IPF1/PDX1 Deficiency and β-Cell Dysfunction in Psammomys obesus, an Animal with Type 2 Diabetes

Diabetes

Volumn 50, Issue 8, 2001, Pages 1799-1806

  Leibowitz, Gil ^a   Ferber, Sarah ^b   Apelqvist, Åsa ^c   Edlund, Helena ^c   Gross, David J ^a   Cerasi, Erol ^a   Melloul, Danielle ^a   Kaiser, Nurit ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; INSULIN PROMOTER FACTOR 1; MESSENGER RNA; RECOMBINANT PROTEIN; TRANSACTIVATOR PROTEIN;

ADENOVIRUS; ANIMAL; ARTICLE; DIET; DISEASE MODEL; DRUG EFFECT; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; GERBIL; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PATHOPHYSIOLOGY; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; GERBILLINAE; GLUCOSE; HOMEODOMAIN PROTEINS; HYPERGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0035431017     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.8.1799     Document Type: Article

References (29)

1. Melloul D, Cerasi E: Transcriptional regulation of proinsulin synthesis by glucose. In Insulin Secretion and Pancreatic B-Cell Research. Flatt PR, Lenzen S, Eds. London, Smith-Gordon, 1994, p. 7-13
2. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H: Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 15:1763-1768, 1998
3. Hart AW, Baeza N, Apelquist Å, Edlund H: Attenuation of FGF-signalling in mouse β-cells leads to diabetes. Nature 408:864-868, 2000
4. Melloul D, Ben-Neriah Y, Cerasi E: Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci U S A 90:3865-3869, 1993
5. Marshak S, Totary H, Cerasi E, Melloul D: Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci U S A 93:15057-15062, 1996
6. 2+. Diabetes 49:418-423, 2000
7. Gremlich S, Bonny C, Waeber G, Thorens B: Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 272:30261-30269, 1997
8. Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP: In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 48:1995-2000, 1999
9. Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC: Reduced insulin, GLUT2, and IDX-1 in β-cells after partial pancreatectomy. Diabetes 46:258-264, 1997
10. Stoffers DA, Ferrer J, Clarke WL, Habener JF: Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 17:138-139, 1997
11. Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LIS, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT: Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest 104:R33-R39, 1999
12. Hani EH, Stoffers DA, Chevre J-C, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P: Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-R48, 1999
13. Habener JF, Stoffers DA: A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians 110:12-21, 1998
14. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15:106-110, 1997
15. Cerasi E: Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible? Diabetologia 38:992-997, 1995
16. Kahn BB: Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92:593-596, 1998
17. Gadot M, Leibowitz G, Shafrir E, Cerasi E, Gross D, Kaiser N: Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus. Endocrinology 135:610-616, 1994
18. Kaiser N, Corcos AP, Sarel I, Cerasi E: Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of B-cell function by chronic exposure to high glucose. Endocrinology 129:2067-2076, 1991
19. Gross DJ, Leibowitz G, Cerasi E, Kaiser N: Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology 137:5610-5615, 1996
20. Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, Cerasi E, Melloul D: Impaired ß-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 48:1230-1236, 1999
21. Seijffers R, Ben David O, Cohen Y, Karasik A, Berezin M, Newgard CB, Ferher S: Increase in PDX-1 levels suppresses insulin gene expression in RIN-1046-38 cells. Endocrinology 140:3311-3317, 1999
22. Odagiri H, Wang J, German MS: Function of the human insulin promoter in primary cultured islet cells. J Biol Chem 271:1909-1915, 1996
23. Sharma A, Fusco-DeMane D, Henderson E, Efrat S, Stein R: The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene. Mol Endocrinol 9:1468-1476, 1995
24. Nesher R, Gross DJ, Donath MY, Cerasi E, Kaiser N: Interaction between genetic and dietary factors determines β-cell function in Psammomys obesus, an animal model of type 2 diabetes. Diabetes 48:731-737, 1999
25. Milewski WM, Duguay SJ, Chan SJ, Steiner DF: Conservation of PDX-1 structure, function and expression in zebrafish. Endocrinology 139:1440-1449, 1998
26. Kalman R, Ziv E, Adler JH, Lazarovici G, Bar-On H: The efficiency of the sand rat metabolism is responsible for the development of obesity and diabetes. J Basic Clin Physiol Pharmacol 4:57-68, 1993
27. Kaneto H, Kajimoto Y, Miyagawa J-i, Matsuoka T-a, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M: Beneficial effects of antioxidants in diabetes: possible protection of pancreatic β-cells against glucose toxicity. Diabetes 48:2398-2406, 1999
28. Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP: Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A 96:10857-10862, 1999
29. Melloul D, Kaiser N, Cerasi E: Chronic exposure to high glucose impairs multiple β-cell functions in cultured human pancreatic islets. Curr Opinion Endocrinol Diabetes 7:44-48, 2000