Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo

Circulation

Volumn 117, Issue 15, 2008, Pages 1991-1996

  Seddon, Michael D ^a   Chowienczyk, Philip J ^a   Brett, Sally E ^a   Casadei, Barbara ^b   Shah, Ajay M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Blood flow; Endothelium; Nitric oxide; Nitric oxide synthase; Vasculature; Vasodilation

Indexed keywords

ACETYLCHOLINE; ARGININE; DEXTRO ARGININE; N(G) METHYLARGININE; NEURONAL NITRIC OXIDE SYNTHASE; S METHYLTHIOCITRULLINE;

ADULT; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; MENTAL STRESS; NORMAL HUMAN; PRIORITY JOURNAL; VASODILATATION;

ACETYLCHOLINE; ADULT; ARGININE; BRACHIAL ARTERY; CITRULLINE; FOREARM; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; OMEGA-N-METHYLARGININE; STRESS, PSYCHOLOGICAL; THIOUREA; VASODILATION; VASOMOTOR SYSTEM;

EID: 42149175901     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.744540     Document Type: Article

References (23)

1. Moncada S, Higgs EA. Nitric oxide and the vascular endothelium. Handbook Exp Pharmacol. 2006;176:213-254.
2. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;8670:997-1000.
3. Haynes WG, Noon JP, Walker BR, Webb DJ. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens. 1993;11:1375-1380.
4. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
5. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653-658.
6. Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, Ferraro A, Chello M, Mastroroberto P, Verdecchia P, Schillaci G. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001;104:191-196.
7. Vallance P. Nitric oxide in human hypertension: up, down or unaffected? Clin Sci (Lond). 1999;97:343-344.
8. Thomas GD, Sander M, Lau KS, Huang PL, Stull JT, Victor RG. Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proc Natl Acad Sci U S A. 1998;95:15090-15095.
9. Toda N, Okamura T. The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacol Rev. 2003;55:271-324.
10. Furfine ES, Harmon MF, Paith JE, Knowles RG, Salter M, Kiff RJ, Duffy C, Hazelwood R, Oplinger JA, Garvey EP. Potent and selective inhibition of human nitric oxide synthases: selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. J Biol Chem. 1994;269:26677-26683.
11. Dawes M, Chowienczyk PJ, Ritter JM. Quantitative aspects of the inhibition by NG-monomethyl- L-arginine of responses to endothelium-dependent vasodilators in human forearm vasculature. Br J Pharmacol. 2001;134:939-944.
12. Ichihara A, Inscho EW, Imig JD, Navar LG. Neuronal nitric oxide synthase modulates rat renal microvascular function. Am J Physiol. 1998;274:F516-F524.
13. Dietz NM, Rivera JM, Eggener SE, Fix RT, Warner DO, Joyner MJ. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol. 1994;480:361-368.
14. Cardillo C, Kilcoyne CM, Quyyumi AA, Cannon RO III, Panza JA. Role of nitric oxide in the vasodilator response to mental stress in normal subjects. Am J Cardiol. 1997;80:1070-1074.
15. Stroop JR. Studies of interferences in serial verbal reactions. J Exp Psychol. 1935;18:643-662.
16. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ, Ritter JM. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol. 2000;36:1233-1238.
17. Wakefield ID, March JE, Kemp PA, Valentin JP, Bennett T, Gardiner SM. Comparative regional haemodynamic effects of the nitric oxide synthase inhibitors, S-methyl-L-thiocitrulline and L-NAME, in conscious rats. Br J Pharmacol. 2003;139:1235-1243.
18. G-nitroarginine. Biochemistry. 1993;32:8512-8517.
19. Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation. 1999;99:1156-1160.
20. Woo KS, Chook P, Lolin YI, Cheung AS, Chan LT, Sun YY, Sanderson JE, Metreweli C, Celermajer DS. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation. 1997;96:2542-2544.
21. Brett SE, Jiang BY, Turner C, Ritter JM, Chowienczyk PJ. Elevation of plasma homocysteine by methionine loading increases the diastolic blood pressure response to exercise. J Hypertens. 2006;24:1985-1989.
22. Webb GD, Lim LH, Oh VM, El Oakley R, Lee CN, Wong PS, Aye WM, Chan ES, Moore PK. Expression of neuronal nitric oxide synthase in the internal thoracic artery and saphenous vein. J Thoracic Cardiovasc Surg. 2006;132:1131-1136.
23. Buchwalow IB, Podzuweit T, Bocker W, Samoilova VE, Thomas S, Wellner M, Baba HA, Robenek H, Schnekenburger J, Lerch MM. Vascular smooth muscle and nitric oxide synthase. FASEB J. 2002;16:500-508.