Viral respiratory infection and the link to asthma

Pediatric Infectious Disease Journal

Volumn 27, Issue SUPPL. 10, 2008, Pages

  Gern, James E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Asthma; Respiratory Syncytial virus; Rhinovirus

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; BRONCHODILATING AGENT; LEUKOTRIENE RECEPTOR BLOCKING AGENT;

ABNORMAL RESPIRATORY SOUND; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHILD; HUMAN; HYGIENE; HYPERSENSITIVITY; IMMUNOLOGY; INFANT; INFLAMMATION; LUNG; NEWBORN; PRESCHOOL CHILD; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; VIRAL BRONCHIOLITIS; VIROLOGY; VIRUS INFECTION;

ANTI-INFLAMMATORY AGENTS; ANTIVIRAL AGENTS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIOLITIS, VIRAL; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; HUMANS; HYGIENE; HYPERSENSITIVITY; INFANT; INFANT, NEWBORN; INFLAMMATION; LEUKOTRIENE ANTAGONISTS; LUNG; RESPIRATORY SOUNDS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; RESPIRATORY TRACT INFECTIONS; VIRUS DISEASES;

EID: 56149097660     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e318168b718     Document Type: Conference Paper

References (85)

1. Lemanske RF Jr, Jackson DJ, Gangnon RE, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol. 2005;116:571-577. (Pubitemid 41267130)
2. Allander T, Jartti T, Gupta S, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis. 2007;44:904-910. (Pubitemid 46452052)
3. Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354:541-545. (Pubitemid 29381367)
4. Wennergren G, Kristjansson S. Relationship between respiratory syncytial virus bronchiolitis and future obstructive airway diseases. Eur Respir J. 2001;18:1044-1058. (Pubitemid 34092880)
5. Kneyber MCJ, Steyerberg EW, de Groot R, Moll HA. Long-term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review. Acta Paediatr. 2000;89:654-660. (Pubitemid 30624907)
6. Castro-Rodriguez JA, Holberg CJ, Wright AL, et al. Association of radiologically ascertained pneumonia before age 3 yr with asthmalike symptoms and pulmonary function during childhood: a prospective study. Am J Respir Crit Care Med. 1999;159:1891-1897. (Pubitemid 29275060)
7. Kotaniemi-Syrjanen A, Vainionpaa R, Reijonen TM, Waris M, Korhonen K, Korppi M. Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma? J Allergy Clin Immunol. 2003;111:66-71. (Pubitemid 36143293)
8. Kusel MM, de Klerk NH, Kebadze T, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007;119:1105-1110. (Pubitemid 46654175)
9. Johnston SL, Pattemore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995;310:1225-1229.
10. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ. 1993;307:982-986. (Pubitemid 23306765)
11. Johnston SL, Pattemore PK, Sanderson G, et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time trend analysis. Am J Respir Crit Care Med. 1996;154:654-660. (Pubitemid 26327287)
12. Rakes GP, Arruda E, Ingram JM, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med. 1999;159:785-790. (Pubitemid 29137774)
13. Atmar RL, Guy E, Guntupalli KK, et al. Respiratory tract viral infections in inner-city asthmatic adults. Arch Intern Med. 1998;158:2453-2459. (Pubitemid 28555504)
14. Doyle WJ, Skoner DP, Fireman P, et al. Rhinovirus 39 infection in allergic and nonallergic subjects. J Allergy Clin Immunol. 1992;89:968-978.
15. Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet. 2002;359:831-834. (Pubitemid 34233753)
16. Gern JE, Vrtis R, Grindle KA, Swenson C, Busse WW. Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med. 2000;162:2226-2231. (Pubitemid 32051692)
17. Green RM, Cusotvic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. Br Med J. 2002;324:763.
18. Tarlo SM, Broder I, Corey P, et al. The role of symptomatic colds in asthma exacerbations: influence of outdoor allergens and air pollutants. J Allergy Clin Immunol. 2001;108:52-58.
19. Smyth AR, Smyth RL, Tong CY, Hart CA, Heaf DP. Effect of respiratory virus infections including rhinovirus on clinical status in cystic fibrosis. Arch Dis Child. 1995;73:117-120.
20. Seemungal TA, Harper-Owen R, Bhowmik A, Jeffries DJ, Wedzicha JA. Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease. Eur Respir J. 2000;16:677-683.
21. Nicholson KG, Kent J, Hammersley V, Cancio E. Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study. BMJ. 1996;313: 1119-1123. (Pubitemid 26362953)
22. Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299: 1259-1260. (Pubitemid 19280051)
23. Bufford JD, Gern JE. The hygiene hypothesis revisited. Immunol Allergy Clin North Am. 2005;25:247-262. (Pubitemid 40692708)
24. Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med. 2000;343:538-543. (Pubitemid 30654817)
25. Oddy WH, de Klerk NH, Sly PD, Holt PG. The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J. 2002;19:899-905. (Pubitemid 34567905)
26. Schaub B, Lauener R, von Mutius E. The many faces of the hygiene hypothesis. J Allergy Clin Immunol. 2006;117:969-977.
27. Liu AH. Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol. 2002;109:379-392. (Pubitemid 34234185)
28. Gereda JE, Leung DY, Thatayatikom A, et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet. 2000;355:1680-1683. (Pubitemid 30248480)
29. Arruda E, Boyle TR, Winther B, Pevear DC, Gwaltney JM, Hayden FG. Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization. J Infect Dis. 1995;171:1329-1333.
30. Mosser AG, Brockman-Schneider RA, Amineva SP, et al. Similar frequency of rhinovirus-infectable cells in upper and lower airway epithelium. J Infect Dis. 2002;185:734-743. (Pubitemid 34226201)
31. Ohrui T, Yamaya M, Sekizawa K, et al. Effects of rhinovirus infection on hydrogen peroxide-induced alterations of barrier function in the cultured human tracheal epithelium. Am J Respir Crit Care Med. 1998;158:241-2248.
32. Kurt-Jones EA, Popova L, Kwinn L, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 2000;1:398-401.
33. Casola A, Burger N, Liu T, Jamaluddin M, Brasier AR, Garofalo RP. Oxidant tone regulates RANTES gene expression in airway epithelial cells infected with respiratory syncytial virus. Role in viral-induced interferon regulatory factor activation. J Biol Chem. 2001;276:19715-19722.
34. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll- like receptor 3. Nature. 2001;413:732-738. (Pubitemid 33009951)
35. Edwards MR, Slater L, Johnston SL. Signalling pathways mediating type I interferon gene expression. Microbes Infect. 2007;9:1245-1251. (Pubitemid 47554534)
36. Edwards MR, Hewson CA, Laza-Stanca V, et al. Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells. Mol Immunol. 2007;44:1587-1597.
37. Gern JE, French DA, Grindle KA, Brockman-Schneider RA, Konno S, Busse WW. Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells. Am J Respir Cell Mol Biol. 2003;28:731-737. (Pubitemid 36677177)
38. Hall DJ, Bates ME, Guar L, Cronan M, Korpi N, Bertics PJ. The role of p38 MAPK in rhinovirus-induced monocyte chemoattractant protein-1 production by monocytic-lineage cells. J Immunol. 2005;174:8056-8063. (Pubitemid 40812371)
39. Korpi-Steiner NL, Bates ME, Lee WM, Hall DJ, Bertics PJ. Human rhinovirus induces robust IP-10 release by monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and STAT1 activation. J Leukoc Biol. 2006;80:1364-1374. (Pubitemid 44904975)
40. Cardell LO, Agusti C, Takeyama K, Stjarne P, Nadel JA. LTB(4)-induced nasal gland serous cell secretion mediated by neutrophil elastase. Am J Respir Crit Care Med. 1999;160:411-414. (Pubitemid 29380650)
41. Grünberg K, Timmers MC, Smits HH, et al. Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy. 1997;27:36-45. (Pubitemid 27051361)
42. Gern JE, Martin MS, Anklam KA, et al. Relationships among specific viral pathogens, virus-induced interleukin- 8, and respiratory symptoms in infancy. Pediatr Allergy Immunol. 2002;13:386-393. (Pubitemid 36069949)
43. Malcolm E, Arruda E, Hayden FG, Kaiser L. Clinical features of patients with acute respiratory illness and rhinovirus in their bronchoalveolar lavages. J Clin Virol. 2001;21:9-16.
44. Cheung D, Dick EC, Timmers MC, De Klerk EP, Spaan WJ, Sterk PJ. Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. Am J Respir Crit Care Med. 1995;152:1490-1496.
45. Jacoby DB. Virus-induced asthma attacks. JAMA. 2002;287:755-761. (Pubitemid 34256350)
46. Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life. N Engl J Med. 1995;332:133-138.
47. Singh AM, Moore PE, Gern JE, Lemanske RF Jr, Hartert TV. Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation. Am J Respir Crit Care Med. 2007;175:108-119. (Pubitemid 46115081)
48. Murray M, Webb MS, O'Callaghan C, Swarbrick AS, Milner AD. Respiratory status and allergy after bronchiolitis. Arch Dis Child. 1992; 67:482-487.
49. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med. 2000;161: 1501-1507. (Pubitemid 30329018)
50. Gern JE, Calhoun WJ, Swenson C, Shen G, Busse WW. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects. Am J Respir Crit Care Med. 1997;155:1872-1876. (Pubitemid 27256111)
51. Avila PC, Abisheganaden JA, Wong H, et al. Delayed onset of rhinovirus (RV)-16 common cold in allergic rhinitic subjects primed with nasal allergen challenges. J Allergy Clin Immunol. 1999;103:S117.
52. De Kluijver J, Evertse CE, Sont JK, et al. Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure? Am J Respir Crit Care Med. 2003;168:1174-1180. (Pubitemid 37421834)
53. Sakamoto M, Ida S, Takishima T. Effect of influenza virus infection on allergic sensitization to aerosolized ovalbumin in mice. J Immunol. 1984;132:2614-2617. (Pubitemid 14136863)
54. Papadopoulos NG, Xepapadaki P, Mallia P, et al. Mechanisms of virus-induced asthma exacerbations: state-of-the-art. Allergy. 2007;62: 457-470.
55. Lemanske RF Jr, Dick EC, Swenson CA, Vrtis RF, Busse WW. Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest. 1989;83:1-10. (Pubitemid 19048397)
56. Calhoun WJ, Swenson CA, Dick EC, Schwartz LB, Lemanske RF Jr, Busse WW. Experimental rhinovirus 16 infection potentiates histamine release after antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis. 1991;144:1267-1273.
57. Calhoun WJ, Dick EC, Schwartz LB, Busse WW. A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J Clin Invest. 1994;94:2200-2208. (Pubitemid 24379589)
58. Kumar A, Sorkness RL, Kaplan MR, Lemanske RF Jr. Chronic, episodic, reversible airway obstruction after viral bronchiolitis in rats. Am J Respir Crit Care Med. 1997;155:130-134. (Pubitemid 27053153)
59. Kaplan MR, Moore J, Sorkness RL, Stokes J, Lemanske RF Jr. Strain differences in mononuclear cell interferon-g in relationship to virusinduced airway dysfunction. J Allergy Clin Immunol. 1997;99:S126.
60. Mikus LD, Rosenthal LA, Sorkness RL, Lemanske RF Jr. Reduced interferon-gamma secretion by natural killer cells from rats susceptible to postviral chronic airway dysfunction. Am J Respir Cell Mol Biol. 2001;24:74-82. (Pubitemid 32097510)
61. Sorkness RL, Castleman WL, Kumar A, Kaplan MR, Lemanske RF Jr. Prevention of chronic postbronchiolitis airway sequelae with IFN-g treatment in rats. Am J Respir Crit Care Med. 1999;160:705-710. (Pubitemid 29380693)
62. Walter MJ, Morton JD, Kajiwara N, Agapov E, Holtzman MJ. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest. 2002;110:165-175. (Pubitemid 34787353)
63. Renzi PM, Turgeon JP, Marcotte JE, et al. Reduced interferon-gamma production in infants with bronchiolitis and asthma. Am J Respir Crit Care Med. 1999;159:1417-1422. (Pubitemid 29227847)
64. Parry DE, Busse WW, Sukow KA, Dick CR, Swenson CA, Gern JE. Rhinovirus-induced peripheral blood mononuclear cell responses and outcome of experimental infection in allergic subjects. J Allergy Clin Immunol. 2000;105:692-698. (Pubitemid 30226441)
65. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type 1 response to rhinovirus in atopic asthma. Thorax. 2002;57:328-332. (Pubitemid 34298930)
66. Contoli M, Message SD, Laza-Stanca V, et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med. 2006; 12:1023-1026. (Pubitemid 44353382)
67. Wark PA, Johnston SL, Bucchieri F, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005;201:937-947. (Pubitemid 40524463)
68. Brooks GD, Buchta KA, Gern JE, Busse WW. Association of rhinovirus-induced IFN-g with increased asthma severity. Am J Respir Crit Care Med. 2003;168:1091-1094.
69. Patel H, Gouin S, Platt RW. Randomized, double-blind, placebo-controlled trial of oral albuterol in infants with mild-to-moderate acute viral bronchiolitis. J Pediatr. 2003;142:509-514. (Pubitemid 36623560)
70. Schindler M. Do bronchodilators have an effect on bronchiolitis? Crit Care. 2002;6:111-112. (Pubitemid 34296336)
71. Reddel H, Ware S, Marks G, Salome C, Jenkins C, Woolcock A. Differences between asthma exacerbations and poor asthma control. Lancet. 1999;353:364-369. (Pubitemid 29088164)
72. Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic corticosteroids in infant bronchiolitis: a meta-analysis. Pediatrics. 2000;105:E44.
73. Gern JE, Lemanske RF. Infectious triggers of pediatric asthma. Pediatr Clin North Am. 2003;50:555-575. (Pubitemid 36807607)
74. Lehtinen P, Ruohola A, Vanto T, Vuorinen T, Ruuskanen O, Jartti T. Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema. J Allergy Clin Immunol. 2007;119:570-575.
75. Brunette MG, Lands L, Thibodeau LP. Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infections. Pediatrics. 1988;81:624-629.
76. Garofalo R, Kimpen JLL, Welliver RC, Ogra PL. Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. J Pediatr. 1992;120:28-32.
77. van Schaik SM, Tristram DA, Nagpal IS, Hintz KM, Welliver RC, Welliver RC. Increased production of IFN-gamma and cysteinyl leukotrienes in virus-induced wheezing. J Allergy Clin Immunol. 1999;103: 630-636. (Pubitemid 29295570)
78. Bisgaard H. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med. 2003;167:379-383. (Pubitemid 36216419)
79. Lee WM, Kiesner C, Pappas T, et al. A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS ONE. 2007;2:e966.
80. Wenzel SE, Gibbs RL, Lehr MV, Simoes EA. Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin. Am J Med. 2002;112:627-633. (Pubitemid 34597163)
81. Simoes EA, Groothuis JR, Carbonell-Estrany X, et al. Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing. J Pediatr. 2007;151:34-42, 42.e1.
82. Rotbart HA. Pleconaril treatment of enterovirus and rhinovirus infections. Infect Med. 2000;17:488-494. (Pubitemid 30484287)
83. Rotbart HA. Treatment of picornavirus infections. Antiviral Res. 2002; 53:83-98. (Pubitemid 34062830)
84. Turner RB, Dutko FJ, Goldstein NH, Lockwood G, Hayden FG. Efficacy of oral WIN 54954 for prophylaxis of experimental rhinovirus infection. Antimicrob Agents Chemother. 1993;37:297-300. (Pubitemid 23046572)
85. Turner RB, Wecker MT, Pohl G, et al. Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection-a randomized clinical trial. J Am Med Assoc. 1999;281:1797-1804. (Pubitemid 29231129)