Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: Tetrahydrobiopterin binding kinetics and role of haem in dimerization

Biochemical Journal

Volumn 323, Issue 1, 1997, Pages 159-165

  List, Barbara M ^a   Klösch, Burkhard ^a   Völker, Christof ^a   Gorren, Antonius C F ^a   Sessa, William C ^b   Werner, Ernst R ^c   Kukovetz, Walter R ^a   Schmidt, Kurt ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Institute for Ion Physics and Applied Physics   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; HEME; NITRIC OXIDE SYNTHASE; RADIOLIGAND; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CATTLE; DIMERIZATION; DISSOCIATION; DOWN REGULATION; ENDOTHELIUM CELL; GEL ELECTROPHORESIS; GEL FILTRATION CHROMATOGRAPHY; HYDRODYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

EID: 0030948345     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3230159     Document Type: Article

References (60)

1. Masters, B. S. S. (1994) Annu. Rev. Nutr. 14, 131-145
2. Griffith, O. W. and Stuehr, D. J. (1995) Annu. Rev. Physiol. 57, 707-736
3. Mayer, B. (1995) in Nitric Oxide in the Nervous System (Vincent, S. R., ed.), pp. 21-42, Academic Press, New York
4. Narhi, L. O. and Fulco, A. J. (1986) J. Biol. Chem. 261, 7160-7169
5. Mayer, B. and Werner, E. R. (1995) Naunyn-Schmiedeberg's Arch. Pharmacol. 351, 453-463
6. Mayer, B., John, M., Heinzel, B., Werner, E. R., Wachter, H., Schultz, G. and Böhme, E. (1991) FEBS Lett. 288, 187-191
7. Heinzel, B., John, M., Klatt, P., Böhme, E. and Mayer, B. (1992) Biochem. J. 281, 627-630
8. Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H. and Rosen, G. M. (1992) J. Biol. Chem. 267, 24173-24176
9. Culcasi, M., Lafon-Cazal, M., Pietri, S. and Bockaert, J. (1994) J. Biol. Chem. 269, 12589-12593
10. Mayer, B., Heinzel, B., Klatt, P., John, M., Schmidt, K. and Böhme, E. (1992) J. Cardiovasc. Pharmacol. 20, S54-S56
11. Abu-Soud, H. M. and Stuehr, D. J. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 10769-10772
12. Olken, N. M. and Marietta, M. A. (1993) Biochemistry 32, 9677-9685
13. Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F. and Nathan, C. F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7773-7777
14. Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U. and Murad, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 365-369
15. Klatt, P., Schmidt, K., Lehner, D., Glatter, O., Bächinger, H. P. and Mayer, B. (1995) EMBO J. 14, 3687-3695
16. Lee, C. M., Robinson, L. J. and Michel, T. (1995) J. Biol. Chem. 270, 27403-27406
17. Baek, K. J., Thiel, B. A., Lucas, S. and Stuehr, D. J. (1993) J. Biol. Chem. 268, 21120-21129
18. Tzeng, E., Billiar, T. R., Bobbins, P. D., Loftus, M. and Stuehr, D. J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 11771-11775
19. Albakri, Q. A. and Stuehr, D. J. (1996) J. Biol. Chem. 271, 5414-5421
20. List, B. M., Klatt, P., Werner, E. R., Schmidt, K. and Mayer, B. (1996) Biochem. J. 315, 57-63
21. Klatt, P., Pfeiffer, S., List, B. M., Lehner, D., Glatter, O., Werner, E. R., Schmidt, K. and Mayer, B. (1996) J. Biol. Chem. 271, 7336-7342
22. Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M. and Murad, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 10480-10484
23. Lamas, S., Marsden, P. A., Li, G. K., Tempst, P. and Michel, T. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6348-6352
24. Sessa, W. C., Harrison, J. K., Barber, C. M., Zeng, D., Durieux, M. E., Dangelo, D. D., Lynch, K. R. and Peach, M. J. (1992) J. Biol. Chem. 267, 15274-15276
25. Marsden, P. A., Schappert, K. T., Chen, H. S., Flowers, M., Sundell, C. L., Wilcox, J. N., Lamas, S. and Michel, T. (1992) FEBS Lett. 307, 287-293
26. Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S. P., Uematsu, M., Nerem, R. M., Alexander, R. W. and Murphy, T. J. (1992) J. Clin. Invest. 90, 2092-2096
27. Sessa, W. C., Barber, C. M. and Lynch, K. R. (1993) Circ. Res. 72, 921-924
28. Busconi, L. and Michel, T. (1993) J. Biol. Chem. 268, 8410-8413
29. Liu, J. W. and Sessa, W. C. (1994) J. Biol. Chem. 269, 11691-11694
30. Obrien, A. J., Young, H. M., Povey, J. M. and Furness, J. B. (1995) Histochem. Cell Biol. 103, 221-225
31. Sessa, W. C., Garcia-Cardena, G., Liu, J. W., Keh, A., Pollock, J. S., Bradley, J., Thiru, S., Braverman, I. M. and Desai, K. M. (1995) J. Biol. Chem. 270, 17641-17644
32. Garcia-Cardena, G., Oh, P., Liu, J., Schnitzer, J. S. and Sessa, W. C. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 6448-6453
33. Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y. S., Anderson, R. G. W. and Michel, T. (1996) J. Biol. Chem. 271, 6518-6522
34. Liu, J. W., Garcia-Cardena, G. and Sessa, W. C. (1995) Biochemistry 34, 12333-12340
35. Robinson, L. J., Busconi, L. and Michel, T. (1995) J. Biol. Chem. 270, 995-998
36. Werner, E. R., Schmid, M., Werner-Felmayer, G., Mayer, B. and Wachter, H. (1994) Biochem. J. 304, 189-193
37. Harteneck, C., Klatt, P., Schmidt, K. and Mayer, B. (1994) Biochem. J. 304, 683-686
38. Mayer, B., List, B. M., Klatt, P., Harteneck, C. and Schmidt, K. (1996) Methods Enzymol. 268, 420-427
39. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
40. Klatt, P., Schmidt, K., Werner, E. R. and Mayer, B. (1996) Methods Enzymol. 268, 358-365
41. Mayer, B., Klatt, P., Harteneck, C., List, B. M., Werner, E. R. and Schmidt, K. (1996) Methods Neurosci. 31, 130-139
42. Mayer, B., Klatt, P., Werner, E. R. and Schmidt, K. (1994) Neuropharmacology 33, 1253-1259
43. Klatt, P., Heinzel, B., John, M., Kastner, M., Böhme, E. and Mayer, B. (1992) J. Biol. Chem. 267, 11374-11378
44. Brunner, F. and Kukovetz, W. R. (1991) Br. J. Pharmacol. 102, 373-380
45. Laemmli, U. K. (1970) Nature (London) 227, 680-685
46. Thomas, P. E., Ryan, D. and Levin, W. (1976) Anal. Biochem. 75, 168-176
47. Seo, H. G., Fujii, J., Soejima, H., Niikawa, N. and Taniguchi, N. (1995) Biochem. Biophys. Res. Commun. 208, 10-18
48. Busconi, L. and Michel, T. (1995) Mol. Pharmacol. 47, 655-659
49. Venema, R. C., Sayegh, H. S., Arnal, J. F. and Harrison, D. G. (1995) J. Biol. Chem. 270, 14705-14711
50. Chen, P. F., Tsai, A. L. and Wu, K. K. (1995) Biochem. Biophys. Res. Commun. 215, 1119-1129
51. Martasek, P., Liu, Q., Liu, J., Roman, L. J., Gross, S. S., Sessa, W. C. and Masters, B. S. S. (1996) Biochem. Biophys. Res. Commun. 219, 359-365
52. Rodriguez-Crespo, I., Gerber, N. C. and Ortiz de Montellano, P. R. (1996) J. Biol. Chem. 271, 11462-11467
53. Wolff, D. J., Lubeskie, A. and Umansky, S. (1994) Arch. Biochem. Biophys. 314, 360-366
54. Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R. and Mayer, B. (1994) J. Biol. Chem. 269, 13861-13866
55. Klaff, P., Schmidt, K., Uray, G. and Mayer, B. (1993) J. Biol. Chem. 268, 14781-14787
56. Mayer, B., Klatt, P., Werner, E. R. and Schmidt, K. (1995) J. Biol. Chem. 270, 655-659
57. Cosentino, F. and Katusic, Z. S. (1995) Circulation 91, 139-144
58. Pritchard, K. A., Groszek, L., Smalley, D. M., Sessa, W. C., Wu, M. D., Villalon, P., Wolin, M. S. and Stemerman, M. B. (1995) Circ. Res. 77, 510-518
59. Huang, Z. H., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C. and Moskowitz, M. A. (1994) Science 265, 1883-1885
60. Huang, Z. H., Huang, P. L., Ma, J. Y., Meng, W., Ayata, C., Fishman, M. C. and Moskowitz, M. A. (1996) J. Cereb. Blood Flow Metab. 16, 981-987