Nitric oxide signalling in the regulation of cardiovascular and platelet function

Frontiers in Bioscience

Volumn 16, Issue 5, 2011, Pages 1873-1897

  Gkaliagkousi, Eugenia ^a   Ferro, Albert ^b  

^a ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Endothelial dysfunction; Flow mediated dilatation; Nitric oxide; Platelets; Review; Thrombosis

Indexed keywords

ANIMALIA;

ANTIINFLAMMATORY AGENT; ANTITHROMBOCYTIC AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ANGIOGENESIS; BLOOD; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CELL PROLIFERATION; DRUG EFFECT; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; THROMBOCYTE; THROMBOCYTE AGGREGATION; VASCULAR ENDOTHELIUM; VASODILATATION;

ANTI-INFLAMMATORY AGENTS; BLOOD PLATELETS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CELL PROLIFERATION; ENDOTHELIUM, VASCULAR; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; VASODILATION;

EID: 79955047965     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3828     Document Type: Article

References (268)

1. S. Moncada, R. M. Palmer and E. A. Higgs: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev, 43(2), 109-42 (1991)
2. S. Moncada, A. Higgs and R. Furchgott: International Union of Pharmacology Nomenclature in Nitric Oxide Research. Pharmacol Rev, 49(2), 137-42 (1997) (Pubitemid 27291031)
3. L. J. Ignarro, J. M. Fukuto, J. M. Griscavage, N. E. Rogers and R. E. Byrns: Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci U S A, 90(17), 8103-7 (1993) (Pubitemid 23260863)
4. G. L. Squadrito and W. A. Pryor: Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radic Biol Med, 25(4-5), 392-403 (1998) (Pubitemid 28390297)
5. L. J. Ignarro, R. G. Harbison, K. S. Wood and P. J. Kadowitz: Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther, 237(3), 893-900 (1986) (Pubitemid 16088110)
6. J. S. Beckman and W. H. Koppenol: Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol, 271(5 Pt 1), C1424-37 (1996)
7. J. Goretski and T. C. Hollocher: Trapping of nitric oxide produced during denitrification by extracellular hemoglobin. J Biol Chem, 263(5), 2316-23 (1988) (Pubitemid 18060291)
8. D. J. Singel and J. S. Stamler: Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin. Annu Rev Physiol, 67, 99-145 (2005) (Pubitemid 40404487)
9. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR and L. J.: Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A., 89(16), 7674-7. (1992)
10. R. M. Palmer, D. D. Rees, D. S. Ashton and S. Moncada: L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun, 153(3), 1251-6 (1988)
11. R. F. Furchgott and J. V. Zawadzki: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature(5789), 373-6 (1980) (Pubitemid 11169009)
12. L. J. Ignarro, G. M. Buga, K. S. Wood, R. E. Byrns and G. Chaudhuri: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A, 84(24), 9265-9 (1987)
13. M. J. R. Palmer, A. G. Ferrige and S. Moncada: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 524-526 (1987) (Pubitemid 17085822)
14. M. D. Radomski, M. J. R. Palmer and S. Moncada: Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br. J. Pharmac., 92, 181-187 (1987) (Pubitemid 17134934)
15. S. Moncada, R. M. Palmer and E. A. Higgs: Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol, 38(11), 1709-15 (1989) (Pubitemid 19138518)
16. D. S. Bredt, P. M. Hwang and S. H. Snyder: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 347(6295), 768-70 (1990)
17. J. A. Mitchell, H. Sheng, U. Forstermann and F. Murad: Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. Br J Pharmacol, 104(2), 289-91 (1991)
18. N. Toda and T. Okamura: Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle. Biochem Biophys Res Commun, 170(1), 308-13 (1990) (Pubitemid 20249420)
19. K. Y. Xu, D. L. Huso, T. M. Dawson, D. S. Bredt and L. C. Becker: Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci U S A, 96(2), 657-62 (1999) (Pubitemid 29061264)
20. L. Kobzik, M. B. Reid, D. S. Bredt and J. S. Stamler: Nitric oxide in skeletal muscle. Nature, 372(6506), 546-8 (1994) (Pubitemid 24368535)
21. C. M. Boulanger, C. Heymes, J. Benessiano, R. S. Geske, B. I. Levy and P. M. Vanhoutte: Neuronal nitric oxide synthase is expressed in rat vascular smooth muscle cells: activation by angiotensin II in hypertension. Circ Res, 83(12), 1271-8 (1998) (Pubitemid 29006042)
22. S. Kashiwagi, M. Kajimura, Y. Yoshimura and M. Suematsu: Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. Circ Res, 91(12), e55-64 (2002)
23. Seddon MD, Chowienczyk PJ, Brett SE, Casadei B and S. AM.: Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation., 117(15), 1991-6 (2008) (Pubitemid 351543475)
24. Seddon M, Melikian N, Dworakowski R, Shabeeh H, Jiang B, Byrne J, Casadei B, Chowienczyk P and S. AM.: Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Circulation., 119(20), 2656-62 (2009)
25. H. J. Cho, Q. W. Xie, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee and C. Nathan: Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med, 176(2), 599-604 (1992)
26. D. J. Stuehr, H. J. Cho, N. S. Kwon, M. F. Weise and C. F. Nathan: Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci U S A, 88(17), 7773-7 (1991) (Pubitemid 21915236)
27. M. A. Wheeler, S. D. Smith, G. Garcia-Cardena, C. F. Nathan, R. M. Weiss and W. C. Sessa: Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest, 99(1), 110-6 (1997) (Pubitemid 27058301)
28. G. K. Hansson, Y. J. Geng, J. Holm, P. Hardhammar, A. Wennmalm and E. Jennische: Arterial smooth muscle cells express nitric oxide synthase in response to endothelial injury. J Exp Med, 180(2), 733-8 (1994) (Pubitemid 24224154)
29. R. Busse and A. Mulsch: Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett, 275(1-2), 87-90 (1990) (Pubitemid 20386182)
30. S. S. Gross, E. A. Jaffe, R. Levi and R. G. Kilbourn: Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. Biochem Biophys Res Commun, 178(3), 823-9 (1991)
31. R. Schulz, E. Nava and S. Moncada: Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium. Br J Pharmacol, 105(3), 575-80 (1992)
32. D. A. Geller, A. K. Nussler, M. Di Silvio, C. J. Lowenstein, R. A. Shapiro, S. C. Wang, R. L. Simmons and T. R. Billiar: Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci U S A, 90(2), 522-6 (1993) (Pubitemid 23028895)
33. J. L. Mehta, L. Y. Chen, B. C. Kone, P. Mehta and P. Turner: Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J Lab Clin Med, 125(3), 370-7 (1995)
34. Goubareva I, Gkaliagkousi E, Shah A, Queen L, Ritter J and F. A.: Age decreases nitric oxide synthesis and responsiveness in human platelets and increases formation of monocyte-platelet aggregates. Cardiovascular Research, 75, 793-802. (2007) (Pubitemid 47238740)
35. S. Lamas, P. A. Marsden, G. K. Li, P. Tempst and T. Michel: Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A, 89(14), 6348-52 (1992)
36. J. S. Pollock, M. Nakane, L. D. Buttery, A. Martinez, D. Springall, J. M. Polak, U. Forstermann and F. Murad: Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol, 265(5 Pt 1), C1379-87 (1993)
37. J. L. Balligand, R. A. Kelly, P. A. Marsden, T. W. Smith and T. Michel: Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci U S A, 90(1), 347-51 (1993) (Pubitemid 23010307)
38. L. Y. Chen and J. L. Mehta: Evidence for the presence of L-arginine-nitric oxide pathway in human red blood cells: relevance in the effects of red blood cells on platelet function. J Cardiovasc Pharmacol, 32(1), 57-61 (1998) (Pubitemid 28304694)
39. Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I, Gharini P, Kabanova S, Ozüyaman B, Schnürch HG, Gödecke A, Weber AA, Robenek M, Robenek H, Bloch W, Rösen P and K. M.: Red blood cells express a functional endothelial nitric oxide synthase. Blood., 107(7), 2943-51 (2006)
40. I. Fleming and R. Busse: Signal transduction of eNOS activation. Cardiovasc Res, 43(3), 532-41 (1999) (Pubitemid 29369252)
41. C. R. Nishida and P. R. Ortiz de Montellano: Autoinhibition of endothelial nitric-oxide synthase. Identification of an electron transfer control element. J Biol Chem, 274(21), 14692-8 (1999)
42. B. M. List, B. Klosch, C. Volker, A. C. Gorren, W. C. Sessa, E. R. Werner, W. R. Kukovetz, K. Schmidt and B. Mayer: Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem J, 323 (Pt 1), 159-65 (1997) (Pubitemid 27153889)
43. O. W. Griffith and D. J. Stuehr: Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol, 57, 707-36 (1995)
44. J. Vasquez-Vivar, B. Kalyanaraman, P. Martasek, N. Hogg, B. S. Masters, H. Karoui, P. Tordo and K. A. Pritchard, Jr.: Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A, 95(16), 9220-5 (1998) (Pubitemid 28506212)
45. E. Stroes, M. Hijmering, M. van Zandvoort, R. Wever, T. J. Rabelink and E. E. van Faassen: Origin of superoxide production by endothelial nitric oxide synthase. FEBS Lett, 438(3), 161-4 (1998) (Pubitemid 28529266)
46. K. A. Pritchard, Jr., L. Groszek, D. M. Smalley, W. C. Sessa, M. Wu, P. Villalon, M. S. Wolin and M. B. Stemerman: Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res, 77(3), 510-8 (1995)
47. M. Ozaki, S. Kawashima, T. Yamashita, T. Hirase, M. Namiki, N. Inoue, K. Hirata, H. Yasui, H. Sakurai, Y. Yoshida, M. Masada and M. Yokoyama: Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest, 110(3), 331-40 (2002) (Pubitemid 34847965)
48. Chalupsky K and C. H.: Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A., 102(25), 9056-61 (2005) (Pubitemid 40881077)
49. J. B. Laursen, M. Somers, S. Kurz, L. McCann, A. Warnholtz, B. A. Freeman, M. Tarpey, T. Fukai and D. G. Harrison: Endothelial regulation of vasomotion in apoEdeficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation, 103(9), 1282-8 (2001) (Pubitemid 32221353)
50. U. Landmesser, S. Dikalov, S. R. Price, L. McCann, T. Fukai, S. M. Holland, W. E. Mitch and D. G. Harrison: Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest, 111(8), 1201-9 (2003) (Pubitemid 36519937)
51. N. J. Alp, M. A. McAteer, J. Khoo, R. P. Choudhury and K. M. Channon: Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTPcyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol, 24(3), 445-50 (2004) (Pubitemid 38326136)
52. E. Stroes, J. Kastelein, F. Cosentino, W. Erkelens, R. Wever, H. Koomans, T. Luscher and T. Rabelink: Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest, 99(1), 41-6 (1997) (Pubitemid 27058292)
53. L. J. Dixon, D. R. Morgan, S. M. Hughes, L. T. McGrath, N. A. El-Sherbeeny, R. D. Plumb, A. Devine, W. Leahey, G. D. Johnston and G. E. McVeigh: Functional consequences of endothelial nitric oxide synthase uncoupling in congestive cardiac failure. Circulation, 107(13), 1725-8 (2003) (Pubitemid 36418350)
54. N. J. Alp, S. Mussa, J. Khoo, S. Cai, T. Guzik, A. Jefferson, N. Goh, K. A. Rockett and K. M. Channon: Tetrahydrobiopterin-dependent preservation of nitric oxidemediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest, 112(5), 725-35 (2003) (Pubitemid 38057713)
55. J. K. Bendall, N. J. Alp, N. Warrick, S. Cai, D. Adlam, K. Rockett, M. Yokoyama, S. Kawashima and K. M. Channon: Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression. Circ Res, 97(9), 864-71 (2005) (Pubitemid 41552671)
56. J. S. Pollock, U. Forstermann, J. A. Mitchell, T. D. Warner, H. H. Schmidt, M. Nakane and F. Murad: Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci U S A, 88(23), 10480-4 (1991) (Pubitemid 21915859)
57. R. Busse and A. Mulsch: Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett, 265(1-2), 133-6 (1990) (Pubitemid 20189413)
58. U. Forstermann, J. S. Pollock, H. H. Schmidt, M. Heller and F. Murad: Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci U S A, 88(5), 1788-92 (1991) (Pubitemid 21916311)
59. H. M. Abu-Soud and D. J. Stuehr: Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer. Proc Natl Acad Sci U S A, 90(22), 10769-72 (1993) (Pubitemid 23347124)
60. P. M. Vanhoutte and V. M. Miller: Alpha 2-adrenoceptors and endothelium-derived relaxing factor. Am J Med, 87(3C), 1S-5S (1989) (Pubitemid 19248359)
61. Z. S. Katusic, J. T. Shepherd and P. M. Vanhoutte: Vasopressin causes endothelium-dependent relaxations of the canine basilar artery. Circ Res, 55(5), 575-9 (1984) (Pubitemid 15176952)
62. H. Li, C. Burkhardt, U. R. Heinrich, I. Brausch, N. Xia and U. Forstermann: Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells. Circulation, 107(18), 2348-54 (2003) (Pubitemid 36578507)
63. P. M. Vanhoutte: Platelet-derived serotonin, the endothelium, and cardiovascular disease. J Cardiovasc Pharmacol, 17 Suppl 5, S6-12 (1991)
64. P. Golino, F. Piscione, J. T. Willerson, M. Cappelli-Bigazzi, A. Focaccio, B. Villari, C. Indolfi, E. Russolillo, M. Condorelli and M. Chiariello: Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. N Engl J Med, 324(10), 641-8 (1991)
65. C. Boulanger, V. B. Schini, S. Moncada and P. M. Vanhoutte: Stimulation of cyclic GMP production in cultured endothelial cells of the pig by bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide. Br J Pharmacol, 101(1), 152-6 (1990) (Pubitemid 20277281)
66. S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse and A. M. Zeiher: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature, 399(6736), 601-5 (1999)
67. D. Fulton, J. P. Gratton, T. J. McCabe, J. Fontana, Y. Fujio, K. Walsh, T. F. Franke, A. Papapetropoulos and W. C. Sessa: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature, 399(6736), 597-601 (1999)
68. T. J. McCabe, D. Fulton, L. J. Roman and W. C. Sessa: Enhanced electron flux and reduced calmodulin dissociation may explain "calcium- independent" eNOS activation by phosphorylation. J Biol Chem, 275(9), 6123-8 (2000) (Pubitemid 30129896)
69. Z. Chen, I. S. Yuhanna, Z. Galcheva-Gargova, R. H. Karas, M. E. Mendelsohn and P. W. Shaul: Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest, 103(3), 401-6 (1999) (Pubitemid 29069990)
70. M. B. Harris, H. Ju, V. J. Venema, H. Liang, R. Zou, B. J. Michell, Z. P. Chen, B. E. Kemp and R. C. Venema: Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem, 276(19), 16587-91 (2001)
71. F. Kim, B. Gallis and M. A. Corson: TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Am J Physiol Cell Physiol, 280(5), C1057-65 (2001)
72. S. R. Thomas, K. Chen and J. F. Keaney, Jr.: Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem, 277(8), 6017-24 (2002) (Pubitemid 34968385)
73. B. J. Michell, M. B. Harris, Z. P. Chen, H. Ju, V. J. Venema, M. A. Blackstone, W. Huang, R. C. Venema and B. E. Kemp: Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem, 277(44), 42344-51 (2002) (Pubitemid 35257555)
74. I. Fleming, B. Fisslthaler, S. Dimmeler, B. E. Kemp and R. Busse: Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res, 88(11), E68-75 (2001)
75. Z. P. Chen, K. I. Mitchelhill, B. J. Michell, D. Stapleton, I. Rodriguez-Crespo, L. A. Witters, D. A. Power, P. R. Ortiz de Montellano and B. E. Kemp: AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett, 443(3), 285-9 (1999) (Pubitemid 29080812)
76. E. Butt, M. Bernhardt, A. Smolenski, P. Kotsonis, L. G. Frohlich, A. Sickmann, H. E. Meyer, S. M. Lohmann and H. H. Schmidt: Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. J Biol Chem, 275(7), 5179-87 (2000) (Pubitemid 30108921)
77. Y. C. Boo, J. Hwang, M. Sykes, B. J. Michell, B. E. Kemp, H. Lum and H. Jo: Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol, 283(5), H1819-28 (2002) (Pubitemid 35217015)
78. L. R. Queen, Y. Ji, B. Xu, L. Young, K. Yao, A. W. Wyatt, D. J. Rowlands, R. C. Siow, G. E. Mann and A. Ferro: Mechanisms underlying beta2- adrenoceptormediated nitric oxide generation by human umbilical vein endothelial cells. J Physiol, 576(Pt 2), 585-94 (2006) (Pubitemid 44490147)
79. Loot AE, Schreiber JG, Fisslthaler B and F. I.: Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. J Exp Med., 206(13), 2889-96. (2009)
80. H. Chen, M. Montagnani, T. Funahashi, I. Shimomura and M. J. Quon: Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem, 278(45), 45021-6 (2003) (Pubitemid 37377262)
81. B. Thors, H. Halldorsson and G. Thorgeirsson: Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt. FEBS Lett, 573(1-3), 175-80 (2004) (Pubitemid 39141054)
82. D. Fulton, J. Fontana, G. Sowa, J. P. Gratton, M. Lin, K. X. Li, B. Michell, B. E. Kemp, D. Rodman and W. C. Sessa: Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem, 277(6), 4277-84 (2002) (Pubitemid 34968692)
83. L. J. Robinson and T. Michel: Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc Natl Acad Sci U S A, 92(25), 11776-80 (1995) (Pubitemid 26014196)
84. G. Garcia-Cardena, P. Oh, J. Liu, J. E. Schnitzer and W. C. Sessa: Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A, 93(13), 6448-53 (1996) (Pubitemid 26230326)
85. G. Sowa, M. Pypaert and W. C. Sessa: Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc Natl Acad Sci U S A, 98(24), 14072-7 (2001) (Pubitemid 33116026)
86. Q. Zhang, J. E. Church, D. Jagnandan, J. D. Catravas, W. C. Sessa and D. Fulton: Functional relevance of Golgiand plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol, 26(5), 1015-21 (2006) (Pubitemid 43732106)
87. G. Garcia-Cardena, R. Fan, V. Shah, R. Sorrentino, G. Cirino, A. Papapetropoulos and W. C. Sessa: Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature, 392(6678), 821-4 (1998) (Pubitemid 28225323)
88. J. Fontana, D. Fulton, Y. Chen, T. A. Fairchild, T. J. McCabe, N. Fujita, T. Tsuruo and W. C. Sessa: Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res, 90(8), 866-73 (2002) (Pubitemid 34633878)
89. J. Dedio, P. Konig, P. Wohlfart, C. Schroeder, W. Kummer and W. Muller-Esterl: NOSIP, a novel modulator of endothelial nitric oxide synthase activity. Faseb J, 15(1), 79-89 (2001) (Pubitemid 32061658)
90. K. Zimmermann, N. Opitz, J. Dedio, C. Renne, W. Muller-Esterl and S. Oess: NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A, 99(26), 17167-72 (2002) (Pubitemid 36034116)
91. S. Cao, J. Yao, T. J. McCabe, Q. Yao, Z. S. Katusic, W. C. Sessa and V. Shah: Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function. J Biol Chem, 276(17), 14249-56 (2001)
92. J. Sun and J. K. Liao: Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel. Proc Natl Acad Sci U S A, 99(20), 13108-13 (2002)
93. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA Jr, García- Cardeña G and J. MK.: KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med., 199(10), 1305-15 (2004) (Pubitemid 38685723)
94. Y. Ji, G. Ferracci, A. Warley, M. Ward, K. Y. Leung, S. Samsuddin, C. Leveque, L. Queen, V. Reebye, P. Pal, E. Gkaliagkousi, M. Seager and A. Ferro: {beta}-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Natl Acad Sci U S A (2007)
95. Kondrikov D, Han HR, Block ER and S. Y.: Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol., 290(1), L41-50. (2006)
96. Fleming I, Fisslthaler B, Dixit M and B. R.: Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. J Cell Sci., 118((Pt 18)), 4103-11. (2005) (Pubitemid 41488949)
97. Bagi Z, Frangos JA, Yeh JC, White CR, Kaley G and K. A.: PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress. Arterioscler Thromb Vasc Biol., 25(8), 1590-5 (2005) (Pubitemid 41098926)
98. Dixit M, Loot AE, Mohamed A, Fisslthaler B, Boulanger CM, Ceacareanu B, Hassid A, Busse R and F. I.: Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress. Circ Res., 97(12), 1236-44 (2005)
99. A. Horowitz, C. B. Menice, R. Laporte and K. G. Morgan: Mechanisms of smooth muscle contraction. Physiol Rev, 76(4), 967-1003 (1996) (Pubitemid 26346813)
100. S. M. Lohmann, A. B. Vaandrager, A. Smolenski, U. Walter and H. R. De Jonge: Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci, 22(8), 307-12 (1997) (Pubitemid 27327088)
101. T. L. Cornwell, K. B. Pryzwansky, T. A. Wyatt and T. M. Lincoln: Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells. Mol Pharmacol, 40(6), 923-31 (1991)
102. J. Schlossmann, A. Ammendola, K. Ashman, X. Zong, A. Huber, G. Neubauer, G. X. Wang, H. D. Allescher, M. Korth, M. Wilm, F. Hofmann and P. Ruth: Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature, 404(6774), 197-201 (2000) (Pubitemid 30154489)
103. R. A. Cohen, R. M. Weisbrod, M. Gericke, M. Yaghoubi, C. Bierl and V. M. Bolotina: Mechanism of nitric oxide-induced vasodilatation: refilling of intracellular stores by sarcoplasmic reticulum Ca2+ ATPase and inhibition of store-operated Ca2+ influx. Circ Res, 84(2), 210-9 (1999) (Pubitemid 29070117)
104. V. M. Bolotina, S. Najibi, J. J. Palacino, P. J. Pagano and R. A. Cohen: Nitric oxide directly activates calciumdependent potassium channels in vascular smooth muscle. Nature, 368(6474), 850-3 (1994) (Pubitemid 24137748)
105. M. Sausbier, R. Schubert, V. Voigt, C. Hirneiss, A. Pfeifer, M. Korth, T. Kleppisch, P. Ruth and F. Hofmann: Mechanisms of NO/cGMP-dependent vasorelaxation. Circ Res, 87(9), 825-30 (2000)
106. L. A. Blatter and W. G. Wier: Nitric oxide decreases [Ca2+]i in vascular smooth muscle by inhibition of the calcium current. Cell Calcium, 15(2), 122-31 (1994)
107. D. D. Rees, R. M. Palmer and S. Moncada: Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A, 86(9), 3375-8 (1989) (Pubitemid 19129614)
108. P. Vallance, J. Collier and S. Moncada: Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet, 2(8670), 997-1000 (1989) (Pubitemid 19257913)
109. W. G. Haynes, J. P. Noon, B. R. Walker and D. J. Webb: Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens, 11(12), 1375-80 (1993) (Pubitemid 24008485)
110. J. S. Stamler, E. Loh, M. A. Roddy, K. E. Currie and M. A. Creager: Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation, 89(5), 2035-40 (1994) (Pubitemid 24142778)
111. J. F. Arnal, A. I. el Amrani, G. Chatellier, J. Menard and J. B. Michel: Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension, 22(3), 380-7 (1993) (Pubitemid 23254087)
112. P. L. Huang, Z. Huang, H. Mashimo, K. D. Bloch, M. A. Moskowitz, J. A. Bevan and M. C. Fishman: Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature, 377(6546), 239-42 (1995)
113. P. L. Huang: Disruption of the endothelial nitric oxide synthase gene: effect on vascular response to injury. Am J Cardiol, 82(10A), 57S-59S (1998)
114. Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, McMahon TJ, Dickfeld T, Marshall HE, Que LG and S. JS.: Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell, 116(4), 617-28 (2004) (Pubitemid 38264436)
115. Sanghani PC, Davis WI, Fears SL, Green SL, Zhai L, Tang Y, Martin E, Bryan NS and S. SP.: Kinetic and cellular characterization of novel inhibitors of Snitrosoglutathione reductase. J Biol Chem., 284(36), 24354-62 (2009)
116. Huang B, Chen SC and W. DL.: Shear flow increases S-nitrosylation of proteins in endothelial cells. Cardiovasc Res., 83(3), 536-46 (2009)
117. Chvanov M, Gerasimenko OV, Petersen OH and T. AV.: Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO J., 25(13), 3024-32 (2006) (Pubitemid 44106755)
118. Selemidis S, Dusting GJ, Peshavariya H, Kemp-Harper BK and D. GR.: Nitric oxide suppresses NADPH oxidase-dependent superoxide production by Snitrosylation in human endothelial cells. Cardiovasc Res., 75(2), 349-58 (2007) (Pubitemid 46961925)
119. Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC and B. DE.: Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol., 107(4), 1249-57 (2009)
120. Rafikova O, Rafikov R and N. E.: Catalysis of Snitrosothiols formation by serum albumin: the mechanism and implication in vascular control. Proc Natl Acad Sci U S A, 99(9), 5913-8. (2002) (Pubitemid 34493239)
121. Tyurin VA, Liu SX, Tyurina YY, Sussman NB, Hubel CA, Roberts JM, Taylor RN and K. VE.: Elevated levels of S-nitrosoalbumin in preeclampsia plasma. Circ Res., 88(11), 1210-5. (2001) (Pubitemid 34132523)
122. Massy ZA, Fumeron C, Borderie D, Tuppin P, Nguyen-Khoa T, Benoit MO, Jacquot C, Buisson C, Drüeke TB, Ekindjian OG, Lacour B and I. MC.: Increased pasma S-nitrosothiol concentrations predict cardiovascular outcomes among patients with end-stage renal disease: a prospective study. J Am Soc Nephrol., 15(2), 470-6 (2004) (Pubitemid 38140789)
123. Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA and K. I.: Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res., 102(5), 607-14 (2008) (Pubitemid 351416757)
124. Sayed N, Baskaran P, Ma X, van den Akker F and B. A.: Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation. Proc Natl Acad Sci U S A., 104(30), 12312-7 (2007) (Pubitemid 47206134)
125. M. D. Radomski, M. J. R. Palmer and S. Moncada: The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochemical and Biophysical Research communication., 148(3), 1482-1489 (1987) (Pubitemid 18074679)
126. M. W. Radomski, R. M. Palmer and S. Moncada: Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet, 2(8567), 1057-8 (1987) (Pubitemid 17154788)
127. M. W. Radomski, R. M. Palmer and S. Moncada: The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol, 92(3), 639-46 (1987)
128. D. I. Simon, J. S. Stamler, E. Loh, J. Loscalzo, S. A. Francis and M. A. Creager: Effect of nitric oxide synthase inhibition on bleeding time in humans. J Cardiovasc Pharmacol, 26(2), 339-42 (1995)
129. M. A. Moro, R. J. Russel, S. Cellek, I. Lizasoain, Y. Su, V. M. Darley-Usmar, M. W. Radomski and S. Moncada: cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc Natl Acad Sci U S A, 93(4), 1480-5 (1996) (Pubitemid 26075149)
130. E. S. Trepakova, R. A. Cohen and V. M. Bolotina: Nitric oxide inhibits capacitative cation influx in human platelets by promoting sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase-dependent refilling of Ca2+ stores. Circ Res, 84(2), 201-9 (1999) (Pubitemid 29070116)
131. G. H. Rao, S. Krishnamurthi, L. Raij and J. G. White: Influence of nitric oxide on agonist-mediated calcium mobilization in platelets. Biochem Med Metab Biol, 43(3), 271-5 (1990) (Pubitemid 20302865)
132. D. H. Maurice and R. J. Haslam: Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol, 37(5), 671-81 (1990) (Pubitemid 20171502)
133. R. Bowen and R. J. Haslam: Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood; role for cyclic AMP in synergistic inhibition of platelet function by SIN-1 and prostaglandin E1. J Cardiovasc Pharmacol, 17(3), 424-33 (1991)
134. A. Pigazzi, S. Heydrick, F. Folli, S. Benoit, A. Michelson and J. Loscalzo: Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem, 274(20), 14368-75 (1999)
135. J. Zhang, S. J. Shattil, M. C. Cunningham and S. E. Rittenhouse: Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin. J Biol Chem, 271(11), 6265-72 (1996)
136. G. R. Wang, Y. Zhu, P. V. Halushka, T. M. Lincoln and M. E. Mendelsohn: Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci U S A, 95(9), 4888-93 (1998) (Pubitemid 28208520)
137. D. Tsikas, M. Ikic, K. Tewes, M. Raida and J. Frolich: Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets. FEBS Lett., 442(2-3), 162-6 (1999) (Pubitemid 29070826)
138. J. Pawlowski, R. Swaminathan and J. Stamler: Cellfree and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation. Circulation, 97(3), 263-7 (1998) (Pubitemid 28067312)
139. M. Beghetti, C. Sparling, P. Cox, D. Stephens and I. Adatia: Inhaled NO inhibits platelet aggregation and elevates plasma but not intraplatelet cGMP in healthy human volunteers. Am J Physiol Heart Circ Physiol., 285(2), H637-42 (2003) (Pubitemid 36885895)
140. M. Pernollet, F. Lantoine and M. Devynck: Nitric oxide inhibits ATP-dependent Ca2+ uptake into platelet membrane vesicles. Biochem Biophys Res Commun., 222(3), 780-785 (1996)
141. C. Morrell, K. Matsushita, K. Chiles, R. B. Scharpf, M. Yamakuchi, R. Mason, W. Bergmeier, J. L. Mankowski, V. Baldwin, N. Faraday and C. Lowenstein: Regulation of platelet granule exocytosis by Snitrosylation. Proc Natl Acad Sci U S A., 102(10), 3782-7 (2005) (Pubitemid 40354689)
142. J. E. Freedman, R. Sauter, E. M. Battinelli, K. Ault, C. Knowles, P. L. Huang and J. Loscalzo: Deficient plateletderived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res, 84(12), 1416-21 (1999) (Pubitemid 29293220)
143. W. Li, S. Mital, C. Ojaimi, A. Csiszar, G. Kaley and T. H. Hintze: Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. J Mol Cell Cardiol, 37(3), 671-80 (2004) (Pubitemid 39194559)
144. P. Vallance, N. Benjamin and J. Collier: The effect of endothelium-derived nitric oxide on ex vivo whole blood platelet aggregation in man. Eur J Clin Pharmacol, 42(1), 37-41 (1992)
145. P. Kubes, M. Suzuki and D. N. Granger: Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A, 88(11), 4651-5 (1991) (Pubitemid 21914599)
146. D. J. Lefer, S. P. Jones, W. G. Girod, A. Baines, M. B. Grisham, A. S. Cockrell, P. L. Huang and R. Scalia: Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol, 276(6 Pt 2), H1943-50 (1999) (Pubitemid 29323478)
147. B. V. Khan, D. G. Harrison, M. T. Olbrych, R. W. Alexander and R. M. Medford: Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci U S A, 93(17), 9114-9 (1996) (Pubitemid 26282027)
148. X. F. Niu, C. W. Smith and P. Kubes: Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res, 74(6), 1133-40 (1994) (Pubitemid 24176908)
149. Marshall HE and S. JS.: Inhibition of NF-kappa B by S-nitrosylation. Biochemistry., 40(6), 1688-93 (2001)
150. Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD and L. CJ.: Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide- sensitive factor. Cell, 115(2), 139-50 (2003) (Pubitemid 37329578)
151. S. M. Schwartz: Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest, 100(11 Suppl), S87-9 (1997) (Pubitemid 28009553)
152. B. C. Berk: Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev, 81(3), 999-1030 (2001) (Pubitemid 32606665)
153. U. C. Garg and A. Hassid: Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 83(5), 1774-7 (1989) (Pubitemid 19124139)
154. M. Moroi, L. Zhang, T. Yasuda, R. Virmani, H. K. Gold, M. C. Fishman and P. L. Huang: Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest, 101(6), 1225-32 (1998) (Pubitemid 28145238)
155. T. L. Cornwell, E. Arnold, N. J. Boerth and T. M. Lincoln: Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol, 267(5 Pt 1), C1405-13 (1994)
156. F. C. Tanner, P. Meier, H. Greutert, C. Champion, E. G. Nabel and T. F. Luscher: Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation. Circulation, 101(16), 1982-9 (2000) (Pubitemid 30225281)
157. Papapetropoulos A, García-Cardeña G, Madri JA and S. WC.: Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest., 100(12), 3131-9 (1997) (Pubitemid 28022851)
158. Pi X, Wu Y, Ferguson JE 3rd, Portbury AL and P. C.: SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Proc Natl Acad Sci U S A., 106(14), 5675-80 (2009)
159. Kang-Decker N, Cao S, Chatterjee S, Yao J, Egan LJ, Semela D, Mukhopadhyay D and S. V.: Nitric oxide promotes endothelial cell survival signaling through Snitrosylation and activation of dynamin-2. J Cell Sci., 120(Pt 3), 492-501 (2007) (Pubitemid 46332512)
160. M. S. Wolin: Interactions of oxidants with vascular signaling systems. Arterioscler Thromb Vasc Biol, 20(6), 1430-42 (2000) (Pubitemid 30353871)
161. M. T. Yates, L. E. Lambert, J. P. Whitten, I. McDonald, M. Mano, G. Ku and S. J. Mao: A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages. FEBS Lett, 309(2), 135-8 (1992)
162. T. Fukai, M. R. Siegfried, M. Ushio-Fukai, Y. Cheng, G. Kojda and D. G. Harrison: Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest, 105(11), 1631-9 (2000)
163. G. R. Drummond, H. Cai, M. E. Davis, S. Ramasamy and D. G. Harrison: Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res, 86(3), 347-54 (2000) (Pubitemid 30108830)
164. W. Durante, M. H. Kroll, N. Christodoulides, K. J. Peyton and A. I. Schafer: Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ Res, 80(4), 557-64 (1997) (Pubitemid 27137293)
165. M. D. Maines: The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol, 37, 517-54 (1997) (Pubitemid 27238886)
166. R. Stocker, Y. Yamamoto, A. F. McDonagh, A. N. Glazer and B. N. Ames: Bilirubin is an antioxidant of possible physiological importance. Science, 235(4792), 1043-6 (1987) (Pubitemid 17049750)
167. V. G. Kharitonov, V. S. Sharma, R. B. Pilz, D. Magde and D. Koesling: Basis of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci U S A, 92(7), 2568-71 (1995)
168. S. Recalcati, D. Taramelli, D. Conte and G. Cairo: Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation. Blood, 91(3), 1059-66 (1998) (Pubitemid 28078311)
169. G. Balla, H. S. Jacob, J. Balla, M. Rosenberg, K. Nath, F. Apple, J. W. Eaton and G. M. Vercellotti: Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem, 267(25), 18148-53 (1992)
170. J. Chen, P. J. Kuhlencordt, J. Astern, R. Gyurko and P. L. Huang: Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation, 104(20), 2391-4 (2001) (Pubitemid 33108369)
171. P. J. Kuhlencordt, E. Rosel, R. E. Gerszten, M. Morales- Ruiz, D. Dombkowski, W. J. Atkinson, F. Han, F. Preffer, A. Rosenzweig, W. C. Sessa, M. A. Gimbrone, Jr., G. Ertl and P. L. Huang: Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol, 286(5), C1195-202 (2004) (Pubitemid 38506935)
172. H. Cai and D. G. Harrison: Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res, 87(10), 840-4 (2000)
173. A. E. Donald, M. Charakida, T. J. Cole, P. Friberg, P. J. Chowienczyk, S. C. Millasseau, J. E. Deanfield and J. P. Halcox: Non-invasive assessment of endothelial function: which technique? J Am Coll Cardiol, 48(9), 1846-50 (2006) (Pubitemid 44648611)
174. Huang AL, Silver AE, Shvenke E, Schopfer DW, Jahangir E, Titas MA, Shpilman A, Menzoian JO, Watkins MT, Raffetto JD, Gibbons G, Woodson J, Shaw PM, Dhadly M, Eberhardt RT, Keaney JF Jr, Gokce N and V. JA.: Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery. Arterioscler Thromb Vasc Biol., 27(10), 2113-9 (2007) (Pubitemid 350287238)
175. Yeboah J, Crouse JR, Hsu FC, Burke GL and H. DM.: Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation., 115(18), 2390-7 (2007) (Pubitemid 46717961)
176. Yeboah J, Folsom AR, Burke GL, Johnson C, Polak JF, Post W, Lima JA, Crouse JR and H. DM.: Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation., 120(6), 502-9. (2009)
177. Corrado E, Rizzo M, Coppola G, Muratori I, Carella M and N. S.: Endothelial dysfunction and carotid lesions are strong predictors of clinical events in patients with early stages of atherosclerosis: a 24-month follow-up study. Coron Artery Dis., 19(3), 139-44 (2008) (Pubitemid 351555966)
178. Witte DR, Westerink J, de Koning EJ, van der Graaf Y, Grobbee DE and B. ML.: Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations? J Am Coll Cardiol., 45(12), 1987-93 (2005) (Pubitemid 40814119)
179. Shimbo D, Grahame-Clarke C, Miyake Y, Rodriguez C, Sciacca R, Di Tullio M, Boden-Albala B, Sacco R and H. S.: The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Atherosclerosis., 192(1), 197-203 (2007) (Pubitemid 46602298)
180. D. S. Celermajer, K. E. Sorensen, D. Georgakopoulos, C. Bull, O. Thomas, J. Robinson and J. E. Deanfield: Cigarette smoking is associated with dose-related and potentially reversible impairment of endotheliumdependent dilation in healthy young adults. Circulation, 88(5 Pt 1), 2149-55 (1993) (Pubitemid 23326094)
181. D. S. Celermajer, M. R. Adams, P. Clarkson, J. Robinson, R. McCredie, A. Donald and J. E. Deanfield: Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med, 334(3), 150-4 (1996) (Pubitemid 26017952)
182. D. E. Newby, R. A. Wright, C. Labinjoh, C. A. Ludlam, K. A. Fox, N. A. Boon and D. J. Webb: Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation, 99(11), 1411-5 (1999) (Pubitemid 29140904)
183. D. S. Celermajer, K. E. Sorensen, C. Bull, J. Robinson and J. E. Deanfield: Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol, 24(6), 1468-74 (1994) (Pubitemid 24344241)
184. K. E. Sorensen, D. S. Celermajer, D. Georgakopoulos, G. Hatcher, D. J. Betteridge and J. E. Deanfield: Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest, 93(1), 50-5 (1994) (Pubitemid 24030819)
185. P. J. Chowienczyk, G. F. Watts, J. R. Cockcroft and J. M. Ritter: Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia. Lancet, 340(8833), 1430-2 (1992)
186. P. Clarkson, M. R. Adams, A. J. Powe, A. E. Donald, R. McCredie, J. Robinson, S. N. McCarthy, A. Keech, D. S. Celermajer and J. E. Deanfield: Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest, 97(8), 1989-94 (1996) (Pubitemid 26129888)
187. G. Lupattelli, S. Marchesi, A. R. Roscini, D. Siepi, F. Gemelli, M. Pirro, H. Sinzinger, G. Schillaci and E. Mannarino: Direct association between high-density lipoprotein cholesterol and endothelial function in hyperlipemia. Am J Cardiol, 90(6), 648-50 (2002) (Pubitemid 35264546)
188. F. F. Willems, W. R. Aengevaeren, G. H. Boers, H. J. Blom and F. W. Verheugt: Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease. J Am Coll Cardiol, 40(4), 766-72 (2002) (Pubitemid 34925625)
189. S. Taddei, A. Virdis, P. Mattei, L. Ghiadoni, A. Gennari, C. B. Fasolo, I. Sudano and A. Salvetti: Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation, 91(7), 1981-7 (1995)
190. P. Clarkson, D. S. Celermajer, A. E. Donald, M. Sampson, K. E. Sorensen, M. Adams, D. K. Yue, D. J. Betteridge and J. E. Deanfield: Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol, 28(3), 573-9 (1996)
191. G. E. McVeigh, G. M. Brennan, G. D. Johnston, B. J. McDermott, L. T. McGrath, W. R. Henry, J. W. Andrews and J. R. Hayes Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 35(8), 771-6 (1992)
192. A. Halkin, N. Benjamin, H. S. Doktor, S. D. Todd, G. Viberti and J. M. Ritter: Vascular responsiveness and cation exchange in insulin-dependent diabetes. Clin Sci (Lond), 81(2), 223-32 (1991)
193. M. D. Enderle, N. Benda, R. M. Schmuelling, H. U. Haering and M. Pfohl: Preserved endothelial function in IDDM patients, but not in NIDDM patients, compared with healthy subjects. Diabetes Care, 21(2), 271-7 (1998) (Pubitemid 28079437)
194. W. A. Hsueh, C. J. Lyon and M. J. Quinones: Insulin resistance and the endothelium. Am J Med, 117(2), 109-17 (2004) (Pubitemid 38953731)
195. P. L. Ludmer, A. P. Selwyn, T. L. Shook, R. R. Wayne, G. H. Mudge, R. W. Alexander and P. Ganz: Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med, 315(17), 1046-51 (1986) (Pubitemid 17170620)
196. T. J. Anderson, A. Uehata, M. D. Gerhard, I. T. Meredith, S. Knab, D. Delagrange, E. H. Lieberman, P. Ganz, M. A. Creager, A. C. Yeung and et al.: Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol, 26(5), 1235-41 (1995)
197. Takase B, Uehata A, Akima T, Nagai T, Nishioka T, Hamabe A, Satomura K, Ohsuzu F and K. A.: Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease. Am J Cardiol., 82(12), 1535-9, A7-8 (1998) (Pubitemid 29006482)
198. J. A. Suwaidi, S. Hamasaki, S. T. Higano, R. A. Nishimura, D. R. Holmes, Jr. and A. Lerman: Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation, 101(9), 948-54 (2000) (Pubitemid 30131694)
199. J. A. Panza, A. A. Quyyumi, J. E. Brush, Jr. and S. E. Epstein: Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med, 323(1), 22-7 (1990) (Pubitemid 20209468)
200. L. Linder, W. Kiowski, F. R. Buhler and T. F. Luscher: Indirect evidence for release of endotheliumderived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation, 81(6), 1762-7 (1990) (Pubitemid 20183824)
201. Egashira K, Suzuki S, Hirooka Y, Kai H, I. Sugimachi M, maizumi T and T. A.: Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P. Hypertension., 25(2), 201-6 (1995)
202. A. Calver, J. Collier, S. Moncada and P. Vallance: Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens, 10(9), 1025-31 (1992)
203. J. R. Cockcroft, P. J. Chowienczyk, N. Benjamin and J. M. Ritter: Preserved endothelium-dependent vasodilatation in patients with essential hypertension. N Engl J Med, 330(15), 1036-40 (1994) (Pubitemid 24106560)
204. B. J. Kneale, P. J. Chowienczyk, S. E. Brett, J. R. Cockcroft and J. M. Ritter: Forearm vasoconstriction in response to noradrenaline and NG-monomethyl-L-arginine in essential hypertension. Clin Sci (Lond), 97(3), 277-82 (1999) (Pubitemid 29425321)
205. K. Iiyama, M. Nagano, Y. Yo, N. Nagano, K. Kamide, J. Higaki, H. Mikami and T. Ogihara: Impaired endothelial function with essential hypertension assessed by ultrasonography. Am Heart J, 132(4), 779-82 (1996) (Pubitemid 26366976)
206. M. L. Muiesan, M. Salvetti, C. Monteduro, C. Corbellini, D. Guelfi, D. Rizzoni, M. Castellano and E. Agabiti-Rosei: Flow-mediated dilatation of the brachial artery and left ventricular geometry in hypertensive patients. J Hypertens, 19(3 Pt 2), 641-7 (2001) (Pubitemid 32280958)
207. M. L. Muiesan, M. Salvetti, C. Monteduro, D. Rizzoni, R. Zulli, C. Corbellini, C. Brun and E. Agabiti-Rosei: Effect of treatment on flow-dependent vasodilation of the brachial artery in essential hypertension. Hypertension, 33(1 Pt 2), 575-80 (1999) (Pubitemid 29065723)
208. Kon Koh K, Yeal Ahn J, Hwan Han S, Kyu Jin D, Sik Kim H, Cheon Lee K, Kyun Shin E and S. I.: Comparison of effects of losartan,Irbesartan, and candesartan on FMD. Am J Cardiol, 93, 1432-1435 (2004)
209. A. Palloshi, G. Fragasso, P. Piatti, L. D. Monti, E. Setola, G. Valsecchi, E. Galluccio, S. L. Chierchia and A. Margonato: Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol, 93(7), 933-5 (2004) (Pubitemid 38429612)
210. Gkaliagkousi E, Douma S, Zamboulis C and F. A.: Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension. J Hypertens., 27(12), 2310-20 (2009)
211. Fraccarollo D, Widder JD, Galuppo P, Thum T, Tsikas D, Hoffmann M, Ruetten H, Ertl G and B. J.: Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction. Circulation, 118(8), 818-27 (2008)
212. Lovren F, Pan Y, Shukla PC, Quan A, Teoh H, Szmitko PE, Peterson MD, Gupta M, Al-Omran M and V. S.: Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis. Am J Physiol Endocrinol Metab., 296(6), E1440-9 (2009)
213. Laufs U, La Fata V, Plutzky J and L. JK.: Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation, 97(12), 1129-35 (1998) (Pubitemid 28152885)
214. Feron O, Dessy C, Desager JP and B. JL.: Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation, 103(1), 113-8 (2001) (Pubitemid 32050445)
215. Kalinowski L, Dobrucki LW, Brovkovych V and M. T.: Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. Circulation, 105(8), 933-8 (2002) (Pubitemid 34184570)
216. Wassmann S, Laufs U, Bäumer AT, Müller K, Konkol C, Sauer H, Böhm M and N. G.: Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol., 59(3), 646-54 (2001) (Pubitemid 32179945)
217. De Gennaro Colonna V, Rossoni G, Rigamonti A, Bonomo S, Manfredi B, Berti F and M. E.: Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats. Eur J Pharmacol., 450(1), 61-6 (2001)
218. De Gennaro Colonna V, F. S. Rigamonti A, Bonomo S, Manfredi B, Ferrario P, Bianchi M, Berti F, Muller EE and R. G.: Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats. Eur J Pharmacol., 516(3), 253-9 (2005) (Pubitemid 40922746)
219. Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Kobayashi K, Muragaki Y, Mochizuki S, Goto M, Yoshida K and A. T.: Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability. Hypertension., 51(3), 734-41 (2008) (Pubitemid 351301528)
220. K. Sase and T. Michel: Expression of constitutive endothelial nitric oxide synthase in human blood platelets. Life Sciences, 57(22), 2049-2055 (1995)
221. M. D. Radomski, M. J. R. Palmer and S. Moncada: An L-arginine/ nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. USA, 87, 5193-5197 (1990)
222. M. D. Radomski, M. J. R. Palmer and S. Moncada: Characterization of the L-arginine:nitric oxide pathway in human platelets. British Journal of Pharmacology, 101, 325-328 (1990) (Pubitemid 20292885)
223. Z. Quansheng, G. R. Hellermann and L. P. Larry P. Solomonson: Nitric oxide release from resting human platelets. Thrombosis Research, 77(1), 87-96 (1995)
224. L. R. Queen, B. Xu, K. Horinouchi, I. Fisher and A. Ferro: beta(2)-adrenoceptors activate nitric oxide synthase in human platelets. Circ Res, 87(1), 39-44 (2000) (Pubitemid 30456933)
225. L. Y. Chen and J. L. Mehta: Further Evidence of the Presence of Constitutive and Inducible Nitric Oxide Synthase Isoforms in Human Platelets. [Article]. Journal of Cardiovascular Pharmacology, 27(1), 154-158 (1996) (Pubitemid 26010653)
226. L. R. Queen, Y. Ji, I. Goubareva and A. Ferro: Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus. Diabetologia, 46(11), 1474-82 (2003) (Pubitemid 37518568)
227. J. E. Freedman, J. Loscalzo, M. R. Barnard, C. Alpert, J. F. Keany and A. D. Michelson: Nitric Oxide Released from Activated Platelets inhibits Platelet Recruitment. J. Clin. Invest., 100(2), 350-356 (1997) (Pubitemid 27349081)
228. R. Kerry and M. C. Scrutton: Platelet betaadrenoceptors. Br J Pharmacol, 79(3), 681-91 (1983)
229. A. Ferro, M. Coash, T. Yamamoto, J. Rob, Y. Ji and L. Queen: Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt. Br J Pharmacol, 143(3), 397-403 (2004) (Pubitemid 39424828)
230. G. Anfossi, I. Russo, P. Massucco, L. Mattiello, F. Cavalot, A. Balbo and M. Trovati: Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect. Thromb Res, 105(1), 71-8 (2002) (Pubitemid 34178311)
231. G. Anfossi, I. Russo, P. Massucco, L. Mattiello and M. Trovati: Catecholamines, via beta-adrenoceptors, increase intracellular concentrations of 3′,5′-cyclic guanosine monophosphate (cGMP) through nitric oxide in human platelets. Thromb Haemost, 87(3), 539-40 (2002) (Pubitemid 34232500)
232. I. Russo, G. Doronzo, L. Mattiello, A. De Salve, M. Trovati and G. Anfossi: The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMPactivated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents. Thromb Res, 114(4), 265-73 (2004) (Pubitemid 39286012)
233. I. Fleming, C. Schulz, B. Fichtlscherer, B. E. Kemp, B. Fisslthaler and R. Busse: AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost, 90(5), 863-71 (2003) (Pubitemid 37427856)
234. M. Trovati, P. Massucco, L. Mattiello, V. Piretto, F. Cavalot, E. Mularoni and G. Anfossi: The insulin-induced increase of guanosine-3′, 5′-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes, 45(6), 768-70 (1996)
235. B. Fisslthaler, T. Benzing, R. Busse and I. Fleming: Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1. Nitric Oxide, 8(4), 253-61 (2003) (Pubitemid 36937112)
236. R. Riba, M. Sharifi, R. W. Farndale and K. M. Naseem: Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen. Thromb Haemost, 94(2), 395-403 (2005) (Pubitemid 41122495)
237. F. Lantoine, A. Brunet, F. Bedioui, J. Denynck and M. Devynck: Direct measurement of nitric oxide production in platelets: Relationshio with cytosolic Ca concentration. Biochemical and Biophysical Research Communications., 215(3), 842-848 (1995)
238. Goubareva I, Gkaliagkousi E, Shah A, Queen L, Ritter J and F. A.: Age decreases nitric oxide synthesis and responsiveness in human platelets and increases formation of monocyte-platelet aggregates. Cardiovascular Research, 75, 793-802. (2007) (Pubitemid 47238740)
239. Wu Y, Liu Y, Han Y, Cui B, Mi Q, Huang Y, Wang L, Jiang Q, Chen Q, Liu N, Ferro A and Ji Y.: Pyridoxine increases nitric oxide biosynthesis in human platelets. Int J Vitam Nutr Res., 79(2), 95-103. (2009)
240. O'Kane P, Xie L, Liu Z, Queen L, Jackson G, Ji Y and Ferro A.: Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity. Cardiovasc Res., 83(1), 123-30 (2009)
241. R. H. Williams and M. U. Nollert: Platelet-derived NO slows thrombus growth on a collagen type III surface. Thromb J, 2(1), 11 (2004)
242. J. E. Freedman, L. Li, R. Sauter and J. J. Keaney: alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. Faseb J, 14(15), 2377-9 (2000)
243. R. Riba, N. G. Oberprieler, W. Roberts and K. M. Naseem: von Willebrand factor activates endothelial nitric oxide synthase in blood platelets by a glycoprotein Ib-dependent mechanism. J Thromb Haemost, 4(12), 2636-44 (2006) (Pubitemid 44741560)
244. P. Massucco, L. Mattiello, I. Russo, M. Traversa, G. Doronzo, G. Anfossi and M. Trovati: High glucose rapidly activates the nitric oxide/cyclic nucleotide pathway in human platelets via an osmotic mechanism. Thromb Haemost, 93(3), 517-26 (2005) (Pubitemid 40392542)
245. J. A. Rosado and S. O. Sage: Protein kinase C activates non-capacitative calcium entry in human platelets. J Physiol, 529 Pt 1, 159-69 (2000)
246. Marcondes S, Cardoso MH, Morganti RP, Thomazzi SM, Lilla S, Murad F, De Nucci G and A. E.: Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: a role for alpha-actinin nitration. Proc Natl Acad Sci U S A., 103(9), 3434-9. (2006) (Pubitemid 43346486)
247. Irwin C, Roberts W and N. KM.: Nitric oxide inhibits platelet adhesion to collagen through cGMPdependent and independent mechanisms: the potential role for S-nitrosylation. Platelets., 20(7), 478-86. (2009)
248. V. Mollace, D. Salvemini and J. Vane: Studies on the importance of the proposed release of nitric oxide from platelets. Thromb Res, 64(5), 533-42 (1991)
249. R. F. Storey and S. Heptinstall: Laboratory investigation of platelet function. Clin Lab Haematol, 21(5), 317-29 (1999) (Pubitemid 30007093)
250. Gkaliagkousi E, Corrigall V, Becker S, de Winter P, Shah A, Zamboulis C, Ritter J and F. A.: Decreased platelet nitric oxide contributes to increased circulating monocyteplatelet aggregates in hypertension. Eur Heart J. (2009)
251. A. D. Michelson, M. R. Barnard, L. A. Krueger, C. R. Valeri and M. I. Furman: Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation, 104(13), 1533-7 (2001) (Pubitemid 32917347)
252. A. Celi, G. Pellegrini, R. Lorenzet, A. De Blasi, N. Ready, B. C. Furie and B. Furie: P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci U S A, 91(19), 8767-71 (1994)
253. L. S. Fernandes, I. D. Conde, C. Wayne Smith, G. S. Kansas, K. R. Snapp, N. Bennet, C. Ballantyne, L. V. McIntire, E. O'Brian Smith, J. A. Klem, S. Mathew, N. Frangogiannis, N. A. Turner, K. J. Maresh and N. S. Kleiman: Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting. Thromb Res, 111(3), 171-7 (2003) (Pubitemid 37532856)
254. A. W. Chung, A. Radomski, D. Alonso-Escolano, P. Jurasz, M. W. Stewart, T. Malinski and M. W. Radomski: Platelet-leukocyte aggregation induced by PAR agonists: regulation by nitric oxide and matrix metalloproteinases. Br J Pharmacol, 143(7), 845-855 (2004) (Pubitemid 39664843)
255. A. J. Lusis: Atherosclerosis. Nature, 407(6801), 233-41 (2000)
256. M. D. Iafrati, O. Vitseva, K. Tanriverdi, P. Blair, S. Rex, S. Chakrabarti, S. Varghese and J. E. Freedman: Compensatory mechanisms influence hemostasis in setting of eNOS deficiency. Am J Physiol Heart Circ Physiol, 288(4), H1627-32 (2005) (Pubitemid 40417985)
257. Z. Li, X. Xi, M. Gu, R. Feil, R. Ye, M. Eigenthaler, F.Hofmann and X. Du: A stimulatory role for cGMPdependent protein kinase in platelet activation. Cell, 112(1), 77-86 (2003) (Pubitemid 36106420)
258. Z. Li, G. Zhang, J. A. Marjanovic, C. Ruan and X. Du: A platelet secretion pathway mediated by cGMP-dependent protein kinase. J Biol Chem, 279(41), 42469-75 (2004) (Pubitemid 39372130)
259. J. E. Freedman, B. Ting, B. Hankin, J. Loscalzo, J. F. Keaney, Jr. and J. A. Vita: Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation, 98(15), 1481-6 (1998) (Pubitemid 28481663)
260. K. Ichiki, H. Ikeda, N. Haramaki, T. Ueno and T. Imaizumi: Long-term smoking impairs platelet-derived nitric oxide release. Circulation, 94(12), 3109-14 (1996) (Pubitemid 26427475)
261. H. Ikeda, Y. Takajo, T. Murohara, K. Ichiki, H. Adachi, N. Haramaki, A. Katoh and T. Imaizumi: Plateletderived nitric oxide and coronary risk factors. Hypertension, 35(4), 904-7 (2000) (Pubitemid 30303948)
262. L. Y. Chen, P. Mehta and J. L. Mehta: Oxidized LDL decreases L-arginine uptake and nitric oxide synthase protein expression in human platelets: relevance of the effect of oxidized LDL on platelet function. Circulation, 93(9), 1740-6 (1996)
263. S. Yokoyama, H. Ikeda, N. Haramaki, H. Yasukawa, A. Katoh and T. Imaizumi: HMG-CoA reductase inhibitor protects against in vivo arterial thrombosis by augmenting platelet-derived nitric oxide release in rats. J Cardiovasc Pharmacol, 45(4), 375-81 (2005) (Pubitemid 40411295)
264. A. Camilletti, N. Moretti, G. Giacchetti, E. Faloia, D. Martarelli, F. Mantero and L. Mazzanti: Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients. Am J Hypertens, 14(4 Pt 1), 382-6 (2001)
265. M. P. Schlaich, M. M. Parnell, B. A. Ahlers, S. Finch, T. Marshall, W. Z. Zhang and D. M. Kaye: Impaired Larginine transport and endothelial function in hypertensive and genetically predisposed normotensive subjects. Circulation, 110(24), 3680-6 (2004) (Pubitemid 39665257)
266. Goubareva I, Gkaliagkousi E, Shah A, Queen L, Ritter J and F. A.: Age decreases nitric oxide synthesis and responsiveness in human platelets and increases formation of monocyte-platelet aggregates. Cardiovascular Research (2007)
267. S. Chakrabarti, P. Clutton, S. Varghese, D. Cox, M. A. Mascelli and J. E. Freedman: Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release. Thromb Res, 113(3-4), 225-33 (2004) (Pubitemid 38609408)
268. P. D. O'Kane, L. R. Queen, Y. Ji, V. Reebye, P. Stratton, G. Jackson and A. Ferro: Aspirin modifies nitric oxide synthase activity in platelets: effects of acute versus chronic aspirin treatment. Cardiovasc Res, 59(1), 152-9 (2003) (Pubitemid 36776381)