Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults

Journal of Clinical Investigation

Volumn 97, Issue 8, 1996, Pages 1989-1994

  Clarkson, Peter ^a   Adams, Mark R ^b   Powe, Amanda J ^a   Donald, Ann E ^a   McCredie, Robin ^b   Robinson, Jacqui ^b   McCarthy, Susan N ^a   Keech, Anthony ^b   Celermajer, David S ^b   Deanfield, John E ^a  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

atherosclerosis; cholesterol; nitric oxide; nitrosoprotein; vascular ultrasound

Indexed keywords

ARGININE;

ADULT; ARTERY DIAMETER; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; HUMAN; HYPERCHOLESTEROLEMIA; PRIORITY JOURNAL; RABBIT; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 15844389652     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118632     Document Type: Article

References (45)

1. Anderson, K.M., W.P. Castelli, and D. Levy. 1987. Cholesterol and mortality 30 years of follow-up from the Framingham study. J. Am Med. Assoc 257:2176-2180.
2. Ross, R. 1993. The pathogenesis of atherosclerosis a perspective for the 1990s. Nature (Lond.). 362:801-809.
3. Palmer, R.M., A.G. Ferrige, and S. Moncada. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond.). 327:524-526.
4. Cooke, J.P., and P.S. Tsao. 1994. Is NO an anti-atherogenic molecule? Arterioscler. Thromb. 14:653-655.
5. Creager, M A., J P. Cooke, M.E. Mendelsohn, S.J. Gallagher, S.M. Coleman, J. Loscalzo, and V.J. Dzau. 1990. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J. Clin. Invest. 86:228-234.
6. Sorensen, K E., D.S. Celermajer, D. Georgakopoulous, G. Hatcher, D.J. Betteridge, and J.E. Deanfield. 1994. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J. Clin. Invest. 93:50-55.
7. Casino, P.R., C.M. Kilcoyne, A.A. Quyyumi, J.M. Hoeg, and J.A. Panza. 1993. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation. 88:2541-2547.
8. Palmer, R M., D.S. Ashton, and S. Moncada. 1988. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (Lond.). 333:664-666
9. Tsao, P.S., G. Theilmeier, A.H. Singer, L.L. Leung, and J.P. Cooke. 1994 L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler. Thromb. 14:1529-1533.
10. Tsao, P S., L.M. McEvoy, H. Drexler, E.C. Butcher, and J.P. Cooke. 1994. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation. 89:2176-2182.
11. Cooke, J.P., A.H. Singer, P Tsao, P. Zera, R.A. Rowan, and M.E. Billingham. 1992 Anti-atherogenic effects of L-arginine in the hypercholesterolemic rabbit. J. Clin. Invest. 90:1168-1172.
12. Wang, B.Y., A H. Singer, P.S. Tsao, H Drexler, J. Kosek, and J.P. Cooke. 1994. Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit J. Am. Coll. Cardiol. 23:452-458.
13. Creager, M.A., S.J. Gallagher, X.J. Girerd, S.M Coleman, V.J Dzau, and J.P. Cooke. 1992. L-argmine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 90:1248-1253.
14. Drexler, H., A.M Zeiher, K. Meinzer, and H. Just. 1991. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet. 338:1546-1550.
15. Sorensen, K E., D S. Celermajer, D.J. Spiegelhalter, J. Robinson, and J.E. Deanfield. 1995. Non-invasive measurement of endothelium-dependent arterial responses in man: accuracy and reproducibility Br. Heart J. 74:347-253.
16. Celermajer, D.S., K.E. Sorensen, V.M. Gooch, D.J. Spiegelhalter, O.I. Miller, I.D. Sullivan, J.K. Lloyd, and J.E. Deanfield. 1992. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 340:1111-1115.
17. Joannides, R., W.E. Haefeli, L. Linder, V. Richard, E.H. Bakkali, C. Thuillez, and T.F. Luscher. 1995 Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 91:1314-1319.
18. Anderson, T.J., A Uehata, M.D. Gerhard, I.T. Meredith, S. Knab, D. Delagrange, E.H. Lieberman, P. Ganz, M.A. Creager, A.C. Yeung, and A.P. Selwyn. 1995. Close relationship of endothelial function in the human coronary and peripheral circulations. J. Am Coll Cardiol. 26(4):1235-1241.
19. Friedwald, W.T., R.I. Levi, and D.S. Fredrickson. 1958. Estimation of the concentration of low density lipoprotein cholesterol in the plasma without the use of the preparative ultracentrifuge. Clin. Chem. 18:499-502.
20. Stamler, J.S., O. Jaraki, and J. Osborne 1992. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin Proc. Natl. Acad. Sci.L USA. 89:7674-7677.
21. Wennmalm, A., G. Benthin, and A. Edlund. 1993. Metabolism and excretion of nitric oxide in humans. Circ. Res. 73:11121-11127.
22. Saville, B. 1958. A scheme for the colorimetric determination of the microgram amounts of thiols. Analyst. 83 670-672.
23. Sonn, S. 1993. Cross over trials in clinical research John Wiley & Sons Ltd. Chichester, UK. 56pp.
24. Hochberg, Y. 1988. A sharper Bonferroni procedure for multiple tests of significance. Biometrika, 75:800-802
25. Girerd, X.J , A.T. Hirsch, J.P. Cooke, V.J Dzau, and M.A. Creager. 1990. L-arginine augments endothelium-dependent vasodilation in cholesterolfed rabbits. Circ. Res. 67:1301-1308.
26. Cooke, J P., N.A. Andon, X.J. Girerd, A.T. Hirsch, and M.A. Creager. 1991. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta [see comments]. Circulation. 83:1057-1062.
27. Rossitch, E , Jr., E. Alexander, P.M. Black, and J.P. Cooke. 1991. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J Clin. Invest. 87:1295-1299.
28. Hirooka, Y., K. Egashira, T. Imaizumi, T. Tagawa, H. Kai, M. Sugimachi, and A. Takeshita. 1994. Effect of L-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans. J. Am Coll. Cardiol. 24:948-955.
29. Kuo, L., M.J. Davis, M.S. Cannon, and W.M. Chilian. 1992 Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation Restoration of endothelium-dependent responses by L-arginine. Circ Res 70:465-476.
30. Celermajer, D.S., K.E. Sorensen, D. Georgakopoulos, C. Bull, O. Thomas, J. Robinson, and J.E. Deanfield. 1993. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 88:2149-2155.
31. Rubanyi, G.M , J.C. Romero, and P.M. Vanhoutte. 1986. Flow-induced release of endothelium-derived relaxing factor. Am. J. Physiol. 250:H1145-1149.
32. Ohno, M., G.H Gibbons, V.J. Dzau, and J.P. Cooke. 1993. Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. Circulation 88:193-197.
33. Ohara, Y., T.E. Peterson, and D.G. Harrison. 1993. Hypercholesterolemia increases endothelial superoxide anion production. J. Clin Invest 91: 2546-2551.
34. Adams, M.R., C.J. Forsyth, W Jessup, J. Robinson, and D.S. Celermajer. 1995. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young adults J. Am Coll. Cardiol. 26(4):1054-1061.
35. Galle, J., J. Bengen, P. Schollmeyer, and C. Wanner. 1995. Impairment of endothelium-dependent dilation in rabbit renal arteries by oxidized lipoprotein (a). Circulation. 96:1582-1589
36. Hecker, M., W.C. Sessa, H J. Harris, E.E. Anggard, and J.R. Vane 1990. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. USA. 87:8612-8616.
37. Arnal, J.F., T. Munzel, R.C. Venema, N.L. James, C.L. Bai, W.E. Mitch, and D.G. Harrison. 1995 Interactions between L-arginine and L-glutamine change endothelial NO production. J. Clin. Invest. 95:2565-2572
38. Kharitonov, A., G. Lubec, B. Lubec, M. Hjelm, and P.J. Barnes. 1995 L-arginine increases exhaled nitric oxide in normal human subjects. Clin Sci 88:135-139.
39. Besset, A , A. Bonardet, G. Rondouin, B. Descomps, and P. Passouant. 1982. Increase in sleep related GH and PrI secretion after chronic arginine aspartate administration in man. Acta Endocrinol. (Copenh). 99 (1):18-23.
40. Elsair, J., K Khelfat, A Ghouini, and F. Ikhlef. 1985. Effects of arginine, administered orally, on the endogenous secretion of the STH-somatomedin complex in young human volunteers. CR Seances Soc. Biol. Fil. 179 (5):608-614
41. Isidori, A., A Lo Monaco, and M. Cappa. 1981. A study of growth hormone release in man after oral administration of amino acids. Curr. Med Res Opin. 7(7):475-481.
42. Hayde, M , H. Vierhapper, B. Lubec, C. Popow, M. Weninger, Z Xi, and G. Lubec. 1994 Low-dose dietary L-arginine increases plasma interleukin 1 alpha but not interleukin 1 beta in patients with diabetes mellitus. Cytokine Jan,6(1):79-82.
43. Daly, J.M , J. Reynolds, A. Thom, L. Kinsley, M. Dietrick-Gallagher, J Shou, and B. Ruggieri 1988. Immune and metabolic effects of Arginine in the surgical patient. Ann. Surg. 208:512-523.
44. Philis-Tsimakis, A., and J L Witztum. 1995. L-arginine may inhibit atherosclerosis through inhibition of LDL oxidation (abstract). Circulation. 92 (Suppl 1):I-422-423.
45. Poston, L., and P. Taylor. 1995. Impairment of endothelium-dependent vascular reactivity in insulin dependent diabetes mellitus. Clin. Sci. 88:245-255.