Role of nasal nitric oxide in the resolution of experimental rhinovirus infection

Journal of Allergy and Clinical Immunology

Volumn 113, Issue 4, 2004, Pages 697-702

  Sanders, Scherer P ^a,c   Proud, David ^b   Permutt, Solbert ^a   Siekierski, Edward S ^a   Yachechko, Robin ^a   Liu, Mark C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Asthma; Common cold; Epithelial cells; Host defense; Inducible nitric oxide synthase; Nitric oxide; Rhinovirus

Indexed keywords

MESSENGER RNA; NITRIC OXIDE;

ARTICLE; BIOASSAY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; EXHALATION; FEMALE; FLOW RATE; HOST RESISTANCE; HUMAN; HUMAN CELL; LUNG CLEARANCE; LYMPHOCYTE; MALE; MONOCYTE; NOSE AIRFLOW; NOSE MUCUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOVIRUS; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYMPTOM; TITRIMETRY; VIRUS SHEDDING;

EID: 1942467837     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.01.755     Document Type: Article

References (32)

1. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995;8:295-7.
2. Murphy AW, Platts-Mills TA, Lobo M, Hayden F. Respiratory nitric oxide levels in experimental human influenza. Chest 1998;114:452-6.
3. de Gouw HWFM, Grunberg K, Schot R, Kroes ACM, Dick EC, Sterk PJ. Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects. Eur Respir J 1998;11:126-32.
4. Gentile DA, Doyle WJ, Belenky S, Ranck H, Angelini B, Skoner DP. Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adults. Acta Otolaryngol 2002;122:61-6.
5. Wu G, Meininger CJ. Regulation of nitric oxide synthesis by dietary factors. Annu Rev Nutr 2002;22:61-86.
6. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357:593-615.
7. Knight V. The use of volunteers in medical virology. Prog Med Virol 1964;6:1-26.
8. Gwaltney JM Jr, Hendley O, Hayden FG, McIntosh K, Hollinger FB, Melnick JL, et al. Updated recommendations for safety-testing of viral inocula used in volunteer experiments on rhinovirus colds. Prog Med Virol 1992;39:256-63.
9. Sanders SP, Siekierski ES, Richards SM, Porter JD, Imani F, Proud D. Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo. J Allergy Clin Immunol 2001;107:235-43.
10. Proud D, Gwaltney JM Jr, Hendley JO, Dinarello CA, Gillis S, Schleimer RP. Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds. J Infect Dis 1994;169:1007-13.
11. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. Am J Respir Crit Care Med 1999;160:2104-17.
12. Silkoff PE, Sylvester JT, Zamel N, Permutt S. Airway nitric oxide diffusion in asthma: Role in pulmonary function and bronchial responsiveness. Am J Respir Crit Care Med 2000;161:1218-28.
13. Sanders SP, Siekierski ES, Porter JD, Richards SM, Proud D. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line. J Virol 1998;72:934-42.
14. Lundberg J, Rinder J, Weitzberg E, Lundberg J, Alving K. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand 1994;152:431-2.
15. Lundberg JON, Farkas-Szallasi T, Weitzberg E, Rinder J, Lidholm J, Anggard A, et al. High nitric oxide production in human paranasal sinuses. Nat Med 1995;1:370-3.
16. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6:1368-70.
17. Kaul P, Singh I, Tumer RB. Effect of nitric oxide on rhinovirus replication and virus-induced interleukin-8 elaboration. Am J Respir Crit Care Med 1999;159:1193-8.
18. Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, et al. Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med 1999;160:100-8.
19. Fraenkel DJ, Bardin PG, Sanderson G, Lampe F, Johnston SL, Holgate ST. Lower airways inflammation during rhinovirus colds in normal and asthmatic subjects. Am J Respir Crit Care Med 1995;151:879-86.
20. Skoner DP, Doyle WJ, Seroky J, Van Deusen MA, Fireman P. Lower airway responses to rhinovirus 39 in healthy allergic and nonallergic subjects. Eur Respir J 1996;9:1402-6.
21. Gern JE, Galagan DM, Jarjour NN, Dick EC, Busse WW. Detection of rhinovirus RNA in lower airway cells during experimentally induced infection. Am J Respir Crit Care Med 1997;155:1159-61.
22. Grünberg K, Timmers MC, Smits HH, de Klerk EPA, Dick EC, Spaan WJM, et al. Effects of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy 1996;27:36-45.
23. Papadopoulos NG, Bates PJ, Bardin PG, Papi A, Leir SH, Fraenkel DJ, et al. Rhinoviruses infect the lower airways. J Infect Dis 2000;181:1875-84.
24. Papadopoulos NG, Sanderson G, Hunter J, Johnston SL. Rhinoviruses replicate effectively at lower airway temperatures. J Med Virol 1999;58:100-4.
25. Togias A. Rhinitis and asthma: evidence for respiratory system integration. J Allergy Clin Immunol 2003;111:1171-83.
26. Tyrrell DA, Cohen S, Schlarb JD. Signs and symptoms in common colds. Epidemiol Infect 1993;111:143-56.
27. Turner RB. The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001;49:1-14.
28. Gwaltney JM, Hendley JO, Simon G, Jordan WS. Rhinovirus infections in an industrial population. II. Characteristics of illness and antibody response. JAMA 1967;202:494-500.
29. Sanders SP, Kim J, Connolly K, Porter JD, Siekierski ES, Proud D. Nitric oxide inhibits rhinovirus-induced GM-CSF production in bronchial epithelial cells. Am J Respir Crit Care Med 2001;24:317-25.
30. Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, et al. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A 1999;96:11000-7.
31. Mannick JB, Stamler JS, Teng E, Simpson N, Lawrence J, Jordan J, et al. Nitric oxide modulates HIV-1 replication. J Acquir Immune Defic Syndr 1999;22:1-9.
32. Saura M, Zaragoza C, McMillan A, Quick RA, Hohenadl C, Lowenstein JM, Lowenstein CJ. An antiviral mechanism of nitric oxide: inhibition of a viral protease. Immunity 1999;10:21-8.