory factor 3, characterized pattern recognition receptors, and viral entry. J. Immunol. 179: 1796-1802.
34. Paladino, P., D. T. Cummings, R. S. Noyce, and K. L. Mossman. 2006. The IFN-independent response to virus particle entry provides a first line of antiviral defense that is independent of TLRs and retinoic acid-inducible gene I. J. Immunol. 177: 8008-8016.
35. Maloy, K. J., B. Odermatt, H. Hengartner, and R. M. Zinkernagel. 1998. Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection. Proc. Natl. Acad. Sci. USA 95: 1160-1165.