Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 1, 2006, Pages

  Kondrikov, Dmitry ^a   Han, Hye Rim ^a   Block, Edward R ^a,b   Su, Yunchao ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Endothelium; Nitric oxide; Proliferation; Regeneration

Indexed keywords

ACTIN; BETA ACTIN; CYTOCHALASIN D; ENDOTHELIAL NITRIC OXIDE SYNTHASE; F ACTIN; G ACTIN; JASPAMIDE; NITRIC OXIDE SYNTHASE; SMALL INTERFERING RNA; TRITON X 100; DEPSIPEPTIDE; NUCLEIC ACID SYNTHESIS INHIBITOR;

ACTIN FILAMENT; ANGIOGENESIS; ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CELL DENSITY; CELL GROWTH; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; ANIMAL; CELL COUNT; CELL CULTURE; CELL DIVISION; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYMOLOGY; GENE SILENCING; GENETICS; HUMAN; IMMUNOPRECIPITATION; METABOLISM; PHYSIOLOGY; SWINE; TISSUE DISTRIBUTION; TWO HYBRID SYSTEM; YEAST;

ACTINS; ANIMALS; CELL COUNT; CELL DIVISION; CELLS, CULTURED; CYTOCHALASIN D; CYTOSKELETON; DEPSIPEPTIDES; ENDOTHELIAL CELLS; GENE SILENCING; HUMANS; IMMUNOPRECIPITATION; NITRIC OXIDE SYNTHASE TYPE III; NUCLEIC ACID SYNTHESIS INHIBITORS; PULMONARY ARTERY; SWINE; TISSUE DISTRIBUTION; TWO-HYBRID SYSTEM TECHNIQUES; YEASTS;

EID: 33644803628     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00444.2004     Document Type: Article

References (29)

1. Arnal JF, Yamin J, Dockery S, and Harrison DG. Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am J Physiol Cell Physiol 267: C1381-C1388, 1994.
2. Babaei S and Stewart DJ. Overexpression of endothelial NO synthase induces angiogenesis in a co-culture model. Cardiovasc Res 55: 190-200, 2002.
3. Bayraktutan U. Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. J Mol Cell Cardiol 36: 277-286, 2004.
4. Dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, Berry DA, and Nosworthy NJ. Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol Rev 83: 433-473, 2003.
5. Dudek SM and Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91: 1487-1500, 2001.
6. Feng Y, Venema VJ, Venema RC, Tsai N, and Caldwell RB. VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase, and caveolin-1 in vascular endothelial cells. Biochem Biophys Res Commun 256: 192-197, 1999.
7. Fleming I and Busse R. Signal transduction of eNOS activation. Cardiovasc Res 43: 532-541, 1999.
8. Goligorsky MS, Li H, Brodsky S, and Chen J. Relationships between caveolae and eNOS: everything in proximity and the proximity of everything. Am J Physiol Renal Physiol 283: F1-F10, 2002.
9. Gonin S, Diaz-Latoud C, Richard MJ, Ursini MV, Imbo A, Manero F, and Arrigo AP. p53/T-antigen complex disruption in T-antigen transformed NIH3T3 fibroblasts exposed to oxidative stress: correlation with the appearance of a Fas/APO-1/CD95 dependent, caspase independent, necrotic pathway. Oncogene 18: 8011-8023, 1999.
10. Govers R, Bevers L, de Bree P, and Rabelink TJ. Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contacts. Biochem J 361: 193-201, 2002.
11. Huang PL. Endothelial nitric oxide synthase and endothelial dysfunction. Curr Hypertens Rep 5: 473-480, 2003.
12. Johnson AR. Human pulmonary endothelial cells in culture. Activities of cells from arteries and cells from veins. J Clin Invest 65: 841- 850, 1980.
13. Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Bohm M, Schoen FJ, Moskowitz MA, and Liao JK. Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest 106: 15-24, 2000.
14. Lee TY, Rosenthal A, and Gotlieb AI. Transition of aortic endothelial cells from resting to migrating cells is associated with three sequential patterns of microfilament organization. J Vasc Res 33: 13-24, 1996.
15. Li B and Fields S. Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system. FASEB J 7: 957-963, 1993.
16. Searles CD, Ide L, Davis ME, Cai H, and Weber M. Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. Circ Res 95: 488-495, 2004.
17. Stenmark KR and Mecham RP. Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 59: 89-144, 1997.
18. Su Y and Block ER. Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 278: L1204-L1212, 2000.
19. Su Y, Cao W, Han Z, and Block ER. Cigarette smoke extract inhibits angiogenesis of pulmonary artery endothelial cells: the role of calpain. Am J Physiol Lung Cell Mol Physiol 287: L794-L800, 2004.
20. Su Y, Edwards-Bennett S, Bubb MR, and Block ER. Regulation of endothelial nitric oxide synthase by the actin cytoskeleton. Am J Physiol Cell Physiol 284: C1542-C1549, 2003.
21. Su Y, Han W, Giraldo C, De Li Y, and Block ER. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol 19: 819-825, 1998.
22. Takemoto M, Sun J, Hiroki J, Shimokawa H, and Liao JK. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 106: 57-62, 2002.
23. Venema VJ, Marrero MB, and Venema RC. Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton. Biochem Biophys Res Commun 226: 703-710, 1996.
24. Whitney JA, German Z, Sherman TS, Yuhanna IS, and Shaul PW. Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 278: L131-L138, 2000.
25. Wong MK and Gotlieb AI. Endothelial cell monolayer integrity. I. Characterization of dense peripheral band of microfilaments. Arteriosclerosis 6: 212-219, 1986.
26. Zhang J, Patel JM, Li YD, and Block ER. Proinflammatory cytokines downregulate gene expression and activity of constitutive nitric oxide synthase in porcine pulmonary artery endothelial cells. Res Commun Mol Pathol Pharmacol 96: 71-87, 1997.
27. Zharikov SI, Krotova KY, Belayev L, and Block ER. Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-α activity. Am J Physiol Lung Cell Mol Physiol 286: L974-L983, 2004.
28. Zharikov SI, Sigova AA, Chen S, Bubb MR, and Block ER. Cytoskeletal regulation of the L-arginine/NO pathway in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 280: L465-L473, 2001.
29. Zollner S, Aberle S, Harvey SE, Polokoff MA, and Rubanyi GM. Changes of endothelial nitric oxide synthase level and activity during endothelial cell proliferation. Endothelium 7: 169-184, 2000.