메뉴 건너뛰기




Volumn 303, Issue 2, 2011, Pages 108-117

Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1α under normoxic condition

Author keywords

HIF 1 ; Invasion; Normoxia; Pancreatic cancer; SCF c kit

Indexed keywords

GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; SMALL INTERFERING RNA; STEM CELL FACTOR; UROKINASE;

EID: 79952040479     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.01.017     Document Type: Article
Times cited : (42)

References (46)
  • 1
    • 0028796630 scopus 로고
    • W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
    • Huizinga J.D., Thuneberg L., Kluppel M., Malysz J., Mikkelsen H.B., Bernstein A. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995, 373:347-349.
    • (1995) Nature , vol.373 , pp. 347-349
    • Huizinga, J.D.1    Thuneberg, L.2    Kluppel, M.3    Malysz, J.4    Mikkelsen, H.B.5    Bernstein, A.6
  • 2
    • 0018344526 scopus 로고
    • Decreased production of mast cells in S1/S1d anemic mice
    • Kitamura Y., Go S. Decreased production of mast cells in S1/S1d anemic mice. Blood 1979, 53:492-497.
    • (1979) Blood , vol.53 , pp. 492-497
    • Kitamura, Y.1    Go, S.2
  • 3
    • 0025160956 scopus 로고
    • Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors
    • Nocka K., Buck J., Levi E., Besmer P. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. The EMBO Journal 1990, 9:3287-3294.
    • (1990) The EMBO Journal , vol.9 , pp. 3287-3294
    • Nocka, K.1    Buck, J.2    Levi, E.3    Besmer, P.4
  • 4
    • 0024280901 scopus 로고
    • The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    • Geissler E.N., Ryan M.A., Housman D.E. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988, 55:185-192.
    • (1988) Cell , vol.55 , pp. 185-192
    • Geissler, E.N.1    Ryan, M.A.2    Housman, D.E.3
  • 8
    • 0025077796 scopus 로고
    • The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus
    • Huang E., Nocka K., Beier D.R., Chu T.Y., Buck J., Lahm H.W., Wellner D., Leder P., Besmer P. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 1990, 63:225-233.
    • (1990) Cell , vol.63 , pp. 225-233
    • Huang, E.1    Nocka, K.2    Beier, D.R.3    Chu, T.Y.4    Buck, J.5    Lahm, H.W.6    Wellner, D.7    Leder, P.8    Besmer, P.9
  • 9
    • 0025093247 scopus 로고
    • Steel locus defines new multipotent growth factor
    • Witte O.N. Steel locus defines new multipotent growth factor. Cell 1990, 63:5-6.
    • (1990) Cell , vol.63 , pp. 5-6
    • Witte, O.N.1
  • 10
    • 0026039464 scopus 로고
    • Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis
    • Blume-Jensen P., Claesson-Welsh L., Siegbahn A., Zsebo K.M., Westermark B., Heldin C.H. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. The EMBO Journal 1991, 10:4121-4128.
    • (1991) The EMBO Journal , vol.10 , pp. 4121-4128
    • Blume-Jensen, P.1    Claesson-Welsh, L.2    Siegbahn, A.3    Zsebo, K.M.4    Westermark, B.5    Heldin, C.H.6
  • 11
    • 33644867457 scopus 로고    scopus 로고
    • The stem cell factor receptor/c-Kit as a drug target in cancer
    • Lennartsson J., Ronnstrand L. The stem cell factor receptor/c-Kit as a drug target in cancer. Current Cancer Drug Targets 2006, 6:65-75.
    • (2006) Current Cancer Drug Targets , vol.6 , pp. 65-75
    • Lennartsson, J.1    Ronnstrand, L.2
  • 12
    • 0038582468 scopus 로고    scopus 로고
    • Immunohistochemical expression of receptor-tyrosine kinase c-kit protein in invasive ductal carcinoma of the pancreas
    • Nio Y., Omori H., Toga T., Hashimoto K., Itakura M., Koike M., Yano S., Higami T. Immunohistochemical expression of receptor-tyrosine kinase c-kit protein in invasive ductal carcinoma of the pancreas. Anti-Cancer Drugs 2003, 14:313-319.
    • (2003) Anti-Cancer Drugs , vol.14 , pp. 313-319
    • Nio, Y.1    Omori, H.2    Toga, T.3    Hashimoto, K.4    Itakura, M.5    Koike, M.6    Yano, S.7    Higami, T.8
  • 14
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: pathophysiology and therapeutics
    • Semenza G.L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends in Molecular Medicine 2002, 8:S62-67.
    • (2002) Trends in Molecular Medicine , vol.8
    • Semenza, G.L.1
  • 15
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks K.L., Turley H., Gatter K.C., Maxwell P.H., Pugh C.W., Ratcliffe P.J., Harris A.L. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. The American Journal of Pathology 2000, 157:411-421.
    • (2000) The American Journal of Pathology , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 16
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nature Reviews 2003, 3:721-732.
    • (2003) Nature Reviews , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 17
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001, 294:1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 19
    • 33747660292 scopus 로고    scopus 로고
    • Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system
    • Stiehl D.P., Wirthner R., Koditz J., Spielmann P., Camenisch G., Wenger R.H. Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. The Journal of Biological Chemistry 2006, 281:23482-23491.
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 23482-23491
    • Stiehl, D.P.1    Wirthner, R.2    Koditz, J.3    Spielmann, P.4    Camenisch, G.5    Wenger, R.H.6
  • 20
    • 0037178551 scopus 로고    scopus 로고
    • Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions
    • Zhong H., Mabjeesh N., Willard M., Simons J. Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions. Cancer Letters 2002, 181:233-238.
    • (2002) Cancer Letters , vol.181 , pp. 233-238
    • Zhong, H.1    Mabjeesh, N.2    Willard, M.3    Simons, J.4
  • 21
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • Akakura N., Kobayashi M., Horiuchi I., Suzuki A., Wang J., Chen J., Niizeki H., Kawamura K., Hosokawa M., Asaka M. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Research 2001, 61:6548-6554.
    • (2001) Cancer Research , vol.61 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3    Suzuki, A.4    Wang, J.5    Chen, J.6    Niizeki, H.7    Kawamura, K.8    Hosokawa, M.9    Asaka, M.10
  • 22
    • 0037131271 scopus 로고    scopus 로고
    • Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha
    • Chan D.A., Sutphin P.D., Denko N.C., Giaccia A.J. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. The Journal of Biological Chemistry 2002, 277:40112-40117.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 40112-40117
    • Chan, D.A.1    Sutphin, P.D.2    Denko, N.C.3    Giaccia, A.J.4
  • 23
    • 34548483434 scopus 로고    scopus 로고
    • Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST)
    • Ali S., Ali S. Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST). Gene 2007, 401:38-45.
    • (2007) Gene , vol.401 , pp. 38-45
    • Ali, S.1    Ali, S.2
  • 24
    • 52149092535 scopus 로고    scopus 로고
    • Hypoxia induced HIF-1 accumulation and VEGF expression in gastric epithelial mucosa cell: involvement of ERK1/2 and PI3K/Akt
    • Liu L., Ning X., Han S., Zhang H., Sun L., Shi Y., Sun S., Guo C., Yin F., Qiao T., Wu K., Fan D. Hypoxia induced HIF-1 accumulation and VEGF expression in gastric epithelial mucosa cell: involvement of ERK1/2 and PI3K/Akt. Molecular Biology 2008, 42:459-469.
    • (2008) Molecular Biology , vol.42 , pp. 459-469
    • Liu, L.1    Ning, X.2    Han, S.3    Zhang, H.4    Sun, L.5    Shi, Y.6    Sun, S.7    Guo, C.8    Yin, F.9    Qiao, T.10    Wu, K.11    Fan, D.12
  • 27
    • 0030669664 scopus 로고    scopus 로고
    • Plasma levels and production of soluble stem cell factor by marrow stromal cells in patients with aplastic anaemia
    • Kojima S., Matsuyama T., Kodera Y. Plasma levels and production of soluble stem cell factor by marrow stromal cells in patients with aplastic anaemia. British Journal of Haematology 1997, 99:440-446.
    • (1997) British Journal of Haematology , vol.99 , pp. 440-446
    • Kojima, S.1    Matsuyama, T.2    Kodera, Y.3
  • 28
  • 29
    • 27644477840 scopus 로고    scopus 로고
    • Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells
    • Kwon S.J., Lee Y.J. Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. Clinical Cancer Research 2005, 11:4694-4700.
    • (2005) Clinical Cancer Research , vol.11 , pp. 4694-4700
    • Kwon, S.J.1    Lee, Y.J.2
  • 30
    • 33745259854 scopus 로고    scopus 로고
    • Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha
    • Li Q.F., Wang X.R., Yang Y.W., Lin H. Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. Cell Research 2006, 16:548-558.
    • (2006) Cell Research , vol.16 , pp. 548-558
    • Li, Q.F.1    Wang, X.R.2    Yang, Y.W.3    Lin, H.4
  • 31
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
    • Wang V., Davis D.A., Haque M., Huang L.E., Yarchoan R. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Research 2005, 65:3299-3306.
    • (2005) Cancer Research , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 33
    • 9744246909 scopus 로고    scopus 로고
    • Signal transduction via the stem cell factor receptor/c-kit
    • Ronnstrand L. Signal transduction via the stem cell factor receptor/c-kit. Cellular and Molecular Life Sciences 2004, 61:2535-2548.
    • (2004) Cellular and Molecular Life Sciences , vol.61 , pp. 2535-2548
    • Ronnstrand, L.1
  • 35
    • 17844364429 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I
    • Treins C., Giorgetti-Peraldi S., Murdaca J., Monthouel-Kartmann M.N., Van Obberghen E. Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. Molecular Endocrinology 2005, 1304-1317.
    • (2005) Molecular Endocrinology , pp. 1304-1317
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Monthouel-Kartmann, M.N.4    Van Obberghen, E.5
  • 36
    • 14944380568 scopus 로고    scopus 로고
    • In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways
    • Shi Y.H., Wang Y.X., Bingle L., Gong L.H., Heng W.J., Li Y., Fang W.G. In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways. The Journal of Pathology 2005, 205:530-536.
    • (2005) The Journal of Pathology , vol.205 , pp. 530-536
    • Shi, Y.H.1    Wang, Y.X.2    Bingle, L.3    Gong, L.H.4    Heng, W.J.5    Li, Y.6    Fang, W.G.7
  • 37
    • 59649102824 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone
    • Alam H., Weck J., Maizels E., Park Y., Lee E.J., Ashcroft M., Hunzicker-Dunn M. Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone. Endocrinology 2009, 150:915-928.
    • (2009) Endocrinology , vol.150 , pp. 915-928
    • Alam, H.1    Weck, J.2    Maizels, E.3    Park, Y.4    Lee, E.J.5    Ashcroft, M.6    Hunzicker-Dunn, M.7
  • 38
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochemical Pharmacology 2002, 64:993-998.
    • (2002) Biochemical Pharmacology , vol.64 , pp. 993-998
    • Semenza, G.1
  • 42
    • 24944488029 scopus 로고    scopus 로고
    • Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK
    • Liu C., Shi Y., Du Y., Ning X., Liu N., Huang D., Liang J., Xue Y., Fan D. Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK. Experimental Cell Research 2005, 309:410-418.
    • (2005) Experimental Cell Research , vol.309 , pp. 410-418
    • Liu, C.1    Shi, Y.2    Du, Y.3    Ning, X.4    Liu, N.5    Huang, D.6    Liang, J.7    Xue, Y.8    Fan, D.9
  • 43
  • 44
    • 77956206294 scopus 로고    scopus 로고
    • Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line
    • Schelter F., Gerg M., Halbgewachs B., Schaten S., Gorlach A., Schrotzlmair F., Kruger A. Identification of a survival-independent metastasis-enhancing role of hypoxia-inducible factor-1alpha with a hypoxia-tolerant tumor cell line. The Journal of Biological Chemistry 2010, 285:26182-26189.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 26182-26189
    • Schelter, F.1    Gerg, M.2    Halbgewachs, B.3    Schaten, S.4    Gorlach, A.5    Schrotzlmair, F.6    Kruger, A.7
  • 46
    • 30544442177 scopus 로고    scopus 로고
    • Front-line therapy of advanced pancreatic cancer
    • Kindler H.L. Front-line therapy of advanced pancreatic cancer. Seminars in Oncology 2005, 32:S33-S36.
    • (2005) Seminars in Oncology , vol.32
    • Kindler, H.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.