Neutralizing interleukin-1β(IL-1β) induces β-cell survival by maintaining PDX1 protein nuclear localization

Journal of Biological Chemistry

Volumn 286, Issue 19, 2011, Pages 17144-17155

  Ardestani, Amin ^a   Sauter, Nadine S ^b   Paroni, Federico ^a   Dharmadhikari, Gitanjali ^a   Cho, Jae Hyoung ^c   Lupi, Roberto ^d   Marchetti, Piero ^d   Oberholzer, José ^e   Conte, Julie Kerr ^f   Maedler, Kathrin ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c The Catholic University of Korea   (South Korea)

^d UNIVERSITY HOSPITAL OF PISA   (Italy)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^f UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROTEINS; TRANSCRIPTION;

INSULIN GENE TRANSCRIPTION; INTERLEUKIN-1; NON-DIABETIC CONTROL; NUCLEAR LOCALIZATION; OVER-EXPRESSION; PROTECTIVE EFFECTS; RECEPTOR ANTAGONISTS; TYPE-2 DIABETES;

CYTOLOGY;

INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; TRANSCRIPTION FACTOR PDX 1; HOMEODOMAIN PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DISEASE COURSE; HORMONAL REGULATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INSULIN RELEASE; MOUSE; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; C57BL MOUSE; CELL NUCLEUS; DIABETES MELLITUS; GENETIC TRANSCRIPTION; METABOLISM; PANCREAS; RAT; TRANSGENIC MOUSE;

MUS;

ANIMALS; CELL NUCLEUS; CELL SURVIVAL; DIABETES MELLITUS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PANCREAS; RATS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 79955763329     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.210526     Document Type: Article

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