Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential

Journal of Virology

Volumn 74, Issue 6, 2000, Pages 2840-2846

  Rahmani, Zohra ^a,b   Kyung Won, Huh ^a   Lasher, Robert ^a   Siddiqui, Aleem ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANION CHANNEL;

ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER INJURY; MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; VIRUS CARCINOGENESIS; VIRUS PATHOGENESIS;

ANIMALS; COS CELLS; HEPATITIS B VIRUS; HUMANS; INTRACELLULAR MEMBRANES; ION CHANNELS; MEMBRANE POTENTIALS; MITOCHONDRIA; PORINS; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATORS; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 0342905085     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.6.2840-2846.2000     Document Type: Article

References (37)

1. Bannasch, P., F. Klimek, and D. Mayer. 1997. Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormone. J. Bioenerg. Biomembr. 29:303-313.
2. Beasley, R. P., C. C. Liu, L. Y. Huang, and C. S. Chien. 1981. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan. Lancet ii: 1129-1133.
3. Benn, J., and R. J. Schneider. 1994. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91:10350-10354.
4. Blachly-Dyson, E., A. Baldini, M. Litt, E. R. McCabe, and M. Forte. 1994. Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms. Genomics 20:62-67.
5. Brideau, A. D., B. W. Banfield, and L. W. Enquist. 1998. The US9 gene product of pseudorabies virus, an alphaherpesvirus is a phosphorylated, tail-anchored type II membrane protein. J. Virol. 72:4560-4570.
6. Chirillo, P., S. Pagano, G. Natoli, P. L. Puri, V. L. Burgio, C. Balsano, and M. Leverero. 1997. The hepatitis B virus X gene induces p53-mediated programmed cell death. Proc. Natl. Acad. Sci. USA 94:8162-8167.
7. Chisari, F. V. 1996. Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis. Curr. Top. Microbiol. Immunol. 206:149-173.
8. Colombini, M. 1979. A candidate for the permeability pathway of the outer mitochondrial membrane. Nature 279:643-645.
9. Cross, J. C., P. Wen, and W. J. Rutter. 1993. Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen activated cellular serine/threonine kinases. Proc. Natl. Acad. Sci. USA 90:8078-8082.
10. Dandri, M., P. Schirmacher, and C. E. Rogler. 1996. Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication. J. Virol. 70:5246-5254.
11. Doria, M., N. Klein, R. Lucito, and R. J. Schneider. 1995. The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activators of transcription factors. EMBO J. 14:4747-4757.
12. Green, D. R., and J. C. Reed. 1998. Mitochondria and apoptosis. Science 281: 1309-1312.
13. Kekule, A. S., U. Lauer, L. Weiss, B. Luber, and P. H. Hofschneider. 1993. Hepatitis B virus transactivator HBx uses a tumor promoter signalling pathway. Nature 361:742-745.
14. Kim, H., H. Lee, and Y. Yun. 1998. X-gene product of Hepatitis B virus induces apoptosis in liver cells. J. Biol. Chem. 273:381-385.
15. Klein, N. P., and R. J. Schneider. 1997. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol. Cell. Biol. 17:6427-6436.
16. Koike, K., K. Moriya, H. Yotsuyanagi, S. Lino, and K. Kurokawa. 1994. Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblast. J. Clin. Investig. 94:1107-1114.
17. Krahenbuhl, S. 1993. Alterations in mitochondrial function and morphology in chronic liver disease: pathogenesis and potential for therapeutic intervention. Pharmacol. Ther. 60:1-38.
18. Liu, M. Y., and M. Colombini. 1992. Regulation of mitochondrial respiration by controlling the permeability of the outer membrane through the mitochondrial channel, VDAC. Biochim. Biophys. Acta 1098:255-260.
19. Maguire, H. F., J. P. Hoeffler, and A. Siddiqui. 1991. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252:842-844.
20. Marzo, I., C. Brenner, N. Zamzami, J. M. Jurgensmeier, S. A. Susin, H. L. A. Vieira, M.-C. Prevost, Z. Xie, S. Matsuyama, J. C. Reed, and G. Kroemer. 1998. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281:2027-2031.
21. Marzo, I., C. Brenner, N. Zazami, S. A. Susin, G. Beutner, D. Brdiczka, R. Remy, Z. Xie, J. C. Reed, and G. Kroemer. 1998. The permeability transition complex: a target for apoptosis regulation by caspase and Bcl2-related proteins. J. Exp. Med. 187:1261-1271.
22. Narita, M., S. Shigeomi, T. Ito, T. Chittenden, R. J. Lutz, H. Matsuda, and Y. Tsujimoto. 1998. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. USA 95:14681-14686.
23. Poot, M., Y.-Z. Zhang, J. A. Kramer, S. Wells, L. J. Jones, D. K. Hanzel, A. G. Lugade, V. L. Singer, and R. P. Haugland. 1996. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains. J. Histochem. Cytochem. 44:1363-1372.
24. Qadri, I., J. W. Conaway, R. C. Conaway, J. Schaack, and A. Siddiqui. 1996. Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH and stimulates the DNA helicase activity of TFIIH. Proc. Natl. Acad. Sci. USA 93:10578-10583.
25. Raff, M. 1998. Cell suicide for beginners. Nature 396:119-122.
26. Rahmani, Z., C. Maunoury, and A. Siddiqui. 1998. Isolation of a novel human voltage-dependent anion channel gene. Eur. J. Hum. Genet. 6:337-340.
27. Rostovtseva, T., and M. Colombini. 1996. ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membrane. J. Biol. Chem. 271: 28006-28008.
28. Shimizu, S., M. Narita, and Y. Tsujimoto. 1999. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399:483-412.
29. Siddiqui, A., R. Gaynor, A. Srinivasan, J. Mapoles, and R. W. Farr. 1989. Trans-activation of viral enhancers including the long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein. Virology 169:479-484.
30. Siddiqui, A., S. Jameel, and J. Mapoles. 1987. Expression of the hepatitis B virus X gene in mammalian cells. Proc. Natl. Acad. Sci. USA 84:2513-2517.
31. Sorgato, M., and O. Moran. 1993. Channels in mitochondrial membranes: knowns, unknowns, and prospects for the future. Crit. Rev. Biochem. Mol. Biol. 18:127-171.
32. Spandau, D. F., and C.-H. Lee. 1988. trans-activation of viral enhancers by the hepatitis B virus X protein. J. Virol. 62:427-434.
33. Su, F., and R. J. Schneider. 1997. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α. Proc. Natl. Acad. Sci. USA 94:8744-8749.
34. Twu, J. S., and R. H. Schloemer. 1989. Transcription of the human beta interferon gene is inhibited by hepatitis B virus. J. Virol. 63:3065-3071.
35. Xu, Q., and J. C. Reed. 1998. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell 1:337-346.
36. Yu, W. H., W. Wolfgang, and M. Forte. 1995. Subcellular localization of human voltage-dependent anion channel isoforms. J. Biol. Chem. 270: 13998-14006.
37. Zentgraf, H. G., R. Hermann, P. Klein, I. Schranz, D. Loncarevic, K. Herrmann, H. Hubnerand, and C. Schroder. 1990. Mouse monoclonal antibody directed against hepatitis B virus X protein synthesized in Escherichia coli: detection of reactive antigen in liver cell carcinoma and chronic hepatitis. Oncology 47:143-148.