Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo

Journal of Virology

Volumn 84, Issue 18, 2010, Pages 9326-9331

  Zhang, Zhensheng ^a   Sun, Eun ^a   Ou, Jing Hsiung James ^b   Liang, T Jake ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CELL ENZYME; HEPATITIS B VIRUS X PROTEIN; MLN 273; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; BORONIC ACID DERIVATIVE; DIPEPTIDE; ENZYME INHIBITOR; N-(4-MORPHOLINE)CARBONYL-BETA-(1-NAPHTHYL)-ALANYL-LEUCINE BORONIC ACID; TRANSACTIVATOR PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; GENE EXPRESSION; HEPATITIS B VIRUS; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; THERAPY EFFECT; TRANSGENIC MOUSE; VIRUS GENOME; VIRUS INHIBITION; VIRUS RECOMBINANT; VIRUS REPLICATION; WILD TYPE; ANIMAL; C57BL MOUSE; DEFICIENCY; HOST PATHOGEN INTERACTION; PHYSIOLOGY;

ANIMALS; BORONIC ACIDS; DIPEPTIDES; ENZYME INHIBITORS; HEPATITIS B VIRUS; HOST-PATHOGEN INTERACTIONS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEASOME INHIBITORS; TRANS-ACTIVATORS; VIRUS REPLICATION;

EID: 77956042333     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00579-10     Document Type: Article

References (32)

1. Aufiero, B., et al. 1990. The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters. EMBO J. 9:497-504. (Pubitemid 20044771)
2. Blanchette, P., and P. E. Branton. 2009. Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses. Virology 384:317-323.
3. Bouchard, M. J., and R. J. Schneider. 2004. The enigmatic X gene of hepatitis B virus. J. Virol. 78:12725-12734.
4. Bouchard, M. J., L. H. Wang, and R. J. Schneider. 2001. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294:2376-2378.
5. Choi, Y. H., H. I. Kim, J. K. Seong, D. Y. Yu, H. Cho, M. O. Lee, J. M. Lee, Y. H. Ahn, S. J. Kim, and J. H. Park. 2004. Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor gamma through protein-protein interaction. FEBS Lett. 557:73-80.
6. Colgrove, R., et al. 1989. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J. Virol. 63:4019-4026.
7. Darwin, K. H., S. Ehrt, J. C. Gutierrez-Ramos, N. Weich, and C. F. Nathan. 2003. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science 302:1963-1966.
8. Dubuquoy, L., A. Louvet, A. Hollebecque, P. Mathurin, and S. Dharancy. 2009. Peroxisome proliferator-activated receptors in HBV-related infection. PPAR Res. doi:10.1155/2009/145124.
9. Ganem, D., and A. M. Prince. 2004. Hepatitis B virus infection-natural history and clinical consequences. N. Engl. J. Med. 350:1118-1129.
10. Garcia, M. L., R. Byfield, and M. D. Robek. 2009. Hepatitis B virus replication and release are independent of core lysine ubiquitination. J. Virol. 83:4923-4933.
11. Hansen, T. H., and M. Bouvier. 2009. MHC class I antigen presentation: learning from viral evasion strategies. Nat. Rev. Immunol. 9:503-513.
12. Hasegawa, K., J. Huang, J. R. Wands, H. H. Obata, and J. Liang. 1991. Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan. Virology 185:460-463.
13. He, T. C., S. Zhou, L. T. da Costa, J. Yu, K. W. Kinzler, and B. Vogelstein. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U. S. A. 95:2509-2514.
14. Hu, Z., Z. Zhang, E. Doo, O. Coux, A. L. Goldberg, and T. J. Liang. 1999. Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex. J. Virol. 73:7231-7240.
15. Huang, J., et al. 1996. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J. Virol. 70:5582-5591.
16. Kisselev, A. F., and A. L. Goldberg. 2001. Proteasome inhibitors: from research tools to drug candidates. Chem. Biol. 8:739-758.
17. Liang, T. J. 2009. Hepatitis B: the virus and disease. Hepatology 49:S13-S21.
18. Liu, C. W., E. Strickland, G. N. Demartino, and P. J. Thomas. 2005. Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome. Methods Mol. Biol. 301:71-81.
19. Lorenzo, M. E., J. U. Jung, and H. L. Ploegh. 2002. Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class I major histocompatibility complexes to late endocytic compartments. J. Virol. 76:5522-5531.
20. Milich, D. R., J. E. Jones, J. L. Hughes, T. Maruyama, J. Price, I. Melhado, and F. Jirik. 1994. Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice. J. Immunol. 152:455-466.
21. Niewiadomska, A. M., and X. F. Yu. 2009. Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif. Curr. Top. Microbiol. Immunol. 339:1-25.
22. Robek, M. D., S. F. Wieland, and F. V. Chisari. 2002. Inhibition of hepatitis B virus replication by interferon requires proteasome activity. J. Virol. 76:3570-3574.
23. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
24. Sherry, B. 2009. Rotavirus and reovirus modulation of the interferon response. J. Interferon Cytokine Res. 29:559-567.
25. Sprinzl, M. F., H. Oberwinkler, H. Schaller, and U. Protzer. 2001. Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier. J. Virol. 75:5108-5118.
26. Stohwasser, R., H. G. Holzhutter, U. Lehmann, P. Henklein, and P. M. Kloetzel. 2003. Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit. Biol. Chem. 384:39-49.
27. Tang, H., N. Oishi, S. Kaneko, and S. Murakami. 2006. Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci. 97:977-983. (Pubitemid 44322542)
28. Xu, Z., T. S. Yen, L. Wu, C. R. Madden, W. Tan, B. L. Slagle, and J. H. Ou. 2002. Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J. Virol. 76:2579-2584.
29. Yu, G. Y., and M. M. Lai. 2005. The ubiquitin-proteasome system facilitates the transfer of murine coronavirus from endosome to cytoplasm during virus entry. J. Virol. 79:644-648.
30. Zhang, Z., U. Protzer, Z. Hu, J. Jacob, and T. J. Liang. 2004. Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner. J. Virol. 78:4566-4572.
31. Zhang, Z., N. Torii, A. Furusaka, N. Malayaman, Z. Hu, and T. J. Liang. 2000. Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. J. Biol. Chem. 275:15157-15165.
32. Zhang, Z., N. Torii, Z. Hu, J. Jacob, and T. J. Liang. 2001. X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo. J. Clin. Invest. 108:1523-1531.