메뉴 건너뛰기




Volumn 4, Issue 7, 2009, Pages 787-791

Class IA phosphatidylinositol 3-kinase signaling in non-small cell lung cancer

Author keywords

AKT; MTOR; NSCLC; Phosphatidylinositol 3 kinase

Indexed keywords

ANTINEOPLASTIC AGENT; BGT 226; BRX 235; ISOENZYME; LY 2994002; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE 1A; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P110; PX 866; SF 1126; UNCLASSIFIED DRUG; XL 147; XL 765;

EID: 68549098158     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181a74dba     Document Type: Article
Times cited : (29)

References (93)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-619. (Pubitemid 44100518)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 5
    • 28244479028 scopus 로고    scopus 로고
    • Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
    • Isakoff SJ, Engelman JA, Irie HY, et al. Breast cancer-associatedPIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 2005;65:10992-11000.
    • (2005) Cancer Res , vol.65 , pp. 10992-11000
    • Isakoff, S.J.1    Engelman, J.A.2    Irie, H.Y.3
  • 8
    • 0035103107 scopus 로고    scopus 로고
    • The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking
    • DOI 10.1016/S1097-2765(01)00191-5
    • Gaidarov I, Smith ME, Domin J, Keen JH. The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell 2001;7:443-449. (Pubitemid 32206511)
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 443-449
    • Gaidarov, I.1    Smith, M.E.K.2    Domin, J.3    Keen, J.H.4
  • 9
    • 33847743064 scopus 로고    scopus 로고
    • Hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling
    • DOI 10.1016/j.ceb.2007.02.019, PII S0955067407000312
    • Nobukuni T, Kozma SC, Thomas G. Hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol 2007;19:135-141. (Pubitemid 46386413)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.2 , pp. 135-141
    • Nobukuni, T.1    Kozma, S.C.2    Thomas, G.3
  • 12
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110[alpha] in insulin signaling
    • Knight ZA, Gonzalez B, Feldman ME, et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110[alpha] in Insulin Signaling. Cell 2006;125:733-747.
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3
  • 17
    • 49649087385 scopus 로고    scopus 로고
    • Essential roles of PI(3)K-p110[bgr] in cell growth, metabolism and tumorigenesis
    • Jia S, Liu Z, Zhang S, et al. Essential roles of PI(3)K-p110[bgr] in cell growth, metabolism and tumorigenesis. Nature 2008;454:776-779.
    • (2008) Nature , vol.454 , pp. 776-779
    • Jia, S.1    Liu, Z.2    Zhang, S.3
  • 19
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008;321:1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 20
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 23
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry M, Parsons R. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene 2008;27:5477-5485.
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 25
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307: 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 26
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 27
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • DOI 10.1016/j.molcel.2005.03.008
    • Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005;18:13-24. (Pubitemid 40444644)
    • (2005) Molecular Cell , vol.18 , Issue.1 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 28
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 29
    • 34247869651 scopus 로고    scopus 로고
    • Targeting mTOR signaling for lung cancer therapy
    • PII 0124389420060200000002
    • Sun SY, Fu H, Khuri FR. Targeting mTOR signaling for lung cancer therapy. J Thorac Oncol 2006;1:109-111. (Pubitemid 47163996)
    • (2006) Journal of Thoracic Oncology , vol.1 , Issue.2 , pp. 109-111
    • Sun, S.-Y.1    Fu, H.2    Khuri, F.R.3
  • 31
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-484. (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 32
    • 33847397874 scopus 로고    scopus 로고
    • Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    • DOI 10.1038/ncb1547, PII NCB1547
    • Haar EV, Lee SI, Bandhakavi S, Griffin TJ, Kim DH. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 2007;9:316-323. (Pubitemid 46344611)
    • (2007) Nature Cell Biology , vol.9 , Issue.3 , pp. 316-323
    • Haar, E.V.1    Lee, S.2    Bandhakavi, S.3    Griffin, T.J.4    Kim, D.-H.5
  • 34
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • DOI 10.1128/MCB.25.14.5834-5845.2005
    • Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 2005;25:5834-5845. (Pubitemid 40946541)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.14 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 36
    • 33750072949 scopus 로고    scopus 로고
    • MTOR and cancer therapy
    • Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006; 25:6436-6446.
    • (2006) Oncogene , vol.25 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 37
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: Of feedbacks and cross-talks
    • Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008;27:5527-5541.
    • (2008) Oncogene , vol.27 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 38
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman JA, Chen L, Tan X, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008;14:1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3
  • 40
    • 56749176442 scopus 로고    scopus 로고
    • LKB1;linking cell structure and tumor suppression
    • Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008;27:6908-6919.
    • (2008) Oncogene , vol.27 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 41
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008;118:3065-3074.
    • (2008) J Clin Invest , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3
  • 45
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene 2008;27:5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 46
    • 33846252977 scopus 로고    scopus 로고
    • PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients
    • PII 0124389420060900000006
    • Endoh H, Yatabe Y, Kosaka T, Kuwano H, Mitsudomi T. PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients. J Thorac Oncol 2006; 1:629-634. (Pubitemid 47163949)
    • (2006) Journal of Thoracic Oncology , vol.1 , Issue.7 , pp. 629-634
    • Endoh, H.1    Yatabe, Y.2    Kosaka, T.3    Kuwano, H.4    Mitsudomi, T.5
  • 49
    • 52049099853 scopus 로고    scopus 로고
    • PIK3CA mutations and copy number gains in human lung cancers
    • Yamamoto H, Shigematsu H, Nomura M, et al. PIK3CA mutations and copy number gains in human lung cancers. Cancer Res 2008;68:6913-6921.
    • (2008) Cancer Res , vol.68 , pp. 6913-6921
    • Yamamoto, H.1    Shigematsu, H.2    Nomura, M.3
  • 50
    • 34548485621 scopus 로고    scopus 로고
    • PIK3CA gene amplification in Japanese non-small cell lung cancer
    • DOI 10.1016/j.lungcan.2007.06.020, PII S0169500207003960
    • Kawano O, Sasaki H, Okuda K, et al. PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer 2007;58:159-160. (Pubitemid 47379973)
    • (2007) Lung Cancer , vol.58 , Issue.1 , pp. 159-160
    • Kawano, O.1    Sasaki, H.2    Okuda, K.3    Yukiue, H.4    Yokoyama, T.5    Yano, M.6    Fujii, Y.7
  • 53
    • 0031596872 scopus 로고    scopus 로고
    • Inactivation of the PTEN/MMACI/TEPI gene in human lung cancers
    • DOI 10.1002/(SICI)1098-2264(199806)22:2<152::AID-GCC10>3.0.CO;2-S
    • Kohno T, Takahashi M, Manda R, Yokota J. Inactivation of the PTEN/ MMAC1/TEP1 gene in human lung cancers. Genes Chromosomes Cancer 1998;22:152-156. (Pubitemid 28208808)
    • (1998) Genes Chromosomes and Cancer , vol.22 , Issue.2 , pp. 152-156
    • Kohno, T.1    Takahashi, M.2    Manda, R.3    Yokota, J.4
  • 55
    • 23444461754 scopus 로고    scopus 로고
    • PTEN expression in non-small-cell lung cancer: Evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    • DOI 10.1016/j.humpath.2005.05.006, PII S0046817705002455
    • Marsit CJ, Zheng S, Aldape K, et al. PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Human Pathology 2005;36:768-776. (Pubitemid 41112032)
    • (2005) Human Pathology , vol.36 , Issue.7 , pp. 768-776
    • Marsit, C.J.1    Zheng, S.2    Aldape, K.3    Hinds, P.W.4    Nelson, H.H.5    Wiencke, J.K.6    Kelsey, K.T.7
  • 56
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • Soria J-C, Lee H-Y, Lee JI, et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002;8:1178-1184.
    • (2002) Clin Cancer Res , vol.8 , pp. 1178-1184
    • Soria, J.-C.1    Lee, H.-Y.2    Lee, J.I.3
  • 58
    • 68549083200 scopus 로고    scopus 로고
    • Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
    • Do H, Solomon B, Mitchell PL, Fox SB, Dobrovic A. Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. BMC Res Notes 2008;1:14.
    • (2008) BMC Res Notes , vol.1 , pp. 14
    • Do, H.1    Solomon, B.2    Mitchell, P.L.3    Fox, S.B.4    Dobrovic, A.5
  • 59
    • 41849132829 scopus 로고    scopus 로고
    • Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
    • Malanga D, Scrima M, De Marco C, et al. Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 2008;7:665-669.
    • (2008) Cell Cycle , vol.7 , pp. 665-669
    • Malanga, D.1    Scrima, M.2    De Marco, C.3
  • 60
    • 52149086562 scopus 로고    scopus 로고
    • AKT1(E17K) in human solid tumours
    • Bleeker FE, Felicioni L, Buttitta F, et al. AKT1(E17K) in human solid tumours. Oncogene. 2008;27:5648-5650.
    • (2008) Oncogene , vol.27 , pp. 5648-5650
    • Bleeker, F.E.1    Felicioni, L.2    Buttitta, F.3
  • 62
    • 2542590883 scopus 로고    scopus 로고
    • Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
    • DOI 10.1038/sj.onc.1207502
    • Carretero J, Medina PP, Pio R, Montuenga LM, Sanchez-Cespedes M. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 2004;23:4037-4040. (Pubitemid 38747933)
    • (2004) Oncogene , vol.23 , Issue.22 , pp. 4037-4040
    • Carretero, J.1    Medina, P.P.2    Pio, R.3    Montuenga, L.M.4    Sanchez-Cespedes, M.5
  • 63
    • 34748845413 scopus 로고    scopus 로고
    • Prevalence and specificity of LKB1 genetic alterations in lung cancers
    • Matsumoto S, Iwakawa R, Takahashi K, et al. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 2007;26:5911-5918.
    • (2007) Oncogene , vol.26 , pp. 5911-5918
    • Matsumoto, S.1    Iwakawa, R.2    Takahashi, K.3
  • 64
    • 48249102662 scopus 로고    scopus 로고
    • Mutations in the LKB1 tumour suppressor are frequently detected in tumours from caucasian but not Asian lung cancer patients
    • Koivunen JP, Kim J, Lee J, et al. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. Br J Cancer 2008;99:245-252.
    • (2008) Br J Cancer , vol.99 , pp. 245-252
    • Koivunen, J.P.1    Kim, J.2    Lee, J.3
  • 68
    • 0033152759 scopus 로고    scopus 로고
    • Competitive and noncompetitive inhibition of the DNA-dependent protein kinase
    • Izzard RA, Jackson SP, Smith GCM. Competitive and Noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res 1999;59: 2581-2586. (Pubitemid 29269102)
    • (1999) Cancer Research , vol.59 , Issue.11 , pp. 2581-2586
    • Izzard, R.A.1    Jackson, S.P.2    Smith, G.C.M.3
  • 69
    • 34247339936 scopus 로고    scopus 로고
    • Exploring the specificity of the PI3K family inhibitor LY294002
    • Gharbi SI, Zvelebil MJ, Shuttleworth SJ, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J 2007;404:15-21.
    • (2007) Biochem J , vol.404 , pp. 15-21
    • Gharbi, S.I.1    Zvelebil, M.J.2    Shuttleworth, S.J.3
  • 70
    • 51849098272 scopus 로고    scopus 로고
    • Drug discovery approaches targeting the PI3K/Akt pathway in cancer
    • Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008;27:5511-5526.
    • (2008) Oncogene , vol.27 , pp. 5511-5526
    • Garcia-Echeverria, C.1    Sellers, W.R.2
  • 71
    • 58149509984 scopus 로고    scopus 로고
    • Take your PIK: Phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
    • Ihle NT, Powis G. Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy. Mol Cancer Ther 2009;8:1-9.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1-9
    • Ihle, N.T.1    Powis, G.2
  • 73
    • 43249131245 scopus 로고    scopus 로고
    • Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase I tumor pharmacodynamic study in patients with advanced solid tumors
    • Tabernero J, Rojo F, Calvo E, et al. Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 2008;26:1603-1610.
    • (2008) J Clin Oncol , vol.26 , pp. 1603-1610
    • Tabernero, J.1    Rojo, F.2    Calvo, E.3
  • 76
    • 33646382364 scopus 로고    scopus 로고
    • A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
    • Fan QW, Knight ZA, Goldenberg DD, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 2006;9: 341-349.
    • (2006) Cancer Cell , vol.9 , pp. 341-349
    • Fan, Q.W.1    Knight, Z.A.2    Goldenberg, D.D.3
  • 77
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V, Markman B, Scaltriti M, et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008;68:8022-8030.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3
  • 78
    • 37049010979 scopus 로고    scopus 로고
    • Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression
    • Legrier ME, Yang CP, Yan HG, et al. Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression. Cancer Res 2007;67:11300-11308.
    • (2007) Cancer Res , vol.67 , pp. 11300-11308
    • Legrier, M.E.1    Yang, C.P.2    Yan, H.G.3
  • 79
    • 51349111250 scopus 로고    scopus 로고
    • Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
    • Kinkade CW, Castillo-Martin M, Puzio-Kuter A, et al. Targeting AKT/ mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest 2008;118:3051-3064.
    • (2008) J Clin Invest , vol.118 , pp. 3051-3064
    • Kinkade, C.W.1    Castillo-Martin, M.2    Puzio-Kuter, A.3
  • 81
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in national cancer institute of Canada clinical trials group study BR.21
    • Zhu CQ, da Cunha Santos G, Ding K, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 21. J Clin Oncol 2008;26:4268-4275.
    • (2008) J Clin Oncol , vol.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha Santos, G.2    Ding, K.3
  • 82
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-5909.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 84
    • 55449116539 scopus 로고    scopus 로고
    • Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    • Okuda K, Sasaki H, Yukiue H, Yano M, Fujii Y. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci 2008;99:2280-2285.
    • (2008) Cancer Sci , vol.99 , pp. 2280-2285
    • Okuda, K.1    Sasaki, H.2    Yukiue, H.3    Yano, M.4    Fujii, Y.5
  • 86
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007;104: 20932-20937.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3
  • 87
    • 62449250134 scopus 로고    scopus 로고
    • MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors
    • Kubo T, Yamamoto H, Lockwood WW, et al. MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors. Int J Cancer 2009;124:1778-1784.
    • (2009) Int J Cancer , vol.124 , pp. 1778-1784
    • Kubo, T.1    Yamamoto, H.2    Lockwood, W.W.3
  • 88
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • Cappuzzo F, Janne PA, Skokan M, et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 2009;20:298-304.
    • (2009) Ann Oncol , vol.20 , pp. 298-304
    • Cappuzzo, F.1    Janne, P.A.2    Skokan, M.3
  • 89
    • 48549098388 scopus 로고    scopus 로고
    • Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
    • Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 2008;68:4971-4976.
    • (2008) Cancer Res , vol.68 , pp. 4971-4976
    • Choi, Y.L.1    Takeuchi, K.2    Soda, M.3
  • 90
    • 37549060017 scopus 로고    scopus 로고
    • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
    • Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 2008;3:13-17.
    • (2008) J Thorac Oncol , vol.3 , pp. 13-17
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 91
    • 48249114422 scopus 로고    scopus 로고
    • EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
    • Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008;14:4275-4283.
    • (2008) Clin Cancer Res , vol.14 , pp. 4275-4283
    • Koivunen, J.P.1    Mermel, C.2    Zejnullahu, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.