Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases

Journal of Biological Chemistry

Volumn 275, Issue 7, 2000, Pages 5179-5187

  Butt, Elke ^a   Bernhardt, Manfred ^b   Smolenski, Albert ^a   Kotsonis, Peter ^b   Fröhlich, Lothar G ^b   Sickmann, Albert ^c   Meyer, Helmut E ^c   Lohmann, Suzanne M ^a   Schmidt, Harald H H W ^b  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM ION; CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PHOSPHOAMINO ACID; PROSTACYCLIN;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CALMODULIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FLAVINS; HUMANS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0034681455     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.7.5179     Document Type: Article

References (54)

1. Sase, K., and Michel, T. (1997) Trends Clin. Med. 7, 28-35
2. Mayer, B., and Hemmens, B. (1997) Trends Biochem. Sci. 22, 477-481
3. Fleming, I., and Busse, R. (1999) Cardiovasc. Res. 43, 532-541
4. Raman, C. S., Li, H., Martasek, P., Kral, V., Masters, B. S. S., and Poulos, T. L. (1998) Cell 95, 939-950
5. Venema, R. C., Sayegh, H. S., Kent, J. D., and Harrison, D. G. (1996) J. Biol. Chem. 271, 6435-6440
6. Nathan, C. (1997) J. Clin. Invest. 100, 2417-2423
7. Ruan, J., Xie, Q., Hutchinson, N., Cho, H., Wolfe, G. C., and Nathan, C. (1996) J Biol. Chem. 271, 22679-22686
8. Michel, T., and Feron, O. (1997) J. Clin. Invest. 100, 2146-2152
9. Bömmel, H. M., Reif, A., Fröhlich, L. G., Frey, A., Hofmann, H., Maecak, D. M., Groehn, V., Kotsonis, P., La, M., Köster, S., Meinecke, M., Bernhardt, M., Weeger, M., Ghisla, S., Prestwich, G. D., Pfleiderer, W., and Schmidt, H. H. H. W. (1998) J. Biol. Chem. 273, 33142-33149
10. Reif, A., Fröhlich, L. G., Kotsonis, P., Frey, A., Bömmel, H. M., Wink, D. A., Pfleiderer, W., and Schmidt, H. H. H. W. (1999) J. Biol. Chem. 274, 24921-24929
11. Fleming, I., Bauersachs, J., Fisslthaler, B., and Busse, R. (1998) Circ. Res. 82, 686-695
12. Fleming, I., Bauersachs, J., Schäfer, A., Scholz, D., Aldershvile, J., and Busse, R. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1123-1128
13. Corson, M. A., James, N. L., Latta, S. E., Nerem, R. M., Berk, B. C., and Harrison, D. G. (1996) Circ. Res. 79, 984-991
14. Ayajiki, K., Kindermann, M., Hecker, M., Fleming, I., and Busse, R. (1996) Circ. Res. 78, 750-758
15. Etter, E. F., Minta, A., Poenie, M., and Fay, F. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5368-5373
16. Bredt, D. S., Ferris, C. D., and Snyder, S. H. (1992) J. Biol. Chem. 267, 10976-10981
17. Dinerman, J. L., Steiner, J. P., Dawson, T. M., Dawson, V., and Snyder, S. H. (1994) Neuropharmacol. 33, 1245-1251
18. Chen, Z. P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodriguez-Crespo, I., Witters, L. A., Power, P. R., de Montellano, O., and Kemp, B. E. (1999) FEBS Lett. 443, 285-289
19. Michel, T., Li, G. K., and Busconi, L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6252-6256
20. Garcia-Cardena, G., Oh. P., Liu, J., Schnitzer, J. E., and Sessa, W. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6448-6453
21. Feron, O., Saldana, F., Michel, J. B., and Michel, T. (1998) J. Biol. Chem. 273, 3125-3128
22. Garcia-Cardena, G., Fan, R., Stern, D. F., Liu, J., and Sessa, W. C. (1996) J. Biol. Chem. 271, 27237-27240
23. Walter, U., Miller, P., Wilson, F., Menkes, D., and Greengard, P. (1980) J. Biol. Chem. 255, 3757-3762
24. Pöhler, D., Butt, E., Meißner, J., Müller, S., Lohse, M., Walter, U., Lohmann, S. M., and Jarchau, T. (1995) FEBS Lett. 374, 419-425
25. Hofmann, H., and Schmidt, H. H. H. W. (1995) Biochem. 34, 13443-13452
26. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
27. Jaffe, E. A., Nachman, R. L., Becker, C. G., and Minick, C. R. (1973) J. Clin. Invest. 52, 2745-2746
28. Kennelly, P. J., and Krebs, E. G. (1991) J. Biol. Chem. 266, 15555-15558
29. Butt, E., Abel, K., Krieger, M., Palm, D., Hoppe, V., Hoppe, J., and Walter, U. (1994) J. Biol Chem. 269, 14509-14517
30. Graier, W. F., Groschner, K, Schmidt, K., and Kukowetz, W. R. (1992) Biochem. J. 288, 345-349
31. Salerno, J. C., Harris, D. E., Irizarry, K., Patel, B., Morales, A. J., Smith, S. M. E., Martasek, P., Roman, L. J., Masters, B. S. S., Jones, C. L., Weissman, B. A., Lane, P., Liu, Q., and Gross, S. S. (1997) J. Biol. Chem. 272, 29769-29777
32. Fulton, D. F., Gratton, J.-P., McCabe, T. J., Fontana, J., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., and Sessa, W. C. (1999) Nature 399, 597-601
33. Dimmler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., and Zeiher, A. M. (1999) Nature 399, 601-605
34. Michell, B. J., Griffiths, J. E., Mitchelhill, K. I., Rodriguez-Crespo, I., Tiganis, T., Bozinovski, S., Ortiz de Montellano, P. R., Kemp, B. E., and Pearson, R. B. (1999) Curr. Biol. 9, 845-848
35. Gallis, B., Corthals, G. L., Goodlett, D. R., Ueba, H., Kim, F., Presnell, S. R., Figeys, D., Harrison, D. G., Berk, B. C., Aebersold, R., and Corson, M. A. (1999) J. Biol. Chem. 274, 30101-30108
36. Du, K., and Montminy, M. (1998) J. Biol. Chem. 273, 32377-32379
37. Filippa, N., Filloux, C. L., Hemmings, B., and Van Obberghen, E. (1999) Mol. Cell. Biol. 19, 4989-5000
38. Draijer, R., Vaandrager, A. B., Nolte, C., de Jonge, H. R., Walter, U., and van Hinsbergh, W. M. (1995) Circ. Res. 77, 897-905
39. Birks, E. J., and Yacoub, M. H. (1997) Coron. Artery Dis. 8, 389-402
40. Dinerman, J. L., Dawson, T. M., Schell, M. J., Snowman, A., and Snyder, S. H. (1994) Proc. Natl Acad. Sci. U. S. A. 91, 4214-4218
41. Fox, S. W., and Chow, J. W. (1998) Bone 23, 1-6
42. Markert, T., Vaandrager, A. B., Gambaryan, S., Pöhler, D., Häusler, C., Walter, U., DeJonge, H. R., Jarchau, T., and Lohmann, S. M. (1995) J. Clin. Invest. 96, 822-830
43. Uhler, M. D. (1993) J. Biol. Chem. 268, 13586-13591
44. Jarchau, T., Häusler, C., Markert, T., Pöhler, D., Vandekerchhove, J., DeJonge H. R., Lohmann, S. M., and Walter, U. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9426-9430
45. Gambaryan, S., Häusler, C., Marken, T., Pöhler, D., Jarchau, T., Walter, U., Haase, W., Kurtz, A., and Lohmann, S. M. (1996) J. Clin. Invest. 98, 662-670
46. Pfeifer, A., Aszodi, A., Seidler, U., Ruth, P., Hofmann, F., and Fässler, R. (1996) Science 274, 2082-2086
47. Belhassen, L., Feron, O., Kaye, D. M., Michel, T., and Kelly, R. A. (1997) J. Biol. Chem. 272, 11198-11204
48. Garcia-Gardena, G., Martasek, P., Masters, B. S. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., and Sessa, W. C. (1997) J. Biol. Chem. 272, 25437-25440
49. Lohmann, S. M., Vaandrager, A. B., Smolenski, A., Walter, U., and de Jonge, H. R. (1997) Trends Biochem. Sci. 22, 307-312
50. Dell'Acqua, M. L., and Scott, J. D. (1997) J. Biol. Chem. 272, 12881-12884
51. Vaandrager, A. B., Tilly, B. C., Smolenski, A., Schneider-Rasp, S., Bot, A. G. M., Edixhoven, M., Scholte, B. J., Jarchau, T., Walter, U., Lohmann, S. M., Poller, W. C., and de Jonge, H. R. (1997) J. Biol. Chem. 272, 4195-4200
52. Vaandrager, A. B., Smolenski, A., Tilly, B. C., Houtsmuller, A. B., Ehlert, E. M. E., Bot, A. G. M., Boomaars, W. E. M., Lohmann, S. M., and DeJonge, H. R. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1466-1471
53. Nishida, C. R., and Ortiz de Montellano, P. R. (1999) J. Biol. Chem. 274, 14692-14698
54. Daff, S., Sagami, I., and Shimizu, T. (1999) J. Biol. Chem. 274, 30589-30595