-
1
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
3
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A 1996;93:3636-41.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
-
4
-
-
0035863411
-
AKT activation up-regulates insulin-like growth factor 1 receptor expression and promotes invasiveness of human pancreatic cancer cells
-
Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. AKT activation up-regulates insulin-like growth factor 1 receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 2001;61: 589-93.
-
(2001)
Cancer Res
, vol.61
, pp. 589-593
-
-
Tanno, S.1
Mitsuuchi, Y.2
Altomare, D.A.3
Xiao, G.H.4
Testa, J.R.5
-
5
-
-
0034307305
-
Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
-
Ng SSW, Tsao MS, Chow S, Hedley DW. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res 2000;60:5451-5.
-
(2000)
Cancer Res
, vol.60
, pp. 5451-5455
-
-
Ng, S.S.W.1
Tsao, M.S.2
Chow, S.3
Hedley, D.W.4
-
6
-
-
0034194348
-
Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent
-
Perugini RA, McDade TP, Vittimberga FJ, Jr., Callery MP. Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent. J Surg Res 2000;90:39-44.
-
(2000)
J Surg Res
, vol.90
, pp. 39-44
-
-
Perugini, R.A.1
McDade, T.P.2
Vittimberga Jr., F.J.3
Callery, M.P.4
-
7
-
-
0041338049
-
Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
-
Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ. Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 2002;1:989-97.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 989-997
-
-
Bondar, V.M.1
Sweeney-Gotsch, B.2
Andreeff, M.3
Mills, G.B.4
McConkey, D.J.5
-
8
-
-
9644253003
-
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells
-
Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells. Oncogene 2004;23:8571-80.
-
(2004)
Oncogene
, vol.23
, pp. 8571-8580
-
-
Asano, T.1
Yao, Y.2
Zhu, J.3
Li, D.4
Abbruzzese, J.L.5
Reddy, S.A.6
-
9
-
-
0037148434
-
Reduced PTEN expression in the pancreas overexpressing transforming growth factor-β 1
-
Ebert MP, Fei G, Schandl L, et al. Reduced PTEN expression in the pancreas overexpressing transforming growth factor-β 1. Br J Cancer 2002;86:257-62.
-
(2002)
Br J Cancer
, vol.86
, pp. 257-262
-
-
Ebert, M.P.1
Fei, G.2
Schandl, L.3
-
11
-
-
0032818440
-
Molecular genetic basis of pancreatic adenocarcinoma
-
Hilgers W, Kern SE. Molecular genetic basis of pancreatic adenocarcinoma. Genes Chromosomes Cancer 1999;26:1-12.
-
(1999)
Genes Chromosomes Cancer
, vol.26
, pp. 1-12
-
-
Hilgers, W.1
Kern, S.E.2
-
12
-
-
0032767855
-
Molecular aspects of pancreatic cancer and future perspectives
-
Friess H, Kleeff J, Korc M, Buchler MW. Molecular aspects of pancreatic cancer and future perspectives. Dig Surg 1999;16:281-90.
-
(1999)
Dig Surg
, vol.16
, pp. 281-290
-
-
Friess, H.1
Kleeff, J.2
Korc, M.3
Buchler, M.W.4
-
13
-
-
0035815613
-
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFκB activation without interfering with the IκB degradation pathway
-
Koul D, Yao Y, Abbruzzese JL, Yung WK, Reddy SA. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFκB activation without interfering with the IκB degradation pathway. J Biol Chem 2001;276:11402-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 11402-11408
-
-
Koul, D.1
Yao, Y.2
Abbruzzese, J.L.3
Yung, W.K.4
Reddy, S.A.5
-
14
-
-
0034458943
-
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling
-
Blake RA, Broome MA, Liu X, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol 2000;20:9018-27.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 9018-9027
-
-
Blake, R.A.1
Broome, M.A.2
Liu, X.3
-
15
-
-
15444361739
-
Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)- pvrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors
-
Rewcastle GW, Murray DK, Elliott WL, et al. Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pvrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors. J Med Chem 1998;41:742-51.
-
(1998)
J Med Chem
, vol.41
, pp. 742-751
-
-
Rewcastle, G.W.1
Murray, D.K.2
Elliott, W.L.3
-
16
-
-
0024240990
-
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors
-
Yaish P, Gazit A, Gilon C, Levitzki A. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 1988;242:933-5.
-
(1988)
Science
, vol.242
, pp. 933-935
-
-
Yaish, P.1
Gazit, A.2
Gilon, C.3
Levitzki, A.4
-
17
-
-
0028095620
-
Structure, regulation and function of phosphoinositide 3-kinases
-
Fry MJ. Structure, regulation and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1994;1226:237-68.
-
(1994)
Biochim Biophys Acta
, vol.1226
, pp. 237-268
-
-
Fry, M.J.1
-
18
-
-
0038398622
-
The insulin-like growth factor system and cancer
-
LeRoith D, Roberts CT, Jr. The insulin-like growth factor system and cancer. Cancer Lett 2003;195:127-37.
-
(2003)
Cancer Lett
, vol.195
, pp. 127-137
-
-
LeRoith, D.1
Roberts Jr., C.T.2
-
19
-
-
0028997487
-
Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
-
Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res 1995;55:2007-11.
-
(1995)
Cancer Res
, vol.55
, pp. 2007-2011
-
-
Bergmann, U.1
Funatomi, H.2
Yokoyama, M.3
Beger, H.G.4
Korc, M.5
-
20
-
-
0029890372
-
Increased expression of insulin receptor substrate-1 in human pancreatic cancer
-
Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M. Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Biochem Biophys Res Commun 1996;220:886-90.
-
(1996)
Biochem Biophys Res Commun
, vol.220
, pp. 886-890
-
-
Bergmann, U.1
Funatomi, H.2
Kornmann, M.3
Beger, H.G.4
Korc, M.5
-
21
-
-
0032189403
-
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer
-
Kornmann M, Maruyama H, Bergmann U, et al. Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res 1998;58:4250-4.
-
(1998)
Cancer Res
, vol.58
, pp. 4250-4254
-
-
Kornmann, M.1
Maruyama, H.2
Bergmann, U.3
-
22
-
-
0035857042
-
Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2
-
Nair PN, De Armond DT, Adamo ML, Strodel WE, Freeman JW. Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2. Oncogene 2001;20:8203-14.
-
(2001)
Oncogene
, vol.20
, pp. 8203-8214
-
-
Nair, P.N.1
De Armond, D.T.2
Adamo, M.L.3
Strodel, W.E.4
Freeman, J.W.5
-
23
-
-
0034988819
-
Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells
-
Esposito DL, Li Y, Cama A, Quon MJ. Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 2001;142: 2833-40.
-
(2001)
Endocrinology
, vol.142
, pp. 2833-2840
-
-
Esposito, D.L.1
Li, Y.2
Cama, A.3
Quon, M.J.4
-
24
-
-
0037115763
-
Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
-
Hers I, Bell CJ, Poole AW, et al. Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J 2002;368: 875-84.
-
(2002)
Biochem J
, vol.368
, pp. 875-884
-
-
Hers, I.1
Bell, C.J.2
Poole, A.W.3
-
25
-
-
0031171216
-
The IRS-signalling system during insulin and cytokine action
-
Yenush L, White MF. The IRS-signalling system during insulin and cytokine action. Bioessays 1997;19: 491-500.
-
(1997)
Bioessays
, vol.19
, pp. 491-500
-
-
Yenush, L.1
White, M.F.2
-
26
-
-
0037183974
-
Epidermal growth factor and transforming growth factor α mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance
-
Gogg S, Smith U. Epidermal growth factor and transforming growth factor α mimic the effects of insulin in human fat cells and augment downstream signaling in insulin resistance. J Biol Chem 2002;277:36045-51.
-
(2002)
J Biol Chem
, vol.277
, pp. 36045-36051
-
-
Gogg, S.1
Smith, U.2
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