The lung HETEs (and EETs) up

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 1 49-1, 2001, Pages

  Jacobs, Elizabeth R ^a   Zeldin, Darryl C ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Arachidnoic acid; Bronchi; Bronchospasm; Cytochrome P 450; Eicosanoids; Hypoxic vasoconstriction; Inflammation; Mitogenesis; Monooxygenases; Pulmonary arteries

Indexed keywords

17 OCTADECYNOIC ACID; ANTISENSE OLIGONUCLEOTIDE; ARACHIDONIC ACID; CYTOCHROME P450; EPOXYICOSATRIENOIC ACID; HYDROXYICOSATETRAENOIC ACID; LIPOXYGENASE; PROADIFEN; PROSTAGLANDIN SYNTHASE;

ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; BRONCHUS MUSCLE; BRONCHUS TONE; CELL DAMAGE; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; HUMAN; HYPOXIA; ION TRANSPORT; LUNG FUNCTION; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; MITOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REOXYGENATION; RESPIRATORY EPITHELIUM; REVIEW; THROMBOCYTE AGGREGATION;

EID: 0035013924     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.1.h1     Document Type: Review

References (115)

1. Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls
2. 20-HETE agonists and antagonists in the renal circulation
3. Induction of P4504A activity improves pressure-natriuresis in Dahl S rats
4. Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries
5. Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue
6. Prostaglandin E receptors and the kidney
7. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone
8. Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence
9. Cytochrome P450 and the arachidonate cascade
10. Eicosanoid metabolism and bioactivation by microsomal cytochrome P450
11. Cytochrome P450 and the metabolism of arachidonic acid and oxygenated eicosanoids
12. Intracellular expression and function of antisense catalytic RNAs
13. Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids
14. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells
15. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor
16. Effects of acute and chronic hypoxia on rat lung cyclooxygenase
17. Pharmacological characterization of leukotriene receptors
18. Leukotriene receptors
19. The cytochrome P450 monooxygenase system of rabbit lung: Enzyme components, activities, and induction in the nonciliated bronchiolar epithelial, alveolar type II cell, and alveolar macrophage
20. The effect of substrate on the expression of activity catalyzed by cytochrome P450: Metabolism mediated by rabbit isozyme 6 in pulmonary microsomal and reconstituted monooxygenase systems
21. Asthma therapy with agents preventing leukotriene synthesis or action
22. Treatment of asthma with drugs modifying the leukotriene pathway
23. Ca channels
24. Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro
25. Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets
26. 2 production in vascular smooth muscle cells
27. Cytochrome P450 2C is an EDHF synthase in coronary arteries
28. Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry
29. Primary structures of multiple forms of cytochrome P450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs
30. Allergic lung responses are increased in prostaglandin H synthase-deficient mice
31. 2+ current
32. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension
33. Human cytochrome P450 enzymes
34. Production of recombinant adeno-associated viral vectors
35. Functional hyperemia in the brain: Hypothesis for astrocyte-derived vasodilator metabolites
36. Identification of a putative microvascular oxygen sensor
37. Bronchoconstrictor and anti-bronchoconstrictor properties of inhaled prostacyclin in asthma
38. + exchange and are mitogenic in cultured rat glomerular mesangial cells
39. Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector mediated lung inflammation and enhances transgene expression
40. Adult respiratory distress syndrome - An update
41. Arachidonic acid metabolism: Implications of biological chemistry for lung function and disease
42. Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids
43. Prostaglandins and the lung
44. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
45. 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice
46. Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats
47. Airway synthesis of 20-HETE: Metabolism by cyclooxygenase to a bronchodilator
48. Effects of epoxyeicosatrienoic acids on ion transport in rabbit collecting tubules
49. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats
50. Ketaoconazole activates Cl conductance and blocks Cl and fluid absorption by cultured cystic fibrosis cells
51. Cloning of the CYP2J2 gene and identification of polymorphisms
52. Bioactivation of arachidonic acid by cytochrome P450 monooxygenases of guinea pig lung: The orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids
53. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
54. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism
55. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries
56. Cytochrome P450, the arachidonic acid cascade, and hypertension: New vistas for an old enzyme system
57. Structure-function studies and physiological roles of eicosanoids metabolized by cytochrome P450 ω hydroxylases
58. Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E coli
59. Pulmonary P-450-mediated eicosanoid metabolism and regulation in the pregnant rabbit
60. Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal epithelium: Involvement of a cytochrome P-450B1 isoform
61. 2 on airway conductance in healthy subjects and asthmatic patients
62. Cytochrome P450 metabolism of arachidonic acid
63. Cytochrome P450 knockout mice: New toxicological models
64. Cerebral microvascular endothelial cell tube formation: Role of astrocytic epoxyeicosatetrienoic acid release
65. Prostanoid receptors: Structures, properties and functions
66. How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress
67. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
68. Kinetic profile of the rat CYP4A isoforms: Arachidonic acid metabolism and isoform-specific inhibitors
69. Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vive
70. Anti inflammatory properties of cytochrome P450 expoxygenase-derived eicosanoids
71. Induction of the monooxygenase enzyme system in human lung
72. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation
73. Analyses of bronchial bulky DNA adduct levels and CYP2C9, GSTP1 and NQO1 genotypes in a Hungarian study population with pulmonary diseases
74. Epoxygenase metabolites of arachidonic acid affect electrophysiologic properties of rat tracheal epithelial cells
75. Effect of inhaled prostaglandin E2 on allergen-induced asthma
76. Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta
77. Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2
78. Formation of 20-hydroxyprostaglandins by lungs of pregnant rabbits
79. Nutritional status modulates rat liver cytochrome P450 arachidonic acid metabolism
80. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity
81. Expression of xenobiotic-metabolizing cytochrome P450s in human pulmonary tissues
82. Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide
83. Direct modulation of tracheal Cl channel activity by 5,6- and 11, 12-EET
84. P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues
85. 1-ATPase
86. The distribution of cytochrome P450 monooxygenase in cells of the rabbit lung: An ultrastructural immunocytochemical characterization
87. Targeting the proteolytic arsenal of neutrophils. A promising approach for postpump syndrome and ARDS
88. Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and support blood flow to hypoxic alveoli in anesthetized rabbits
89. Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats
90. Inhibition of cytochrome P-450 attenuates hypoxemia of acute lung injury in dogs
91. 5,6-Epoxyeicosatrienoic acid reduces increase in pulmonary vascular resistance in the dog
92. Inhibition of renal AA ω-hydroxylase activity with ABT reduced blood pressure in the SHR
93. Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles
94. Nitric oxide and prostaglandins mediate vasodilation to 5,6-EET in rabbit lung
95. Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in rat kidneys
96. Mechanisms of hypoxic pulmonary vasoconstriction: Can anyone be right?
97. Arachidonic acid metabolites: Mediators of inflammation in asthma
98. Generation of transgenic mouse with lung-specific overexpression of the human interleukin-1 receptor antagonist protein
99. Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells
100. 14(R),15(S)-epoxyeicosatrienoic acid (14(R),15(S)-EET) receptor in guinea pig mononuclear cell membranes
101. Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes
102. Production of viral vectors for gene therapy applications
103. Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes
104. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
105. 2+ channels and contraction in mammalian heart cells
106. Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity
107. CYP2J subfamily P450s in the lung: Expression, localization and potential functional significance
108. Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway
109. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: Characterization and significance
110. Airway inflammation and responsiveness in prostaglandin H deficient mice exposed to bacterial lipopolysaccharide
111. Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites
112. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries
113. Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs
114. Cytochrome P450 isoforms are present in airway microsomes and P450 metabolites modulate human bronchial tone
115. A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis