Nitric oxide generation mediated by β-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus

Diabetologia

Volumn 46, Issue 11, 2003, Pages 1474-1482

  Queen, L R ^a,b   Ji, Y ^a   Goubareva, I ^a   Ferro, A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

adrenoceptors; Cyclic GMP; Nitric oxide; Nitric oxide synthase; Platelets; Type 2 diabetes mellitus

Indexed keywords

ADENYLATE CYCLASE; ARGININE; BETA ADRENERGIC RECEPTOR; CHOLESTEROL; CITRULLINE; CYCLIC GMP; DICLOFENAC; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXAZOSIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FORSKOLIN; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOPRENALINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; NITRIC OXIDE; SIMVASTATIN; TRIACYLGLYCEROL; TRITIUM;

ADULT; ARTICLE; ATHEROSCLEROSIS; BIOSYNTHESIS; CELL CULTURE; CELL ISOLATION; CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOIMMUNOASSAY; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOSIS; WESTERN BLOTTING;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BLOOD GLUCOSE; BLOOD PLATELETS; CHOLESTEROL; CYCLIC GMP; DIABETES MELLITUS, TYPE 2; FEMALE; GLYBURIDE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECEPTORS, ADRENERGIC, BETA; REGRESSION ANALYSIS; TRIGLYCERIDES;

EID: 0344255514     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1219-0     Document Type: Article

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