Enhanced Ca2+ leak from ER Ca2+ stores induced by hepatitis C NS5A protein

Biochemical and Biophysical Research Communications

Volumn 368, Issue 3, 2008, Pages 593-599

  Robinson, Lisbeth C ^a   Marchant, Jonathan S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Ca2+ signaling; Endoplasmic reticulum

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATE; CALCIUM ION; NONSTRUCTURAL PROTEIN 5A; CALCIUM; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CALCIUM TRANSPORT; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; ANIMAL; CELL LINE; CELL MEMBRANE; DRUG EFFECT; KIDNEY; METABOLISM;

HEPATITIS C VIRUS;

ANIMALS; CALCIUM; CELL LINE; CELL MEMBRANE; ENDOPLASMIC RETICULUM; KIDNEY; VIRAL NONSTRUCTURAL PROTEINS;

EID: 39749118497     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.01.127     Document Type: Article

References (18)

1. Giannini C., and Brechot C. Hepatitis C virus biology. Cell Death Differ. 10 Suppl. 1 (2003) S27-S38
2. Shepard C.W., Finelli L., and Alter M.J. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis. 5 (2005) 558-567
3. Houghton M., and Abrignani S. Prospects for a vaccine against the hepatitis C virus. Nature 436 (2005) 961-966
4. De Francesco R., and Migliaccio G. Challenges and successes in developing new therapies for hepatitis C. Nature 436 (2005) 953-960
5. Lindenbach B.D., and Rice C.M. Unravelling hepatitis C virus replication from genome to function. Nature 436 (2005) 933-938
6. Moradpour D., Penin F., and Rice C.M. Replication of hepatitis C virus. Nat Rev Microbiol 5 (2007) 453-463
7. Mottola G., Cardinali G., Ceccacci A., Trozzi C., Bartholomew L., Torrisi M.R., Pedrazzini E., Bonatti S., and Migliaccio G. Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons. Virology 293 (2002) 31-43
8. Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas M., Bartenschlager R., Wakita T., Hijikata M., and Shimotohno K. The lipid droplet is an important organelle for hepatitis C virus production. Nat. Cell Biol. 9 (2007) 1089-1097
9. Macdonald A., and Harris M. Hepatitis C virus NS5A: tales of a promiscuous protein. J, Gen, Virol. 85 (2004) 2485-2502
10. Gong G., Waris G., Tanveer R., and Siddiqui A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc. Natl. Acad. Sci. USA 98 (2001) 9599-9604
11. Tardif K.D., Mori K., and Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J. Virol. 76 (2002) 7453-7459
12. Machida K., Cheng K.T., Lai C.K., Jeng K.S., Sung V.M., and Lai M.M. Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation. J. Virol. 80 (2006) 7199-7207
13. Garcia-Mediavilla M.V., Sanchez-Campos S., Gonzalez-Perez P., Gomez-Gonzalo M., Majano P.L., Lopez-Cabrera M., Clemente G., Garcia-Monzon C., and Gonzalez-Gallego J. Differential contribution of hepatitis C virus NS5A and core proteins to the induction of oxidative and nitrosative stress in human hepatocyte-derived cells. J. Hepatol. 43 (2005) 606-613
14. Moradpour D., Evans M.J., Gosert R., Yuan Z., Blum H.E., Goff S.P., Lindenbach B.D., and Rice C.M. Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J. Virol. 78 (2004) 7400-7409
15. Wang T., and Weinman S.A. Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C. J. Gastroenterol. Hepatol. 21 Suppl. 3 (2006) S34-S37
16. 2+ uniporter activity. FASEB J. 21 (2007) 2474-2485
17. Benali-Furet N.L., Chami M., Houel L., De Giorgi F., Vernejoul F., Lagorce D., Buscail L., Bartenschlager R., Ichas F., Rizzuto R., and Paterlini-Brechot P. Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene 24 (2005) 4921-4933
18. 2+ oscillations. J. Biol. Chem. 278 (2003) 18877-18883