EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2

Biochemical and Biophysical Research Communications

Volumn 379, Issue 2, 2009, Pages 445-450

  Binker, Marcelo G ^a   Binker Cosen, Andres A ^a   Richards, Daniel ^a   Oliver, Brenda ^a   Cosen Binker, Laura I ^a  

^a CBRHC Research Center   (Argentina)

Author keywords

Cancer invasion; Epidermal growth factor (EGF); Matrix metalloproteinase 2 (MMP 2); PANC 1 cells; Rac1; Reactive oxygen species (ROS)

Indexed keywords

COLLAGENASE; EPIDERMAL GROWTH FACTOR; GELATINASE A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BASEMENT MEMBRANE; CELL INVASION; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN CELL; METASTASIS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN SECRETION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE, TUMOR; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; HUMANS; MATRIX METALLOPROTEINASE 2; NADP; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SRC-FAMILY KINASES;

EID: 58249109706     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.12.080     Document Type: Article

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