Immunogenetics in PSC

Best Practice and Research: Clinical Gastroenterology

Volumn 15, Issue 4, 2001, Pages 611-627

  Donaldson, Peter T ^a   Norris, Suzanne ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Autoimmunity; Chemokine; Complex disease; Cytokine; Fibrosis; Human leukocyte antigens (HLA); Interleukin (IL); Major histocompatability complex (MHC); Metalloproteinase; Non Mendelian disease; Polymorphism

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; HLA ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN; STROMELYSIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; IMMUNOGENETICS; INHERITANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIMARY SCLEROSING CHOLANGITIS; REGULATOR GENE; RISK;

EID: 0034879479     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.2001.0208     Document Type: Article

References (64)

1. Ulcerative colitis: A genetic disease
2. Immunogenetics of liver disease
3. CTLA-4 in autoimmune diseases - A general susceptibility gene to autoimmunity
4. HLA and disease associations: Detecting the strongest association
5. Measuring the strength of associations between HLA and diseases
6. The immune system. First of two parts
7. The immune system. Second of two parts
8. Primary sclerosing cholangitis as an autoimmune disease: The pros and cons
9. Chemokines and leukocyte traffic
10. Mature T lymphocyte apoptosis - Immune regulation in a dynamic and unpredictable antigenic environment
11. Cytokine gene polymorphisms in human disease: On-line database
12. HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease
13. Ulcerative colitis and persistent liver dysfunction
14. Association of primary sclerosing cholangitis with HLA-B8
15. Dual association of HLA DR2 and DR3 with primary sclerosing cholangitis
16. HLA-DRB and DQB typing by a combination of serology, restriction fragment length polymorphism analysis and oligonucleotide probing
17. Amino acid substitutions at position 38 of DRβ polypeptide confers susceptibility and protection from primary sclerosing cholangitis
18. HLA DR4 is a market for rapid disease progression in primary sclerosing cholangitis
19. HLA DPB polymorphism in primary sclerosing cholangitis and primary biliary cirrhosis
20. HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis
21. Association of tumour necrosis factor polymorphism with primary sclerosing cholangitis
22. HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations
23. Strong association between PSC and HLA-encoded gene MICA *008: Is this the primary susceptibility allele?
24. HLA associations in primary sclerosing cholangitis (PSC): DR4 has a protective role?
25. HLA-C genes and susceptibility to primary sclerosing cholangitis
26. Is the 308 polymorphism in the tumour necrosis factor (TNF-α) promoter region a marker of disease susceptibility in European patients with primary sclerosing cholangitis (PSC)?
27. HLA DRBI valine/glycine-86 dimorphism versus lysine-71 as primary MHC encoded susceptibility determinants in primary sclerosing cholangitis and type 1 autoimmune hepatitis: A study of 448 adult patients
28. Remodelling the HLA associations with the primary sclerosing cholangitis: Novel associations with phenylalanine at position 87 on DQβ-polypeptide
29. Crystal structure of human class II MHC protein HLA-DRI complexed with influenza virus peptide
30. Pediatric and adult forms of type 1 autoimmune hepatitis in Argentina: Evidence for differential genetic predisposition
31. Infection por virus de hepatitus A (HAV) en niños en Argentina, ensayo piloto
32. Cell stress regulated human major histocompatibility complex class I gene-regulated in gastrointestinal epithelium
33. Activation of NK cells and T cells by NKG2D, a receptor for the stress inducable MICA
34. Natural T cells in the human liver: Cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogeneous and include Vα24JαQ and gd T cell receptor bearing cells
35. Elevation of γδ T lymphocytes in the blood and livers of patients with primary sclerosing sclerosing cholangitis and other autoimmune disease
36. Phenotypic and functional characteristics of lymphocytes isolated from liver biopsy specimens from patients with active liver disease
37. Rapid DNA typing for HLA-C using sequence specific primers (PCR-SSP): Identification of serological and non-serologically defined HLA-C alleles including several new alleles
38. Freely associating
39. Interpretation of results from genetic studies of multi-factorial disease
40. Contribution of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease
41. Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analysis
42. HLA associations in primary sclerosing cholangitis are present only in those patients with concurrent inflammatory bowel disease
43. The interleukin-1 and interleukin-10 gene polymorphisms in primary sclerosing cholangitis: No associations with disease susceptibility/resistance
44. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist
45. Absence of a genetic association between IL-IRN and IL-IB gene polymorphisms in ulcerative colitis (UC) and Crohn's disease (CD) in multiple populations from N.E. England
46. An investigation of polymorphism in the interleukin-10 promoter
47. CTLA-4 gene polymorphism associated with primary sclerosing cholangitis (PSC)
48. No association between primary sclerosing cholangitis (PSC) and CTLA-4 gene polymorphism: Evidence against an autoimmune aetiology?
49. Investigation of CCR5 Δ32 deletion and Fas/Apo-I (CD95) single nucleotide polymorphisms in primary sclerosing cholangitis (PSC)
50. CCR5 D32 polymorphism in inflammatory bowel disease: Further association with ulcerative colitis and with primary sclerosing cholangitis
51. CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis
52. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type I autoimmune hepatitis
53. Histopathology of primary sclerosing cholangitis
54. Surgical pathology of the syndrome of primary sclerosing cholangitis
55. Matrix metalloproteinases: A critical review
56. Metalloproteinases in the rheumatic diseases
57. Mechanisms of liver damage and repair
58. Expression of tissue inhibitor of metalloproteinase 1 and 2 is increased in human fibrotic liver
59. Preliminary report: Genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis
60. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-I promoter which results in reduced gene expression
61. A functional polymorphism of the stromelysin gene (MMP-3) determines susceptibility and disease progression in primary sclerosing cholangitis
62. Transcriptional regulation of human stromelysin
63. Transforming growth cell factor B-I(TGFBI) gene polymorphisms in primary sclerosing cholangitis and primary biliary cirrhosis
64. Searching for genetic determinants in the new millennium