Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath

Thorax

Volumn 59, Issue 9, 2004, Pages 757-760

  Lane, C ^b   Knight, D ^c   Burgess, S ^a,b   Franklin, P ^b   Horak, F ^a,b   Legg, J ^a,b   Moeller, A ^a,b   Stick, S ^a,b  

^a PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ADOLESCENT; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; EPITHELIUM CELL; EXPIRED AIR; FEMALE; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; STAINING;

ADOLESCENT; ASTHMA; BREATH TESTS; BRONCHI; CHILD; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RNA;

EID: 4544317836     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2003.014894     Document Type: Article

References (21)

1. Maziak W, Loukides S, Culpitt S, et al. Exhaled nitric oxide in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:998-1002.
2. Wang CH, Liu CY, Lin HC, et al. Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages. Eur Respir J 1998;11:809-15.
3. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995;8:295-7.
4. Kharitonov SA, Yates D, Springall DR, et al. Exhaled nitric oxide is increased in asthma. Chest 1995;107:156-75.
5. Silkoff PE, Robbins RA, Gaston B, et al. Endogenous nitric oxide in allergic airway disease. J Allergy Clin Immunol 2000;105:438-48.
6. Kobzik L, Bredt DS, Lowenstein CJ, et al. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 1993;9:371-7.
7. Asano K, Chee CB, Gaston B, et al. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci USA 1994;91:10089-93.
8. Yates DH, Kharitonov SA, Thomas PS, et al. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am J Respir Crit Care Med 1996;154:247-50.
9. Hansel TT, Kharitonov SA, Donnelly LE, et al. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J 2003;17:1298-300.
10. De Sanctis GT, Mehta S, Kobzik L, et al. Contribution of type I NOS to expired gas NO and bronchial responsiveness in mice. Am J Physiol 1997;273:L883-8.
11. Tulic MK, Wale JL, Holt PG, et al. Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model. Eur Respir J 2000;15:870-7.
12. Cook S, Vollenweider P, Menard B, et al. Increased eNO and pulmonary iNOS expression in eNOS null mice. Eur Respir J 2003;21:770-3.
13. Vaughan DJ, Brogan TV, Kerr ME, et al. Contributions of nitric oxide synthase isozymes to exhaled nitric oxide and hypoxic pulmonary vasoconstriction in rabbit lungs. Am J Physiol Lung Cell Mol Physiol 2003;284:L834-43.
14. Silkoff PE, McClean PA, Slutsky AS, et al. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med 1997;155:260-7.
15. Dotsch J, Puls J, Klimek T, et al. Reduction of neuronal and inducible nitric oxide synthase gene expression in patients with cystic fibrosis. Eur Arch Otorhinolaryngol 2002;259:222-6.
16. Saur D, Seidler B, Paehge H, et al. Complex regulation of human neuronal nitric-oxide synthase exon 1c gene transcription. Essential role of Sp and ZNF family members of transcription factors. J Biol Chem 2002;277:25798-814.
17. Chambers RC. Gene expression profiling: good housekeeping and a clean message. Thorax 2002;57:754-6.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT- PCR. Nucleic Acids Res 2001;29:e45.
19. Geigel EJ, Hyde RW, Perillo IB, et al. Rate of nitric oxide production by lower alveolar airways of human lungs. J Appl Physiol 1999;86:211-21.
20. Franklin PJ, Taplin R, Stick SM. A community study of exhaled nitric oxide in healthy children. Am J Respir Crit Care Med 1999;159:69-73.
21. Pedroletti C, Hogman M, Merilainen P, et al. Nitric oxide airway diffusing capacity and mucosal concentration in asthmatic schoolchildren. Pediatr Res 2003;54:496-501.