NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 7779-7787

  Edderkaoui, Mouad ^a   Nitsche, Claudia ^a   Zheng, Ling ^a   Pandol, Stephen J ^a   Gukovsky, Ilya ^a   Gukovskaya, Anna S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAPOPTOTIC; APOPTOSIS; CATALYTIC SUBUNITS; COMPLEX FORMATIONS; DUCTAL ADENOCARCINOMAS; GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR-I; NADPH OXIDASE; PANCREATIC CANCERS; REGULATORY SUBUNITS; UP-REGULATION;

CELL DEATH; DISEASES; INSULIN; PHOSPHORYLATION; TRANSCRIPTION FACTORS;

PEPTIDES;

ANTINEOPLASTIC AGENT; CELL PROTEIN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; PROTEIN NOX3; PROTEIN NOX5; PROTEIN P22 PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NADPH OXIDASE; NF-KAPPA B; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; UP-REGULATION;

AGOUTI PACA;

EID: 79953160606     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.200063     Document Type: Article

References (32)

1. Babior, B. M., Lambeth, J. D., and Nauseef, W. (2002) Arch. Biochem. Biophys. 397, 342-344
2. Bedard, K., and Krause, K. H. (2007) Physiol. Rev. 87, 245-313
3. Lambeth, J. D. (2007) Free Radic. Biol. Med. 43, 332-347
4. von Löhneysen, K., Noack, D., Jesaitis, A. J., Dinauer, M. C., and Knaus, U. G. (2008) J. Biol. Chem. 283, 35273-35282
5. Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., and Knaus, U. G. (2006) Cell. Signal. 18, 69-82
6. Xu, H., Goettsch, C., Xia, N., Horke, S., Morawietz, H., Förstermann, U., and Li, H. (2008) Free Radic. Biol. Med. 44, 1656-1667
7. Govindarajan, B., Sligh, J. E., Vincent, B. J., Li, M., Canter, J. A., Nickoloff, B. J., Rodenburg, R. J., Smeitink, J. A., Oberley, L., Zhang, Y., Slingerland, J., Arnold, R. S., Lambeth, J. D., Cohen, C., Hilenski, L., Griendling, K., Martínez- Diez, M., Cuezva, J. M., and Arbiser, J. L. (2007) J. Clin. Invest. 117, 719-729
8. Hoyal, C. R., Gutierrez, A., Young, B. M., Catz, S. D., Lin, J. H., Tsichlis, P. N., and Babior, B. M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 5130-5135
9. Vaquero, E. C., Edderkaoui, M., Pandol, S. J., Gukovsky, I., and Gukovskaya, A. S. (2004) J. Biol. Chem. 279, 34643-34654
10. Ismail, S., Sturrock, A., Wu, P., Cahill, B., Norman, K., Huecksteadt, T., Sanders, K., Kennedy, T., and Hoidal, J. (2009) Am. J. Physiol. Lung Cell. Mol. Physiol. 296, L489-L499
11. Maloney, E., Sweet, I. R., Hockenbery, D. M., Pham, M., Rizzo, N. O., Tateya, S., Handa, P., Schwartz, M. W., and Kim, F. (2009) Arterioscler. Thromb. Vasc. Biol. 29, 1370-1375
12. Mahadev, K., Motoshima, H., Wu, X., Ruddy, J. M., Arnold, R. S., Cheng, G., Lambeth, J. D., and Goldstein, B. J. (2004) Mol. Cell. Biol. 24, 1844-1854
13. Moe, K. T., Aulia, S., Jiang, F., Chua, Y. L., Koh, T. H., Wong, M. C., and Dusting, G. J. (2006) J. Cell. Mol. Med. 10, 231-239
14. Edderkaoui, M., Hong, P., Vaquero, E. C., Lee, J. K., Fischer, L., Friess, H., Buchler, M. W., Lerch, M. M., Pandol, S. J., and Gukovskaya, A. S. (2005) Am. J. Physiol. Gastrointest. Liver Physiol. 289, G1137-G1147
15. Lee, J. K., Edderkaoui, M., Truong, P., Ohno, I., Jang, K. T., Berti, A., Pandol, S. J., and Gukovskaya, A. S. (2007) Gastroenterology 133, 1637-1648
16. Bhandarkar, S. S., Jaconi, M., Fried, L. E., Bonner, M. Y., Lefkove, B., Govindarajan, B., Perry, B. N., Parhar, R., Mackelfresh, J., Sohn, A., Stouffs, M., Knaus, U., Yancopoulos, G., Reiss, Y., Benest, A. V., Augustin, H. G., and Arbiser, J. L. (2009) J. Clin. Invest. 119, 2359-2365
17. Kawahara, T., Ritsick, D., Cheng, G., and Lambeth, J. D. (2005) J. Biol. Chem. 280, 31859-31869
18. Edderkaoui, M., Hong, P., Lee, J. K., Pandol, S. J., and Gukovskaya, A. S. (2007) J. Biol. Chem. 282, 26646-26655
19. Maccarrone, M., Melino, G., and Finazzi-Agrò, A. (2001) Cell Death Differ. 8, 776-784
20. Gukovsky, I., Cheng, J. H., Nam, K. J., Lee, O. T., Lugea, A., Fischer, L., Penninger, J. M., Pandol, S. J., and Gukovskaya, A. S. (2004) Gastroenterology 126, 554-566
21. Mouria, M., Gukovskaya, A. S., Jung, Y., Buechler, P., Hines, O. J., Reber, H. A., and Pandol, S. J. (2002) Int. J. Cancer. 98, 761-769
22. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y., and Ballard, D. W. (1995) Mol. Cell. Biol. 15, 2809-2818
23. Ambasta, R. K., Kumar, P., Griendling, K. K., Schmidt, H. H., Busse, R., and Brandes, R. P. (2004) J. Biol. Chem. 279, 45935-45941
24. Dinauer, M. C., Pierce, E. A., Bruns, G. A., Curnutte, J. T., and Orkin, S. H. (1990) J. Clin. Invest. 86, 1729-1737
25. Niu, J., Chang, Z., Peng, B., Xia, Q., Lu, W., Huang, P., Tsao, M. S., and Chiao, P. J. (2007) J. Biol. Chem. 282, 6001-6011
26. Manea, A., Manea, S. A., Gafencu, A. V., and Raicu, M. (2007) Arch. Physiol. Biochem. 113, 163-172
27. Oeckinghaus, A., and Ghosh, S. (2009) Cold Spring Harb. Perspect. Biol. 1, a000034
28. Mochizuki, T., Furuta, S., Mitsushita, J., Shang, W. H., Ito, M., Yokoo, Y., Yamaura, M., Ishizone, S., Nakayama, J., Konagai, A., Hirose, K., Kiyosawa, K., and Kamata, T. (2006) Oncogene 25, 3699-3707
29. Korc, M. (1998) Surg. Oncol. Clin. N. Am. 7, 25-41
30. Min, Y., Adachi, Y., Yamamoto, H., Ito, H., Itoh, F., Lee, C. T., Nadaf, S., Carbone, D. P., and Imai, K. (2003) Cancer Res. 63, 6432-6441
31. Dusi, S., Donini, M., Lissandrini, D., Mazzi, P., Bianca, V. D., and Rossi, F. (2001) Eur. J. Immunol. 31, 929-938
32. Madrid, L. V., Mayo, M. W., Reuther, J. Y., and Baldwin, A. S., Jr. (2001) J. Biol. Chem. 276, 18934-18940