메뉴 건너뛰기




Volumn 31, Issue 2, 2011, Pages 188-207

Deciphering the genetic predisposition to primary sclerosing cholangitis

Author keywords

comorbidities; genetic predisposition; major histocompatibility complex; Primary sclerosing cholangitis; T lymphocytes

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; PROTEIN BCL 2;

EID: 79955623661     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0031-1276647     Document Type: Article
Times cited : (25)

References (213)
  • 2
    • 67649205149 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of cholestatic liver diseases
    • European Association for the Study of the Liver 2
    • European Association for the Study of the Liver. EASL clinical practice guidelines: management of cholestatic liver diseases. J Hepatol 2009 51 2 237-267
    • (2009) J Hepatol , vol.51 , pp. 237-267
  • 3
    • 75449104123 scopus 로고    scopus 로고
    • Diagnosis and management of primary sclerosing cholangitis
    • American Association for the Study of Liver Diseases 2
    • Chapman R, Fevery J, Kalloo A et al, American Association for the Study of Liver Diseases. Diagnosis and management of primary sclerosing cholangitis. Hepatology 2010 51 2 660-678
    • (2010) Hepatology , vol.51 , pp. 660-678
    • Chapman, R.1    Fevery, J.2    Kalloo, A.3
  • 5
    • 33847064667 scopus 로고    scopus 로고
    • MDR3 (ABCB4) defects: A paradigm for the genetics of adult cholestatic syndromes
    • 1
    • Trauner M, Fickert P, Wagner M. MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes. Semin Liver Dis 2007 27 1 77-98
    • (2007) Semin Liver Dis , vol.27 , pp. 77-98
    • Trauner, M.1    Fickert, P.2    Wagner, M.3
  • 6
    • 77957940106 scopus 로고    scopus 로고
    • The biliary HCO(3)(-) umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    • 4
    • Beuers U, Hohenester S, de Buy Wenniger L J., Kremer A E., Jansen P L., Elferink R P. The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 2010 52 4 1489-1496
    • (2010) Hepatology , vol.52 , pp. 1489-1496
    • Beuers, U.1    Hohenester, S.2    De Buy Wenniger, L.J.3    Kremer, A.E.4    Jansen, P.L.5    Elferink, R.P.6
  • 7
    • 0025801063 scopus 로고
    • Biliary tract disease in rats with experimental small bowel bacterial overgrowth
    • 4
    • Lichtman S N., Keku J, Clark R L., Schwab J H., Sartor R B. Biliary tract disease in rats with experimental small bowel bacterial overgrowth. Hepatology 1991 13 4 766-772
    • (1991) Hepatology , vol.13 , pp. 766-772
    • Lichtman, S.N.1    Keku, J.2    Clark, R.L.3    Schwab, J.H.4    Sartor, R.B.5
  • 8
    • 0037065563 scopus 로고    scopus 로고
    • Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
    • DOI 10.1016/S0140-6736(02)07374-9
    • Grant A J., Lalor P F., Salmi M, Jalkanen S, Adams D H. Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease. Lancet 2002 359 9301 150-157 (Pubitemid 34112549)
    • (2002) Lancet , vol.359 , Issue.9301 , pp. 150-157
    • Grant, A.J.1    Lalor, P.F.2    Salmi, M.3    Jalkanen, S.4    Adams, D.H.5
  • 9
    • 77953718694 scopus 로고    scopus 로고
    • P-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ
    • 6
    • Terjung B, Söhne J, Lechtenberg B et al. p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ. Gut 2010 59 6 808-816
    • (2010) Gut , vol.59 , pp. 808-816
    • Terjung, B.1    Söhne, J.2    Lechtenberg, B.3
  • 10
    • 33644617718 scopus 로고    scopus 로고
    • Etiopathogenesis of primary sclerosing cholangitis
    • O'Mahony C A., Vierling J M. Etiopathogenesis of primary sclerosing cholangitis. Semin Liver Dis 2006 26 1 3-21 (Pubitemid 43320723)
    • (2006) Seminars in Liver Disease , vol.26 , Issue.1 , pp. 3-21
    • O'Mahony, C.A.1    Vierling, J.M.2
  • 11
    • 77951487491 scopus 로고    scopus 로고
    • The utility of genome-wide association studies in hepatology
    • 5
    • Karlsen T H., Melum E, Franke A. The utility of genome-wide association studies in hepatology. Hepatology 2010 51 5 1833-1842
    • (2010) Hepatology , vol.51 , pp. 1833-1842
    • Karlsen, T.H.1    Melum, E.2    Franke, A.3
  • 12
    • 0020043880 scopus 로고
    • HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease
    • Schrumpf E, Fausa O, F?rre O, Dobloug J H., Ritland S, Thorsby E. HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease. Scand J Gastroenterol 1982 17 2 187-191 (Pubitemid 12185520)
    • (1982) Scandinavian Journal of Gastroenterology , vol.17 , Issue.2 , pp. 187-191
    • Schrumpf, E.1    Fausa, O.2    Forre, O.3
  • 13
    • 77249164222 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis
    • 3
    • Karlsen T H., Franke A, Melum E et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010 138 3 1102-1111
    • (2010) Gastroenterology , vol.138 , pp. 1102-1111
    • Karlsen, T.H.1    Franke, A.2    Melum, E.3
  • 14
    • 0024384431 scopus 로고
    • Surgical pathology of the syndrome of primary sclerosing cholangitis
    • Ludwig J. Surgical pathology of the syndrome of primary sclerosing cholangitis. Am J Surg Pathol 1989 13 Suppl 1 43-49 (Pubitemid 19142063)
    • (1989) American Journal of Surgical Pathology , vol.13 , Issue.SUPPL. 1 , pp. 43-49
    • Ludwig, J.1
  • 15
    • 0025801192 scopus 로고
    • Relationship of inflammatory bowel disease and primary sclerosing cholangitis
    • 1
    • Fausa O, Schrumpf E, Elgjo K. Relationship of inflammatory bowel disease and primary sclerosing cholangitis. Semin Liver Dis 1991 11 1 31-39
    • (1991) Semin Liver Dis , vol.11 , pp. 31-39
    • Fausa, O.1    Schrumpf, E.2    Elgjo, K.3
  • 17
    • 0033755636 scopus 로고    scopus 로고
    • Increased frequency of autoimmune diseases in patients with primary sclerosing cholangitis
    • 11
    • Saarinen S, Olerup O, Broom U. Increased frequency of autoimmune diseases in patients with primary sclerosing cholangitis. Am J Gastroenterol 2000 95 11 3195-3199
    • (2000) Am J Gastroenterol , vol.95 , pp. 3195-3199
    • Saarinen, S.1    Olerup, O.2    Broom, U.3
  • 18
    • 57749193136 scopus 로고    scopus 로고
    • Detecting shared pathogenesis from the shared genetics of immune-related diseases
    • 1
    • Zhernakova A, van Diemen C C., Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet 2009 10 1 43-55
    • (2009) Nat Rev Genet , vol.10 , pp. 43-55
    • Zhernakova, A.1    Van Diemen, C.C.2    Wijmenga, C.3
  • 20
    • 67651099221 scopus 로고    scopus 로고
    • A conceptual proposal for staging ductal cholangiocarcinoma
    • 3
    • Blechacz B R., Sanchez W, Gores G J. A conceptual proposal for staging ductal cholangiocarcinoma. Curr Opin Gastroenterol 2009 25 3 238-239
    • (2009) Curr Opin Gastroenterol , vol.25 , pp. 238-239
    • Blechacz, B.R.1    Sanchez, W.2    Gores, G.J.3
  • 21
    • 77951266788 scopus 로고    scopus 로고
    • Genetics of cholestatic liver disease in 2010
    • 3
    • Karlsen T H., Hov J R. Genetics of cholestatic liver disease in 2010. Curr Opin Gastroenterol 2010 26 3 251-258
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 251-258
    • Karlsen, T.H.1    Hov, J.R.2
  • 22
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • 23
    • Hindorff L A., Sethupathy P, Junkins H A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 2009 106 23 9362-9367
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 23
    • 0031941458 scopus 로고    scopus 로고
    • Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a norwegian population
    • DOI 10.1080/00365529850166284
    • Boberg K M., Aadland E, Jahnsen J, Raknerud N, Stiris M, Bell H. Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population. Scand J Gastroenterol 1998 33 1 99-103 (Pubitemid 28114077)
    • (1998) Scandinavian Journal of Gastroenterology , vol.33 , Issue.1 , pp. 99-103
    • Boberg, K.M.1    Aadland, E.2    Jahnsen, J.3    Raknerud, N.4    Stiris, M.5    Bell, H.6
  • 24
    • 47949124659 scopus 로고    scopus 로고
    • Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis
    • 8
    • Bergquist A, Montgomery S M., Bahmanyar S et al. Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis. Clin Gastroenterol Hepatol 2008 6 8 939-943
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 939-943
    • Bergquist, A.1    Montgomery, S.M.2    Bahmanyar, S.3
  • 25
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • 7265
    • Manolio T A., Collins F S., Cox N J. et al. Finding the missing heritability of complex diseases. Nature 2009 461 7265 747-753
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 26
    • 78651227093 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    • 1
    • Melum E, Franke A, Schramm C et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet 2011 43 1 17-19
    • (2011) Nat Genet , vol.43 , pp. 17-19
    • Melum, E.1    Franke, A.2    Schramm, C.3
  • 27
    • 68249108329 scopus 로고    scopus 로고
    • Prediction and interaction in complex disease genetics: Experience in type 1 diabetes
    • 7
    • Clayton D G. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet 2009 5 7 e1000540
    • (2009) PLoS Genet , vol.5
    • Clayton, D.G.1
  • 29
    • 0028939546 scopus 로고
    • Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: Results of an open-label preliminary trial
    • 3
    • Van Thiel D H., Carroll P, Abu-Elmagd K et al. Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial. Am J Gastroenterol 1995 90 3 455-459
    • (1995) Am J Gastroenterol , vol.90 , pp. 455-459
    • Van Thiel, D.H.1    Carroll, P.2    Abu-Elmagd, K.3
  • 30
    • 0000796368 scopus 로고
    • A controlled clinical trial evaluating cyclosporine in the treatment of primary sclerosing cholangitis
    • (Abstract)
    • Wiesner R H., Steiner B, LaRusso N F. et al. A controlled clinical trial evaluating cyclosporine in the treatment of primary sclerosing cholangitis. Hepatology 1991 14 A64 (Abstract)
    • (1991) Hepatology , vol.14
    • Wiesner, R.H.1    Steiner, B.2    Larusso, N.F.3
  • 31
    • 0027537517 scopus 로고
    • Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin
    • Sandborn W J., Wiesner R H., Tremaine W J., Larusso N F. Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin. Gut 1993 34 2 242-246 (Pubitemid 23049120)
    • (1993) Gut , vol.34 , Issue.2 , pp. 242-246
    • Sandborn, W.J.1    Wiesner, R.H.2    Tremaine, W.J.3    Larusso, N.F.4
  • 32
    • 33644627078 scopus 로고    scopus 로고
    • The medical management of primary sclerosing cholangitis
    • Cullen S N., Chapman R W. The medical management of primary sclerosing cholangitis. Semin Liver Dis 2006 26 1 52-61 (Pubitemid 43320727)
    • (2006) Seminars in Liver Disease , vol.26 , Issue.1 , pp. 52-61
    • Cullen, S.W.1    Chapman, R.W.2
  • 33
    • 0141606272 scopus 로고    scopus 로고
    • Long-term effect of corticosteroid treatment in primary sclerosing cholangitis patients
    • DOI 10.1080/00365520310005172
    • Boberg K M., Egeland T, Schrumpf E. Long-term effect of corticosteroid treatment in primary sclerosing cholangitis patients. Scand J Gastroenterol 2003 38 9 991-995 (Pubitemid 37158028)
    • (2003) Scandinavian Journal of Gastroenterology , vol.38 , Issue.9 , pp. 991-995
    • Boberg, K.M.1    Egeland, T.2    Schrumpf, E.3
  • 34
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen H, Estrada K, Lettre G et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 457 832-838
    • (2010) Nature , vol.457 , pp. 832-838
    • Lango Allen, H.1    Estrada, K.2    Lettre, G.3
  • 35
    • 43549121020 scopus 로고    scopus 로고
    • Human MHC architecture and evolution: Implications for disease association studies
    • DOI 10.1111/j.1744-313X.2008.00765.x
    • Traherne J A. Human MHC architecture and evolution: implications for disease association studies. Int J Immunogenet 2008 35 3 179-192 (Pubitemid 351678693)
    • (2008) International Journal of Immunogenetics , vol.35 , Issue.3 , pp. 179-192
    • Traherne, J.A.1
  • 38
    • 0024492512 scopus 로고
    • Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer
    • DOI 10.1084/jem.169.1.345
    • Sollid L M., Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med 1989 169 1 345-350 (Pubitemid 19035567)
    • (1989) Journal of Experimental Medicine , vol.169 , Issue.1 , pp. 345-350
    • Sollid, L.M.1    Markussen, G.2    Ek, J.3    Gjerde, H.4    Vartdal, F.5    Thorsby, E.6
  • 39
    • 0023252262 scopus 로고
    • HLA-DQ(β) gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • DOI 10.1038/329599a0
    • Todd J A., Bell J I., McDevitt H O. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987 329 6140 599-604 (Pubitemid 17140111)
    • (1987) Nature , vol.329 , Issue.6140 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 41
    • 0015914854 scopus 로고
    • High association of an HL-A antigen, W27, with ankylosing spondylitis
    • 14
    • Schlosstein L, Terasaki P I., Bluestone R, Pearson C M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 1973 288 14 704-706
    • (1973) N Engl J Med , vol.288 , pp. 704-706
    • Schlosstein, L.1    Terasaki, P.I.2    Bluestone, R.3    Pearson, C.M.4
  • 42
    • 33646049742 scopus 로고    scopus 로고
    • Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene
    • 5
    • Nair R P., Stuart P E., Nistor I et al. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet 2006 78 5 827-851
    • (2006) Am J Hum Genet , vol.78 , pp. 827-851
    • Nair, R.P.1    Stuart, P.E.2    Nistor, I.3
  • 43
    • 24044517208 scopus 로고    scopus 로고
    • Several genes in the extended human MHC contribute to predisposition to autoimmune diseases
    • DOI 10.1016/j.coi.2005.07.001, PII S0952791505001056
    • Lie B A., Thorsby E. Several genes in the extended human MHC contribute to predisposition to autoimmune diseases. Curr Opin Immunol 2005 17 5 526-531 (Pubitemid 41213322)
    • (2005) Current Opinion in Immunology , vol.17 , Issue.5 , pp. 526-531
    • Lie, B.A.1    Thorsby, E.2
  • 45
    • 43249119095 scopus 로고    scopus 로고
    • Defining the role of the MHC in autoimmunity: A review and pooled analysis
    • 4
    • Fernando M M., Stevens C R., Walsh E C. et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet 2008 4 4 e1000024
    • (2008) PLoS Genet , vol.4
    • Fernando, M.M.1    Stevens, C.R.2    Walsh, E.C.3
  • 46
    • 73249122274 scopus 로고    scopus 로고
    • Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
    • International MHC and Autoimmunity Genetics Network 44
    • Rioux J D., Goyette P, Vyse T J. et al, International MHC and Autoimmunity Genetics Network. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009 106 44 18680-18685
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18680-18685
    • Rioux, J.D.1    Goyette, P.2    Vyse, T.J.3
  • 47
    • 78650084232 scopus 로고    scopus 로고
    • The major genetic determinants of HIV-1 control affect HLA class i peptide presentation
    • The International HIV Controllers Study 6010
    • The International HIV Controllers Study. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 2010 330 6010 1551-1557
    • (2010) Science , vol.330 , pp. 1551-1557
  • 48
    • 34047187448 scopus 로고    scopus 로고
    • Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
    • DOI 10.1016/j.jhep.2007.01.032, PII S0168827807001092
    • Karlsen T H., Boberg K M., Olsson M et al. Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis. J Hepatol 2007 46 5 899-906 (Pubitemid 46529047)
    • (2007) Journal of Hepatology , vol.46 , Issue.5 , pp. 899-906
    • Karlsen, T.H.1    Boberg, K.M.2    Olsson, M.3    Sun, J.-Y.4    Senitzer, D.5    Bergquist, A.6    Schrumpf, E.7    Thorsby, E.8    Lie, B.A.9
  • 49
    • 77951620945 scopus 로고    scopus 로고
    • Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C
    • 5
    • Hov J R., Lleo A, Selmi C et al. Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C. J Hepatol 2010 52 5 712-717
    • (2010) J Hepatol , vol.52 , pp. 712-717
    • Hov, J.R.1    Lleo, A.2    Selmi, C.3
  • 50
    • 54349124373 scopus 로고    scopus 로고
    • Autoantibodies in primary sclerosing cholangitis
    • 24
    • Hov J R., Boberg K M., Karlsen T H. Autoantibodies in primary sclerosing cholangitis. World J Gastroenterol 2008 14 24 3781-3791
    • (2008) World J Gastroenterol , vol.14 , pp. 3781-3791
    • Hov, J.R.1    Boberg, K.M.2    Karlsen, T.H.3
  • 52
    • 64549104048 scopus 로고    scopus 로고
    • Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
    • 6
    • Festen E A., Goyette P, Scott R et al. Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 2009 58 6 799-804
    • (2009) Gut , vol.58 , pp. 799-804
    • Festen, E.A.1    Goyette, P.2    Scott, R.3
  • 53
    • 77953492918 scopus 로고    scopus 로고
    • Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
    • 3
    • Hollis-Moffatt J E., Chen-Xu M, Topless R et al. Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Res Ther 2010 12 3 R116
    • (2010) Arthritis Res Ther , vol.12
    • Hollis-Moffatt, J.E.1    Chen-Xu, M.2    Topless, R.3
  • 57
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • 12
    • Franke A, McGovern D P., Barrett J C. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010 42 12 1118-1125
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 58
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • 3
    • Anderson C A., Boucher G, Lees C W. et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011 43 3 246-252
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3
  • 61
    • 67349258910 scopus 로고    scopus 로고
    • Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus
    • 1-2
    • Perera D, Stankovich J, Butzkueven H et al. Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. J Neuroimmunol 2009 211 1-2 105-109
    • (2009) J Neuroimmunol , vol.211 , pp. 105-109
    • Perera, D.1    Stankovich, J.2    Butzkueven, H.3
  • 62
    • 77954134112 scopus 로고    scopus 로고
    • A cis-acting regulatory variant in the IL2RA locus
    • 8
    • Qu H Q., Verlaan D J., Ge B et al. A cis-acting regulatory variant in the IL2RA locus. J Immunol 2009 183 8 5158-5162
    • (2009) J Immunol , vol.183 , pp. 5158-5162
    • Qu, H.Q.1    Verlaan, D.J.2    Ge, B.3
  • 63
    • 69349102624 scopus 로고    scopus 로고
    • Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    • 9
    • Dendrou C A., Plagnol V, Fung E et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 2009 41 9 1011-1015
    • (2009) Nat Genet , vol.41 , pp. 1011-1015
    • Dendrou, C.A.1    Plagnol, V.2    Fung, E.3
  • 64
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • 2
    • Malek T R., Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 2010 33 2 153-165
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 67
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • DOI 10.1016/0092-8674(93)80067-O
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller A C., Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993 75 2 253-261 (Pubitemid 23320289)
    • (1993) Cell , vol.75 , Issue.2 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 68
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • 4
    • Willerford D M., Chen J, Ferry J A., Davidson L, Ma A, Alt F W. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995 3 4 521-530
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 69
    • 58949098337 scopus 로고    scopus 로고
    • Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha( / ) mice
    • 1
    • Hsu W, Zhang W, Tsuneyama K et al. Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha( / ) mice. Hepatology 2009 49 1 133-140
    • (2009) Hepatology , vol.49 , pp. 133-140
    • Hsu, W.1    Zhang, W.2    Tsuneyama, K.3
  • 70
    • 61949143670 scopus 로고    scopus 로고
    • Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis
    • 2
    • Zhang W, Sharma R, Ju S T. et al. Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis. Hepatology 2009 49 2 545-552
    • (2009) Hepatology , vol.49 , pp. 545-552
    • Zhang, W.1    Sharma, R.2    Ju, S.T.3
  • 71
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • DOI 10.1038/ni1179
    • Fontenot J D., Rudensky A Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005 6 4 331-337 (Pubitemid 41716769)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 72
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    • 24
    • Hirschfield G M., Liu X, Xu C et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 2009 360 24 2544-2555
    • (2009) N Engl J Med , vol.360 , pp. 2544-2555
    • Hirschfield, G.M.1    Liu, X.2    Xu, C.3
  • 73
    • 77955087537 scopus 로고    scopus 로고
    • Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
    • 8
    • Hirschfield G M., Liu X, Han Y et al. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis. Nat Genet 2010 42 8 655-657
    • (2010) Nat Genet , vol.42 , pp. 655-657
    • Hirschfield, G.M.1    Liu, X.2    Han, Y.3
  • 74
    • 77955088582 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    • 8
    • Liu X, Invernizzi P, Lu Y et al. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet 2010 42 8 658-660
    • (2010) Nat Genet , vol.42 , pp. 658-660
    • Liu, X.1    Invernizzi, P.2    Lu, Y.3
  • 77
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: Basic biology and implications for cancer and autoimmunity
    • DOI 10.1146/annurev.immunol.26.021607.090316
    • Spolski R, Leonard W J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008 26 57-79 (Pubitemid 351600371)
    • (2008) Annual Review of Immunology , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 78
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • 6808
    • Parrish-Novak J, Dillon S R., Nelson A et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000 408 6808 57-63
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 82
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • 5943
    • Nurieva R I., Chung Y, Martinez G J. et al. Bcl6 mediates the development of T follicular helper cells. Science 2009 325 5943 1001-1005
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1    Chung, Y.2    Martinez, G.J.3
  • 85
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H, Carrio R, Yu A, Malek T R. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 2004 173 1 657-665 (Pubitemid 38797396)
    • (2004) Journal of Immunology , vol.173 , Issue.1 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 88
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D, Brown T P., Liang S, Young D A., Collins M, Dunussi-Joannopoulos K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007 178 6 3822-3830 (Pubitemid 46417651)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulos, K.6
  • 89
    • 14044262247 scopus 로고    scopus 로고
    • Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen
    • Vollmer T L., Liu R, Price M, Rhodes S, La Cava A, Shi F D. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 2005 174 5 2696-2701 (Pubitemid 40279684)
    • (2005) Journal of Immunology , vol.174 , Issue.5 , pp. 2696-2701
    • Vollmer, T.L.1    Liu, R.2    Price, M.3    Rhodes, S.4    La Cava, A.5    Shi, F.-D.6
  • 90
    • 77956408137 scopus 로고    scopus 로고
    • Altered effector CD4 + T cell function in IL-21R / CD4 + T cell-mediated graft-versus-host disease
    • 3
    • Oh I, Ozaki K, Meguro A et al. Altered effector CD4 + T cell function in IL-21R / CD4 + T cell-mediated graft-versus-host disease. J Immunol 2010 185 3 1920-1926
    • (2010) J Immunol , vol.185 , pp. 1920-1926
    • Oh, I.1    Ozaki, K.2    Meguro, A.3
  • 91
    • 66649110262 scopus 로고    scopus 로고
    • Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development
    • 4
    • Morton L M., Purdue M P., Zheng T et al. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. Cancer Epidemiol Biomarkers Prev 2009 18 4 1259-1270
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 1259-1270
    • Morton, L.M.1    Purdue, M.P.2    Zheng, T.3
  • 93
    • 39849087851 scopus 로고    scopus 로고
    • Is there any association between non-Hodgkin's lymphoma and primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome?
    • DOI 10.1007/s10620-007-9908-z
    • Cholongitas E, Pipili C, Kaklamanis L, Dasenaki M. Is there any association between non-Hodgkin's lymphoma and primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome? Dig Dis Sci 2008 53 3 867-868 (Pubitemid 351317063)
    • (2008) Digestive Diseases and Sciences , vol.53 , Issue.3 , pp. 867-868
    • Cholongitas, E.1    Pipili, C.2    Kaklamanis, L.3    Dasenaki, M.4
  • 94
    • 14944348965 scopus 로고    scopus 로고
    • The role of BH3-only proteins in the immune system
    • DOI 10.1038/nri1568
    • Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005 5 3 189-200 (Pubitemid 40364821)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.3 , pp. 189-200
    • Strasser, A.1
  • 95
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang D C. et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999 286 5445 1735-1738 (Pubitemid 129515880)
    • (1999) Science , vol.286 , Issue.5445 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.S.3    Tarlinton, D.M.4    Kay, T.W.H.5    Kontgen, F.6    Adams, J.M.7    Strasser, A.8
  • 100
    • 48349122755 scopus 로고    scopus 로고
    • Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis
    • 2
    • Goyette P, Lefebvre C, Ng A et al. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol 2008 1 2 131-138
    • (2008) Mucosal Immunol , vol.1 , pp. 131-138
    • Goyette, P.1    Lefebvre, C.2    Ng, A.3
  • 104
    • 0027204250 scopus 로고
    • Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3
    • Yoshimura T, Yuhki N, Wang M H., Skeel A, Leonard E J. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem 1993 268 21 15461-15468 (Pubitemid 23222036)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.21 , pp. 15461-15468
    • Yoshimura, T.1    Yuhki, N.2    Wang, M.-H.3    Skeel, A.4    Leonard, E.J.5
  • 105
    • 0030056374 scopus 로고    scopus 로고
    • Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases
    • Wang M H., Skeel A, Leonard E J. Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases. J Clin Invest 1996 97 3 720-727 (Pubitemid 26057091)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.3 , pp. 720-727
    • Wang, M.-H.1    Skeel, A.2    Leonard, E.J.3
  • 108
    • 0030578404 scopus 로고    scopus 로고
    • Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes
    • DOI 10.1006/excr.1996.0200
    • Wang M H., Dlugosz A A., Sun Y, Suda T, Skeel A, Leonard E J. Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. Exp Cell Res 1996 226 1 39-46 (Pubitemid 26238925)
    • (1996) Experimental Cell Research , vol.226 , Issue.1 , pp. 39-46
    • Wang, M.-H.1    Dlugosz, A.A.2    Sun, Y.3    Suda, T.4    Skeel, A.5    Leonard, E.J.6
  • 109
    • 0028139182 scopus 로고
    • Identification of the ron gene product as the receptor for the human macrophage stimulating protein
    • Wang M H., Ronsin C, Gesnel M C. et al. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science 1994 266 5182 117-119 (Pubitemid 24345331)
    • (1994) Science , vol.266 , Issue.5182 , pp. 117-119
    • Wang, M.-H.1    Ronsin, C.2    Gesnel, M.-C.3    Coupey, L.4    Skeel, A.5    Leonard, E.J.6    Breathnach, R.7
  • 110
    • 0029933168 scopus 로고    scopus 로고
    • Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells
    • Kurihara N, Iwama A, Tatsumi J, Ikeda K, Suda T. Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells. Blood 1996 87 9 3704-3710 (Pubitemid 26129598)
    • (1996) Blood , vol.87 , Issue.9 , pp. 3704-3710
    • Kurihara, N.1    Iwama, A.2    Tatsumi, J.3    Ikeda, K.4    Suda, T.5
  • 111
    • 48349122755 scopus 로고    scopus 로고
    • Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis
    • 2
    • Goyette P, Lefebvre C, Ng A et al. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. Mucosal Immunol 2008 1 2 131-138
    • (2008) Mucosal Immunol , vol.1 , pp. 131-138
    • Goyette, P.1    Lefebvre, C.2    Ng, A.3
  • 112
    • 1642443959 scopus 로고    scopus 로고
    • Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-γ and Lipopolysaccharide
    • Morrison A C., Wilson C B., Ray M, Correll P H. Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide. J Immunol 2004 172 3 1825-1832 (Pubitemid 38116831)
    • (2004) Journal of Immunology , vol.172 , Issue.3 , pp. 1825-1832
    • Morrison, A.C.1    Wilson, C.B.2    Ray, M.3    Correll, P.H.4
  • 113
    • 0032211131 scopus 로고    scopus 로고
    • Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression
    • Chen Y Q., Fisher J H., Wang M H. Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression. J Immunol 1998 161 9 4950-4959 (Pubitemid 28492076)
    • (1998) Journal of Immunology , vol.161 , Issue.9 , pp. 4950-4959
    • Chen, Y.-Q.1    Fisher, J.H.2    Wang, M.-H.3
  • 114
    • 0037064056 scopus 로고    scopus 로고
    • Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages
    • DOI 10.1074/jbc.M206167200
    • Zhou Y Q., Chen Y Q., Fisher J H., Wang M H. Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages. J Biol Chem 2002 277 41 38104-38110 (Pubitemid 35154662)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 38104-38110
    • Zhou, Y.-Q.1    Chen, Y.-Q.2    Fisher, J.H.3    Wang, M.-H.4
  • 115
    • 0032741542 scopus 로고    scopus 로고
    • Negative regulation of macrophage activation in response to IFN-gamma and lipopolysaccharide by the STK/RON receptor tyrosine kinase
    • 12
    • Liu Q P., Fruit K, Ward J, Correll P H. Negative regulation of macrophage activation in response to IFN-gamma and lipopolysaccharide by the STK/RON receptor tyrosine kinase. J Immunol 1999 163 12 6606-6613
    • (1999) J Immunol , vol.163 , pp. 6606-6613
    • Liu, Q.P.1    Fruit, K.2    Ward, J.3    Correll, P.H.4
  • 116
    • 0031061689 scopus 로고    scopus 로고
    • Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase
    • 1
    • Correll P H., Iwama A, Tondat S, Mayrhofer G, Suda T, Bernstein A. Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase. Genes Funct 1997 1 1 69-83
    • (1997) Genes Funct , vol.1 , pp. 69-83
    • Correll, P.H.1    Iwama, A.2    Tondat, S.3    Mayrhofer, G.4    Suda, T.5    Bernstein, A.6
  • 117
    • 26444476026 scopus 로고    scopus 로고
    • New roles for an old selenoenzyme: Evidence from glutathione peroxidase-1 null and overexpressing mice
    • Lei X G., Cheng W H. New roles for an old selenoenzyme: evidence from glutathione peroxidase-1 null and overexpressing mice. J Nutr 2005 135 10 2295-2298 (Pubitemid 41429580)
    • (2005) Journal of Nutrition , vol.135 , Issue.10 , pp. 2295-2298
    • Lei, X.G.1    Cheng, W.-H.2
  • 118
    • 0037621467 scopus 로고    scopus 로고
    • Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression
    • DOI 10.1515/BC.2003.067
    • Esworthy R S., Binder S W., Doroshow J H., Chu F F. Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem 2003 384 4 597-607 (Pubitemid 36609175)
    • (2003) Biological Chemistry , vol.384 , Issue.4 , pp. 597-607
    • Esworthy, R.S.1    Binder, S.W.2    Doroshow, J.H.3    Chu, F.-F.4
  • 119
    • 78649538645 scopus 로고    scopus 로고
    • Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase
    • 12
    • Gao Q, Esworthy R S., Kim B W., Synold T W., Smith D D., Chu F F. Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase. Inflamm Bowel Dis 2010 16 12 2043-2054
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 2043-2054
    • Gao, Q.1    Esworthy, R.S.2    Kim, B.W.3    Synold, T.W.4    Smith, D.D.5    Chu, F.F.6
  • 120
    • 50249116184 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response in immunity and autoimmunity
    • 9
    • Todd D J., Lee A H., Glimcher L H. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008 8 9 663-674
    • (2008) Nat Rev Immunol , vol.8 , pp. 663-674
    • Todd, D.J.1    Lee, A.H.2    Glimcher, L.H.3
  • 121
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • 5
    • Kaser A, Lee A H., Franke A et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008 134 5 743-756
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3
  • 123
    • 33750543992 scopus 로고    scopus 로고
    • Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases
    • DOI 10.1158/0008-5472.CAN-06-0732
    • Lee D H., Esworthy R S., Chu C, Pfeifer G P., Chu F F. Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases. Cancer Res 2006 66 20 9845-9851 (Pubitemid 44672035)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 9845-9851
    • Lee, D.-H.1    Esworthy, R.S.2    Chu, C.3    Pfeifer, G.P.4    Chu, F.-F.5
  • 125
    • 70349512259 scopus 로고    scopus 로고
    • Reactive oxygen species enhance insulin sensitivity
    • 4
    • Loh K, Deng H, Fukushima A et al. Reactive oxygen species enhance insulin sensitivity. Cell Metab 2009 10 4 260-272
    • (2009) Cell Metab , vol.10 , pp. 260-272
    • Loh, K.1    Deng, H.2    Fukushima, A.3
  • 126
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • IBSEN study group 11
    • Franke A, Balschun T, Karlsen T H. et al, IBSEN study group. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008 40 11 1319-1323
    • (2008) Nat Genet , vol.40 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 127
    • 77957877682 scopus 로고    scopus 로고
    • Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
    • IBSEN Study Group 8
    • Hov J R., Keitel V, Laerdahl J K. et al, IBSEN Study Group. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS ONE 2010 5 8 e12403
    • (2010) PLoS ONE , vol.5
    • Hov, J.R.1    Keitel, V.2    Laerdahl, J.K.3
  • 128
    • 77957877682 scopus 로고    scopus 로고
    • Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
    • IBSEN Study Group 8
    • Hov J R., Keitel V, Laerdahl J K. et al, IBSEN Study Group. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS ONE 2010 5 8 e12403
    • (2010) PLoS ONE , vol.5
    • Hov, J.R.1    Keitel, V.2    Laerdahl, J.K.3
  • 131
    • 70350292362 scopus 로고    scopus 로고
    • Bile-acid-activated receptors: Targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
    • 11
    • Fiorucci S, Mencarelli A, Palladino G, Cipriani S. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci 2009 30 11 570-580
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 570-580
    • Fiorucci, S.1    Mencarelli, A.2    Palladino, G.3    Cipriani, S.4
  • 133
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • 3
    • Thomas C, Gioiello A, Noriega L et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009 10 3 167-177
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 134
    • 34848927902 scopus 로고    scopus 로고
    • The many faces of actin: Matching assembly factors with cellular structures
    • DOI 10.1038/ncb1007-1110, PII NCB1007-1110
    • Chhabra E S., Higgs H N. The many faces of actin: matching assembly factors with cellular structures. Nat Cell Biol 2007 9 10 1110-1121 (Pubitemid 47500485)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1110-1121
    • Chhabra, E.S.1    Higgs, H.N.2
  • 135
    • 34247644614 scopus 로고    scopus 로고
    • Regulation of actin filament assembly by Arp2/3 complex and formins
    • DOI 10.1146/annurev.biophys.35.040405.101936
    • Pollard T D. Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 2007 36 451-477 (Pubitemid 47007562)
    • (2007) Annual Review of Biophysics and Biomolecular Structure , vol.36 , pp. 451-477
    • Pollard, T.D.1
  • 136
    • 0035930328 scopus 로고    scopus 로고
    • Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity
    • DOI 10.1016/S1097-2765(01)00393-8
    • Gournier H, Goley E D., Niederstrasser H, Trinh T, Welch M D. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. Mol Cell 2001 8 5 1041-1052 (Pubitemid 34031806)
    • (2001) Molecular Cell , vol.8 , Issue.5 , pp. 1041-1052
    • Gournier, H.1    Goley, E.D.2    Niederstrasser, H.3    Trinh, T.4    Welch, M.D.5
  • 138
    • 77953637330 scopus 로고    scopus 로고
    • Physical mechanisms of signal integration by WASP family proteins
    • Padrick S B., Rosen M K. Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem 2010 79 707-735
    • (2010) Annu Rev Biochem , vol.79 , pp. 707-735
    • Padrick, S.B.1    Rosen, M.K.2
  • 139
    • 33847420825 scopus 로고    scopus 로고
    • Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading Edge
    • DOI 10.1016/j.cell.2007.01.031, PII S0092867407001328
    • Cai L, Marshall T W., Uetrecht A C., Schafer D A., Bear J E. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell 2007 128 5 915-929 (Pubitemid 46341411)
    • (2007) Cell , vol.128 , Issue.5 , pp. 915-929
    • Cai, L.1    Marshall, T.W.2    Uetrecht, A.C.3    Schafer, D.A.4    Bear, J.E.5
  • 140
    • 54549117897 scopus 로고    scopus 로고
    • The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
    • 11
    • Shiow L R., Roadcap D W., Paris K et al. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol 2008 9 11 1307-1315
    • (2008) Nat Immunol , vol.9 , pp. 1307-1315
    • Shiow, L.R.1    Roadcap, D.W.2    Paris, K.3
  • 144
    • 69849084692 scopus 로고    scopus 로고
    • Recent advances in the biology of WASP and WIP
    • 1-3
    • Ramesh N, Geha R. Recent advances in the biology of WASP and WIP. Immunol Res 2009 44 1-3 99-111
    • (2009) Immunol Res , vol.44 , pp. 99-111
    • Ramesh, N.1    Geha, R.2
  • 146
    • 58149232586 scopus 로고    scopus 로고
    • The interleukin-8 pathway in cancer
    • 21
    • Waugh D J., Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res 2008 14 21 6735-6741
    • (2008) Clin Cancer Res , vol.14 , pp. 6735-6741
    • Waugh, D.J.1    Wilson, C.2
  • 147
    • 70149115487 scopus 로고    scopus 로고
    • The functional significance behind expressing two IL-8 receptor types on PMN
    • 3
    • Stillie R, Farooq S M., Gordon J R., Stadnyk A W. The functional significance behind expressing two IL-8 receptor types on PMN. J Leukoc Biol 2009 86 3 529-543
    • (2009) J Leukoc Biol , vol.86 , pp. 529-543
    • Stillie, R.1    Farooq, S.M.2    Gordon, J.R.3    Stadnyk, A.W.4
  • 148
    • 34547118328 scopus 로고    scopus 로고
    • IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules
    • DOI 10.1111/j.1478-3231.2007.01465.x
    • Isse K, Harada K, Nakanuma Y. IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules. Liver Int 2007 27 5 672-680 (Pubitemid 47097318)
    • (2007) Liver International , vol.27 , Issue.5 , pp. 672-680
    • Isse, K.1    Harada, K.2    Nakanuma, Y.3
  • 149
    • 35348886057 scopus 로고    scopus 로고
    • Human intrahepatic biliary epithelial cell as a possible modulator of hepatic regeneration: Potential role of biliary epithelial cell for hepatic remodeling in vivo
    • DOI 10.1111/j.1872-034X.2007.00237.x
    • Komori A, Nakamura M, Fujiwara S et al. Human intrahepatic biliary epithelial cell as a possible modulator of hepatic regeneration: Potential role of biliary epithelial cell for hepatic remodeling in vivo. Hepatol Res 2007 37 Suppl 3 S438-S443 (Pubitemid 47570657)
    • (2007) Hepatology Research , vol.37 , Issue.SUPPL. 3
    • Komori, A.1    Nakamura, M.2    Fujiwara, S.3    Yano, K.4    Fujioka, H.5    Migita, K.6    Yatsuhashi, H.7    Ishibashi, H.8
  • 150
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004 4 7 540-550 (Pubitemid 38868623)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.7 , pp. 540-550
    • Balkwill, F.1
  • 151
    • 77955022787 scopus 로고    scopus 로고
    • Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: Implications for antiangiogenic therapy
    • 14
    • Agarwal A, Tressel S L., Kaimal R et al. Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy. Cancer Res 2010 70 14 5880-5890
    • (2010) Cancer Res , vol.70 , pp. 5880-5890
    • Agarwal, A.1    Tressel, S.L.2    Kaimal, R.3
  • 152
    • 58949099391 scopus 로고    scopus 로고
    • Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
    • 4
    • Baranzini S E., Wang J, Gibson R A. et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 2009 18 4 767-778
    • (2009) Hum Mol Genet , vol.18 , pp. 767-778
    • Baranzini, S.E.1    Wang, J.2    Gibson, R.A.3
  • 153
    • 55849139823 scopus 로고    scopus 로고
    • Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms
    • BiomarkerMS Study Group 10
    • Comabella M, Craig D W., Camia-Tato M et al, BiomarkerMS Study Group. Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. PLoS ONE 2008 3 10 e3490
    • (2008) PLoS ONE , vol.3
    • Comabella, M.1    Craig, D.W.2    Camia-Tato, M.3
  • 154
    • 69549135691 scopus 로고    scopus 로고
    • Glypican 5 is an interferon-beta response gene: A replication study
    • 8
    • Cnit M D., Blanco-Kelly F, de las Heras V et al. Glypican 5 is an interferon-beta response gene: a replication study. Mult Scler 2009 15 8 913-917
    • (2009) Mult Scler , vol.15 , pp. 913-917
    • Cnit, M.D.1    Blanco-Kelly, F.2    De Las Heras, V.3
  • 155
    • 77953507639 scopus 로고    scopus 로고
    • A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci
    • 11
    • Okada Y, Kamatani Y, Takahashi A et al. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum Mol Genet 2010 19 11 2303-2312
    • (2010) Hum Mol Genet , vol.19 , pp. 2303-2312
    • Okada, Y.1    Kamatani, Y.2    Takahashi, A.3
  • 156
    • 77955345855 scopus 로고    scopus 로고
    • A genome-wide association study of neuroticism in a population-based sample
    • 7
    • Calboli F C., Tozzi F, Galwey N W. et al. A genome-wide association study of neuroticism in a population-based sample. PLoS ONE 2010 5 7 e11504
    • (2010) PLoS ONE , vol.5
    • Calboli, F.C.1    Tozzi, F.2    Galwey, N.W.3
  • 157
    • 55349128167 scopus 로고    scopus 로고
    • Molecular genetics of adult ADHD: Converging evidence from genome-wide association and extended pedigree linkage studies
    • 11
    • Lesch K P., Timmesfeld N, Renner T J. et al. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm 2008 115 11 1573-1585
    • (2008) J Neural Transm , vol.115 , pp. 1573-1585
    • Lesch, K.P.1    Timmesfeld, N.2    Renner, T.J.3
  • 158
    • 77950341944 scopus 로고    scopus 로고
    • Genetic variants and risk of lung cancer in never smokers: A genome-wide association study
    • 4
    • Li Y, Sheu C C., Ye Y et al. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol 2010 11 4 321-330
    • (2010) Lancet Oncol , vol.11 , pp. 321-330
    • Li, Y.1    Sheu, C.C.2    Ye, Y.3
  • 159
    • 77950229250 scopus 로고    scopus 로고
    • Host determinants of HIV-1 control in African Americans
    • Infectious Disease Clinical Research Program HIV Working Group National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) 8
    • Pelak K, Goldstein D B., Walley N M. et al, Infectious Disease Clinical Research Program HIV Working Group National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI). Host determinants of HIV-1 control in African Americans. J Infect Dis 2010 201 8 1141-1149
    • (2010) J Infect Dis , vol.201 , pp. 1141-1149
    • Pelak, K.1    Goldstein, D.B.2    Walley, N.M.3
  • 161
    • 0031568877 scopus 로고    scopus 로고
    • Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family
    • DOI 10.1006/geno.1996.4518
    • Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G. Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family. Genomics 1997 40 1 24-30 (Pubitemid 27108243)
    • (1997) Genomics , vol.40 , Issue.1 , pp. 24-30
    • Veugelers, M.1    Vermeesch, J.2    Reekmans, G.3    Steinfeld, R.4    Marynen, P.5    David, G.6
  • 162
    • 0031259923 scopus 로고    scopus 로고
    • Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain
    • DOI 10.1006/dbio.1997.8690
    • Saunders S, Paine-Saunders S, Lander A D. Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol 1997 190 1 78-93 (Pubitemid 27444739)
    • (1997) Developmental Biology , vol.190 , Issue.1 , pp. 78-93
    • Saunders, S.1    Paine-Saunders, S.2    Lander, A.D.3
  • 163
    • 0033578871 scopus 로고    scopus 로고
    • Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans
    • 38
    • Veugelers M, De Cat B, Ceulemans H et al. Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. J Biol Chem 1999 274 38 26968-26977
    • (1999) J Biol Chem , vol.274 , pp. 26968-26977
    • Veugelers, M.1    De Cat, B.2    Ceulemans, H.3
  • 164
    • 0033135066 scopus 로고    scopus 로고
    • GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13
    • DOI 10.1006/geno.1999.5793
    • Paine-Saunders S, Viviano B L., Saunders S. GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. Genomics 1999 57 3 455-458 (Pubitemid 29239237)
    • (1999) Genomics , vol.57 , Issue.3 , pp. 455-458
    • Paine-Saunders, S.1    Viviano, B.L.2    Saunders, S.3
  • 165
    • 66449083531 scopus 로고    scopus 로고
    • Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia
    • 6
    • Campos-Xavier A B., Martinet D, Bateman J et al. Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia. Am J Hum Genet 2009 84 6 760-770
    • (2009) Am J Hum Genet , vol.84 , pp. 760-770
    • Campos-Xavier, A.B.1    Martinet, D.2    Bateman, J.3
  • 166
    • 67649880295 scopus 로고    scopus 로고
    • REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
    • 7
    • Gregersen P K., Amos C I., Lee A T. et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 2009 41 7 820-823
    • (2009) Nat Genet , vol.41 , pp. 820-823
    • Gregersen, P.K.1    Amos, C.I.2    Lee, A.T.3
  • 167
    • 77950243833 scopus 로고    scopus 로고
    • Multiple common variants for celiac disease influencing immune gene expression
    • 4
    • Dubois P C., Trynka G, Franke L et al. Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010 42 4 295-302
    • (2010) Nat Genet , vol.42 , pp. 295-302
    • Dubois, P.C.1    Trynka, G.2    Franke, L.3
  • 168
    • 77950298959 scopus 로고    scopus 로고
    • Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    • NIDDK IBD Genetics Consortium 4
    • McGovern D P., Gardet A, Törkvist L et al, NIDDK IBD Genetics Consortium. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 2010 42 4 332-337
    • (2010) Nat Genet , vol.42 , pp. 332-337
    • McGovern, D.P.1    Gardet, A.2    Törkvist, L.3
  • 169
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 2009 27 693-733
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 170
    • 0043092575 scopus 로고    scopus 로고
    • Distinctions between c-Rel and other NF-κB proteins in immunity and disease
    • DOI 10.1002/bies.10306
    • Liou H C., Hsia C Y. Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease. Bioessays 2003 25 8 767-780 (Pubitemid 36966377)
    • (2003) BioEssays , vol.25 , Issue.8 , pp. 767-780
    • Liou, H.-C.1    Hsia, C.Y.2
  • 171
    • 0036738421 scopus 로고    scopus 로고
    • Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
    • 6
    • Hilliard B A., Mason N, Xu L et al. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J Clin Invest 2002 110 6 843-850
    • (2002) J Clin Invest , vol.110 , pp. 843-850
    • Hilliard, B.A.1    Mason, N.2    Xu, L.3
  • 172
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • 16
    • Köntgen F, Grumont R J., Strasser A et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 1995 9 16 1965-1977
    • (1995) Genes Dev , vol.9 , pp. 1965-1977
    • Köntgen, F.1    Grumont, R.J.2    Strasser, A.3
  • 173
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • 6
    • Long M, Park S G., Strickland I, Hayden M S., Ghosh S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009 31 6 921-931
    • (2009) Immunity , vol.31 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 174
    • 0346195644 scopus 로고    scopus 로고
    • c-Rel is required for chromatin remodeling across the IL-2 gene promoter
    • Rao S, Gerondakis S, Woltring D, Shannon M F. c-Rel is required for chromatin remodeling across the IL-2 gene promoter. J Immunol 2003 170 7 3724-3731 (Pubitemid 36359242)
    • (2003) Journal of Immunology , vol.170 , Issue.7 , pp. 3724-3731
    • Rao, S.1    Gerondakis, S.2    Woltring, D.3    Shannon, M.F.4
  • 175
    • 77956944349 scopus 로고    scopus 로고
    • Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel
    • 4
    • Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon M F. Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel. J Immunol 2010 185 4 2350-2359
    • (2010) J Immunol , vol.185 , pp. 2350-2359
    • Chen, G.1    Hardy, K.2    Bunting, K.3    Daley, S.4    Ma, L.5    Shannon, M.F.6
  • 176
    • 0034423508 scopus 로고    scopus 로고
    • The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
    • 23
    • Grossmann M, O'Reilly L A., Gugasyan R, Strasser A, Adams J M., Gerondakis S. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J 2000 19 23 6351-6360
    • (2000) EMBO J , vol.19 , pp. 6351-6360
    • Grossmann, M.1    O'Reilly, L.A.2    Gugasyan, R.3    Strasser, A.4    Adams, J.M.5    Gerondakis, S.6
  • 178
    • 77950616462 scopus 로고    scopus 로고
    • The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation
    • 3
    • Gieling R G., Elsharkawy A M., Caamao J H. et al. The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology 2010 51 3 922-931
    • (2010) Hepatology , vol.51 , pp. 922-931
    • Gieling, R.G.1    Elsharkawy, A.M.2    Caamao, J.H.3
  • 179
    • 67651205715 scopus 로고    scopus 로고
    • Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions
    • International Schizophrenia Consortium 6
    • Raychaudhuri S, Plenge R M., Rossin E J. et al, International Schizophrenia Consortium. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 2009 5 6 e1000534
    • (2009) PLoS Genet , vol.5
    • Raychaudhuri, S.1    Plenge, R.M.2    Rossin, E.J.3
  • 180
    • 77449121614 scopus 로고    scopus 로고
    • Target-enrichment strategies for next-generation sequencing
    • 2
    • Mamanova L, Coffey A J., Scott C E. et al. Target-enrichment strategies for next-generation sequencing. Nat Methods 2010 7 2 111-118
    • (2010) Nat Methods , vol.7 , pp. 111-118
    • Mamanova, L.1    Coffey, A.J.2    Scott, C.E.3
  • 181
    • 77954121752 scopus 로고    scopus 로고
    • SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region
    • 7
    • Melum E, May S, Schilhabel M B. et al. SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region. Hum Mutat 2010 31 7 875-885
    • (2010) Hum Mutat , vol.31 , pp. 875-885
    • Melum, E.1    May, S.2    Schilhabel, M.B.3
  • 184
    • 0030615212 scopus 로고    scopus 로고
    • Preferential Vβ3 usage by hepatic T lymphocytes in patients with primary sclerosing cholangitis
    • DOI 10.1016/S0168-8278(97)80417-5
    • Broom? U, Grunewald J, Scheynius A, Olerup O, Hultcrantz R. Preferential V beta3 usage by hepatic T lymphocytes in patients with primary sclerosing cholangitis. J Hepatol 1997 26 3 527-534 (Pubitemid 27112717)
    • (1997) Journal of Hepatology , vol.26 , Issue.3 , pp. 527-534
    • Bromme, U.1    Grunewald, J.2    Scheynius, A.3    Olerup, O.4    Hultcrantz, R.5
  • 187
    • 61849085112 scopus 로고    scopus 로고
    • Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation
    • 1
    • Liu J O. Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunol Rev 2009 228 1 184-198
    • (2009) Immunol Rev , vol.228 , pp. 184-198
    • Liu, J.O.1
  • 188
    • 77951926420 scopus 로고    scopus 로고
    • Etiology of type 1 diabetes
    • 4
    • Todd J A. Etiology of type 1 diabetes. Immunity 2010 32 4 457-467
    • (2010) Immunity , vol.32 , pp. 457-467
    • Todd, J.A.1
  • 189
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • 5
    • Tang Q, Adams J Y., Penaranda C et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008 28 5 687-697
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 190
    • 65249131713 scopus 로고    scopus 로고
    • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    • 5925
    • Nejentsev S, Walker N, Riches D, Egholm M, Todd J A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009 324 5925 387-389
    • (2009) Science , vol.324 , pp. 387-389
    • Nejentsev, S.1    Walker, N.2    Riches, D.3    Egholm, M.4    Todd, J.A.5
  • 192
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • 7089
    • Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 441 7089 101-105
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3
  • 195
    • 0036936696 scopus 로고    scopus 로고
    • Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis
    • DOI 10.1080/0891693021000054093
    • Donaldson P T., Norris S. Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis. Autoimmunity 2002 35 8 555-564 (Pubitemid 36321898)
    • (2002) Autoimmunity , vol.35 , Issue.8 , pp. 555-564
    • Donaldson, P.T.1    Norris, S.2
  • 197
    • 72949089936 scopus 로고    scopus 로고
    • The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway
    • 8B
    • Zhao B, Schlesiger C, Masucci M G., Lindsten K. The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway. J Cell Mol Med 2009 13 8B 1886-1895
    • (2009) J Cell Mol Med , vol.13 , pp. 1886-1895
    • Zhao, B.1    Schlesiger, C.2    Masucci, M.G.3    Lindsten, K.4
  • 198
    • 33747810129 scopus 로고    scopus 로고
    • Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis
    • DOI 10.1136/gut.2005.081059
    • Zhou Q, Hennenberg M, Trebicka J et al. Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis. Gut 2006 55 9 1296-1305 (Pubitemid 44277362)
    • (2006) Gut , vol.55 , Issue.9 , pp. 1296-1305
    • Zhou, Q.1    Hennenberg, M.2    Trebicka, J.3    Jochem, K.4    Leifeld, L.5    Biecker, E.6    Sauerbruch, T.7    Heller, J.8
  • 199
    • 0037015674 scopus 로고    scopus 로고
    • Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways
    • DOI 10.1038/sj.onc.1205729
    • Debruyne P R., Bruyneel E A., Karaguni I M. et al. Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways. Oncogene 2002 21 44 6740-6750 (Pubitemid 35221916)
    • (2002) Oncogene , vol.21 , Issue.44 , pp. 6740-6750
    • Debruyne, P.R.1    Bruyneel, E.A.2    Karaguni, I.-M.3    Li, X.D.4    Flatau, G.5    Muller, O.6    Zimber, A.7    Gespach, C.8    Mareel, M.M.9
  • 200
    • 2942592526 scopus 로고    scopus 로고
    • Glycine encephalopathy (nonketotic hyperglycinaemia): Review and update
    • DOI 10.1023/B:BOLI.0000031222.38328.59
    • Applegarth D A., Toone J R. Glycine encephalopathy (nonketotic hyperglycinaemia): review and update. J Inherit Metab Dis 2004 27 3 417-422 (Pubitemid 38756325)
    • (2004) Journal of Inherited Metabolic Disease , vol.27 , Issue.3 , pp. 417-422
    • Applegarth, D.A.1    Toone, J.R.2
  • 201
    • 32244440192 scopus 로고    scopus 로고
    • Dystroglycan: From biosynthesis to pathogenesis of human disease
    • DOI 10.1242/jcs.02814
    • Barresi R, Campbell K P. Dystroglycan: from biosynthesis to pathogenesis of human disease. J Cell Sci 2006 119 Pt 2 199-207 (Pubitemid 43210689)
    • (2006) Journal of Cell Science , vol.119 , Issue.2 , pp. 199-207
    • Barresi, R.1    Campbell, K.P.2
  • 202
    • 66149125273 scopus 로고    scopus 로고
    • The molecular architecture of ribbon presynaptic terminals
    • 2
    • Zanazzi G, Matthews G. The molecular architecture of ribbon presynaptic terminals. Mol Neurobiol 2009 39 2 130-148
    • (2009) Mol Neurobiol , vol.39 , pp. 130-148
    • Zanazzi, G.1    Matthews, G.2
  • 204
    • 2342592655 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and the regulation of macrophage activation
    • DOI 10.1189/jlb.0703347
    • Correll P H., Morrison A C., Lutz M A. Receptor tyrosine kinases and the regulation of macrophage activation. J Leukoc Biol 2004 75 5 731-737 (Pubitemid 38580051)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.5 , pp. 731-737
    • Correll, P.H.1    Morrison, A.C.2    Lutz, M.A.3
  • 205
    • 0030067724 scopus 로고    scopus 로고
    • Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease
    • 2
    • Daig R, Andus T, Aschenbrenner E, Falk W, Schölmerich J, Gross V. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996 38 2 216-222
    • (1996) Gut , vol.38 , pp. 216-222
    • Daig, R.1    Andus, T.2    Aschenbrenner, E.3    Falk, W.4    Schölmerich, J.5    Gross, V.6
  • 207
    • 50249125136 scopus 로고    scopus 로고
    • Variants in inflammation genes and the risk of biliary tract cancers and stones: A population-based study in China
    • 15
    • Hsing A W., Sakoda L C., Rashid A et al. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. Cancer Res 2008 68 15 6442-6452
    • (2008) Cancer Res , vol.68 , pp. 6442-6452
    • Hsing, A.W.1    Sakoda, L.C.2    Rashid, A.3
  • 208
    • 0037736679 scopus 로고    scopus 로고
    • Autoimmunity in Wiskott-Aldrich syndrome: Risk factors, clinical features, and outcome in a single-center cohort of 55 patients
    • 5 Pt 1
    • Dupuis-Girod S, Medioni J, Haddad E et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics 2003 111 5 Pt 1 e622-e627
    • (2003) Pediatrics , vol.111
    • Dupuis-Girod, S.1    Medioni, J.2    Haddad, E.3
  • 210
    • 70349255713 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
    • 3
    • Keitel V, Cupisti K, Ullmer C, Knoefel W T., Kubitz R, Hussinger D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009 50 3 861-870
    • (2009) Hepatology , vol.50 , pp. 861-870
    • Keitel, V.1    Cupisti, K.2    Ullmer, C.3    Knoefel, W.T.4    Kubitz, R.5    Hussinger, D.6
  • 211
    • 67650357976 scopus 로고    scopus 로고
    • A function for AAMP in Nod2-mediated NF-kappaB activation
    • 13
    • Bielig H, Zurek B, Kutsch A et al. A function for AAMP in Nod2-mediated NF-kappaB activation. Mol Immunol 2009 46 13 2647-2654
    • (2009) Mol Immunol , vol.46 , pp. 2647-2654
    • Bielig, H.1    Zurek, B.2    Kutsch, A.3
  • 212
    • 70349784903 scopus 로고    scopus 로고
    • LFG: A candidate apoptosis regulatory gene family
    • 11
    • Hu L, Smith T F., Goldberger G. LFG: a candidate apoptosis regulatory gene family. Apoptosis 2009 14 11 1255-1265
    • (2009) Apoptosis , vol.14 , pp. 1255-1265
    • Hu, L.1    Smith, T.F.2    Goldberger, G.3
  • 213
    • 33646079377 scopus 로고    scopus 로고
    • RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation
    • 5
    • Zhao H, Ito A, Sakai N, Matsuzawa Y, Yamashita S, Nojima H. RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation. Circ J 2006 70 5 615-624
    • (2006) Circ J , vol.70 , pp. 615-624
    • Zhao, H.1    Ito, A.2    Sakai, N.3    Matsuzawa, Y.4    Yamashita, S.5    Nojima, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.