메뉴 건너뛰기




Volumn 65, Issue 24, 2005, Pages 11354-11360

Negative regulation of TSC1-TSC2 by mammalian D-type cyclins

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; RETINOBLASTOMA PROTEIN; S6 KINASE; TSC1 PROTEIN; TUBERIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 29244477527     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2236     Document Type: Article
Times cited : (64)

References (63)
  • 1
    • 0016793098 scopus 로고
    • Genetic control of cell size at cell division in yeast
    • Nurse P. Genetic control of cell size at cell division in yeast. Nature 1975;256:547-51.
    • (1975) Nature , vol.256 , pp. 547-551
    • Nurse, P.1
  • 2
    • 0017660982 scopus 로고
    • Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division
    • Hartwell LH, Unger MW. Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division. J Cell Biol 1977;75:422-35.
    • (1977) J Cell Biol , vol.75 , pp. 422-435
    • Hartwell, L.H.1    Unger, M.W.2
  • 3
    • 10344222155 scopus 로고    scopus 로고
    • How cells coordinate growth and division
    • Jorgensen P, Tyers M. How cells coordinate growth and division. Curr Biol 2004;14:R1014-27.
    • (2004) Curr Biol , vol.14
    • Jorgensen, P.1    Tyers, M.2
  • 4
    • 18344372831 scopus 로고    scopus 로고
    • Cyclins and cdks in development and cancer: A perspective
    • Deshpande A, Sicinski P, Hinds PW. Cyclins and cdks in development and cancer: a perspective. Oncogene 2005;24:2909-15.
    • (2005) Oncogene , vol.24 , pp. 2909-2915
    • Deshpande, A.1    Sicinski, P.2    Hinds, P.W.3
  • 5
    • 0141923009 scopus 로고    scopus 로고
    • Integration of growth factor and nutrient signaling: Implications for cancer biology
    • Shamji AF, Nghiem P, Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell 2003;12:271-80.
    • (2003) Mol Cell , vol.12 , pp. 271-280
    • Shamji, A.F.1    Nghiem, P.2    Schreiber, S.L.3
  • 6
    • 18344369616 scopus 로고    scopus 로고
    • Biochemical and cellular mechanisms of mammalian CDK inhibitors: A few unresolved issues
    • Pei XH, Xiong Y. Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene 2005;24:2787-95.
    • (2005) Oncogene , vol.24 , pp. 2787-2795
    • Pei, X.H.1    Xiong, Y.2
  • 7
    • 0029658034 scopus 로고    scopus 로고
    • Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation
    • Franklin DS, Xiong Y. Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation. Mol Biol Cell 1996;7:1587-99.
    • (1996) Mol Biol Cell , vol.7 , pp. 1587-1599
    • Franklin, D.S.1    Xiong, Y.2
  • 8
    • 0033531241 scopus 로고    scopus 로고
    • Functional domains in cyclin D1: PRb-kinase activity is not essential for transformation
    • Zwicker J, Brusselbach S, Jooss KU, et al. Functional domains in cyclin D1: pRb-kinase activity is not essential for transformation. Oncogene 1999;18:19-25.
    • (1999) Oncogene , vol.18 , pp. 19-25
    • Zwicker, J.1    Brusselbach, S.2    Jooss, K.U.3
  • 9
    • 0345598896 scopus 로고    scopus 로고
    • Distinct and nonoverlapping roles for pRB and cyclin D: Cyclin-dependent kinases 4/6 activity in melanocyte survival
    • Yu BD, Becker-Hapak M, Snyder EL, et al. Distinct and nonoverlapping roles for pRB and cyclin D: cyclin-dependent kinases 4/6 activity in melanocyte survival. Proc Natl Acad Sci U S A 2003;100:14881-6.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14881-14886
    • Yu, B.D.1    Becker-Hapak, M.2    Snyder, E.L.3
  • 10
    • 0034282517 scopus 로고    scopus 로고
    • Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression
    • Meyer CA, Jacobs HW, Datar SA, et al. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J 2000;19:4533-42.
    • (2000) EMBO J , vol.19 , pp. 4533-4542
    • Meyer, C.A.1    Jacobs, H.W.2    Datar, S.A.3
  • 12
    • 4444307411 scopus 로고    scopus 로고
    • Mouse development and cell proliferation in the absence of D-cyclins
    • Kozar K, Ciemerych MA, Rebel VI, et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 2004;118:477-91.
    • (2004) Cell , vol.118 , pp. 477-491
    • Kozar, K.1    Ciemerych, M.A.2    Rebel, V.I.3
  • 13
    • 4444247138 scopus 로고    scopus 로고
    • Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    • Malumbres M, Sotillo R, Santamaria D, et al. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004;118: 493-504.
    • (2004) Cell , vol.118 , pp. 493-504
    • Malumbres, M.1    Sotillo, R.2    Santamaria, D.3
  • 14
    • 0042856301 scopus 로고    scopus 로고
    • Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number
    • Martin J, Hunt SL, Dubus P, et al. Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number. Oncogene 2003;22: 5261-9.
    • (2003) Oncogene , vol.22 , pp. 5261-5269
    • Martin, J.1    Hunt, S.L.2    Dubus, P.3
  • 15
    • 0036333186 scopus 로고    scopus 로고
    • The role of RBF in developmentally regulated cell proliferation in the eye disc and in cyclin D/Cdk4 induced cellular growth
    • Xin S, Weng L, Xu J, Du W. The role of RBF in developmentally regulated cell proliferation in the eye disc and in cyclin D/Cdk4 induced cellular growth. Development 2002;129:1345-56.
    • (2002) Development , vol.129 , pp. 1345-1356
    • Xin, S.1    Weng, L.2    Xu, J.3    Du, W.4
  • 16
    • 14844315660 scopus 로고    scopus 로고
    • The Drosophila mitochondrial ribosomal protein mRpL12 is required for cyclin D/Cdk4-driven growth
    • Frei C, Galloni M, Hafen E, Edgar BA. The Drosophila mitochondrial ribosomal protein mRpL12 is required for cyclin D/Cdk4-driven growth. EMBO J 2005;24:623-34.
    • (2005) EMBO J , vol.24 , pp. 623-634
    • Frei, C.1    Galloni, M.2    Hafen, E.3    Edgar, B.A.4
  • 17
    • 0442278330 scopus 로고    scopus 로고
    • Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    • Frei C, Edgar BA. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Dev Cell 2004;6:241-51.
    • (2004) Dev Cell , vol.6 , pp. 241-251
    • Frei, C.1    Edgar, B.A.2
  • 18
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura I, Denissova NG, Wang G, et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004;430:226-31.
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3
  • 19
  • 20
    • 0028802451 scopus 로고
    • The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
    • Pearson RB, Dennis PB, Han JW, et al. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J 1995;14:5279-87.
    • (1995) EMBO J , vol.14 , pp. 5279-5287
    • Pearson, R.B.1    Dennis, P.B.2    Han, J.W.3
  • 21
    • 0035805180 scopus 로고    scopus 로고
    • The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    • Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 2001;105:345-55.
    • (2001) Cell , vol.105 , pp. 345-355
    • Tapon, N.1    Ito, N.2    Dickson, B.J.3    Treisman, J.E.4    Hariharan, I.K.5
  • 22
    • 0036712905 scopus 로고    scopus 로고
    • Tsc tumour suppressor proteins antagonize amino acid-TOR signalling
    • Gao X, Zhang Y, Arrazola P, et al. Tsc tumour suppressor proteins antagonize amino acid-TOR signalling. Nat Cell Biol 2002;4:699-704.
    • (2002) Nat Cell Biol , vol.4 , pp. 699-704
    • Gao, X.1    Zhang, Y.2    Arrazola, P.3
  • 23
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002;4:648-57.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 24
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, et al. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002;99:13571-6.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3
  • 25
    • 0842325813 scopus 로고    scopus 로고
    • Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
    • Han S, Santos TM, Puga A, et al. Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions. Cancer Res 2004;64:812-6.
    • (2004) Cancer Res , vol.64 , pp. 812-816
    • Han, S.1    Santos, T.M.2    Puga, A.3
  • 26
    • 0038190932 scopus 로고    scopus 로고
    • The p38 and MK2 kinase cascade phosphorylates tuberin the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
    • Li Y, Inoki K, Vacratsis P, Guan KL. The p38 and MK2 kinase cascade phosphorylates tuberin the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem 2003;278:13663-71.
    • (2003) J Biol Chem , vol.278 , pp. 13663-13671
    • Li, Y.1    Inoki, K.2    Vacratsis, P.3    Guan, K.L.4
  • 27
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005;121:179-93.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 28
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002;10:151-62.
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 29
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002;4: 658-65.
    • (2002) Nat Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 30
    • 4544384577 scopus 로고    scopus 로고
    • Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    • Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A 2004;101:13489-94.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13489-13494
    • Roux, P.P.1    Ballif, B.A.2    Anjum, R.3    Gygi, S.P.4    Blenis, J.5
  • 31
    • 17844369428 scopus 로고    scopus 로고
    • The tuberous sclerosis 1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
    • Benvenuto G, Li S, Brown SJ, et al. The tuberous sclerosis 1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 2000;19:6306-16.
    • (2000) Oncogene , vol.19 , pp. 6306-6316
    • Benvenuto, G.1    Li, S.2    Brown, S.J.3
  • 32
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao X, Pan D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 2001;15:1383-92.
    • (2001) Genes Dev , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 33
    • 0043068043 scopus 로고    scopus 로고
    • Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38
    • Rosner M, Hofer K, Kubista M, Hengstschlager M. Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Oncogene 2003;22:4786-98.
    • (2003) Oncogene , vol.22 , pp. 4786-4798
    • Rosner, M.1    Hofer, K.2    Kubista, M.3    Hengstschlager, M.4
  • 34
    • 0033861013 scopus 로고    scopus 로고
    • The TSC1 gene product hamartin, negatively regulates cell proliferation
    • Miloloza A, Rosner M, Nellist M, et al. The TSC1 gene product hamartin, negatively regulates cell proliferation. Hum Mol Genet 2000;9:1721-7.
    • (2000) Hum Mol Genet , vol.9 , pp. 1721-1727
    • Miloloza, A.1    Rosner, M.2    Nellist, M.3
  • 35
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth cell proliferation, and organ size
    • Potter CJ, Huang H, Xu T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth cell proliferation, and organ size. Cell 2001;105:357-68.
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 36
    • 0030663735 scopus 로고    scopus 로고
    • Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
    • Soucek T, Pusch O, Wienecke R, DeClue JE, Hengstschlager M. Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J Biol Chem 1997;272:29301-8.
    • (1997) J Biol Chem , vol.272 , pp. 29301-29308
    • Soucek, T.1    Pusch, O.2    Wienecke, R.3    Declue, J.E.4    Hengstschlager, M.5
  • 37
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002;16:1472-87.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 39
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1 a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 4E-BP1 a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 1998;12:502-13.
    • (1998) Genes Dev , vol.12 , pp. 502-513
    • Gingras, A.C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 40
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 2002;11: 525-34.
    • (2002) Hum Mol Genet , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3
  • 41
    • 0037191045 scopus 로고    scopus 로고
    • Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
    • Jaeschke A, Hartkamp J, Saitoh M, et al. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J Cell Biol 2002;159:217-24.
    • (2002) J Cell Biol , vol.159 , pp. 217-224
    • Jaeschke, A.1    Hartkamp, J.2    Saitoh, M.3
  • 42
    • 0347065349 scopus 로고    scopus 로고
    • Cell cycle-regulated phosphorylation of hamartin the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B
    • Astrinidis A, Senapedis W, Coleman TR, Henske EP. Cell cycle-regulated phosphorylation of hamartin the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J Biol Chem 2003;278:51372-9.
    • (2003) J Biol Chem , vol.278 , pp. 51372-51379
    • Astrinidis, A.1    Senapedis, W.2    Coleman, T.R.3    Henske, E.P.4
  • 43
    • 14144254701 scopus 로고    scopus 로고
    • Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets the tuberous sclerosis tumor suppressors
    • Ballif BA, Roux PP, Gerber SA, et al. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci USA 2005;102:667-72.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 667-672
    • Ballif, B.A.1    Roux, P.P.2    Gerber, S.A.3
  • 44
    • 0030968438 scopus 로고    scopus 로고
    • CDK-independent activation of estrogen receptor by cyclin D1
    • Zwijsen RM, Wientjens E, Klompmaker R, et al. CDK-independent activation of estrogen receptor by cyclin D1. Cell 1997;88:405-15.
    • (1997) Cell , vol.88 , pp. 405-415
    • Zwijsen, R.M.1    Wientjens, E.2    Klompmaker, R.3
  • 45
    • 0031937638 scopus 로고    scopus 로고
    • Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase- independent mechanism
    • Inoue K, Sherr CJ. Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol Cell Biol 1998;18:1590-600.
    • (1998) Mol Cell Biol , vol.18 , pp. 1590-1600
    • Inoue, K.1    Sherr, C.J.2
  • 46
    • 0035660247 scopus 로고    scopus 로고
    • TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex
    • Nellist M, Verhaaf B, Goedbloed MA, et al. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Hum Mol Genet 2001;10:2889-98.
    • (2001) Hum Mol Genet , vol.10 , pp. 2889-2898
    • Nellist, M.1    Verhaaf, B.2    Goedbloed, M.A.3
  • 47
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002;2:103-12.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 48
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • The European Chromosome 16 Tuberous Sclerosis Consortium
    • Consortium TECTS. Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium. Cell 1993;75:1305-15.
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 49
    • 0030879277 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
    • van Slegtenhorst M, de Hoogt R, Hermans C, et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997;277:805-8.
    • (1997) Science , vol.277 , pp. 805-808
    • Van Slegtenhorst, M.1    De Hoogt, R.2    Hermans, C.3
  • 50
    • 0033582748 scopus 로고    scopus 로고
    • Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • Ito N, Rubin GM. gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 1999;96:529-39.
    • (1999) Cell , vol.96 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 51
    • 14844363721 scopus 로고    scopus 로고
    • Signaling by target of rapamycin proteins in cell growth control
    • Inoki K, Ouyang H, Li Y, Guan KL. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 2005;69:79-100.
    • (2005) Microbiol Mol Biol Rev , vol.69 , pp. 79-100
    • Inoki, K.1    Ouyang, H.2    Li, Y.3    Guan, K.L.4
  • 52
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang Y, Gao X, Saucedo LJ, et al. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 2003;5:578-81.
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3
  • 53
    • 0038304516 scopus 로고    scopus 로고
    • Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    • Stocker H, Radimerski T, Schindelholz B, et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 2003;5:559-65.
    • (2003) Nat Cell Biol , vol.5 , pp. 559-565
    • Stocker, H.1    Radimerski, T.2    Schindelholz, B.3
  • 54
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003;13:1259-68.
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 55
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo LJ, Gao X, Chiarelli DA, et al. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 2003;5:566-71.
    • (2003) Nat Cell Biol , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3
  • 56
    • 4444276510 scopus 로고    scopus 로고
    • Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity
    • Li Y, Inoki K, Guan KL. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mo Cell Biol 2004;24:7965-75.
    • (2004) Mo Cell Biol , vol.24 , pp. 7965-7975
    • Li, Y.1    Inoki, K.2    Guan, K.L.3
  • 57
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829-34.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 58
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSCl and 2
    • Garami A, Zwartkruis FJ, Nobukuni T, et al. Insulin activation of Rheb a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSCl and 2. Mol Cell 2003;11: 1457-66.
    • (2003) Mol Cell , vol.11 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.2    Nobukuni, T.3
  • 59
    • 0033593316 scopus 로고    scopus 로고
    • Size control in animal development
    • Conlon I, Raff M. Size control in animal development. Cell 1999;96:235-44.
    • (1999) Cell , vol.96 , pp. 235-244
    • Conlon, I.1    Raff, M.2
  • 60
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004;23:3151-71.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 61
    • 0034936816 scopus 로고    scopus 로고
    • Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B
    • Catania MG, Mischel PS, Vinters HV. Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. J Neuropathol Exp Neurol 2001;60:711-23.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 711-723
    • Catania, M.G.1    Mischel, P.S.2    Vinters, H.V.3
  • 62
    • 0041695213 scopus 로고    scopus 로고
    • Growth during the cell cycle
    • Mitchison JM. Growth during the cell cycle. Int Rev Cytol 2003;226:165-258.
    • (2003) Int Rev Cytol , vol.226 , pp. 165-258
    • Mitchison, J.M.1
  • 63
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • Ruggero D, Pandolfi PP. Does the ribosome translate cancer? Nat Rev Cancer 2003;3:179-92.
    • (2003) Nat Rev Cancer , vol.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.