Oxidized LDL Decreases L-Arginine Uptake and Nitric Oxide Synthase Protein Expression in Human Platelets: Relevance of the Effect of Oxidized LDL on Platelet Function

Circulation

Volumn 93, Issue 9, 1996, Pages 1740-1746

  Chen, L Y ^a   Mehta, P ^a,b   Mehta, J L ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Amino acids; Lipoproteins; Platelets; Vasoconstriction; Vasodilation

Indexed keywords

ARGININE; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE SYNTHASE;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; LIPOPROTEIN METABOLISM; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; VASOCONSTRICTION; VASODILATATION;

ARGININE; BLOOD PLATELETS; BLOTTING, WESTERN; CELL SURVIVAL; CHOLESTEROL; CYCLIC GMP; HUMANS; LIPOPROTEINS, LDL; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION;

EID: 0029873036     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.9.1740     Document Type: Article

References (40)

1. Palinski W, Rosenfeld ME, Herttuala SY, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1376.
2. Moncada S, Higgs E, Palmer R. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
3. Chin JH, Azhar S, Hoffman BB. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J Clin Invest. 1992;89:10-18.
4. Kugiyama K, Kerns SA, Morrisett JD, Roberts R, Henry PD. Impairment of endothclium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature. 1990;344: 160-162.
5. Russell R. The pathogcnesis of atherosclerosis: a perspective tor the 1990s. Nature. 1993;362:801-809.
6. Aviram M, Brook JG. The effect of human plasma on platelet function in familial hypercholesterolemia. Thromb Res. 1982;26: 101-109.
7. Carvallho ACA, Colman RW, Lees RS. Platelet function in hyperlipoproteinemia. N Engl J Med. 1974;290:434-438.
8. Hassall DG, Owen JS, Bruckdorfer KR. The aggregation of isolated human platelets in the presence of lipoproteins and prostacyclin. Biochem J. 1983;216:43-49.
9. Koller E, Vukovich T, Doleschel W, Auerswald W. The influence of lipoproteins on ADP-induced platelet aggregation. Atherogenase. 1979;4(suppl IV):53-58.
10. Fuhrman B, Brook GJ, Aviram M. Activated platelets secrete a protein-like factor that stimulates oxidized-LDL receptor activity in macrophages. J Lipid Res. 1991;32:1113-1123.
11. Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ. Evidence for the inhibitory role of guanosme 3′,5′-monophosphatc in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood. 1981;57: 946-955.
12. Durante W, Kroll MH, Vanhoutte PM, Schafer AI. Endothelium-derived relaxing factor inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C. Blood. 1992;79: 110-116.
13. Nakane M, Schmidt HHHW, Pollock JS, Forstermann U, Murad F. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett. 1993;316:175-180.
14. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 1992;267: 14519-14522.
15. Mehta JL, Chen LY, Mehta P, Kone BC, Turner P. Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J Lab Clin Med. 1995;125:370-377.
16. Fisher WR. Heterogeneity of plasma low density lipoproteins manifestation of the physiologic phenomenon in man. Metabolism. 1983;32:283-291.
17. Steinbrecher VP, Witztum JL, Parthasarathy S, Steinberg D. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Arteriosclerosis. 1987;7:135-143.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal biochem. 1976;72:248-254.
19. Chen LY, Mehta JL. Lys- and glu-plasminogen potentiate the inhibitory effect of recombinant tissue plasminogen activator on human platelet aggregation. Thromb Res. 1994;74:555-563.
20. Nicolini FA, Wilson AC, Mehta P, Mehta JL. Comparative platelet inhibitory effects of human neutrophils and lymphocytes. J Lab Clin Med. 1990;116:147-152.
21. Zlatski A, Zak B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med. 1953;41:486-492.
22. Rose HG, Oklander M. Improved procedure for the extraction of lipids from human erythrocytes. J Lipid Res. 1965;6:428-431.
23. Chen LY, Mehta JL. Inhibitory effect of high density lipoprotein on platelet function is mediated by increase in nitric oxide synthase activity in platelets. Life Sci. 1994;55:1815-1821.
24. 15N]nitrate in biological fluids. Anal Biochem. 1982;126:131-138.
25. Pedreño J, de Castellarnau C, Sánchez J, Gómez-Gerique J, Ordóñez-LIanos J, González-Sastre F. LDL binding sites on platelets differ from the 'classical' receptor of nucleated cells. Arterioscler Thromb. 1992;12:1353-1362.
26. Shmulewitz A, Brook JG, Aviram M. Native and modified low-density-lipoprotein interaction with human platelets in normal and homozygous familial-hypercholesterolemic subjects. Biochem J. 1984;224:13-20.
27. Aviram M, Brook JCT. Platelet interaction with high and low density lipoproteins. Atherosclerosis. 1983;46:259-263.
28. Chatterjee S. Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation. Mol Cell Biochem. 1992;111:143-147.
29. Hassall DG, Bruckdorfer KR. Platelet low-density lipoprotein receptors. Biochem Soc Trans. 1985;13:1189-1190.
30. Tanner FC, Noll G, Boulanger CM, Lüscher TF. Oxidized low-density lipoproteins inhibit relaxations of porcine coronary arteries. Circulation. 1991;83:2012-2020.
31. Plane F, Bruckdorfer KR, Kerr P, Steuer A, Jacobs M. Oxidative modification of low-density lipoproteins and the inhibition of relaxations mediated by endothelium-derived nitric oxide in rabbit aorta. Br J Pharmacol. 1992;105:216-222.
32. Bereta M, Bereta J, Cohen S, Cohen MC. Low density lipoprotein inhibits accumulation of nitrites in murine brain endothelial cell cultures. Biochem Biophys Res Commun. 1992;186:315-320.
33. Yang X, Cai B, Sciacca RR, Cannon PJ. Inhibition of inducible nitric oxide synthase in macrophages by oxidized low-density lipoproteins. Circ Res. 1994;74:318-328.
34. Liao JK, Shin WS, Lee WY, Clark SL. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem. 1995;270:319-324.
35. + RNA. Biochem Biophys Res Commun. 1989;160:705-710.
36. Aviram M, Fuhrman B, Keidar S, Maor I, Rosenblat M, Dankner G, Brook G. Platelet-modified low density lipoprotein induces macrophage cholesterol accumulation and platelet activation. J Clin Chem Clin Biochem. 1989;27:3-12.
37. Esterbauer H, Jurgens G, Quehenberger O, Koller E. Autooxidation of human LDL: loss of polyunsaturated fatty acid, vitamin E and generation of aldehydes. J Lipid Res. 1987;28:495-509.
38. Gardaz JP, Py P, Suter PM, Junod AA. Effects of oleic acid-, alpha-naphthylthiourea-, and phorbol myristate-induced microvascular damage on indexes of pulmonary endothelium function in anesthetized dogs. Am Rev Respir Dis. 1988;137:1350-1355.
39. Creager MA, Gallagher SJ, Girard XJ, Coleman SM, Dzau VJ, Cooke JP. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest. 1992;90: 1248-1253.
40. Stuart MJ, Gerrard JM, White JG. Effect of cholesterol on production of thromboxane B2 by platelets in vitro. N Engl J Med. 1980; 302:6-10.