Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 42, 2009, Pages 17769-17774

  Laklai, Hanane ^a,b   Laval, Séverine ^a,b   Dumartin, Laurent ^b,e,f   Rochaix, Philippe ^d,e   Hagedorn, Martin ^b,e,f   Bikfalvi, Andreas ^b,e,f   Le Guellec, Sophie ^c,f   Delisle, Marie Bernadette ^c,f   Schally, Andrew V ^d,g   Susini, Christiane ^a,b   Pyronnet, Stéphane ^a,b   Bousquet, Corinne ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c CHU RANGUEIL   (France)

^d INSTITUT CLAUDIUS REGAUD   (France)

^e Institut National de la Santé et de la Recherche Médicale 1NSERM U915   (France)

^f UNIVERSITÉ DE BORDEAUX   (France)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Chick chorioallantoic membrane model; IRES dependent translation

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOSTATIN RECEPTOR 2; THROMBOSPONDIN 1; VASCULOTROPIN;

5' UNTRANSLATED REGION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL CULTURE; CELL GROWTH; CHORIOALLANTOIS; CONTROLLED STUDY; EFFECTOR CELL; ENDOTHELIUM CELL; ENZYME INHIBITION; EXOCRINE CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERNAL RIBOSOME ENTRY SITE; MOUSE; NONHUMAN; PANCREAS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TRANSCRIPTION INITIATION; TRANSLATION INITIATION; TUMOR CELL;

ANIMALS; CELL LINE, TUMOR; CHICK EMBRYO; GENE EXPRESSION PROFILING; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, SOMATOSTATIN; RNA, MESSENGER; RNA, NEOPLASM; THROMBOSPONDIN 1; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70449578255     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908674106     Document Type: Article

References (28)

1. Weckbecker G, et al. (2003) Opportunities in somatostatin research: Biological, chemical and therapeutic aspects. Nat Rev Drug Discov 2:999-1017. (Pubitemid 37540581)
2. Pyronnet S, et al. Antitumor effects of somatostatin. Mol Cell Endocrinol 286:230-237, 2008.
3. Susini C, Buscail L (2006) Rationale for the use of somatostatin analogs as antitumor agents. Ann Oncol 17:1733-1742. (Pubitemid 44884046)
4. Delesque N, et al. (1997) sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells. Cancer Res 57:956-962. (Pubitemid 27098024)
5. Vernejoul F, et al. (2002) Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models. Cancer Res 62:6124-6131. (Pubitemid 35244461)
6. Guillermet J, et al. (2003) Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. Proc Natl Acad Sci USA 100:155-160. (Pubitemid 36078044)
7. Buscail L, et al. (1996) Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer. Cancer Res 56:1823-1827. (Pubitemid 26118217)
8. Kumar M, et al. (2004) Mechanisms of inhibition of growth of human pancreatic carcinoma implanted in nude mice by somatostatin receptor subtype 2. Pancreas 29:141-151. (Pubitemid 38971804)
9. Carrere N, et al. (2005) Characterization of the bystander effect of somatostatin receptor sst2 after in vivo gene transfer into human pancreatic cancer cells. Hum Gene Ther 16:1175-1193. (Pubitemid 41443710)
10. Bousquet C, et al. (2004) Somatostatin receptors and regulation of cell proliferation. Dig Liver Dis 36 Suppl 1:S2-7.
11. Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18.
12. Adams RL, Adams IP, Lindow SW, Zhong W, Atkin SL (2005) Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium. Br J Cancer 92:1493-1498. (Pubitemid 40705017)
13. Woltering EA (2003) Development of targeted somatostatin-based antiangiogenic therapy: A review and future perspectives. Cancer Biother Radiopharm 18:601-609.
14. Reubi JC, Waser B, Schaer JC, Laissue JA (2001) Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur J Nucl Med 28:836-846. (Pubitemid 32662546)
15. Bousquet C, et al. (2006) Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway. EMBO J 25:3943-3954. (Pubitemid 44338737)
16. Campbell PM, et al. (2007) K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res 67:2098-2106.
17. Azar R, Najib S, Lahlou H, Susini C, Pyronnet S (2008) Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1. Cell Mol Life Sci 65:3110-3117.
18. Lahlou H, Fanjul M, Pradayrol L, Susini C, Pyronnet S (2005) Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells. Mol Cell Biol 25:4034-4045. (Pubitemid 40617652)
19. Hagedorn M, et al. (2005) Accessing key steps of human tumor progression in vivo by using an avian embryo model. Proc Natl Acad Sci USA 102:1643-1648. (Pubitemid 40209221)
20. Papoutsi M, Sleeman JP, Wilting J (2001) Interaction of rat tumor cells with blood vessels and lymphatics of the avian chorioallantoic membrane. Microsc Res Tech 55:100-107. (Pubitemid 32988911)
21. Ren B, Yee KO, Lawler J, Khosravi-Far R (2006) Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta 1765:178-188.
22. Almog N, et al. (2009) Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. Cancer Res 69:836-844.
23. Mazan-Mamczarz K, et al. (2008) Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene 27:6151-6163.
24. Wu MP, et al. (2008) A novel role of thrombospondin-1 in cervical carcinogenesis: Inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer. Carcinogenesis 29:1115-1123.
25. Torrisani J, et al. (2008) Identification of an upstream promoter of the human somatostatin receptor, hSSTR2, which is controlled by epigenetic modifications. Endocrinology 149:3137-3147. (Pubitemid 351728032)
26. Kalas W, et al. (2005) Oncogenes and angiogenesis: Downregulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras. Cancer Res 65:8878-8886. (Pubitemid 41377377)
27. van Hagen PM, Dalm VA, Staal F, Hofland LJ (2008) The role of cortistatin in the human immune system. Mol Cell Endocrinol 286:141-147.
28. Xu Y, Song J, Berelowitz M, Bruno JF (1996) Estrogen regulates somatostatin receptor subtype 2 messenger ribonucleic acid expression in human breast cancer cells. Endocrinology 137:5634-5640. (Pubitemid 26423134)