Recent advances in the biology of WASP and WIP

Immunologic Research

Volumn 44, Issue 1-3, 2009, Pages 99-111

  Ramesh, Narayanaswamy ^a   Geha, Raif ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Actin cytoskeleton; Lymphocytes; WASP; WIP; Wiskott Aldrich syndrome

Indexed keywords

ACTIN; CHAPERONE; MULTIPROTEIN COMPLEX; MUTANT PROTEIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN; PROTEIN CDC42; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN; WISKOTT ALDRICH SYNDROME PROTEIN INTERACTING PROTEIN; ACTIN RELATED PROTEIN 2-3 COMPLEX; CYTOSKELETON PROTEIN; SIGNAL PEPTIDE; WIPF1 PROTEIN, HUMAN;

ATTENUATION; B LYMPHOCYTE; BIOLOGY; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL FUNCTION; CELL MATURATION; CYTOKINESIS; CYTOSKELETON; HUMAN; IMMUNOCOMPETENT CELL; INTRACELLULAR SPACE; LYMPHOCYTE FUNCTION; MAST CELL; MITOSIS; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THROMBOCYTOPENIA; WISKOTT ALDRICH SYNDROME; X CHROMOSOME LINKED DISORDER; ANIMAL; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; ANIMALS; B-LYMPHOCYTES; CDC42 GTP-BINDING PROTEIN; CYTOSKELETAL PROTEINS; CYTOSKELETON; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; MAST CELLS; MICE; PROTEIN STRUCTURE, TERTIARY; T-LYMPHOCYTES, REGULATORY; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 69849084692     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-008-8086-1     Document Type: Review

References (74)

1. JMJ Derry HD Ochs U Francke 1994 Isolation of a novel gene mutated in Wiskott-Aldrich Syndrome Cell 78 635 44 8069912 10.1016/0092-8674(94)90528-2 1:CAS:528:DyaK2cXmt1ymtr0%3D (Pubitemid 24268586)
2. LD Notarangelo CH Miao HD Ochs 2008 Wiskott-Aldrich Syndrome Curr Opin Hematol 15 30 6 18043243 10.1097/MOH.0b013e3282f30448 1:CAS:528: DC%2BD1cXnvFWmtQ%3D%3D (Pubitemid 350191026)
3. LD Notarangelo HD Ochs 2005 WASP and the phenotypic range associated with deficiency Curr Opin Allergy Clin Immunol 5 485 90 16264326 1:CAS:528:DC%2BD2MXhtleqsb%2FF
4. T Takenawa S Suetsugu 2007 The WASP-WAVE protein network: connecting the membrane to the cytoskeleton Nat Rev Mol Cell Biol 8 37 48 17183359 10.1038/nrm2069 1:CAS:528:DC%2BD28XhtlCjt7bO (Pubitemid 46012013)
5. MA de la Fuente Y Sasahara M Calamito IM Anton A Elkhal MD Gallego K Suresh K Siminovitch HD Ochs KC Anderson FS Rosen RS Geha N Ramesh 2007 WIP is a chaperone for Wiskott-Aldrich Syndrome protein (WASP) Proc Natl Acad Sci USA 104 926 31 17213309 10.1073/pnas.0610275104 1:CAS:528:DC%2BD2sXhtVegt7c%3D (Pubitemid 46154713)
6. K Imai S Nonoyama HD Ochs 2003 WASP (Wiskott-Aldrich Syndrome protein) gene mutations and phenotype Curr Opin Allergy Clin Immunol 3 427 36 14612666 10.1097/00130832-200312000-00003 1:CAS:528:DC%2BD2cXkvFGrsw%3D%3D (Pubitemid 39149556)
7. Y Jin C Mazza JR Christie S Giliani M Fiorini P Mella F Gandellini DM Stewart Q Zhu DL Nelson LD Notarangelo HD Ochs 2004 Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation Blood 104 4010 9 15284122 10.1182/blood-2003-05-1592 1:CAS:528:DC%2BD2cXhtFaju7jO (Pubitemid 39620151)
8. DM Stewart L Tian DL Nelson 1999 Mutations that cause the Wiskott-Aldrich Syndrome impair the interaction of Wiskott-Aldrich Syndrome Protein (WASP) with WASP interacting protein J Immunol 162 5019 24 10202051 1:CAS:528: DyaK1MXisFOrtLc%3D
9. JE Bear JF Rawls CL Saxe 1998 SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late dictyostelium development [In Process Citation] J Cell Biol 142 1325 35 9732292 10.1083/jcb.142.5.1325 1:CAS:528:DyaK1cXlvFejurc%3D (Pubitemid 28429113)
10. L Ma R Rohatgi MW Kirschner 1998 The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein cdc42 Proc Natl Acad Sci USA 95 15362 7 9860974 10.1073/pnas.95.26.15362 1:CAS:528:DyaK1MXhvFaltg%3D%3D (Pubitemid 29018704)
11. H Miki K Miura T Takenawa 1996 N-WASP, a novel actin-polymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases EMBO J 15 5326 35 8895577
12. H Miki S Suetsugu T Takenawa 1998 WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac EMBO J 17 6932 41 9843499 10.1093/emboj/17.23.6932 1:CAS:528:DyaK1MXivFaqtQ%3D%3D
13. KG Campellone NJ Webb EA Znameroski MD Welch 2008 WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport Cell 134 148 61 18614018 10.1016/j.cell.2008.05.032 1:CAS:528: DC%2BD1cXoslyjtb8%3D (Pubitemid 351905739)
14. N Ramesh IM Anton JH Hartwig RS Geha 1997 WIP, a protein associated with Wiskott-Aldrich Syndrome protein, induces actin polymerization and redistribution in lymphoid cells Proc Natl Acad Sci USA 94 14671 6 9405671 10.1073/pnas.94.26.14671 1:CAS:528:DyaK1cXis1Ogtg%3D%3D (Pubitemid 28041432)
15. G Vaduva N Martinez-Quiles IM Anton NC Martin RS Geha AK Hopper N Ramesh 1999 The Human WASP-interacting Protein, WIP, activates the cell polarity pathway in yeast J Biol Chem 274 17103 8 10358064 10.1074/jbc.274.24.17103 1:CAS:528:DyaK1MXjvVGkur0%3D (Pubitemid 29275170)
16. FC Peterson Q Deng M Zettl KE Prehoda WA Lim M Way BF Volkman 2007 Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP J Biol Chem 282 8446 53 17229736 10.1074/jbc.M609902200 1:CAS:528:DC%2BD2sXis1Knsro%3D (Pubitemid 47093567)
17. BF Volkman KE Prehoda JA Scott FC Peterson WA Lim 2002 Structure of the N-Wasp EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome Cell 111 565 76 12437929 10.1016/S0092-8674(02)01076-0 1:CAS:528:DC%2BD38XptVyltbk%3D (Pubitemid 35356561)
18. I Anton N Ramesh RS Geha 1998 Interaction between Nck and a novel protein that binds to the Wiskott Aldrich protein (WASP), a potential link between receptor tyrosine kinases and the actin cytoskeleton J Biol Chem 273 20992 5 9694849 10.1074/jbc.273.33.20992 1:CAS:528:DyaK1cXlsFOrs7s%3D (Pubitemid 28385382)
19. Y Sasahara R Rachid MJ Byrne MA de la Fuente RT Abraham N Ramesh RS Geha 2002 Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation Mol Cell 10 1269 81 12504004 10.1016/S1097-2765(02)00728-1 1:CAS:528:DC%2BD3sXjslOjsA%3D%3D (Pubitemid 36050870)
20. IM Anton GE Jones F Wandosell R Geha N Ramesh 2007 WASP-interacting protein (WIP): working in polymerisation and much more Trends Cell Biol 17 555 62 17949983 10.1016/j.tcb.2007.08.005 1:CAS:528:DC%2BD2sXhtlWrs7zE (Pubitemid 350087660)
21. M Symons JMJ Derry B Kariak S Jiang V Lemahieu F McCormick U Francke A Abo 1996 Wiskott-Aldrich Syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization Cell 84 723 34 8625410 10.1016/S0092-8674(00)81050-8 1:CAS:528:DyaK28Xhs1Cgu7k%3D (Pubitemid 26094202)
22. HN Higgs TD Pollard 1999 Regulation of actin polymerization by Arp2/3 complex and Wasp/SCAR proteins J Biol Chem 274 32531 4 10551802 10.1074/jbc.274.46.32531 1:CAS:528:DyaK1MXntlygsL4%3D
23. LM Machesky KL Gould 1999 The Arp2/3 complex: a multifunctional actin organizer Curr Opin Cell Biol 11 117 21 10047519 10.1016/S0955-0674(99)80014-3 1:CAS:528:DyaK1MXhsFSnurk%3D (Pubitemid 29084139)
24. HN Higgs TD Pollard 2000 Activation by Cdc42 and PIP2 of Wiskott-Aldrich Syndrome Protein (WASp) stimulates actin nucleation by Arp2/3 complex J Cell Biol 150 1311 20 10995437 10.1083/jcb.150.6.1311 1:CAS:528:DC%2BD3cXmslGmur0%3D (Pubitemid 30728904)
25. R Rohatgi L Ma H Miki M Lopez T Kirchhausen T Takenawa M Kirschner 1999 The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly Cell 97 221 31 10219243 10.1016/S0092-8674(00)80732-1 1:CAS:528:DyaK1MXislent70%3D
26. GO Cory R Garg R Cramer AJ Ridley 2002 Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation J Biol Chem 277 45115 21 12235133 10.1074/jbc.M203346200 1:CAS:528:DC%2BD38Xosl2lsr0%3D (Pubitemid 36159113)
27. GO Cory R Cramer L Blanchoin AJ Ridley 2003 Phosphorylation of the WASP-VCA domain increases its affinity for the Arp 2/3 complex and enhances actin polymerization by WASP Mol Cell 11 1229 39 12769847 10.1016/S1097-2765(03) 00172-2 1:CAS:528:DC%2BD3sXksVOjt7s%3D (Pubitemid 36645142)
28. E Torres MK Rosen 2003 Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP Mol Cell 11 1215 27 12769846 10.1016/S1097-2765(03)00139-4 1:CAS:528:DC%2BD3sXksVOjt7o%3D (Pubitemid 36645141)
29. H Miki T Sasaki Y Takai T Takenawa 1998 Induction of filopodium formation by a WASP-related actin- depolymerizing protein N-WASP Nature 391 93 6 9422512 10.1038/34208 1:CAS:528:DyaK1cXktVSqtw%3D%3D (Pubitemid 28079222)
30. N Martinez-Quiles R Rohatgi IM Anton M Medina SP Saville H Miki H Yamaguchi T Takenawa JH Hartwig RS Geha N Ramesh 2001 WIP regulates N-WASP-mediated actin polymerization and filopodium formation Nat Cell Biol 3 484 91 11331876 10.1038/35074551 1:CAS:528:DC%2BD3MXjsFCksrs%3D (Pubitemid 32422084)
31. E Haddad E Cramer C Rivire P Rameau F Louache J Guichard DL Nelson A Fischer W Vainchenker N Debili 1999 The thrombocytopenia of Wiskott-Aldrich Syndrome is not related to a defect in proplatelet formation Blood 94 509 18 10397718 1:CAS:528:DyaK1MXksVemtLo%3D
32. S Linder D Nelson M Aepfelbacher 1999 Wiskott-Aldrich Syndrome protein regulates podosomes in primary human macrophages Proc Natl Acad Sci USA 96 9648 53 10449748 10.1073/pnas.96.17.9648 1:CAS:528:DyaK1MXlsVymsbs%3D (Pubitemid 29398786)
33. HD Ochs AJ Thrasher 2006 The Wiskott-Aldrich Syndrome J Allergy Clin Immunol 117 725 38 16630926 10.1016/j.jaci.2006.02.005 1:CAS:528: DC%2BD28Xjslels7w%3D quiz 739 (Pubitemid 44313817)
34. SB Snapper FS Rosen E Mizoguchi P Cohen W Khan C-H Liu TL Hagemann S-P Kwan R Ferrini L Davidson AK Bhan FW Alt 1998 Wiskott-Aldrich Syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation Immunity 9 81 91 9697838 10.1016/S1074-7613(00)80590-7 1:CAS:528: DyaK1cXltVSit7w%3D (Pubitemid 28361297)
35. HC Chou IM Anton MR Holt C Curcio S Lanzardo A Worth S Burns AJ Thrasher GE Jones Y Calle 2006 WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells Curr Biol 16 2337 44 17141616 10.1016/j.cub.2006.10.037 1:CAS:528:DC%2BD28Xht1OhtL3F (Pubitemid 44821843)
36. A Konno M Kirby SA Anderson PL Schwartzberg F Candotti 2007 The expression of Wiskott-Aldrich Syndrome protein (WASP) is dependent on WASP-interacting protein (WIP) Int Immunol 19 185 92 17205972 10.1093/intimm/dxl135 1:CAS:528:DC%2BD2sXhtVKktr4%3D (Pubitemid 46179013)
37. S Vetterkind H Miki T Takenawa I Klawitz KH Scheidtmann U Preuss 2002 The rat homologue of Wiskott-Aldrich Syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation J Biol Chem 277 87 95 11687573 10.1074/jbc.M104555200 1:CAS:528:DC%2BD38XjslCrsQ%3D%3D (Pubitemid 34952031)
38. V Moreau F Frischknecht I Reckmann R Vincentelli G Rabut D Stewart M Way 2000 A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization Nat Cell Biol 2 441 8 10878810 10.1038/35017080 1:CAS:528:DC%2BD3cXkvFCqt74%3D (Pubitemid 30781070)
39. IM Anton MA de la Fuente TN Sims S Freeman N Ramesh JH Hartwig ML Dustin RS Geha 2002 WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation Immunity 16 193 204 11869681 10.1016/S1074-7613(02)00268-6 1:CAS:528:DC%2BD38XitVCisr4%3D (Pubitemid 34211960)
40. HY Ho R Rohatgi AM Lebensohn M Le SP Gygi MW Kirschner 2004 Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex Cell 118 203 16 15260990 10.1016/j.cell.2004.06.027 1:CAS:528: DC%2BD2cXmtlKntro%3D (Pubitemid 38962576)
41. X Dong G Patino-Lopez F Candotti S Shaw 2007 Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory J Biol Chem 282 30303 10 17711847 10.1074/jbc.M704972200 1:CAS:528:DC%2BD2sXhtFagurzI (Pubitemid 350035300)
42. S Koduru M Massaad C Wilbur L Kumar R Geha N Ramesh 2007 A novel anti-WIP monoclonal antibody detects an isoform of WIP that lacks the WASP binding domain Biochem Biophys Res Commun 353 875 81 17207458 10.1016/j.bbrc.2006.12.079 1:CAS:528:DC%2BD2sXmtVakuw%3D%3D (Pubitemid 46098953)
43. C Egile TP Loisel V Laurent R Li D Pantaloni PJ Sansonetti MF Carlier 1999 Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility J Cell Biol 146 1319 32 10491394 10.1083/jcb.146.6.1319 1:CAS:528:DyaK1MXmt1Gns7w%3D (Pubitemid 29477698)
44. Y Leung S Ally MB Goldberg 2008 Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition Cell Host Microbe 3 39 47 18191793 10.1016/j.chom.2007.10.011 1:CAS:528:DC%2BD1cXhsFSjtLs%3D
45. HC Cheng BM Skehan KG Campellone JM Leong MK Rosen 2008 Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U) Nature 454 1009 13 18650809 10.1038/nature07160 1:CAS:528:DC%2BD1cXhtVWns7zK
46. NA Sallee GM Rivera JE Dueber D Vasilescu RD Mullins BJ Mayer WA Lim 2008 The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency Nature 454 1005 8 18650806 10.1038/nature07170 1:CAS:528: DC%2BD1cXhtVWns7%2FJ
47. SB Snapper F Takeshima I Anton CH Liu SM Thomas D Nguyen D Dudley H Fraser D Purich M Lopez-Ilasaca C Klein L Davidson R Bronson RC Mulligan F Southwick R Geha MB Goldberg FS Rosen JH Hartwig FW Alt 2001 N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility Nat Cell Biol 3 897 904 11584271 10.1038/ncb1001-897 1:CAS:528:DC%2BD3MXnslejtbw%3D (Pubitemid 32952254)
48. SB Snapper FS Rosen 2003 A family of WASPs N Engl J Med 348 350 1 12540651 10.1056/NEJMcibr001155 (Pubitemid 36119993)
49. JL Cannon CM Labno G Bosco A Seth MH McGavin KA Siminovitch MK Rosen JK Burkhardt 2001 Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation Immunity 15 249 59 11520460 10.1016/S1074-7613(01)00178-9 1:CAS:528:DC%2BD3MXmsF2itrw%3D (Pubitemid 32816874)
50. MF Carlier P Nioche I Broutin-L'Hermite R Boujemaa C Clainche C Egile C Garbay A DuCruis P Sansonetti D Pantaloni 2000 GRB2 links signalling to actin assembly by enhancing interaction of neural Wiskott-Aldrich Syndrome protein (N-WASp) with actin-related protein (Arp2/3) complex J Biol Chem 275 21946 52 10781580 10.1074/jbc.M000687200 1:CAS:528:DC%2BD3cXltFGjtb4%3D (Pubitemid 30621767)
51. K Badour J Zhang KA Siminovitch 2003 The Wiskott-Aldrich Syndrome protein: forging a link between actin and cell activation Immunol Rev 192 98 112 12670398 10.1034/j.1600-065X.2003.00031.x 1:CAS:528:DC%2BD3sXjsVOnt7s%3D (Pubitemid 36613326)
52. ML Dustin 2005 A dynamic view of the immunological synapse Semin Immunol 17 400 10 16266811 10.1016/j.smim.2005.09.002 1:CAS:528:DC%2BD2MXht1GnsL7F (Pubitemid 41654692)
53. TN Sims TJ Soos HS Xenias B Dubin-Thaler JM Hofman JC Waite TO Cameron VK Thomas R Varma CH Wiggins MP Sheetz DR Littman ML Dustin 2007 Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse Cell 129 773 85 17512410 10.1016/j.cell.2007.03.037 1:CAS:528: DC%2BD2sXmtFKjsr4%3D (Pubitemid 46802378)
54. GO Cory L MacCarthy-Morrogh S Banin I Gout PM Brickell RJ Levinsky C Kinnon RC Lovering 1996 Evidence that the Wiskott-Aldrich Syndrome protein may be involved in lymphoid cell signaling pathways J Immunol 157 3791 5 8892607 1:CAS:528:DyaK28XmsF2msrk%3D
55. R Guinamard P Aspenstrom M Fougereau P Chavrier JC Guillemot 1998 Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42 FEBS Lett 434 431 6 9742969 10.1016/S0014-5793(98)01016-3 1:CAS:528:DyaK1cXmt1yhu74%3D (Pubitemid 29052271)
56. G Greicius L Westerberg EJ Davey E Buentke A Scheynius J Thyberg E Severinson 2004 Microvilli structures on B lymphocytes: inducible functional domains? Int Immunol 16 353 64 14734621 10.1093/intimm/dxh031 1:CAS:528:DC%2BD2cXmtl2jsQ%3D%3D (Pubitemid 38195666)
57. E Severinson L Westerberg 2003 Regulation of adhesion and motility in B lymphocytes Scand J Immunol 58 139 44 12869134 10.1046/j.1365-3083.2003.01295.x 1:CAS:528:DC%2BD3sXmsl2ms70%3D (Pubitemid 36904305)
58. L Westerberg M Larsson SJ Hardy C Fernandez AJ Thrasher E Severinson 2005 Wiskott-Aldrich Syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response Blood 105 1144 52 15383456 10.1182/blood-2004-03-1003 1:CAS:528:DC%2BD2MXhtFCgt74%3D (Pubitemid 40170887)
59. Westerberg L, de la Fuente MA, Wermeling F, Ochs HD, Karlsson MC, Snapper SB, et al. WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. Blood. 2008.
60. MH Maillard V Cotta-de-Almeida F Takeshima DD Nguyen P Michetti C Nagler AK Bhan SB Snapper 2007 The Wiskott-Aldrich Syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells J Exp Med 204 381 91 17296786 10.1084/jem.20061338 1:CAS:528:DC%2BD2sXitVektLg%3D (Pubitemid 46294553)
61. DA Moulding MP Blundell DG Spiller MR White GO Cory Y Calle H Kempski J Sinclair PJ Ancliff C Kinnon GE Jones AJ Thrasher 2007 Unregulated actin polymerization by WASP causes defects of mitosis and cytokinesis in X-linked neutropenia J Exp Med 204 2213 24 17724125 1:CAS:528:DC%2BD2sXhtVWnurnK
62. Y Calle IM Anton AJ Thrasher GE Jones 2008 WASP and WIP regulate podosomes in migrating leukocytes J Microsc 231 494 505 18755005 10.1111/j.1365-2818.2008.02062.x 1:CAS:528:DC%2BD1cXhtF2rt7bF
63. A Kettner L Kumar IM Anton Y Sasahara M de la Fuente VI Pivniouk H Falet JH Hartwig RS Geha 2004 WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells J Exp Med 199 357 68 14757742 10.1084/jem.20030652 1:CAS:528:DC%2BD2cXhtVCitLg%3D (Pubitemid 38252048)
64. K Krzewski X Chen JL Strominger 2008 WIP is essential for lytic granule polarization and NK cell cytotoxicity Proc Natl Acad Sci USA 105 2568 73 18258743 10.1073/pnas.0711593105
65. K Krzewski X Chen JS Orange JL Strominger 2006 Formation of a WIP-, WASP-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling J Cell Biol 173 121 32 16606694 10.1083/jcb.200509076 1:CAS:528:DC%2BD28XjsFCgtL8%3D
66. K Krzewski JL Strominger 2008 The killer's kiss: the many functions of NK cell immunological synapses Curr Opin Cell Biol 20 597 605 18639449 10.1016/j.ceb.2008.05.006 1:CAS:528:DC%2BD1cXhtVyks7vK
67. OM Rivero-Lezcano A Marcilla JH Sameshima KC Robbins 1995 Wiskott-Aldrich Syndrome protein physically associates with Nck through Src homology 3 domains Mol Cell Biol 15 5725 31 7565724 1:CAS:528:DyaK2MXotlanu7s%3D
68. HY She S Rockow J Tang R Nishimura EY Skolnik M Chen B Margolis W Li 1997 Wiskott-Aldrich Syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells Mol Biol Cell 8 1709 21 9307968 1:CAS:528:DyaK2sXmsVKisL4%3D
69. HY Ho R Rohatgi L Ma MW Kirschner 2001 CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family Proc Natl Acad Sci USA 98 11306 11 11553796 10.1073/pnas.211420498 1:CAS:528:DC%2BD3MXnt1yqtLs%3D (Pubitemid 32928724)
70. S Suetsugu Y Banzai M Kato K Fukami Y Kataoka Y Takai N Yoshida T Takenawa 2007 Male-specific sterility caused by the loss of CR16 Genes Cells 12 721 33 17573773 1:CAS:528:DC%2BD2sXmvF2qsrs%3D
71. P Aspenstorm 2002 The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor Exp Cell Res 279 21 33 10.1006/excr.2002.5576 1:CAS:528:DC%2BD38XmsV2ksbo%3D
72. M Kato H Miki S Kurita T Endo H Nakagawa S Miyamoto T Takenawa 2002 WICH, a novel verproline homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation Biochem Biophys Res Commun 291 41 7 11829459 10.1006/bbrc.2002.6406 1:CAS:528:DC%2BD38XpslymsQ%3D%3D (Pubitemid 34681135)
73. P Aspenstrom 2004 The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms Exp Cell Res 298 485 98 15265696 10.1016/j.yexcr.2004.04.050 1:CAS:528:DC%2BD2cXlvVWht74%3D (Pubitemid 38950865)
74. MD Gallego MA de la Fuente IM Anton S Snapper R Fuhlbrigge RS Geha 2006 WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha Int Immunol 18 221 32 16141245 10.1093/intimm/dxh310 1:CAS:528:DC%2BD28XovVGjsw%3D%3D (Pubitemid 43160135)