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By studying a unique touch assay between polymorphonuclear leukocytes (PMNs) and the epithelial monolayer, the authors demonstrate sequential signaling events and enhanced paracellular permeability of epithelial cell monolayer that are independent of PMN transjunctional migration.
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This paper demonstrates that fucoidin is a novel ligand for CD11b/CD18, and that certain epithelial fucosylated proteoglycans might serve as adhesive ligands in CD11b/CD18-mediated polymorphonuclear leukocyte transepithelial migration.
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