Pdx1 restores β cell function in Irs2 knockout mice

Journal of Clinical Investigation

Volumn 109, Issue 9, 2002, Pages 1193-1201

  Kushner, Jake A ^a,b   Ye, Jing ^a   Schubert, Markus ^a   Burks, Deborah J ^a   Dow, Matthew A ^a   Flint, Carrie L ^a   Dutta, Sanjoy ^c   Wright, Christopher V E ^d   Montminy, Marc R ^e   White, Morris F ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; RNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; DIABETOGENESIS; GLUCOSE TOLERANCE TEST; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

EID: 0036246856     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214439     Document Type: Article

References (38)

1. The IRS-signaling system during insulin and cytokine action
2. Disruption of IRS-2 causes type 2 diabetes in mice
3. Contrasting effects of IRS-1 vs. IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo
4. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
5. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
6. Regulation of a transcription factor network required for differentiation and metabolism
7. Insulin-promoter-factor 1 is required for pancreas development in mice
8. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
9. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
10. The human glucokinase gene beta-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells
11. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
12. Attenuation of FGF signalling in mouse beta-cells leads to diabetes
13. β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
14. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
15. Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1
16. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development
17. Isolation of rat pancreatic islets by ductal injection of collagenase
18. IRS-2 pathways integrate female reproduction and energy homeostasis
19. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
20. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
21. Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians
22. Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with type 2 diabetes: No evidence for a major susceptibility role
23. 307 via distinct pathways
24. TNFα: A key component of the obesity-diabetes link
25. β-cell death during progression to diabetes
26. IRS-4 mediates activation of PKB/Akt during insulin stimulation without inhibition of apoptosis
27. IRS proteins and beta-cell function
28. Insulin receptor substrate-2 binds to the insulin receptor through its phopshotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
29. Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein
30. Insulin signalling and the regulation of glucose and lipid metabolism
31. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
32. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
33. Ten years of protein kinase B signalling: A hard Akt to follow
34. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
35. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction
36. The transcription factor FKHR promotes beta cell survival in IRS-2 knockout mice
37. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites
38. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia