Reduced insulin, GLUT2, and IDX-1 in β-cells after partial pancreatectomy

Diabetes

Volumn 46, Issue 2, 1997, Pages 258-264

  Zangen, David H ^a,b   Bonner Weir, Susan ^a   Lee, Chung H ^a   Latimer, John B ^a   Miller, Christopher P ^c   Habener, Joel F ^b   Weir, Gordon C ^a  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPERGLYCEMIA; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PRIORITY JOURNAL; RAT;

EID: 0030955416     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.258     Document Type: Article

References (56)

1. Calles-Escandon J, Robbins DC: Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes 36:1167-1172, 1987
2. Luzi L, DeFronzo RA: Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans. Am J Physiol 257:E241-E246, 1989
3. Leahy JL, Bonner-Weir S, Weir GC: Beta-cell dysfunction induced by chronic hyperglycemia: current ideas on the mechanism of the impaired glucose-induced insulin secretion. Diabetes Care 15:442-455, 1992
4. Eisenbarth GS: Type 1 diabetes mellitus: a chronic autoimmune disease. N Engl J Med 314:1360-1368, 1986
5. Pfeiffer MA, Halter JB, Porte D: Insulin secretion in diabetes mellitus. Am J Med 70:579-588, 1981
6. Ward WK, Beard JC, Halter JB, Pfeiffer MA, Porte D: Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care 7:491-502, 1984
7. Unger RH: Diabetic hyperglycemia: link to impaired glucose transport in pancreatic B cells. Science 251:1200-1205, 1991
8. Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S: Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic β-cells of diabetic rats. Proc Natl Acad Sci USA 87:6492-6496, 1990
9. Orci L, Unger RH , Ravazzola M, Ogawa A, Komiya I, Baetens D, Lodish HF, Thorens B: Reduced beta-cell glucose transporter in new onset diabetic BB rats. J Clin Invest 86:1615-1622, 1990
10. Thorens B, Wu YJ, Leahy JL, Weir GC: The loss of GLUT-2 expression by glucose-unresponsive β-cells of db/db mice is reversible and is induced by the diabetic environment. J Clin Invest 90:77-85, 1992
11. Ogawa Y, Noma Y, Davalli AM, Wu YJ, Thorens B, Bonner-Weir S, Weir GC: Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted B-cells. Diabetes 44:75-79, 1995
12. Efrat S, Tal M, Lodish HF: The pancreatic beta-cell glucose sensor. Trends Biochem Sci 19:535-538, 1994
13. Tal M, Wu YJ, Leiser M, Surana M, Lodish H, Fleischer N, Weir GC, Efrat S: HRAS downregulates GLUT2 in β-cells of transgenic mice without affecting glucose homeostasis. Proc Natl Acad Sci USA 89:5744-5748,1992
14. Tokuyama Y, Stuns J, Depaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI: Evolution of β-cell dysfunction in the male Zucker Diabetic Fatty rat Diabetes 44:1447-1457, 1995
15. Tal M, Liang Y, Najafl H, Lodish HF, Matschinsky FM: Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. J Biol Chem 267:17241-17247, 1992
16. Bonner-Weir S, Trent DF, Weir GC: Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 71:1544-1553, 1983
17. Brockenbrough JS, Weir GC, Bonner-Weir S: Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes 37:232-236, 1988
18. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE: A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 42:1715-1720, 1993
19. Ohlsson H, Karlsson K, Edlund T: IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259, 1993
20. Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MR: Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7:1275-1283, 1993
21. Miller CP, McGehee RE, Habener JF: IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 13:1145-1156, 1994
22. Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609, 1994
23. Offield MF, Jetton TL, Labosky PA, Ray M, Stein R, Magnuson MA, Hogan BLM, Wright CVE: PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995, 1996
24. Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD: Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci USA 91:10465-10469, 1994
25. Leibiger B, Leibiger IB: Analysis of cis-elements of the human GLUT2 gene promoter involved in transcriptional control in βTC-3 cells (Abstract). Diabetologia 38 (Suppl. 1):A68, 1995
26. Olson LK, Sharma A, Peshavaria M, Wright CVE, Towle HC, Robertson RP, Stein R: Reduction of insulin gene transcription in HTT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci USA 92:9127-9131, 1995
27. Montana E, Bonner-Weir S, Weir GC: β-cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin-diabetic C57BL/6 mice. J Clin Invest 91:780-787, 1993
28. Chomczynski P: A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15:532-537, 1993
29. Abhyankar S, Gilliland DG, Ferrara JL: Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens. Transplant 56:1518-1523, 1993
30. Feinberg AP, Vogelstein B: A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 137:166-167, 1984
31. Thorpe GHG, Kricka LI, Mosely SB, Whitehead TP: Phenols are enhancers of the chemiluminescent horseradish peroxidase-luminol-hydrogen peroxide reaction: application in luminescence-monitored enzyme immunoassay. Clin Chem 31:1335-1341,1985
32. Sambrook J, Fritch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
33. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
34. Ogawa A, Johnson JH, Ohneda M, McAllister CT, Inman L, Alam T, Unger RH: Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. J Clin Invest 90:497-504, 1992
35. Orci L, Ravazzola M, Baetens D, Inman L, Amherdt M, Peterson RG, Newgard CB, Johnson JH, Unger RH: Evidence that down-regulation of beta-cell glucose transporters in non-insulin dependent diabetes may be the cause of diabetic hyperglycemia. Proc Natl Acad Sci USA 87:9953-9957, 1990
36. Johnson JH, Ogawa A, Chen L, Orci L, Newgard CB, Alam T, Unger RH: Underexpression of β-cell high Km glucose transporters in non-insulin-dependent diabetes. Science 250:546-549, 1990
37. De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F: Human and rat β-cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96:2489-2495, 1995
38. Lachaal M, Jung CY: Interaction of facilitative glucose transporter with glucokinase and its modulation by ADP and glucose-6-phosphale. J Cell Physiol 156:326-332, 1993
39. Lachaal M, Spangler RA, Jung CY: High Km of GLUT-2 glucose transporter does not explain its role in insulin secretion. Am J Physiol 265:E914-E919, 1993
40. Tiedge M, Hohne M, Lenzen S: Insulin secretion, insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose-transporter cDNA. Biochem J 296:113-118, 1993
41. Ferber S, BeltrandelRio H, Johnson JH, Noel RJ, Cassidy LE, Clark S, Becker TC: GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. J Biol Chem 269:11523-11529, 1994
42. Chen L, Alam T, Johnson JH, Hughes S, Newgard CB, Unger RH: Regulation of B-cell glucose transporter gene expression. Proc Natl Acad Sci USA 87:4088-4092, 1990
43. Ferrer J, Gomis R, Fernandez Alvarez J, Casamitjana R, Vilardell E: Signals derived from glucose metabolism are required for glucose regulation of pancreatic islet GLUT2 mRNA and protein. Diabetes 42:1273-1280, 1993
44. Yasuda K, Yamada Y, Inagaki N, Yano H, Okamoto Y, Tsuji K, Fukumoto H, Imura H, Seino S, Seino Y: Expression of GLUT1 and GLUT2 glucose transporter isoforms in rat islets of Langerhans and their regulation by glucose. Diabetes 41:76-81, 1992
45. Liang, Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM: Concordant glucose induction of glucokinase, glucose usage and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41:792-806, 1992
46. Orland MJ, Chyn R, Permutt MA: Modulation of proinsulin messenger RNA after partial pancreatectomy in rats: relationships to glucose homeostasis. J Clin Invest 75:2047-2055, 1985
47. Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CVE, Teitelman G: Expression of murine STF-1, a putative insulin gene transcription factor, in B cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11-18, 1995
48. Zangen DH, Miller CP, Smith FE, Lissauer ME, Habener JF, Bonner-Weir S: Ipf-1/Idx-1 levels are increased during pancreatic regeneration (Abstract). Diabetes 44 (Suppl. 1):188A, 1995
49. Melloul D, Ben-Neriah Y, Cerasi E: Glucose modulates the binding of an isletspecific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci USA 90:3865-3869, 1993
50. MacFarlane WM, Read ML, Gilligan M, Bujalska I, Docherty K: Glucose modulates the binding activity of the B-cell transcription factor IUF1 in a phosphorylation-dependent manner. Biochem J 303:625-631, 1994
51. Sharma A, Olson LK, Robertson RP, Stein R: The reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to high glucose concentrations is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. Mol Endocrinol 9:1127-1134, 1995
52. Smith FE, Rosen KM, Villa-Komaroff L, Weir GC, Bonner-Weir S: Enhanced insulin-like growth factor 1 gene expression in regenerating rat pancreas. Proc Natl Acad Sci USA 88:6152-6156, 1991
53. Smith FE, Bonner-Weir S, Leahy JL, Laufgraben MJ, Ogawa Y, Rosen KM, VillaKomaroff L: Pancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats. Diabetologia 37:994-999, 1994
54. Leibiger IB, Moede T, Walther R, Leibiger B: The role of E-box-like and TAAT-motifs in the transcriptional control of the rat glucokinase gene in insulin-producing cells (Abstract). Diabetologia 38 (Suppl. 1):A115, 1995
55. Clark AR, Docherty K: Cell-specific gene expression in the islets of Langerhans: E boxes and TAAT boxes. Biochem Soc Trans 21:154-159, 1993
56. Bonny C, Thompson N, Nicod P, Waeber G: Pancreatic-specific expression of the glucose transporter type2 gene: identification of cis-elements and islet-specific trans-acting factors. Mol Endocrinol 9:1413-1426, 1995