Coronary endothelial function in hyperhomocysteinemia: Improvement after treatment with folic acid and cobalamin in patients with coronary artery disease

Journal of the American College of Cardiology

Volumn 40, Issue 4, 2002, Pages 766-772

  Willems, Frank F ^a   Aengevaeren, Wim R M ^b   Boers, Godfried H J ^b   Blom, Henk J ^b   Verheugt, Freek W A ^b  

^a RIJNSTATE HOSPITAL   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; COBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO;

ADULT; ANGIOCARDIOGRAPHY; ARTERY ENDOTHELIUM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; DOPPLER ECHOGRAPHY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INFUSION; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

ADULT; AGED; CORONARY CIRCULATION; CORONARY DISEASE; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; FOLIC ACID; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; VITAMIN B 12;

EID: 0037151686     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(02)02016-8     Document Type: Article

References (25)

1. Mild hyperhomocysteinemia is an independent risk factor for arterial vascular disease
2. Vitamin supplements and cardiovascular risk: Review of the randomized trials of homocysteine-lowering vitamin supplements
3. Hyperhomocysteinemia, vascular pathology and endothelial function
4. Long-term follow up of patients with mild coronary artery disease and endothelial dysfunction
5. A randomized double blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease
6. Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity
7. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects
8. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents
9. Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilatation in humans
10. Hyperhomocysteinemia is a risk factor for arterial endothelial dysfunction in humans
11. Endothelial dysfunction by acute hyperhomocysteinemia: Restoration by folic acid
12. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolaemia
13. Effect of folic acid supplementation on endothelial function in familial hypercholesterolaemia: A randomized placebo-controlled trial
14. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease
15. Endothelium mediated coronary blood-flow modulation in humans: Effects of age, atherosclerosis, hypercholesterolaemia and hypertension
16. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
17. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolaemia
18. Intracoronary Doppler flow velocity
19. Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inemia in humans
20. Lowering blood homocysteine with folic acid based supplements
21. Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase
22. Tetrahydrobiopterin restores endothelial function in hypercholesterolaemia
23. Oral vitamin C and endothelial function in smokers: Short-term improvement but no sustained beneficial effect
24. The natural history of homocystinuria due to cysthationine β-synthase deficiency
25. Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine B-synthase deficiency: Effects of homocysteine-lowering therapy