The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection

Hepatology

Volumn 47, Issue 3, 2008, Pages 827-835

  Einav, Shirit ^a   Sklan, Ella H ^a   Hyang, Mi Moon ^a,c   Gehrig, Elizabeth ^a   Liu, Ping ^a   Hao, Ying ^a   Lowe, Anson W ^a   Glenn, Jeffrey S ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 4B; NS4 PROTEIN, HEPATITIS C VIRUS; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENETIC DISORDER; GENETIC TRANSFECTION; HEPATITIS C VIRUS; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HUMAN; LIVER TUMOR; METABOLISM; MOLECULAR GENETICS; MUTATION; ONCOGENE RAS; PHENOTYPE; VIROLOGY; VIRUS CELL TRANSFORMATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; GENES, RAS; HUMANS; LIVER NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; PHENOTYPE; TRANSFECTION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 40949100394     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22108     Document Type: Article

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