메뉴 건너뛰기




Volumn 305, Issue 2, 2011, Pages 123-143

Hepatitis B and C virus hepatocarcinogenesis: Lessons learned and future challenges

Author keywords

Hepatitis B virus; Hepatitis C virus; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver

Indexed keywords

GLYCOPROTEIN E1; GLYCOPROTEIN E2; HEPATITIS B VIRUS X PROTEIN; MICRORNA; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4B; NONSTRUCTURAL PROTEIN 5A; STRUCTURAL PROTEIN;

EID: 79955482701     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.11.014     Document Type: Review
Times cited : (129)

References (214)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag H.B., Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 3
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • Guidotti L.G., Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 2006, 1:23-61.
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 4
    • 70249126860 scopus 로고    scopus 로고
    • Hepatitis C virus-induced hepatocarcinogenesis
    • Bartosch B., Thimme R., Blum H.E., Zoulim F. Hepatitis C virus-induced hepatocarcinogenesis. J. Hepatol. 2009, 51:810-820.
    • (2009) J. Hepatol. , vol.51 , pp. 810-820
    • Bartosch, B.1    Thimme, R.2    Blum, H.E.3    Zoulim, F.4
  • 5
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • Bouchard M.J., Schneider R.J. The enigmatic X gene of hepatitis B virus. J. Virol. 2004, 78:12725-12734.
    • (2004) J. Virol. , vol.78 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 6
    • 34547755447 scopus 로고    scopus 로고
    • Hepadnaviridae
    • Lippincott Williams & Wilkins, Philadelphia, D. Knipe, P. Howley (Eds.) Fields Virology
    • Seeger C., Zoulim F., Mason W. Hepadnaviridae. Wolters Kluwer Health 2007, 2977-3030. Lippincott Williams & Wilkins, Philadelphia. D. Knipe, P. Howley (Eds.).
    • (2007) Wolters Kluwer Health , pp. 2977-3030
    • Seeger, C.1    Zoulim, F.2    Mason, W.3
  • 7
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology, risk factors, and screening
    • Sherman M. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin. Liver Dis. 2005, 25:143-154.
    • (2005) Semin. Liver Dis. , vol.25 , pp. 143-154
    • Sherman, M.1
  • 8
    • 20344366296 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: molecular pathways and new therapeutic targets
    • Roberts L.R., Gores G.J. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin. Liver Dis. 2005, 25:212-225.
    • (2005) Semin. Liver Dis. , vol.25 , pp. 212-225
    • Roberts, L.R.1    Gores, G.J.2
  • 9
    • 5044234897 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis
    • Anzola M. Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J. Viral Hepat. 2004, 11:383-393.
    • (2004) J. Viral Hepat. , vol.11 , pp. 383-393
    • Anzola, M.1
  • 10
    • 67749135236 scopus 로고    scopus 로고
    • History taking and physical examination for the patient with liver diseases
    • Lippincott Williams & Wilkins, Philadelphia, E.R. Schiff, M.F. Sorell, W.C. Maddrey (Eds.)
    • Greenberger N. History taking and physical examination for the patient with liver diseases. Schiff's Diseases of the Liver 2007, 3-19. Lippincott Williams & Wilkins, Philadelphia. E.R. Schiff, M.F. Sorell, W.C. Maddrey (Eds.).
    • (2007) Schiff's Diseases of the Liver , pp. 3-19
    • Greenberger, N.1
  • 11
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22 707 men in Taiwan
    • Beasley R., Lin C.-C., Hwang L.-Y., Chien C.-S. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22 707 men in Taiwan. Lancet 1981, 1129-1133.
    • (1981) Lancet , pp. 1129-1133
    • Beasley, R.1    Lin, C.-C.2    Hwang, L.-Y.3    Chien, C.-S.4
  • 14
    • 0027966147 scopus 로고
    • Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice
    • Guidotti L.G., Martinez V., Loh Y.T., Rogler C.E., Chisari F.V. Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice. J. Virol. 1994, 68:5469-5475.
    • (1994) J. Virol. , vol.68 , pp. 5469-5475
    • Guidotti, L.G.1    Martinez, V.2    Loh, Y.T.3    Rogler, C.E.4    Chisari, F.V.5
  • 16
    • 0037871412 scopus 로고    scopus 로고
    • Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein
    • Hartmann-Stuhler C., Prange R. Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein. J. Virol. 2001, 75:5343-5351.
    • (2001) J. Virol. , vol.75 , pp. 5343-5351
    • Hartmann-Stuhler, C.1    Prange, R.2
  • 17
    • 33748969348 scopus 로고    scopus 로고
    • Potent inhibition of human hepatitis B virus replication by a host factor Vps4
    • Kian Chua P., Lin M.H., Shih C. Potent inhibition of human hepatitis B virus replication by a host factor Vps4. Virology 2006, 354:1-6.
    • (2006) Virology , vol.354 , pp. 1-6
    • Kian Chua, P.1    Lin, M.H.2    Shih, C.3
  • 18
    • 33749394947 scopus 로고    scopus 로고
    • Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation
    • Rost M., Mann S., Lambert C., Doring T., Thome N., Prange R. Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation. J. Biol. Chem. 2006, 281:29297-29308.
    • (2006) J. Biol. Chem. , vol.281 , pp. 29297-29308
    • Rost, M.1    Mann, S.2    Lambert, C.3    Doring, T.4    Thome, N.5    Prange, R.6
  • 20
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • Guidotti L., Rochford R., Chung J., Shapiro M., Purcell R., Chisari F. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999, 284:825-829.
    • (1999) Science , vol.284 , pp. 825-829
    • Guidotti, L.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.6
  • 21
    • 0037137532 scopus 로고    scopus 로고
    • The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection
    • Guidotti L.G. The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection. Vaccine 2002, 20(Suppl 4):A80-82.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 4
    • Guidotti, L.G.1
  • 22
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolytic control of viral infections by the innate and adaptive immune response
    • Guidotti L.G., Chisari F.V. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu. Rev. Immunol. 2001, 19:65-91.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 23
    • 0035223977 scopus 로고    scopus 로고
    • Perspectives on hepatitis B studies with chimpanzees
    • Prince A.M., Brotman B. Perspectives on hepatitis B studies with chimpanzees. ILAR J. 2001, 42:85-88.
    • (2001) ILAR J. , vol.42 , pp. 85-88
    • Prince, A.M.1    Brotman, B.2
  • 24
    • 0029130068 scopus 로고
    • High-level hepatitis B virus replication in transgenic mice
    • Guidotti L., Matzke B., Schaller H., Chisari F. High-level hepatitis B virus replication in transgenic mice. J. Virol. 1995, 69:6158-6169.
    • (1995) J. Virol. , vol.69 , pp. 6158-6169
    • Guidotti, L.1    Matzke, B.2    Schaller, H.3    Chisari, F.4
  • 25
    • 33846432330 scopus 로고    scopus 로고
    • Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice
    • Zheng Y., Chen W.L., Louie S.G., Yen T.S., Ou J.H. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 2007, 45:16-21.
    • (2007) Hepatology , vol.45 , pp. 16-21
    • Zheng, Y.1    Chen, W.L.2    Louie, S.G.3    Yen, T.S.4    Ou, J.H.5
  • 29
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134:1655-1669.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 30
    • 3342946559 scopus 로고    scopus 로고
    • Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration
    • Bill C.A., Summers J. Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc. Natl. Acad. Sci. USA 2004, 101:11135-11140.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 11135-11140
    • Bill, C.A.1    Summers, J.2
  • 31
    • 17044402909 scopus 로고    scopus 로고
    • The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma
    • Bonilla Guerrero R., Roberts L.R. The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma. J. Hepatol. 2005, 42:760-777.
    • (2005) J. Hepatol. , vol.42 , pp. 760-777
    • Bonilla Guerrero, R.1    Roberts, L.R.2
  • 32
    • 33846534236 scopus 로고    scopus 로고
    • The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection
    • Menne S., Cote P.J. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J. Gastroenterol. 2007, 13:104-124.
    • (2007) World J. Gastroenterol. , vol.13 , pp. 104-124
    • Menne, S.1    Cote, P.J.2
  • 33
    • 0026793219 scopus 로고
    • Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors
    • Wei Y., Fourel G., Ponzetto A., Silvestro M., Tiolais P., Buendia M.-A. Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors. J. Virol. 1992, 5265-5276.
    • (1992) J. Virol. , pp. 5265-5276
    • Wei, Y.1    Fourel, G.2    Ponzetto, A.3    Silvestro, M.4    Tiolais, P.5    Buendia, M.-A.6
  • 34
    • 0020147001 scopus 로고
    • Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks
    • Ogston C.W., Jonak G.J., Rogler C.E., Astrin S.M., Summers J. Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks. Cell 1982, 29:385-394.
    • (1982) Cell , vol.29 , pp. 385-394
    • Ogston, C.W.1    Jonak, G.J.2    Rogler, C.E.3    Astrin, S.M.4    Summers, J.5
  • 35
    • 0023005611 scopus 로고
    • Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks
    • Moroy T., Marchio A., Etiemble J., Trepo C., Tiollais P., Buendia M.A. Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks. Nature 1986, 324:276-279.
    • (1986) Nature , vol.324 , pp. 276-279
    • Moroy, T.1    Marchio, A.2    Etiemble, J.3    Trepo, C.4    Tiollais, P.5    Buendia, M.A.6
  • 37
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary S., Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 2005, 6:635-645.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 38
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • Feitelson M.A., Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. 2007, 252:157-170.
    • (2007) Cancer Lett. , vol.252 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 41
    • 0942289920 scopus 로고    scopus 로고
    • Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis
    • Wang Y., Lau S.H., Sham J.S., Wu M.C., Wang T., Guan X.Y. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis. Oncogene 2004, 23:142-148.
    • (2004) Oncogene , vol.23 , pp. 142-148
    • Wang, Y.1    Lau, S.H.2    Sham, J.S.3    Wu, M.C.4    Wang, T.5    Guan, X.Y.6
  • 42
    • 0025098651 scopus 로고
    • The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
    • Kekule A.S., Lauer U., Meyer M., Caselmann W.H., Hofschneider P.H., Koshy R. The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 1990, 343:457-461.
    • (1990) Nature , vol.343 , pp. 457-461
    • Kekule, A.S.1    Lauer, U.2    Meyer, M.3    Caselmann, W.H.4    Hofschneider, P.H.5    Koshy, R.6
  • 44
    • 0030041821 scopus 로고    scopus 로고
    • Hepadnaviral X protein: review of recent progress
    • Yen T.S. Hepadnaviral X protein: review of recent progress. J. Biomed. Sci. 1996, 3:20-30.
    • (1996) J. Biomed. Sci. , vol.3 , pp. 20-30
    • Yen, T.S.1
  • 45
    • 0028342986 scopus 로고
    • Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein
    • Murakami S., Cheong J., Kaneko S. Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein. J. Biol. Chem. 1994, 269:15118-15123.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15118-15123
    • Murakami, S.1    Cheong, J.2    Kaneko, S.3
  • 47
    • 0028013064 scopus 로고
    • Woodchuck hepatitis virus X protein is required for viral infection in vivo
    • Zoulim F., Saputelli J., Seeger C. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J. Virol. 1994, 68:2026-2030.
    • (1994) J. Virol. , vol.68 , pp. 2026-2030
    • Zoulim, F.1    Saputelli, J.2    Seeger, C.3
  • 48
    • 0035178992 scopus 로고    scopus 로고
    • X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo
    • Zhang Z., Torii N., Hu Z., Jacob J., Liang T. X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo. J. Clin. Invest. 2001, 108:1523-1531.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1523-1531
    • Zhang, Z.1    Torii, N.2    Hu, Z.3    Jacob, J.4    Liang, T.5
  • 49
    • 0036171745 scopus 로고    scopus 로고
    • Enhancement of hepatitis B virus replication by its X protein in transgenic mice
    • Xu Z., Yen T., Wu L., Madden C., Tan W., Slagle B., Ou J.-h. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J. Virol. 2002, 76:2579-2584.
    • (2002) J. Virol. , vol.76 , pp. 2579-2584
    • Xu, Z.1    Yen, T.2    Wu, L.3    Madden, C.4    Tan, W.5    Slagle, B.6    Ou, J.-H.7
  • 51
    • 33947413521 scopus 로고    scopus 로고
    • Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo
    • Keasler V.V., Hodgson A.J., Madden C.R., Slagle B.L. Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J. Virol. 2007, 81:2656-2662.
    • (2007) J. Virol. , vol.81 , pp. 2656-2662
    • Keasler, V.V.1    Hodgson, A.J.2    Madden, C.R.3    Slagle, B.L.4
  • 55
    • 15244357567 scopus 로고    scopus 로고
    • Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death
    • Leupin O., Bontron S., Schaeffer C., Strubin M. Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J. Virol. 2005, 79:4238-4245.
    • (2005) J. Virol. , vol.79 , pp. 4238-4245
    • Leupin, O.1    Bontron, S.2    Schaeffer, C.3    Strubin, M.4
  • 56
    • 0034618437 scopus 로고    scopus 로고
    • Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses
    • Sitterlin D., Bergametti F., Tiollais P., Tennant B.C., Transy C. Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses. Oncogene 2000, 19:4427-4431.
    • (2000) Oncogene , vol.19 , pp. 4427-4431
    • Sitterlin, D.1    Bergametti, F.2    Tiollais, P.3    Tennant, B.C.4    Transy, C.5
  • 57
    • 77956042333 scopus 로고    scopus 로고
    • Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo
    • Zhang Z., Sun E., Ou J.H., Liang T.J. Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo. J. Virol. 2010.
    • (2010) J. Virol.
    • Zhang, Z.1    Sun, E.2    Ou, J.H.3    Liang, T.J.4
  • 58
    • 16544364359 scopus 로고    scopus 로고
    • Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner
    • Zhang Z., Protzer U., Hu Z., Jacob J., Liang T.J. Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner. J. Virol. 2004, 78:4566-4572.
    • (2004) J. Virol. , vol.78 , pp. 4566-4572
    • Zhang, Z.1    Protzer, U.2    Hu, Z.3    Jacob, J.4    Liang, T.J.5
  • 62
    • 0036776554 scopus 로고    scopus 로고
    • Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes
    • Tarn C., Zou L., Hullinger R., Andrisani O. Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. J. Virol. 2002, 76:9763-9772.
    • (2002) J. Virol. , vol.76 , pp. 9763-9772
    • Tarn, C.1    Zou, L.2    Hullinger, R.3    Andrisani, O.4
  • 63
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Bouchard M., Wang L.-H., Schneider R. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 2001, 294:2376-2378.
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.1    Wang, L.-H.2    Schneider, R.3
  • 64
    • 0035861455 scopus 로고    scopus 로고
    • Calcium signaling by HBx protein in hepatitis B virus DNA replication
    • Bouchard M.J., Wang L.H., Schneider R.J. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 2001, 294:2376-2378.
    • (2001) Science , vol.294 , pp. 2376-2378
    • Bouchard, M.J.1    Wang, L.H.2    Schneider, R.J.3
  • 65
    • 0041355327 scopus 로고    scopus 로고
    • Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein
    • Chami M., Ferrari D., Nicotera P., Paterlini-Brechot P., Rizzuto R. Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein. J. Biol. Chem. 2003, 278:31745-31755.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31745-31755
    • Chami, M.1    Ferrari, D.2    Nicotera, P.3    Paterlini-Brechot, P.4    Rizzuto, R.5
  • 66
    • 0141515617 scopus 로고    scopus 로고
    • Activation of calcium signaling by hepatitis B virus-X protein in liver cells
    • Oh J.C., Jeong D.L., Kim I.K., Oh S.H. Activation of calcium signaling by hepatitis B virus-X protein in liver cells. Exp. Mol. Med. 2003, 35:301-309.
    • (2003) Exp. Mol. Med. , vol.35 , pp. 301-309
    • Oh, J.C.1    Jeong, D.L.2    Kim, I.K.3    Oh, S.H.4
  • 67
    • 65349104743 scopus 로고    scopus 로고
    • Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-κB and the mitochondrial permeability transition pore
    • Clippinger A.J., Gearhart T.L., Bouchard M.J. Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-κB and the mitochondrial permeability transition pore. J. Virol. 2009, 83:4718-4731.
    • (2009) J. Virol. , vol.83 , pp. 4718-4731
    • Clippinger, A.J.1    Gearhart, T.L.2    Bouchard, M.J.3
  • 68
    • 77649112712 scopus 로고    scopus 로고
    • The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication
    • Gearhart T.L., Bouchard M.J. The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. J. Virol. 2010.
    • (2010) J. Virol.
    • Gearhart, T.L.1    Bouchard, M.J.2
  • 69
    • 0037744950 scopus 로고    scopus 로고
    • Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication
    • Bouchard M.J., Puro R.J., Wang L., Schneider R.J. Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. J. Virol. 2003, 77:7713-7719.
    • (2003) J. Virol. , vol.77 , pp. 7713-7719
    • Bouchard, M.J.1    Puro, R.J.2    Wang, L.3    Schneider, R.J.4
  • 70
    • 35448949218 scopus 로고    scopus 로고
    • HBV replication is associated with an HBx-dependent mitochondrial regulated increase in cytosolic calcium levels
    • McClain S.L., Clippinger A.J., Lizzano R., Bouchard M.J. HBV replication is associated with an HBx-dependent mitochondrial regulated increase in cytosolic calcium levels. J. Virol. 2007.
    • (2007) J. Virol.
    • McClain, S.L.1    Clippinger, A.J.2    Lizzano, R.3    Bouchard, M.J.4
  • 71
    • 0342905085 scopus 로고    scopus 로고
    • Hepatitis B virus X protein colocalizes to mitochondria with human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential
    • Rahmani Z., Huh K.-W., Lasher R., Siddiqui A. Hepatitis B virus X protein colocalizes to mitochondria with human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J. Virol. 2000, 74:2840-2846.
    • (2000) J. Virol. , vol.74 , pp. 2840-2846
    • Rahmani, Z.1    Huh, K.-W.2    Lasher, R.3    Siddiqui, A.4
  • 72
    • 47049100688 scopus 로고    scopus 로고
    • The hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential
    • Clippinger A.J., Bouchard M.J. The hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J. Virol. 2008.
    • (2008) J. Virol.
    • Clippinger, A.J.1    Bouchard, M.J.2
  • 73
    • 0035155733 scopus 로고    scopus 로고
    • Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B
    • Pan J., Duan L.X., Sun B.S., Feitelson M.A. Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B. J. Gen. Virol. 2001, 82:171-182.
    • (2001) J. Gen. Virol. , vol.82 , pp. 171-182
    • Pan, J.1    Duan, L.X.2    Sun, B.S.3    Feitelson, M.A.4
  • 75
    • 0034682769 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits transforming growth factor-b-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
    • Shih W.-L., Kuo M.-L., Chuang S.-E., Cheng A.-L., Doong S.-L. Hepatitis B virus X protein inhibits transforming growth factor-b-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J. Biol. Chem. 2000, 275:25858-25864.
    • (2000) J. Biol. Chem. , vol.275 , pp. 25858-25864
    • Shih, W.-L.1    Kuo, M.-L.2    Chuang, S.-E.3    Cheng, A.-L.4    Doong, S.-L.5
  • 76
    • 0030787584 scopus 로고    scopus 로고
    • Hepatits B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor a
    • Su F., Schneider R. Hepatits B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor a. Proc. Natl. Acad. Sci. USA 1997, 94:8744-8749.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8744-8749
    • Su, F.1    Schneider, R.2
  • 79
    • 0038158319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential
    • Shirakata Y., Koike K. Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. J. Biol. Chem. 2003, 278:22071-22078.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22071-22078
    • Shirakata, Y.1    Koike, K.2
  • 80
    • 0033604446 scopus 로고    scopus 로고
    • Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death
    • Takada S., Shirakata Y., Kaneniwa N., Koike K. Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death. Oncogene 1999, 18:6965-6973.
    • (1999) Oncogene , vol.18 , pp. 6965-6973
    • Takada, S.1    Shirakata, Y.2    Kaneniwa, N.3    Koike, K.4
  • 81
    • 33846783316 scopus 로고    scopus 로고
    • Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners
    • Kim S., Kim H.Y., Lee S., Kim S.W., Sohn S., Kim K., Cho H. Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners. J. Virol. 2007, 81:1714-1726.
    • (2007) J. Virol. , vol.81 , pp. 1714-1726
    • Kim, S.1    Kim, H.Y.2    Lee, S.3    Kim, S.W.4    Sohn, S.5    Kim, K.6    Cho, H.7
  • 82
    • 0034739918 scopus 로고    scopus 로고
    • Role of NF-kB and myc proteins in apoptosis induced by hepatitis B virus HBx protein
    • Su F., Theodosis C., Schneider R. Role of NF-kB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. J. Virol. 2001, 75:215-225.
    • (2001) J. Virol. , vol.75 , pp. 215-225
    • Su, F.1    Theodosis, C.2    Schneider, R.3
  • 83
    • 0038558163 scopus 로고    scopus 로고
    • Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
    • Kim K.H., Seong B.L. Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J. 2003, 22:2104-2116.
    • (2003) EMBO J. , vol.22 , pp. 2104-2116
    • Kim, K.H.1    Seong, B.L.2
  • 84
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
    • Karin M., Lawrence T., Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 2006, 124:823-835.
    • (2006) Cell , vol.124 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 85
    • 0035659925 scopus 로고    scopus 로고
    • Stimulation of cellular proliferation by hepatitis B virus X protein
    • Madden C.R., Slagle B.L. Stimulation of cellular proliferation by hepatitis B virus X protein. Dis. Markers 2001, 17:153-157.
    • (2001) Dis. Markers , vol.17 , pp. 153-157
    • Madden, C.R.1    Slagle, B.L.2
  • 86
    • 0035048023 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway
    • Bouchard M., Giannakopoulos S., Wang E.H., Tanese N., Schneider R.J. Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway. J. Virol. 2001, 75:4247-4257.
    • (2001) J. Virol. , vol.75 , pp. 4247-4257
    • Bouchard, M.1    Giannakopoulos, S.2    Wang, E.H.3    Tanese, N.4    Schneider, R.J.5
  • 87
    • 0037040927 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines
    • Lee S., Tarn C., Wang W.H., Chen S., Hullinger R.L., Andrisani O.M. Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines. J. Biol. Chem. 2002, 277:8730-8740.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8730-8740
    • Lee, S.1    Tarn, C.2    Wang, W.H.3    Chen, S.4    Hullinger, R.L.5    Andrisani, O.M.6
  • 88
    • 57749106581 scopus 로고    scopus 로고
    • Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration
    • Hodgson A.J., Keasler V.V., Slagle B.L. Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Res. 2008, 68:10341-10348.
    • (2008) Cancer Res. , vol.68 , pp. 10341-10348
    • Hodgson, A.J.1    Keasler, V.V.2    Slagle, B.L.3
  • 91
    • 0034761676 scopus 로고    scopus 로고
    • Hepatitis B virus X protein increases expression of p21Cip-1/WAF1/MDA6 and p27Kip-1 in primary mouse hepatocytes, leading to a reduced cell cycle progression
    • Qiao L., Leach K., McKinstry R., Gilfor D., Yacoub A., Park J.-S., Grant S., Hylemon P., Fisher P., Dent P. Hepatitis B virus X protein increases expression of p21Cip-1/WAF1/MDA6 and p27Kip-1 in primary mouse hepatocytes, leading to a reduced cell cycle progression. Hepatology 2001, 34:906-917.
    • (2001) Hepatology , vol.34 , pp. 906-917
    • Qiao, L.1    Leach, K.2    McKinstry, R.3    Gilfor, D.4    Yacoub, A.5    Park, J.-S.6    Grant, S.7    Hylemon, P.8    Fisher, P.9    Dent, P.10
  • 92
    • 77956941978 scopus 로고    scopus 로고
    • Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes
    • Gearhart T.L., Bouchard M.J. Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes. Virology 2010, 407:14-25.
    • (2010) Virology , vol.407 , pp. 14-25
    • Gearhart, T.L.1    Bouchard, M.J.2
  • 93
    • 77951481786 scopus 로고    scopus 로고
    • Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene
    • Cohen D., Adamovich Y., Reuven N., Shaul Y. Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene. Hepatology 2010, 51:1538-1546.
    • (2010) Hepatology , vol.51 , pp. 1538-1546
    • Cohen, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 94
    • 70350566149 scopus 로고    scopus 로고
    • Hepatitis B virus X gene is implicated in liver carcinogenesis
    • Koike K. Hepatitis B virus X gene is implicated in liver carcinogenesis. Cancer Lett. 2009, 286:60-68.
    • (2009) Cancer Lett. , vol.286 , pp. 60-68
    • Koike, K.1
  • 95
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • Kim C., Koike K., Saito I., Miyamura T., Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 1991, 353:317-320.
    • (1991) Nature , vol.353 , pp. 317-320
    • Kim, C.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 97
    • 0029870749 scopus 로고    scopus 로고
    • Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene
    • Slagle B.L., Lee T.H., Medina D., Finegold M.J., Butel J.S. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol. Carcinogen. 1996, 15:261-269.
    • (1996) Mol. Carcinogen. , vol.15 , pp. 261-269
    • Slagle, B.L.1    Lee, T.H.2    Medina, D.3    Finegold, M.J.4    Butel, J.S.5
  • 99
    • 0035084167 scopus 로고    scopus 로고
    • Hepatitis B virus X protein acts a a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions
    • Madden C., Finegold M., Slagle B. Hepatitis B virus X protein acts a a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J. Virol. 2001, 75:3851-3858.
    • (2001) J. Virol. , vol.75 , pp. 3851-3858
    • Madden, C.1    Finegold, M.2    Slagle, B.3
  • 100
    • 0031985778 scopus 로고    scopus 로고
    • Hepatitis B virus X protein interferes with cellular DNA repair
    • Becker S., Lee T.-H., Butel J., Slagle B. Hepatitis B virus X protein interferes with cellular DNA repair. J. Virol. 1998, 72:266-272.
    • (1998) J. Virol. , vol.72 , pp. 266-272
    • Becker, S.1    Lee, T.-H.2    Butel, J.3    Slagle, B.4
  • 101
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo Q.L., Kuo G., Weiner A.J., Overby L.R., Bradley D.W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989, 244:359-362.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 102
    • 0036835382 scopus 로고    scopus 로고
    • Recommendations from the National Institutes of Health consensus development conference statement: management of hepatitis C: 2002
    • Recommendations from the National Institutes of Health consensus development conference statement: management of hepatitis C: 2002. Hepatology 36 (2002) 1039.
    • (2002) Hepatology , vol.36 , pp. 1039
  • 103
    • 33644875265 scopus 로고    scopus 로고
    • Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies
    • Micallef J.M., Kaldor J.M., Dore G.J. Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J. Viral. Hepat. 2006, 13:34-41.
    • (2006) J. Viral. Hepat. , vol.13 , pp. 34-41
    • Micallef, J.M.1    Kaldor, J.M.2    Dore, G.J.3
  • 104
    • 0028898609 scopus 로고
    • Epidemiology of hepatitis C in the West
    • Alter M.J. Epidemiology of hepatitis C in the West. Semin. Liver Dis. 1995, 15:5-14.
    • (1995) Semin. Liver Dis. , vol.15 , pp. 5-14
    • Alter, M.J.1
  • 106
    • 23944481107 scopus 로고    scopus 로고
    • Unscrambling hepatitis C virus-host interactions
    • Chisari F.V. Unscrambling hepatitis C virus-host interactions. Nature 2005, 436:930-932.
    • (2005) Nature , vol.436 , pp. 930-932
    • Chisari, F.V.1
  • 109
    • 38549086984 scopus 로고    scopus 로고
    • Hepatitis C virus entry into host cells
    • Helle F., Dubuisson J. Hepatitis C virus entry into host cells. Cell Mol. Life Sci. 2008, 65:100-112.
    • (2008) Cell Mol. Life Sci. , vol.65 , pp. 100-112
    • Helle, F.1    Dubuisson, J.2
  • 112
    • 70350266403 scopus 로고    scopus 로고
    • Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation
    • Brohm C., Steinmann E., Friesland M., Lorenz I.C., Patel A., Penin F., Bartenschlager R., Pietschmann T. Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation. J. Virol. 2009, 83:11682-11693.
    • (2009) J. Virol. , vol.83 , pp. 11682-11693
    • Brohm, C.1    Steinmann, E.2    Friesland, M.3    Lorenz, I.C.4    Patel, A.5    Penin, F.6    Bartenschlager, R.7    Pietschmann, T.8
  • 113
    • 67249088420 scopus 로고    scopus 로고
    • Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation
    • Yi M., Ma Y., Yates J., Lemon S.M. Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation. PLoS Pathog. 2009, 5:e1000403.
    • (2009) PLoS Pathog. , vol.5
    • Yi, M.1    Ma, Y.2    Yates, J.3    Lemon, S.M.4
  • 114
    • 63149134943 scopus 로고    scopus 로고
    • The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase
    • Beran R.K., Lindenbach B.D., Pyle A.M. The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase. J. Virol. 2009, 83:3268-3275.
    • (2009) J. Virol. , vol.83 , pp. 3268-3275
    • Beran, R.K.1    Lindenbach, B.D.2    Pyle, A.M.3
  • 115
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E., Li K., Wang C., Sumpter R., Ikeda M., Lemon S.M., Gale M. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003, 300:1145-1148.
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3    Sumpter, R.4    Ikeda, M.5    Lemon, S.M.6    Gale, M.7
  • 116
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E., Curran J., Hofmann K., Moradpour D., Binder M., Bartenschlager R., Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005, 437:1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 117
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • Behrens S.E., Tomei L., De Francesco R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 1996, 15:12-22.
    • (1996) EMBO J. , vol.15 , pp. 12-22
    • Behrens, S.E.1    Tomei, L.2    De Francesco, R.3
  • 118
    • 34848881072 scopus 로고    scopus 로고
    • Sequence diversity of hepatitis C virus: implications for immune control and therapy
    • Timm J., Roggendorf M. Sequence diversity of hepatitis C virus: implications for immune control and therapy. World J. Gastroenterol. 2007, 13:4808-4817.
    • (2007) World J. Gastroenterol. , vol.13 , pp. 4808-4817
    • Timm, J.1    Roggendorf, M.2
  • 119
    • 72949123800 scopus 로고    scopus 로고
    • Hepatitis C virus-infected patients with a persistently normal alanine aminotransferase: do they exist and is this really a group with mild disease?
    • Lawson A. Hepatitis C virus-infected patients with a persistently normal alanine aminotransferase: do they exist and is this really a group with mild disease?. J. Viral. Hepat. 2010, 17:51-58.
    • (2010) J. Viral. Hepat. , vol.17 , pp. 51-58
    • Lawson, A.1
  • 120
    • 33947240383 scopus 로고    scopus 로고
    • Progression to cirrhosis in hepatitis C patients: an age-dependent process
    • Pradat P., Voirin N., Tillmann H.L., Chevallier M., Trepo C. Progression to cirrhosis in hepatitis C patients: an age-dependent process. Liver Int. 2007, 27:335-339.
    • (2007) Liver Int. , vol.27 , pp. 335-339
    • Pradat, P.1    Voirin, N.2    Tillmann, H.L.3    Chevallier, M.4    Trepo, C.5
  • 121
    • 33644660193 scopus 로고    scopus 로고
    • Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C
    • Kumar D., Farrell G.C., Kench J., George J. Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C. J. Gastroenterol. Hepatol. 2005, 20:1395-1400.
    • (2005) J. Gastroenterol. Hepatol. , vol.20 , pp. 1395-1400
    • Kumar, D.1    Farrell, G.C.2    Kench, J.3    George, J.4
  • 123
    • 77956610423 scopus 로고    scopus 로고
    • Progression of initially mild hepatic fibrosis in patients with chronic hepatitis C infection
    • Williams M.J., Lang-Lenton M. Progression of initially mild hepatic fibrosis in patients with chronic hepatitis C infection. J. Viral. Hepat. 2010.
    • (2010) J. Viral. Hepat.
    • Williams, M.J.1    Lang-Lenton, M.2
  • 126
    • 79955480977 scopus 로고    scopus 로고
    • Role of host genetic factors in the outcome of hepatitis C virus infection
    • Bengsch B., Thimme R., Blum H.E. Role of host genetic factors in the outcome of hepatitis C virus infection. Viruses 2009, 1:104-105.
    • (2009) Viruses , vol.1 , pp. 104-105
    • Bengsch, B.1    Thimme, R.2    Blum, H.E.3
  • 127
    • 66149135640 scopus 로고    scopus 로고
    • Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer
    • McGivern D.R., Lemon S.M. Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer. Annu. Rev. Pathol. 2009, 4:399-415.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 399-415
    • McGivern, D.R.1    Lemon, S.M.2
  • 130
    • 0031088467 scopus 로고    scopus 로고
    • Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis
    • Swietek K., Juszczyk J. Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis. J. Viral. Hepat. 1997, 4:139-141.
    • (1997) J. Viral. Hepat. , vol.4 , pp. 139-141
    • Swietek, K.1    Juszczyk, J.2
  • 132
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M., Li K., Beard M.R., Showalter L.A., Scholle F., Lemon S.M., Weinman S.A. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002, 122:366-375.
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3    Showalter, L.A.4    Scholle, F.5    Lemon, S.M.6    Weinman, S.A.7
  • 133
    • 39749118497 scopus 로고    scopus 로고
    • Enhanced Ca2+ leak from ER Ca2+ stores induced by hepatitis C NS5A protein
    • Robinson L.C., Marchant J.S. Enhanced Ca2+ leak from ER Ca2+ stores induced by hepatitis C NS5A protein. Biochem. Biophys. Res. Commun. 2008, 368:593-599.
    • (2008) Biochem. Biophys. Res. Commun. , vol.368 , pp. 593-599
    • Robinson, L.C.1    Marchant, J.S.2
  • 134
    • 70349735843 scopus 로고    scopus 로고
    • Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis
    • Park C.Y., Choi S.H., Kang S.M., Kang J.I., Ahn B.Y., Kim H., Jung G., Choi K.Y., Hwang S.B. Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis. J. Hepatol. 2009, 51:853-864.
    • (2009) J. Hepatol. , vol.51 , pp. 853-864
    • Park, C.Y.1    Choi, S.H.2    Kang, S.M.3    Kang, J.I.4    Ahn, B.Y.5    Kim, H.6    Jung, G.7    Choi, K.Y.8    Hwang, S.B.9
  • 135
    • 76249125464 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion
    • Milward A., Mankouri J., Harris M. Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashion. J. Gen. Virol. 2010, 91:373-381.
    • (2010) J. Gen. Virol. , vol.91 , pp. 373-381
    • Milward, A.1    Mankouri, J.2    Harris, M.3
  • 136
    • 77951622187 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis
    • Tsai W.L., Chung R.T. Viral hepatocarcinogenesis. Oncogene 2010, 29:2309-2324.
    • (2010) Oncogene , vol.29 , pp. 2309-2324
    • Tsai, W.L.1    Chung, R.T.2
  • 137
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A., Adinolfi L.E., Loria P., Carulli N., Ruggiero G., Day C.P. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004, 126:586-597.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 138
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • Nishida N., Nagasaka T., Nishimura T., Ikai I., Boland C.R., Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 2008, 47:908-918.
    • (2008) Hepatology , vol.47 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 139
    • 70350567326 scopus 로고    scopus 로고
    • Hepatic iron overload and hepatocellular carcinoma
    • Kew M.C. Hepatic iron overload and hepatocellular carcinoma. Cancer Lett. 2009, 286:38-43.
    • (2009) Cancer Lett. , vol.286 , pp. 38-43
    • Kew, M.C.1
  • 140
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 141
    • 53249142510 scopus 로고    scopus 로고
    • Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion
    • Fujita N., Sugimoto R., Motonishi S., Tomosugi N., Tanaka H., Takeo M., Iwasa M., Kobayashi Y., Hayashi H., Kaito M., Takei Y. Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J. Hepatol. 2008, 49:702-710.
    • (2008) J. Hepatol. , vol.49 , pp. 702-710
    • Fujita, N.1    Sugimoto, R.2    Motonishi, S.3    Tomosugi, N.4    Tanaka, H.5    Takeo, M.6    Iwasa, M.7    Kobayashi, Y.8    Hayashi, H.9    Kaito, M.10    Takei, Y.11
  • 142
    • 0035933837 scopus 로고    scopus 로고
    • Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase
    • Bureau C., Bernad J., Chaouche N., Orfila C., Beraud M., Gonindard C., Alric L., Vinel J.P., Pipy B. Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase. J. Biol. Chem. 2001, 276:23077-23083.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23077-23083
    • Bureau, C.1    Bernad, J.2    Chaouche, N.3    Orfila, C.4    Beraud, M.5    Gonindard, C.6    Alric, L.7    Vinel, J.P.8    Pipy, B.9
  • 143
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G., Waris G., Tanveer R., Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc. Natl. Acad. Sci. USA 2001, 98:9599-9604.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 144
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T., Ratziu V., McHutchison J., Manns M., Goodman Z., Zeuzem S., Younossi Z., Albrecht J. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003, 38:75-85.
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1    Ratziu, V.2    McHutchison, J.3    Manns, M.4    Goodman, Z.5    Zeuzem, S.6    Younossi, Z.7    Albrecht, J.8
  • 147
    • 77649312075 scopus 로고    scopus 로고
    • Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP)
    • Mirandola S., Bowman D., Hussain M.M., Alberti A. Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP). Nutr. Metab. (Lond.) 2010, 7:13.
    • (2010) Nutr. Metab. (Lond.) , vol.7 , pp. 13
    • Mirandola, S.1    Bowman, D.2    Hussain, M.M.3    Alberti, A.4
  • 148
    • 66149149803 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway
    • Park C.Y., Jun H.J., Wakita T., Cheong J.H., Hwang S.B. Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway. J. Biol. Chem. 2009, 284:9237-9246.
    • (2009) J. Biol. Chem. , vol.284 , pp. 9237-9246
    • Park, C.Y.1    Jun, H.J.2    Wakita, T.3    Cheong, J.H.4    Hwang, S.B.5
  • 150
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    • Shintani Y., Fujie H., Miyoshi H., Tsutsumi T., Tsukamoto K., Kimura S., Moriya K., Koike K. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004, 126:840-848.
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3    Tsutsumi, T.4    Tsukamoto, K.5    Kimura, S.6    Moriya, K.7    Koike, K.8
  • 151
    • 29144524312 scopus 로고    scopus 로고
    • Hepatitis C as a metabolic disease: Implication for the pathogenesis of NASH
    • Koike K. Hepatitis C as a metabolic disease: Implication for the pathogenesis of NASH. Hepatol. Res. 2005, 33:145-150.
    • (2005) Hepatol. Res. , vol.33 , pp. 145-150
    • Koike, K.1
  • 153
    • 67650860275 scopus 로고    scopus 로고
    • Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif
    • McGivern D.R., Villanueva R.A., Chinnaswamy S., Kao C.C., Lemon S.M. Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif. J. Virol. 2009, 83:7422-7433.
    • (2009) J. Virol. , vol.83 , pp. 7422-7433
    • McGivern, D.R.1    Villanueva, R.A.2    Chinnaswamy, S.3    Kao, C.C.4    Lemon, S.M.5
  • 158
    • 14644415892 scopus 로고    scopus 로고
    • The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others
    • Branch A.D., Stump D.D., Gutierrez J.A., Eng F., Walewski J.L. The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others. Semin. Liver Dis. 2005, 25:105-117.
    • (2005) Semin. Liver Dis. , vol.25 , pp. 105-117
    • Branch, A.D.1    Stump, D.D.2    Gutierrez, J.A.3    Eng, F.4    Walewski, J.L.5
  • 160
    • 38449108483 scopus 로고    scopus 로고
    • Hepatitis C virus core protein, lipid droplets and steatosis
    • Roingeard P., Hourioux C. Hepatitis C virus core protein, lipid droplets and steatosis. J. Viral. Hepat. 2008, 15:157-164.
    • (2008) J. Viral. Hepat. , vol.15 , pp. 157-164
    • Roingeard, P.1    Hourioux, C.2
  • 161
    • 0031018612 scopus 로고    scopus 로고
    • Separate domains of MBP-1 involved in c-myc promoter binding and growth suppressive activity
    • Ray R.B., Steele R. Separate domains of MBP-1 involved in c-myc promoter binding and growth suppressive activity. Gene 1997, 186:175-180.
    • (1997) Gene , vol.186 , pp. 175-180
    • Ray, R.B.1    Steele, R.2
  • 163
    • 0035809057 scopus 로고    scopus 로고
    • HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation
    • Cho J., Baek W., Yang S., Chang J., Sung Y.C., Suh M. HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation. Biochim. Biophys. Acta 2001, 1538:59-66.
    • (2001) Biochim. Biophys. Acta , vol.1538 , pp. 59-66
    • Cho, J.1    Baek, W.2    Yang, S.3    Chang, J.4    Sung, Y.C.5    Suh, M.6
  • 165
    • 19944411839 scopus 로고    scopus 로고
    • Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta
    • Joo M., Hahn Y.S., Kwon M., Sadikot R.T., Blackwell T.S., Christman J.W. Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. J. Virol. 2005, 79:7648-7657.
    • (2005) J. Virol. , vol.79 , pp. 7648-7657
    • Joo, M.1    Hahn, Y.S.2    Kwon, M.3    Sadikot, R.T.4    Blackwell, T.S.5    Christman, J.W.6
  • 166
  • 167
    • 0033755010 scopus 로고    scopus 로고
    • Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor a
    • Hayashi J., Aoki H., Kajino K., Moriyama M., Arakawa Y., Hino O. Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor a. Hepatology 2000, 32:958-961.
    • (2000) Hepatology , vol.32 , pp. 958-961
    • Hayashi, J.1    Aoki, H.2    Kajino, K.3    Moriyama, M.4    Arakawa, Y.5    Hino, O.6
  • 168
    • 17844372967 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression
    • Fukutomi T., Zhou Y., Kawai S., Eguchi H., Wands J.R., Li J. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology 2005, 41:1096-1105.
    • (2005) Hepatology , vol.41 , pp. 1096-1105
    • Fukutomi, T.1    Zhou, Y.2    Kawai, S.3    Eguchi, H.4    Wands, J.R.5    Li, J.6
  • 171
    • 26944444737 scopus 로고    scopus 로고
    • Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
    • Pavio N., Battaglia S., Boucreux D., Arnulf B., Sobesky R., Hermine O., Brechot C. Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway. Oncogene 2005, 24:6119-6132.
    • (2005) Oncogene , vol.24 , pp. 6119-6132
    • Pavio, N.1    Battaglia, S.2    Boucreux, D.3    Arnulf, B.4    Sobesky, R.5    Hermine, O.6    Brechot, C.7
  • 173
    • 0842300376 scopus 로고    scopus 로고
    • Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells
    • Bataller R., Paik Y.H., Lindquist J.N., Lemasters J.J., Brenner D.A. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004, 126:529-540.
    • (2004) Gastroenterology , vol.126 , pp. 529-540
    • Bataller, R.1    Paik, Y.H.2    Lindquist, J.N.3    Lemasters, J.J.4    Brenner, D.A.5
  • 174
    • 0026514433 scopus 로고
    • The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis
    • Bach N., Thung S.N., Schaffner F. The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis. Hepatology 1992, 15:572-577.
    • (1992) Hepatology , vol.15 , pp. 572-577
    • Bach, N.1    Thung, S.N.2    Schaffner, F.3
  • 176
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • Taylor D.R., Shi S.T., Romano P.R., Barber G.N., Lai M.M. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 1999, 285:107-110.
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.M.5
  • 177
    • 0037333913 scopus 로고    scopus 로고
    • Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK
    • Pavio N., Romano P.R., Graczyk T.M., Feinstone S.M., Taylor D.R. Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK. J. Virol. 2003, 77:3578-3585.
    • (2003) J. Virol. , vol.77 , pp. 3578-3585
    • Pavio, N.1    Romano, P.R.2    Graczyk, T.M.3    Feinstone, S.M.4    Taylor, D.R.5
  • 178
    • 15044359246 scopus 로고    scopus 로고
    • Hepatitis C virus E2 protein promotes human hepatoma cell proliferation through the MAPK/ERK signaling pathway via cellular receptors
    • Zhao L.J., Wang L., Ren H., Cao J., Li L., Ke J.S., Qi Z.T. Hepatitis C virus E2 protein promotes human hepatoma cell proliferation through the MAPK/ERK signaling pathway via cellular receptors. Exp. Cell Res. 2005, 305:23-32.
    • (2005) Exp. Cell Res. , vol.305 , pp. 23-32
    • Zhao, L.J.1    Wang, L.2    Ren, H.3    Cao, J.4    Li, L.5    Ke, J.S.6    Qi, Z.T.7
  • 180
    • 34247612265 scopus 로고    scopus 로고
    • Flying under the radar: the immunobiology of hepatitis C
    • Dustin L.B., Rice C.M. Flying under the radar: the immunobiology of hepatitis C. Annu. Rev. Immunol. 2007, 25:71-99.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 71-99
    • Dustin, L.B.1    Rice, C.M.2
  • 181
    • 0037455560 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines
    • Dumoulin F.L., von dem Bussche A., Li J., Khamzina L., Wands J.R., Sauerbruch T., Spengler U. Hepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines. Virology 2003, 305:260-266.
    • (2003) Virology , vol.305 , pp. 260-266
    • Dumoulin, F.L.1    von dem Bussche, A.2    Li, J.3    Khamzina, L.4    Wands, J.R.5    Sauerbruch, T.6    Spengler, U.7
  • 183
    • 33750344724 scopus 로고    scopus 로고
    • Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins
    • Smirnova I.S., Aksenov N.D., Vonsky M.S., Isaguliants M.G. Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins. Cell Biol. Int. 2006, 30:915-919.
    • (2006) Cell Biol. Int. , vol.30 , pp. 915-919
    • Smirnova, I.S.1    Aksenov, N.D.2    Vonsky, M.S.3    Isaguliants, M.G.4
  • 185
    • 0034852454 scopus 로고    scopus 로고
    • P53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3
    • Kwun H.J., Jung E.Y., Ahn J.Y., Lee M.N., Jang K.L. p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3. J. Gen. Virol. 2001, 82:2235-2241.
    • (2001) J. Gen. Virol. , vol.82 , pp. 2235-2241
    • Kwun, H.J.1    Jung, E.Y.2    Ahn, J.Y.3    Lee, M.N.4    Jang, K.L.5
  • 186
    • 47949092573 scopus 로고    scopus 로고
    • Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
    • Saito T., Owen D.M., Jiang F., Marcotrigiano J., Gale M. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature 2008, 454:523-527.
    • (2008) Nature , vol.454 , pp. 523-527
    • Saito, T.1    Owen, D.M.2    Jiang, F.3    Marcotrigiano, J.4    Gale, M.5
  • 187
    • 77649175920 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory
    • Gouttenoire J., Penin F., Moradpour D. Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory. Rev. Med. Virol. 2010, 20:117-129.
    • (2010) Rev. Med. Virol. , vol.20 , pp. 117-129
    • Gouttenoire, J.1    Penin, F.2    Moradpour, D.3
  • 189
    • 0034684968 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene
    • Park J.S., Yang J.M., Min M.K. Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene. Biochem. Biophys. Res. Commun. 2000, 267:581-587.
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , pp. 581-587
    • Park, J.S.1    Yang, J.M.2    Min, M.K.3
  • 190
    • 40949100394 scopus 로고    scopus 로고
    • The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection
    • Einav S., Sklan E.H., Moon H.M., Gehrig E., Liu P., Hao Y., Lowe A.W., Glenn J.S. The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection. Hepatology 2008, 47:827-835.
    • (2008) Hepatology , vol.47 , pp. 827-835
    • Einav, S.1    Sklan, E.H.2    Moon, H.M.3    Gehrig, E.4    Liu, P.5    Hao, Y.6    Lowe, A.W.7    Glenn, J.S.8
  • 192
    • 0041914260 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
    • Chung Y.L., Sheu M.L., Yen S.H. Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma. Int. J. Cancer 2003, 107:65-73.
    • (2003) Int. J. Cancer , vol.107 , pp. 65-73
    • Chung, Y.L.1    Sheu, M.L.2    Yen, S.H.3
  • 194
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001, 294:853-858.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 195
    • 33847311819 scopus 로고    scopus 로고
    • MicroRNAs and immunity: tiny players in a big field
    • Taganov K.D., Boldin M.P., Baltimore D. MicroRNAs and immunity: tiny players in a big field. Immunity 2007, 26:133-137.
    • (2007) Immunity , vol.26 , pp. 133-137
    • Taganov, K.D.1    Boldin, M.P.2    Baltimore, D.3
  • 198
    • 46249125127 scopus 로고    scopus 로고
    • MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1
    • Wong Q.W., Lung R.W., Law P.T., Lai P.B., Chan K.Y., To K.F., Wong N. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology 2008, 135:257-269.
    • (2008) Gastroenterology , vol.135 , pp. 257-269
    • Wong, Q.W.1    Lung, R.W.2    Law, P.T.3    Lai, P.B.4    Chan, K.Y.5    To, K.F.6    Wong, N.7
  • 200
    • 33646157967 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
    • Murakami Y., Yasuda T., Saigo K., Urashima T., Toyoda H., Okanoue T., Shimotohno K. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 2006, 25:2537-2545.
    • (2006) Oncogene , vol.25 , pp. 2537-2545
    • Murakami, Y.1    Yasuda, T.2    Saigo, K.3    Urashima, T.4    Toyoda, H.5    Okanoue, T.6    Shimotohno, K.7
  • 202
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling C.L., Yi M., Lancaster A.M., Lemon S.M., Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005, 309:1577-1581.
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 209
    • 0035798399 scopus 로고    scopus 로고
    • RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
    • Lipardi C., Wei Q., Paterson B.M. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell 2001, 107:297-307.
    • (2001) Cell , vol.107 , pp. 297-307
    • Lipardi, C.1    Wei, Q.2    Paterson, B.M.3
  • 210
    • 77953574309 scopus 로고    scopus 로고
    • Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
    • Wang Y., Lu Y., Toh S.T., Sung W.K., Tan P., Chow P., Chung A.Y., Jooi L.L., Lee C.G. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J. Hepatol. 2010, 53:57-66.
    • (2010) J. Hepatol. , vol.53 , pp. 57-66
    • Wang, Y.1    Lu, Y.2    Toh, S.T.3    Sung, W.K.4    Tan, P.5    Chow, P.6    Chung, A.Y.7    Jooi, L.L.8    Lee, C.G.9
  • 211
    • 77953727116 scopus 로고    scopus 로고
    • MicroRNA-602 regulating tumor suppressive gene RASSF1A is overexpressed in hepatitis B virus-infected liver and hepatocellular carcinoma
    • Yang L., Ma Z., Wang D., Zhao W., Chen L., Wang G. MicroRNA-602 regulating tumor suppressive gene RASSF1A is overexpressed in hepatitis B virus-infected liver and hepatocellular carcinoma. Cancer Biol. Ther. 2010, 9.
    • (2010) Cancer Biol. Ther. , vol.9
    • Yang, L.1    Ma, Z.2    Wang, D.3    Zhao, W.4    Chen, L.5    Wang, G.6
  • 212
    • 77954234485 scopus 로고    scopus 로고
    • Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
    • Huang J., Wang Y., Guo Y., Sun S. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 2010, 52:60-70.
    • (2010) Hepatology , vol.52 , pp. 60-70
    • Huang, J.1    Wang, Y.2    Guo, Y.3    Sun, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.