메뉴 건너뛰기




Volumn 11, Issue 2, 2011, Pages 252-260

The role of phosphatidylinositol 3-kinase signaling pathways in pancreatic cancer

Author keywords

Pancreatic cancer; PI3K; Signaling pathway

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 DIALLYLAMINOMETHYLENE 1,3,4,7,10,11,12,13,14,15,16,17 DODECAHYDRO 6 HYDROXY 1 METHOXYMETHYL 10,13 DIMETHYL 3,7,17 TRIOXO 2 OXACYCLOPENTA[A]PHENANTHREN 11 YL ACETATE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

EID: 79957576837     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000327715     Document Type: Review
Times cited : (8)

References (96)
  • 1
    • 77956938598 scopus 로고    scopus 로고
    • Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Aktdependent pathway
    • Yao J, Qian C: Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Aktdependent pathway. Med Oncol 2010; 27: 1017-1022.
    • (2010) Med Oncol , vol.27 , pp. 1017-1022
    • Yao, J.1    Qian, C.2
  • 2
    • 18844375044 scopus 로고    scopus 로고
    • Treatment for pancreatic cancer: Current therapy and continued progress
    • Lockhart AC, Rothenberg ML, Berlin JD: Treatment for pancreatic cancer: Current therapy and continued progress. Gastroenterology 2005; 128: 1642-1654.
    • (2005) Gastroenterology , vol.128 , pp. 1642-1654
    • Lockhart, A.C.1    Rothenberg, M.L.2    Berlin, J.D.3
  • 4
    • 0344858928 scopus 로고    scopus 로고
    • Apoptosis: Targets in pancreatic cancer
    • Westphal S, Kalthoff H: Apoptosis: Targets in pancreatic cancer. Mol Cancer 2003; 2: 6.
    • (2003) Mol Cancer , vol.2 , pp. 6
    • Westphal, S.1    Kalthoff, H.2
  • 5
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin DM, Bray FI, Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 2001; 37(suppl 8):S4-S66.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 8
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 7
    • 68449100485 scopus 로고    scopus 로고
    • Recent advances and developments in treatment strategies against pancreatic cancer
    • Fryer RA, Galustian C, Dalgleish AG: Recent advances and developments in treatment strategies against pancreatic cancer. Curr Clin Pharmacol 2009; 4: 102-112.
    • (2009) Curr Clin Pharmacol , vol.4 , pp. 102-112
    • Fryer, R.A.1    Galustian, C.2    Dalgleish, A.G.3
  • 9
    • 34547445606 scopus 로고    scopus 로고
    • Cytotoxic therapy for advanced pancreatic adenocarcinoma
    • O'Reilly EM, Abou-Alfa GK: Cytotoxic therapy for advanced pancreatic adenocarcinoma. Semin Oncol 2007; 34: 347-353.
    • (2007) Semin Oncol , vol.34 , pp. 347-353
    • O'Reilly, E.M.1    Abou-Alfa, G.K.2
  • 13
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao L, Vogt PK: Class I PI3K in oncogenic cellular transformation. Oncogene 2008; 27: 5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 14
    • 68549098158 scopus 로고    scopus 로고
    • Class IA phosphatidylinositol 3-kinase signaling in non-small cell lung cancer
    • Solomon B, Pearson RB: Class IA phosphatidylinositol 3-kinase signaling in non-small cell lung cancer. J Thorac Oncol 2009; 4: 787-791.
    • (2009) J Thorac Oncol , vol.4 , pp. 787-791
    • Solomon, B.1    Pearson, R.B.2
  • 15
    • 18244410381 scopus 로고    scopus 로고
    • The phosphoinositol-3-kinaseprotein kinase B/Akt pathway is critical for pseudomonas aeruginosa strain PAK internalization
    • Kierbel A, Gassama-Diagne A, Mostov K, Engel JN: The phosphoinositol-3- kinaseprotein kinase B/Akt pathway is critical for pseudomonas aeruginosa strain PAK internalization. Mol Biol Cell 2005; 16: 2577-2585.
    • (2005) Mol Biol Cell , vol.16 , pp. 2577-2585
    • Kierbel, A.1    Gassama-Diagne, A.2    Mostov, K.3    Engel, J.N.4
  • 16
    • 0034653608 scopus 로고    scopus 로고
    • The PI3KPDK1 connection: More than just a road to PKB
    • Vanhaesebroeck B, Alessi DR: The PI3KPDK1 connection: More than just a road to PKB. Biochem J 2000; 346(Pt 3):561-576.
    • (2000) Biochem J , vol.346 , Issue.PART 3 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 17
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC: The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 18
    • 4644333142 scopus 로고    scopus 로고
    • Crosstalk between phosphatidylinositol 3-kinase/ Akt and c-Jun NH2-terminal kinase mediates survival of isolated human islets
    • Aikin R, Maysinger D, Rosenberg L: Crosstalk between phosphatidylinositol 3-kinase/ Akt and c-Jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology 2004; 145: 4522-4531.
    • (2004) Endocrinology , vol.145 , pp. 4522-4531
    • Aikin, R.1    Maysinger, D.2    Rosenberg, L.3
  • 19
    • 34249335357 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells
    • Reichert M, Saur D, Hamacher R, Schmid RM, Schneider G: Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells. Cancer Res 2007; 67: 4149-4156.
    • (2007) Cancer Res , vol.67 , pp. 4149-4156
    • Reichert, M.1    Saur, D.2    Hamacher, R.3    Schmid, R.M.4    Schneider, G.5
  • 20
    • 73349115238 scopus 로고    scopus 로고
    • PI3K signaling maintains c-Myc expression to regulate transcription of E2F1 in pancreatic cancer cells
    • Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G: PI3K signaling maintains c-Myc expression to regulate transcription of E2F1 in pancreatic cancer cells. Mol Carcinog 2009; 48: 1149-1158.
    • (2009) Mol Carcinog , vol.48 , pp. 1149-1158
    • Schild, C.1    Wirth, M.2    Reichert, M.3    Schmid, R.M.4    Saur, D.5    Schneider, G.6
  • 21
    • 9744256274 scopus 로고    scopus 로고
    • Transcriptional regulation of Akt activation by E2F
    • Chaussepied M, Ginsberg D: Transcriptional regulation of Akt activation by E2F. Mol Cell 2004; 16: 831-837.
    • (2004) Mol Cell , vol.16 , pp. 831-837
    • Chaussepied, M.1    Ginsberg, D.2
  • 22
    • 53049092599 scopus 로고    scopus 로고
    • E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/ mTOR and COX-2 in a mouse model of human liver cancer
    • Ladu S, Calvisi DF, Conner EA, Farina M, Factor VM, Thorgeirsson SS: E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/ mTOR and COX-2 in a mouse model of human liver cancer. Gastroenterology 2008; 135: 1322-1332.
    • (2008) Gastroenterology , vol.135 , pp. 1322-1332
    • Ladu, S.1    Calvisi, D.F.2    Conner, E.A.3    Farina, M.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 24
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, Sherr CJ: Glycogen synthase kinase-3 regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998; 12: 3499-3511.
    • (1998) Genes Dev , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 26
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, Vogt PK: Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5: 921-929.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 28
    • 29244477527 scopus 로고    scopus 로고
    • Negative regulation of TSC1-TSC2 by mammalian D-type cyclins
    • Zacharek SJ, Xiong Y, Shumway SD: Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. Cancer Res 2005; 65: 11354-11360.
    • (2005) Cancer Res , vol.65 , pp. 11354-11360
    • Zacharek, S.J.1    Xiong, Y.2    Shumway, S.D.3
  • 32
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah OJ, Wang Z, Hunter T: Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004; 14: 1650-1656.
    • (2004) Curr Biol , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 33
    • 23744484194 scopus 로고    scopus 로고
    • Genetic analysis of PTEN and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
    • Ma L, Teruya-Feldstein J, Behrendt N, Chen Z, Noda T, Hino O, Cordon-Cardo C, Pandolfi PP: Genetic analysis of PTEN and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev 2005; 19: 1779-1786.
    • (2005) Genes Dev , vol.19 , pp. 1779-1786
    • Ma, L.1    Teruya-Feldstein, J.2    Behrendt, N.3    Chen, Z.4    Noda, T.5    Hino, O.6    Cordon-Cardo, C.7    Pandolfi, P.P.8
  • 35
    • 27144478642 scopus 로고    scopus 로고
    • Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells
    • Asano T, Yao Y, Shin S, McCubrey J, Abbruzzese JL, Reddy SA: Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells. Cancer Res 2005; 65: 9164-9168.
    • (2005) Cancer Res , vol.65 , pp. 9164-9168
    • Asano, T.1    Yao, Y.2    Shin, S.3    McCubrey, J.4    Abbruzzese, J.L.5    Reddy, S.A.6
  • 37
    • 25444494176 scopus 로고    scopus 로고
    • Epidermal growth factor mediates detachment from and invasion through collagen I and matrigel in capan-1 pancreatic cancer cells
    • Shirk AJ, Kuver R: Epidermal growth factor mediates detachment from and invasion through collagen I and matrigel in capan-1 pancreatic cancer cells. BMC Gastroenterol 2005; 5: 12.
    • (2005) BMC Gastroenterol , vol.5 , pp. 12
    • Shirk, A.J.1    Kuver, R.2
  • 38
    • 77951221760 scopus 로고    scopus 로고
    • Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells
    • Xu Z, Zhang Y, Jiang J, Yang Y, Shi R, Hao B, Zhang Z, Huang Z, Kim JW, Zhang G: Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells. BMC Cancer 2010; 10: 161.
    • (2010) BMC Cancer , vol.10 , pp. 161
    • Xu, Z.1    Zhang, Y.2    Jiang, J.3    Yang, Y.4    Shi, R.5    Hao, B.6    Zhang, Z.7    Huang, Z.8    Kim, J.W.9    Zhang, G.10
  • 40
    • 70349569525 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth
    • Johnson SK, Haun RS: Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. World J Gastroenterol 2009; 15: 3355-3366.
    • (2009) World J Gastroenterol , vol.15 , pp. 3355-3366
    • Johnson, S.K.1    Haun, R.S.2
  • 41
    • 4143146567 scopus 로고    scopus 로고
    • Oncogenic K-Ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells
    • Agbunag C, Bar-Sagi D: Oncogenic K-Ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res 2004; 64: 5659-5663.
    • (2004) Cancer Res , vol.64 , pp. 5659-5663
    • Agbunag, C.1    Bar-Sagi, D.2
  • 42
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC , but not S6K1
    • Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM: Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC , but not S6K1. Dev Cell 2006; 11: 859-871.
    • (2006) Dev Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5    Moffat, J.6    Brown, M.7    Fitzgerald, K.J.8    Sabatini, D.M.9
  • 43
    • 33644824991 scopus 로고    scopus 로고
    • Irs-1: Auditing the effectiveness of mTOR inhibitors
    • Easton JB, Kurmasheva RT, Houghton PJ: Irs-1: Auditing the effectiveness of mTOR inhibitors. Cancer Cell 2006; 9: 153-155.
    • (2006) Cancer Cell , vol.9 , pp. 153-155
    • Easton, J.B.1    Kurmasheva, R.T.2    Houghton, P.J.3
  • 44
    • 0037439835 scopus 로고    scopus 로고
    • Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3α-kinase-Akt signaling pathways
    • Thimmaiah KN, Easton J, Huang S, Veverka KA, Germain GS, Harwood FC, Houghton PJ: Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3α-kinase-Akt signaling pathways. Cancer Res 2003; 63: 364-374.
    • (2003) Cancer Res , vol.63 , pp. 364-374
    • Thimmaiah, K.N.1    Easton, J.2    Huang, S.3    Veverka, K.A.4    Germain, G.S.5    Harwood, F.C.6    Houghton, P.J.7
  • 45
    • 33845227643 scopus 로고    scopus 로고
    • Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors
    • Buck E, Eyzaguirre A, Brown E, Petti F, Mc-Cormack S, Haley JD, Iwata KK, Gibson NW, Griffin G: Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther 2006; 5: 2676-2684.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2676-2684
    • Buck, E.1    Eyzaguirre, A.2    Brown, E.3    Petti, F.4    Mc-Cormack, S.5    Haley, J.D.6    Iwata, K.K.7    Gibson, N.W.8    Griffin, G.9
  • 47
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu PP, Sabatini DM: Cancer cell metabolism: Warburg and beyond. Cell 2008; 134: 703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 48
    • 77957327505 scopus 로고    scopus 로고
    • Visually isoattenuating pancreatic adenocarcinoma at dynamic-enhanced CT: Frequency, clinical and pathologic characteristics, and diagnosis at imaging examinations
    • Kim JH, Park SH, Yu ES, Kim MH, Kim J, Byun JH, Lee SS, Hwang HJ, Hwang JY, Lee MG: Visually isoattenuating pancreatic adenocarcinoma at dynamic-enhanced CT: Frequency, clinical and pathologic characteristics, and diagnosis at imaging examinations. Radiology 2010; 257: 87-96.
    • (2010) Radiology , vol.257 , pp. 87-96
    • Kim, J.H.1    Park, S.H.2    Yu, E.S.3    Kim, M.H.4    Kim, J.5    Byun, J.H.6    Lee, S.S.7    Hwang, H.J.8    Hwang, J.Y.9    Lee, M.G.10
  • 49
    • 58149172000 scopus 로고    scopus 로고
    • Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/ Akt pathway in human pancreatic cancer cells
    • Melstrom LG, Salabat MR, Ding XZ, Milam BM, Strouch M, Pelling JC, Bentrem DJ: Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide 3-kinase/ Akt pathway in human pancreatic cancer cells. Pancreas 2008; 37: 426-431.
    • (2008) Pancreas , vol.37 , pp. 426-431
    • Melstrom, L.G.1    Salabat, M.R.2    Ding, X.Z.3    Milam, B.M.4    Strouch, M.5    Pelling, J.C.6    Bentrem, D.J.7
  • 50
    • 0034902724 scopus 로고    scopus 로고
    • The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3
    • Sanchez S, Sayas CL, Lim F, Diaz-Nido J, Avila J, Wandosell F: The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3. J Neurochem 2001; 78: 468-481.
    • (2001) J Neurochem , vol.78 , pp. 468-481
    • Sanchez, S.1    Sayas, C.L.2    Lim, F.3    Diaz-Nido, J.4    Avila, J.5    Wandosell, F.6
  • 51
    • 79952040479 scopus 로고    scopus 로고
    • Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1 under normoxic condition
    • Zhang M, Ma Q, Hu H, Zhang D, Li J, Ma G, Bhat K, Wu E: Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1 under normoxic condition. Cancer Lett 2011; 303: 108-117.
    • (2011) Cancer Lett , vol.303 , pp. 108-117
    • Zhang, M.1    Ma, Q.2    Hu, H.3    Zhang, D.4    Li, J.5    Ma, G.6    Bhat, K.7    Wu, E.8
  • 54
    • 79953160606 scopus 로고    scopus 로고
    • NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox
    • Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS: NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem 2011; 286: 7779-7787.
    • (2011) J Biol Chem , vol.286 , pp. 7779-7787
    • Edderkaoui, M.1    Nitsche, C.2    Zheng, L.3    Pandol, S.J.4    Gukovsky, I.5    Gukovskaya, A.S.6
  • 55
    • 0034127430 scopus 로고    scopus 로고
    • Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis
    • Gerwins P, Skoldenberg E, Claesson-Welsh L: Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis. Crit Rev Oncol Hematol 2000; 34: 185-194.
    • (2000) Crit Rev Oncol Hematol , vol.34 , pp. 185-194
    • Gerwins, P.1    Skoldenberg, E.2    Claesson-Welsh, L.3
  • 57
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang BH, Zheng JZ, Aoki M, Vogt PK: Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 2000; 97: 1749-1753.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 60
    • 25844467656 scopus 로고    scopus 로고
    • C-Src regulates constitutive and EGFmediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK
    • Summy JM, Trevino JG, Baker CH, Gallick GE: C-Src regulates constitutive and EGFmediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK. Pancreas 2005; 31: 263-274.
    • (2005) Pancreas , vol.31 , pp. 263-274
    • Summy, J.M.1    Trevino, J.G.2    Baker, C.H.3    Gallick, G.E.4
  • 61
    • 8744248268 scopus 로고    scopus 로고
    • Molecular targeting therapy for pancreatic cancer
    • Xiong HQ: Molecular targeting therapy for pancreatic cancer. Cancer Chemother Pharmacol 2004; 54(suppl 1):S69-S77.
    • (2004) Cancer Chemother Pharmacol , vol.54 , Issue.SUPPL. 1
    • Xiong, H.Q.1
  • 62
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant PTEN expression and targets transcription factors NF-α B and c-Myc in pancreatic cancer cells
    • Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA: The PI 3-kinase/Akt signaling pathway is activated due to aberrant PTEN expression and targets transcription factors NF-α B and c-Myc in pancreatic cancer cells. Oncogene 2004; 23: 8571-8580.
    • (2004) Oncogene , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Li, D.4    Abbruzzese, J.L.5    Reddy, S.A.6
  • 63
    • 10844282781 scopus 로고    scopus 로고
    • Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer
    • Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR: Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer. Gut 2005; 54: 109-116.
    • (2005) Gut , vol.54 , pp. 109-116
    • Stoll, V.1    Calleja, V.2    Vassaux, G.3    Downward, J.4    Lemoine, N.R.5
  • 64
    • 0034194348 scopus 로고    scopus 로고
    • Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent
    • Perugini RA, McDade TP, Vittimberga FJ Jr, Callery MP: Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent. J Surg Res 2000; 90: 39-44.
    • (2000) J Surg Res , vol.90 , pp. 39-44
    • Perugini, R.A.1    McDade, T.P.2    Vittimberga Jr., F.J.3    Callery, M.P.4
  • 65
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
    • Ng SSW, Tsao MS, Chow S, Hedley DW: Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res 2000; 60: 5451-5455.
    • (2000) Cancer Res , vol.60 , pp. 5451-5455
    • Ng, S.S.W.1    Tsao, M.S.2    Chow, S.3    Hedley, D.W.4
  • 66
    • 0037380304 scopus 로고    scopus 로고
    • Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas
    • Semba S, Moriya T, Kimura W, Yamakawa M: Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas. Pancreas 2003; 26: 250-257.
    • (2003) Pancreas , vol.26 , pp. 250-257
    • Semba, S.1    Moriya, T.2    Kimura, W.3    Yamakawa, M.4
  • 67
    • 1842430485 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3α-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
    • Takeda A, Osaki M, Adachi K, Honjo S, Ito H: Role of the phosphatidylinositol 3α-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines. Pancreas 2004; 28: 353-358.
    • (2004) Pancreas , vol.28 , pp. 353-358
    • Takeda, A.1    Osaki, M.2    Adachi, K.3    Honjo, S.4    Ito, H.5
  • 68
    • 58849100438 scopus 로고    scopus 로고
    • Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF B-dependent pathway
    • Chen PH, Yang CR: Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF B-dependent pathway. J Immunol 2008; 181: 8441-8449.
    • (2008) J Immunol , vol.181 , pp. 8441-8449
    • Chen, P.H.1    Yang, C.R.2
  • 69
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME: Akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 70
    • 0025923970 scopus 로고
    • Species-specific differences in heterogonic development of serially transferred free-living generations of strongyloides planiceps and strongyloides stercoralis
    • Yamada M, Matsuda S, Nakazawa M, Arizono N: Species-specific differences in heterogonic development of serially transferred free-living generations of strongyloides planiceps and strongyloides stercoralis. J Parasitol 1991; 77: 592-594.
    • (1991) J Parasitol , vol.77 , pp. 592-594
    • Yamada, M.1    Matsuda, S.2    Nakazawa, M.3    Arizono, N.4
  • 72
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • Ng SS, Tsao MS, Nicklee T, Hedley DW: Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res 2001; 7: 3269-3275.
    • (2001) Clin Cancer Res , vol.7 , pp. 3269-3275
    • Ng, S.S.1    Tsao, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 73
    • 0043122940 scopus 로고    scopus 로고
    • Akt inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2
    • Fahy BN, Schlieman M, Virudachalam S, Bold RJ: Akt inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer 2003; 89: 391-397.
    • (2003) Br J Cancer , vol.89 , pp. 391-397
    • Fahy, B.N.1    Schlieman, M.2    Virudachalam, S.3    Bold, R.J.4
  • 74
    • 1842609941 scopus 로고    scopus 로고
    • Inhibition of Akt abrogates chemotherapy-induced NF B survival mechanisms: Implications for therapy in pancreatic cancer
    • Fahy BN, Schlieman MG, Virudachalam S, Bold RJ: Inhibition of Akt abrogates chemotherapy-induced NF B survival mechanisms: Implications for therapy in pancreatic cancer. J Am Coll Surg 2004; 198: 591-599.
    • (2004) J Am Coll Surg , vol.198 , pp. 591-599
    • Fahy, B.N.1    Schlieman, M.G.2    Virudachalam, S.3    Bold, R.J.4
  • 75
    • 0041338049 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3α-kinase-Akt pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
    • Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ: Inhibition of the phosphatidylinositol 3α-kinase-Akt pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 2002; 1: 989-997.
    • (2002) Mol Cancer Ther , vol.1 , pp. 989-997
    • Bondar, V.M.1    Sweeney-Gotsch, B.2    Andreeff, M.3    Mills, G.B.4    McConkey, D.J.5
  • 77
    • 38349137362 scopus 로고    scopus 로고
    • Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration
    • Dise RS, Frey MR, Whitehead RH, Polk DB: Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 2008; 294:G276-G285.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Dise, R.S.1    Frey, M.R.2    Whitehead, R.H.3    Polk, D.B.4
  • 80
    • 33846223450 scopus 로고    scopus 로고
    • HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma
    • Liau SS, Jazag A, Whang EE: HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma. Cancer Res 2006; 66: 11613-11622.
    • (2006) Cancer Res , vol.66 , pp. 11613-11622
    • Liau, S.S.1    Jazag, A.2    Whang, E.E.3
  • 81
    • 77950188361 scopus 로고    scopus 로고
    • IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/ PI3K/Akt signaling pathway in pancreatic cancer cells
    • Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Takeyama H: IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/ PI3K/Akt signaling pathway in pancreatic cancer cells. J Surg Res 2010; 160: 90-101.
    • (2010) J Surg Res , vol.160 , pp. 90-101
    • Ma, J.1    Sawai, H.2    Matsuo, Y.3    Ochi, N.4    Yasuda, A.5    Takahashi, H.6    Wakasugi, T.7    Funahashi, H.8    Sato, M.9    Takeyama, H.10
  • 82
    • 67449104757 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo
    • Teranishi F, Takahashi N, Gao N, Akamo Y, Takeyama H, Manabe T, Okamoto T: Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo. Cancer Sci 2009; 100: 770-777.
    • (2009) Cancer Sci , vol.100 , pp. 770-777
    • Teranishi, F.1    Takahashi, N.2    Gao, N.3    Akamo, Y.4    Takeyama, H.5    Manabe, T.6    Okamoto, T.7
  • 83
    • 77950883533 scopus 로고    scopus 로고
    • TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin 5 and its signaling pathways
    • Kim S, Kang HY, Nam EH, Choi MS, Zhao XF, Hong CS, Lee JW, Lee JH, Park YK: TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin 5 and its signaling pathways. Carcinogenesis 2010; 31: 597-606.
    • (2010) Carcinogenesis , vol.31 , pp. 597-606
    • Kim, S.1    Kang, H.Y.2    Nam, E.H.3    Choi, M.S.4    Zhao, X.F.5    Hong, C.S.6    Lee, J.W.7    Lee, J.H.8    Park, Y.K.9
  • 84
    • 84871455735 scopus 로고    scopus 로고
    • Effect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cells (in Chinese)
    • Xia QS, Ishigaki Y, Sun L, Chen R, Motoo Y: Effect of anti-cancer drugs on the expression of BIC/miR-155 in human pancreatic cancer PANC-1 cells (in Chinese). Zhonghua Yi Xue Za Zhi 2010; 90: 123-127.
    • (2010) Zhonghua Yi Xue Za Zhi , vol.90 , pp. 123-127
    • Xia, Q.S.1    Ishigaki, Y.2    Sun, L.3    Chen, R.4    Motoo, Y.5
  • 86
    • 38449108441 scopus 로고    scopus 로고
    • SiRNA directed against TRKA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K/Akt-dependent pathway
    • Liu D, Zhang Y, Dang C, Ma Q, Lee W, Chen W: SiRNA directed against TRKA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K/Akt-dependent pathway. Oncol Rep 2007; 18: 673-677.
    • (2007) Oncol Rep , vol.18 , pp. 673-677
    • Liu, D.1    Zhang, Y.2    Dang, C.3    Ma, Q.4    Lee, W.5    Chen, W.6
  • 91
    • 34247163550 scopus 로고    scopus 로고
    • Chemically targeting the PI3K family
    • Knight ZA, Shokat KM: Chemically targeting the PI3K family. Biochem Soc Trans 2007; 35: 245-249.
    • (2007) Biochem Soc Trans , vol.35 , pp. 245-249
    • Knight, Z.A.1    Shokat, K.M.2
  • 94
    • 64949155000 scopus 로고    scopus 로고
    • Activity of a novel, dual PI3-kinase/ mTOR inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts
    • Cao P, Maira SM, Garcia-Echeverria C, Hedley DW: Activity of a novel, dual PI3-kinase/ mTOR inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts. Br J Cancer 2009; 100: 1267-1276.
    • (2009) Br J Cancer , vol.100 , pp. 1267-1276
    • Cao, P.1    Maira, S.M.2    Garcia-Echeverria, C.3    Hedley, D.W.4
  • 96
    • 77954829252 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells (in Chinese)
    • Zhou J, Wang CY, Liu T, Wu HS, Zhou F, Xiong JX, Zhao G, Yang M, Yin T, Zhou MT: Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells (in Chinese). Zhonghua Yi Xue Za Zhi 2008; 88: 2994-2998.
    • (2008) Zhonghua Yi Xue Za Zhi , vol.88 , pp. 2994-2998
    • Zhou, J.1    Wang, C.Y.2    Liu, T.3    Wu, H.S.4    Zhou, F.5    Xiong, J.X.6    Zhao, G.7    Yang, M.8    Yin, T.9    Zhou, M.T.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.