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Volumn 7, Issue 2, 2011, Pages 213-225

Regulatory T-cell adoptive immunotherapy: Potential for treatment of autoimmunity

Author keywords

Ag specific; autoimmunity; regulatory T cells; T cell receptor gene transfer

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 79953114328     PISSN: 1744666X     EISSN: None     Source Type: Journal    
DOI: 10.1586/eci.10.96     Document Type: Review
Times cited : (24)

References (133)
  • 2
    • 62449228000 scopus 로고    scopus 로고
    • T cell-mediated immunoregulation in the gastrointestinal tract
    • Saurer L, Mueller C. T cell-mediated immunoregulation in the gastrointestinal tract. Allergy 64, 505-519 (2009).
    • (2009) Allergy , vol.64 , pp. 505-519
    • Saurer, L.1    Mueller, C.2
  • 3
    • 45549107134 scopus 로고    scopus 로고
    • Revival of CD8+ Treg-mediated suppression
    • Smith TR, Kumar V. Revival of CD8+ Treg-mediated suppression. Trends Immunol. 29, 337-342 (2008).
    • (2008) Trends Immunol. , vol.29 , pp. 337-342
    • Smith, T.R.1    Kumar, V.2
  • 7
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • DOI 10.1126/science.1079490
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor FoxP3. Science 299, 1057-1061 (2003). (Pubitemid 36222930)
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 9
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7, 401-410 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 401-410
    • Hsieh, C.S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 11
    • 0033985780 scopus 로고    scopus 로고
    • + immunoregulatory T cells is antigen nonspecific
    • + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164, 183-190 (2000). Demonstrates that Tregs can suppress conventional T cells of distinct specificity provided the cognate antigen (Ag) for both cell types are presented on the same or adjacent antigen-presenting cells. (Pubitemid 30012989)
    • (2000) Journal of Immunology , vol.164 , Issue.1 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 21
    • 65549136983 scopus 로고    scopus 로고
    • + T regulatory cell-mediated suppression
    • + T regulatory cell-mediated suppression. Immunity 30, 636-645 (2009).
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 22
    • 33746342782 scopus 로고    scopus 로고
    • Infectious tolerance and the long-term acceptance of transplanted tissue
    • DOI 10.1111/j.0105-2896.2006.00406.x
    • Waldmann H, Adams E, Fairchild P, Cobbold S. Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol. Rev. 212, 301-313 (2006). (Pubitemid 44116716)
    • (2006) Immunological Reviews , vol.212 , pp. 301-313
    • Waldmann, H.1    Adams, E.2    Fairchild, P.J.3    Cobbold, S.4
  • 26
    • 56249117354 scopus 로고    scopus 로고
    • Natural Treg in autoimmune diabetes: All present and correct?
    • Thorough review and discussion of the conflicting data regarding the role of Tregs in autoimmunity. Whilst thisreview focuses primarily on diabetes, the concepts can be readily extended to cover a broad range of autoimmune disorders
    • Walker LS, Natural Treg in autoimmune diabetes: All present and correct? Expert Opin. Biol. Ther. 8, 1691-1703 (2008). Thorough review and discussion of the conflicting data regarding the role of Tregs in autoimmunity. Whilst thisreview focuses primarily on diabetes, the concepts can be readily extended to cover a broad range of autoimmune disorders.
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 1691-1703
    • Walker, L.S.1
  • 28
    • 44849086531 scopus 로고    scopus 로고
    • Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis
    • Flores-Borja F, Mauri C, Ehrenstein MR. Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis. Eur. J. Immunol. 38, 934-937 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 934-937
    • Flores-Borja, F.1    Mauri, C.2    Ehrenstein, M.R.3
  • 29
    • 61349083564 scopus 로고    scopus 로고
    • Identification of regulatory T cells in systemic lupus erythematosus
    • Gerli R, Nocentini G, Alunno A et al. Identification of regulatory T cells in systemic lupus erythematosus. Autoimmun. Rev. 8, 426-430 (2009).
    • (2009) Autoimmun. Rev. , vol.8 , pp. 426-430
    • Gerli, R.1    Nocentini, G.2    Alunno, A.3
  • 32
    • 37149003363 scopus 로고    scopus 로고
    • high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
    • DOI 10.1111/j.1365-2567.2007.02690.x
    • + CD25 (high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FoxP3-positive cells and reduced FoxP3 expression at the single-cell level. Immunology 123, 79-89 (2008). (Pubitemid 350255996)
    • (2008) Immunology , vol.123 , Issue.1 , pp. 79-89
    • Venken, K.1    Hellings, N.2    Thewissen, M.3    Somers, V.4    Hensen, K.5    Rummens, J.-L.6    Medaer, R.7    Hupperts, R.8    Stinissen, P.9
  • 35
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 37
    • 0036838536 scopus 로고    scopus 로고
    • + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • + regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169, 4712-4716 (2002). (Pubitemid 35217131)
    • (2002) Journal of Immunology , vol.169 , Issue.9 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 38
    • 33746214867 scopus 로고    scopus 로고
    • Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells
    • Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J. Immunol. 177, 1451-1459 (2006). (Pubitemid 44092478)
    • (2006) Journal of Immunology , vol.177 , Issue.3 , pp. 1451-1459
    • Scalapino, K.J.1    Tang, Q.2    Bluestone, J.A.3    Bonyhadi, M.L.4    Daikh, D.I.5
  • 39
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • DOI 10.1084/jem.20040139
    • Tang Q, Henriksen KJ, Bi M et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 199, 1455-1465 (2004). This study demonstrates that islet-specific Tregs, obtained from T-cell receptor (TCR)-transgenic mice, are capable of reverting ongoing diabetes. Importantly, the Tregs were specific for a single Ag, yet were able to suppress a complex multiepitope immune response. (Pubitemid 38780401)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.11 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5    Ye, J.6    Masteller, E.L.7    McDevitt, H.8    Bonyhadi, M.9    Bluestone, J.A.10
  • 40
    • 2942692039 scopus 로고    scopus 로고
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • DOI 10.1084/jem.20040180
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199, 1467-1477 (2004). This study demonstrates that islet-specific Tregs, obtained from TCR-transgenic mice, are capable of reverting ongoing diabetes. Importantly, the Tregs were specific for a single Ag, yet were able to suppress a complex multi-epitope immune response. (Pubitemid 38780402)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.11 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 42
    • 65449122461 scopus 로고    scopus 로고
    • + Treg
    • Using TCR-transgenic Tregs, this study demonstrated that Ag-specific Tregs were able to revert disease in a model of multiple sclerosis. This was achieved using Tregs with distinct specificity to the T cells initiating disease
    • + Treg. Eur. J. Immunol. 39, 1108-1117 (2009). Using TCR-transgenic Tregs, this study demonstrated that Ag-specific Tregs were able to revert disease in a model of multiple sclerosis. This was achieved using Tregs with distinct specificity to the T cells initiating disease.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1108-1117
    • Stephens, L.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 43
    • 70350238332 scopus 로고    scopus 로고
    • Differences in tumor regulatory T-cell localization and activation status impact patient outcome
    • Ménétrier-Caux C, Gobert M, Caux C. Differences in tumor regulatory T-cell localization and activation status impact patient outcome. Cancer Res. 69, 7895-7898 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 7895-7898
    • Ménétrier-Caux, C.1    Gobert, M.2    Caux, C.3
  • 48
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FoxP3-mutant human T cells: FoxP3 expression without regulatory T cell development
    • Gavin MA, Torgerson TR, Houston E et al. Single-cell analysis of normal and FoxP3-mutant human T cells: FoxP3 expression without regulatory T cell development. Proc. Natl Acad. Sci. USA 103, 6659-6664 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6659-6664
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3
  • 49
    • 33845491455 scopus 로고    scopus 로고
    • high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • DOI 10.1182/blood-2006-06-027409
    • +CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108, 4260-4267 (2006). (Pubitemid 44913302)
    • (2006) Blood , vol.108 , Issue.13 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3    Doser, K.4    Piseshka, B.5    Andreesen, R.6    Edinger, M.7
  • 50
    • 33751175422 scopus 로고    scopus 로고
    • Naive regulatory T cells: A novel subpopulation defined by resistance toward CD95L-mediated cell death
    • Fritzsching B, Oberle N, Pauly E et al. Naive regulatory T cells: A novel subpopulation defined by resistance toward CD95L-mediated cell death. Blood 108, 3371-3378 (2006).
    • (2006) Blood , vol.108 , pp. 3371-3378
    • Fritzsching, B.1    Oberle, N.2    Pauly, E.3
  • 56
    • 34249284512 scopus 로고    scopus 로고
    • mTOR at the crossroads of T cell proliferation and tolerance
    • DOI 10.1016/j.smim.2007.02.008, PII S1044532307000140, Molecular Mechanisms Supporting Peripheral T cell Tolerance: Potential Therapeutic Approaches to Autoimmunity and Allograft Rejection
    • Mondino A, Mueller DL. mTOR at the crossroads of T cell proliferation and tolerance. Semin. Immunol. 19, 162-172 (2007). (Pubitemid 46810293)
    • (2007) Seminars in Immunology , vol.19 , Issue.3 , pp. 162-172
    • Mondino, A.1    Mueller, D.L.2
  • 63
    • 48249143387 scopus 로고    scopus 로고
    • + regulatory T lymphocytes through the induction of anergy and infectious tolerance
    • + regulatory T lymphocytes through the induction of anergy and infectious tolerance. J. Immunol. 180, 2830-2838 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 2830-2838
    • Selvaraj, R.K.1    Geiger, T.L.2
  • 64
    • 49649095420 scopus 로고    scopus 로고
    • Polyclonal adaptive regulatory CD4 cells that can reverse Type I diabetes become oligoclonal long-term protective memory cells
    • Godebu E, Summers-Torres D, Lin MM, Baaten BJ, Bradley LM. Polyclonal adaptive regulatory CD4 cells that can reverse Type I diabetes become oligoclonal long-term protective memory cells. J. Immunol. 181, 1798-1805 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 1798-1805
    • Godebu, E.1    Summers-Torres, D.2    Lin, M.M.3    Baaten, B.J.4    Bradley, L.M.5
  • 65
    • 33645786794 scopus 로고    scopus 로고
    • Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo
    • Using islet-specific TCR-transgenic conventional T cells, this study demonstrated that induced adaptive Tregs were capable of reverting ongoing diabetes
    • Weber SE, Harbertson J, Godebu E et al. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J. Immunol. 176, 4730-4739 (2006). Using islet-specific TCR-transgenic conventional T cells, this study demonstrated that induced adaptive Tregs were capable of reverting ongoing diabetes.
    • (2006) J. Immunol. , vol.176 , pp. 4730-4739
    • Weber, S.E.1    Harbertson, J.2    Godebu, E.3
  • 66
    • 58849112222 scopus 로고    scopus 로고
    • Cutting edge: Antigen-specific TGF b-induced regulatory T cells suppress Th17-mediated autoimmune disease
    • Huter EN, Stummvoll GH, DiPaolo RJ, Glass DD, Shevach EM. Cutting edge: Antigen-specific TGF b-induced regulatory T cells suppress Th17-mediated autoimmune disease. J. Immunol. 181, 8209-8213 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8209-8213
    • Huter, E.N.1    Stummvoll, G.H.2    DiPaolo, R.J.3    Glass, D.D.4    Shevach, E.M.5
  • 67
    • 60749130247 scopus 로고    scopus 로고
    • - T cells of healthy and Type 1 diabetic subjects
    • Demonstrated that islet-specific adaptive Tregs could be induced from the peripheral blood of diabetic patients. The adaptive Tregs were equally efficient at suppression in vitro as those obtained from control samples
    • - T cells of healthy and Type 1 diabetic subjects. Eur. J. Immunol. 39, 612-620 (2009). Demonstrated that islet-specific adaptive Tregs could be induced from the peripheral blood of diabetic patients. The adaptive Tregs were equally efficient at suppression in vitro as those obtained from control samples.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 612-620
    • Long, S.A.1    Walker, M.R.2    Rieck, M.3
  • 68
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of FoxP3 expression in regulatory T cells by DNA methylation
    • Lal G, Zhang N, van der Touw W et al. Epigenetic regulation of FoxP3 expression in regulatory T cells by DNA methylation. J. Immunol. 182, 259-273 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    Van Der Touw, W.3
  • 71
    • 73149093194 scopus 로고    scopus 로고
    • Adoptive therapy with redirected primary regulatory T cells results in antigenspecific suppression of arthritis
    • Wright GP, Notley CA, Xue SA et al. Adoptive therapy with redirected primary regulatory T cells results in antigenspecific suppression of arthritis. Proc. Natl Acad. Sci. USA 6(45), 19078-19083 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.6 , Issue.45 , pp. 19078-19083
    • Wright, G.P.1    Notley, C.A.2    Xue, S.A.3
  • 72
    • 77955380678 scopus 로고    scopus 로고
    • Human antigen-specific regulatory T cells generated by T cell receptor gene transfer
    • In this study, TCR gene transfer was utilized to generated a large population of functional Ag-specific human Tregs. This approach would be applicable to treat human autoimmune disease
    • Brusko TM, Koya RC, Zhu S et al. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PLoS One. 5, e11726 (2010). In this study, TCR gene transfer was utilized to generated a large population of functional Ag-specific human Tregs. This approach would be applicable to treat human autoimmune disease.
    • (2010) PLoS One. , vol.5
    • Brusko, T.M.1    Koya, R.C.2    Zhu, S.3
  • 73
    • 0034680105 scopus 로고    scopus 로고
    • Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
    • Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406, 739-742 (2000).
    • (2000) Nature , vol.406 , pp. 739-742
    • Amrani, A.1    Verdaguer, J.2    Serra, P.3    Tafuro, S.4    Tan, R.5    Santamaria, P.6
  • 75
    • 55449096941 scopus 로고    scopus 로고
    • Analysis of the interindividual conservation of T cell receptor a- and b-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus
    • Luo W, Ma L, Wen Q, Wang N, Zhou MQ, Wang XN. Analysis of the interindividual conservation of T cell receptor a- and b-chain variable regions gene in the peripheral blood of patients with systemic lupus erythematosus. Clin. Exp. Immunol. 154, 316-324 (2008).
    • (2008) Clin. Exp. Immunol. , vol.154 , pp. 316-324
    • Luo, W.1    Ma, L.2    Wen, Q.3    Wang, N.4    Zhou, M.Q.5    Wang, X.N.6
  • 77
    • 0023893102 scopus 로고
    • Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis
    • Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL. Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 167, 1313-1322 (1988).
    • (1988) J. Exp. Med. , vol.167 , pp. 1313-1322
    • Hafler, D.A.1    Duby, A.D.2    Lee, S.J.3    Benjamin, D.4    Seidman, J.G.5    Weiner, H.L.6
  • 78
    • 33646889967 scopus 로고    scopus 로고
    • Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derviative is governed by the CD8 coreceptor and affects natural human TCR expression
    • DOI 10.1385/IR:34:1:67
    • Voss RH, Kuball J, Engel R et al. Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression. Immunol. Res. 34, 67-87 (2006). (Pubitemid 43780377)
    • (2006) Immunologic Research , vol.34 , Issue.1 , pp. 67-87
    • Voss, R.-H.1    Kuball, J.2    Engel, R.3    Guillaume, P.4    Romero, P.5    Huber, C.6    Theobald, M.7
  • 79
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
    • DOI 10.1016/S1074-7613(00)00080-7
    • Bouneaud C, Kourilsky P, Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion. Immunity 13, 829-840 (2000). (Pubitemid 32041805)
    • (2000) Immunity , vol.13 , Issue.6 , pp. 829-840
    • Bouneaud, C.1    Kourilsky, P.2    Bousso, P.3
  • 80
    • 0029826486 scopus 로고    scopus 로고
    • Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy
    • DOI 10.1073/pnas.93.23.13114
    • Sadovnikova E, Stauss HJ. Peptidespecific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy. Proc. Natl Acad. Sci. USA 93, 13114-13118 (1996). (Pubitemid 26382778)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.23 , pp. 13114-13118
    • Sadovnikova, E.1    Stauss, H.J.2
  • 81
    • 73949100822 scopus 로고    scopus 로고
    • Molecular immunology lessons from therapeutic T-cell receptor gene transfer
    • Thomas S, Stauss HJ, Morris EC. Molecular immunology lessons from therapeutic T-cell receptor gene transfer. Immunology 129, 170-177 (2010).
    • (2010) Immunology , vol.129 , pp. 170-177
    • Thomas, S.1    Stauss, H.J.2    Morris, E.C.3
  • 83
    • 0034669972 scopus 로고    scopus 로고
    • Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen
    • Setoguchi K, Misaki Y, Araki Y et al. Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen. J. Immunol. 165, 5980-5986 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 5980-5986
    • Setoguchi, K.1    Misaki, Y.2    Araki, Y.3
  • 86
    • 12744262844 scopus 로고    scopus 로고
    • Antigen-specific FoxP3-transduced T-cells can control established Type 1 diabetes
    • Jaeckel E, von Boehmer H, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established Type 1 diabetes. Diabetes 54, 306-310 (2005).
    • (2005) Diabetes , vol.54 , pp. 306-310
    • Jaeckel, E.1    Von Boehmer, H.2    Manns, M.P.3
  • 89
    • 37549032709 scopus 로고    scopus 로고
    • + T regulatory cells by activationindependent expression of FoxP3
    • + T regulatory cells by activationindependent expression of FoxP3. Mol. Ther. 16, 194-202 (2008).
    • (2008) Mol. Ther. , vol.16 , pp. 194-202
    • Allan, S.E.1    Alstad, A.N.2    Merindol, N.3
  • 90
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxP3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I. Human CD25highFoxP3pos regulatory T cells differentiate into IL-17-producing cells. Blood 112, 2340-2352 (2008).
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    Van Rijssen, E.4    Boots, A.M.5    Joosten, I.6
  • 91
    • 65549088243 scopus 로고    scopus 로고
    • IL-17-producing human peripheral regulatory T cells retain suppressive function
    • Beriou G, Costantino CM, Ashley CW et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 113, 4240-4249 (2009).
    • (2009) Blood , vol.113 , pp. 4240-4249
    • Beriou, G.1    Costantino, C.M.2    Ashley, C.W.3
  • 92
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells
    • Using a double-transgenic mouse model, this study demonstrated that a minority population of Tregs could lose FoxP3 expression and switch to a pathogenic phenotype. These cells were capable of inducing diabetes. This is an important safety concern for adoptive Treg therapy that must be addressed before translation into the clinic can proceed
    • Zhou X, Bailey-Bucktrout SL, Jeker LT et al. Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007 (2009). Using a double-transgenic mouse model, this study demonstrated that a minority population of Tregs could lose FoxP3 expression and switch to a pathogenic phenotype. These cells were capable of inducing diabetes. This is an important safety concern for adoptive Treg therapy that must be addressed before translation into the clinic can proceed.
    • (2009) Vivo. Nat. Immunol. , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 93
    • 65449141433 scopus 로고    scopus 로고
    • + regulatory T cells upon repetitive in vitro stimulation
    • + regulatory T cells upon repetitive in vitro stimulation. Eur. J. Immunol. 39, 1088-1097 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1088-1097
    • Hoffmann, P.1    Boeld, T.J.2    Eder, R.3
  • 96
    • 55249087037 scopus 로고    scopus 로고
    • Resistance of mature T cells to oncogene transformation
    • Newrzela S, Cornils K, Li Z et al. Resistance of mature T cells to oncogene transformation. Blood 112, 2278-2286 (2008).
    • (2008) Blood , vol.112 , pp. 2278-2286
    • Newrzela, S.1    Cornils, K.2    Li, Z.3
  • 99
    • 0026050864 scopus 로고
    • Investigating the HLA component in rheumatoid arthritis: An additive (dominant) mode of inheritance is rejected, a recessive mode is preferred
    • Rigby AS, Silman AJ, Voelm L et al. Investigating the HLA component in rheumatoid arthritis: An additive (dominant) mode of inheritance is rejected, a recessive mode is preferred. Genet. Epidemiol. 8, 153-175 (1991).
    • (1991) Genet. Epidemiol. , vol.8 , pp. 153-175
    • Rigby, A.S.1    Silman, A.J.2    Voelm, L.3
  • 100
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • DOI 10.1002/art.1780301102
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205-1213 (1987). (Pubitemid 18005792)
    • (1987) Arthritis and Rheumatism , vol.30 , Issue.11 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 101
    • 33745049883 scopus 로고    scopus 로고
    • Variation in radiologic joint destruction in rheumatoid arthritis differs between monozygotic and dizygotic twins and pairs of unrelated patients
    • DOI 10.1002/art.21872
    • van der Helm-van Mil AH, Kern M, Gregersen PK, Huizinga TW. Variation in radiologic joint destruction in rheumatoid arthritis differs between monozygotic and dizygotic twins and pairs of unrelated patients. Arthritis Rheum. 54, 2028-2030 (2006). (Pubitemid 43877957)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.6 , pp. 2028-2030
    • Van Der Helm-Van Mil, A.H.M.1    Kern, M.2    Gregersen, P.K.3    Huizinga, T.W.J.4
  • 104
    • 43249119095 scopus 로고    scopus 로고
    • Defining the role of the MHC in autoimmunity: A review and pooled analysis
    • Fernando MM, Stevens CR, Walsh EC et al. Defining the role of the MHC in autoimmunity: A review and pooled analysis. PLoS Genet. 4, e1000024 (2008).
    • (2008) PLoS Genet. , vol.4
    • Fernando, M.M.1    Stevens, C.R.2    Walsh, E.C.3
  • 106
    • 0029360443 scopus 로고
    • Similar peptides from two b cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes
    • Rudy G, Stone N, Harrison LC et al. Similar peptides from two b cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol. Med. 1, 625-633 (1995).
    • (1995) Mol. Med. , vol.1 , pp. 625-633
    • Rudy, G.1    Stone, N.2    Harrison, L.C.3
  • 112
    • 7844239774 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: Analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice
    • Boyton RJ, Lohmann T, Londei M et al. Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to Type I diabetes: Analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. Int. Immunol. 10, 1765-1776 (1998). (Pubitemid 28566038)
    • (1998) International Immunology , vol.10 , Issue.12 , pp. 1765-1776
    • Boyton, R.J.1    Lohmann, T.2    Londei, M.3    Kalbacher, H.4    Halder, T.5    Frater, A.J.6    Douek, D.C.7    Leslie, R.D.G.8    Flavell, R.A.9    Altmann, D.M.10
  • 113
    • 0033485917 scopus 로고    scopus 로고
    • Determination of glutamic acid decarboxylase 65 peptides presented by the Type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif
    • Herman AE, Tisch RM, Patel SD et al. Determination of glutamic acid decarboxylase 65 peptides presented by the Type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif. J. Immunol. 163, 6275-6282 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 6275-6282
    • Herman, A.E.1    Tisch, R.M.2    Patel, S.D.3
  • 114
    • 0033179486 scopus 로고    scopus 로고
    • Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1 0401-positive individuals
    • Reijonen H, Elliott JF, van Endert P, Nepom G. Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401- positive individuals. J. Immunol. 163, 1674-1681 (1999). (Pubitemid 29352793)
    • (1999) Journal of Immunology , vol.163 , Issue.3 , pp. 1674-1681
    • Reijonen, H.1    Elliott, J.F.2    Van Endert, P.3    Nepom, G.4
  • 115
    • 0032701129 scopus 로고    scopus 로고
    • Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4
    • Peakman M, Stevens EJ, Lohmann T et al. Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J. Clin. Invest. 104, 1449-1457 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1449-1457
    • Peakman, M.1    Stevens, E.J.2    Lohmann, T.3
  • 116
    • 0031823777 scopus 로고    scopus 로고
    • T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA- 2: Potential for mimicry with rotavirus and other environmental agents
    • Honeyman MC, Stone NL, Harrison LC. T-cell epitopes in Type 1 diabetes autoantigen tyrosine phosphatase IA-2: Potential for mimicry with rotavirus and other environmental agents. Mol. Med. 4, 231-239 (1998). (Pubitemid 28331640)
    • (1998) Molecular Medicine , vol.4 , Issue.4 , pp. 231-239
    • Honeyman, M.C.1    Stone, N.L.2    Harrison, L.C.3
  • 118
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346, 183-187 (1990).
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 119
    • 0032522194 scopus 로고    scopus 로고
    • T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects
    • DOI 10.1016/S0165-5728(97)00260-9, PII S0165572897002609
    • Trotter JL, Pelfrey CM, Trotter AL et al. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects. J. Neuroimmunol. 84, 172-178 (1998). (Pubitemid 28248403)
    • (1998) Journal of Neuroimmunology , vol.84 , Issue.2 , pp. 172-178
    • Trotter, J.L.1    Pelfrey, C.M.2    Trotter, A.L.3    Selvidge, J.A.4    Gushleff, K.C.5    Mohanakumar, T.6    McFarland, H.F.7
  • 121
    • 0029060142 scopus 로고
    • The small heat-shock protein a B-crystallin as candidate autoantigen in multiple sclerosis
    • van Noort JM, van Sechel AC, Bajramovic JJ et al. The small heat-shock protein a B-crystallin as candidate autoantigen in multiple sclerosis. Nature 375, 798-801 (1995).
    • (1995) Nature , vol.375 , pp. 798-801
    • Van Noort, J.M.1    Van Sechel, A.C.2    Bajramovic, J.J.3
  • 124
    • 0033508320 scopus 로고    scopus 로고
    • Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis
    • Kim HY, Kim WU, Cho ML et al. Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis. Arthritis Rheum. 42, 2085-2093 (1999).
    • (1999) Arthritis Rheum. , vol.42 , pp. 2085-2093
    • Kim, H.Y.1    Kim, W.U.2    Cho, M.L.3
  • 128
    • 74849135762 scopus 로고    scopus 로고
    • Identification of citrullinated vimentin peptides as T cell epitopes in HLA-DR4-positive patients with rheumatoid arthritis
    • Feitsma AL, van der Voort EI, Franken KL et al. Identification of citrullinated vimentin peptides as T cell epitopes in HLA-DR4-positive patients with rheumatoid arthritis. Arthritis Rheum. 62, 117-125 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 117-125
    • Feitsma, A.L.1    Van Der Voort, E.I.2    Franken, K.L.3
  • 129
    • 0029953857 scopus 로고    scopus 로고
    • Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus
    • DOI 10.1084/jem.183.6.2459
    • Kaliyaperumal A, Mohan C, Wu W, Datta SK. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J. Exp. Med. 183, 2459-2469 (1996). (Pubitemid 26192355)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.6 , pp. 2459-2469
    • Kaliyaperumal, A.1    Mohan, C.2    Wu, W.3    Datta, S.K.4
  • 130
    • 0032728568 scopus 로고    scopus 로고
    • Major peptide autoepitopes for nucleosome-specific T cells of human lupus
    • Lu L, Kaliyaperumal A, Boumpas DT, Datta SK. Major peptide autoepitopes for nucleosome-specific T cells of human lupus. J. Clin. Invest. 104, 345-355 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 345-355
    • Lu, L.1    Kaliyaperumal, A.2    Boumpas, D.T.3    Datta, S.K.4
  • 131
    • 0036720310 scopus 로고    scopus 로고
    • T cell reactivity against the SmD1 (83-119) C terminal peptide in patients with systemic lupus erythematosus
    • Riemekasten G, Weiss C, Schneider S et al. T cell reactivity against the SmD1 (83-119) C terminal peptide in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 61, 779-785 (2002).
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. 779-785
    • Riemekasten, G.1    Weiss, C.2    Schneider, S.3
  • 132
    • 0025651814 scopus 로고
    • T-cell epitopes on the 70-kDa protein of the (U1)RNP complex in autoimmune rheumatologic disorders
    • O'Brien RM, Cram DS, Coppel RL, Harrison LC. T-cell epitopes on the 70-kDa protein of the (U1)RNP complex in autoimmune rheumatologic disorders. J. Autoimmun. 3, 747-757 (1990).
    • (1990) J. Autoimmun. , vol.3 , pp. 747-757
    • O'Brien, R.M.1    Cram, D.S.2    Coppel, R.L.3    Harrison, L.C.4
  • 133
    • 0031901273 scopus 로고    scopus 로고
    • Influence of antigen organization on the development of lupus autoantibodies
    • DOI 10.1002/1529-0131(199804)41:4<603::AID-ART7>3.0.CO;2-E
    • Fatenejad S, Bennett M, Moslehi J, Craft J. Influence of antigen organization on the development of lupus autoantibodies. Arthritis Rheum. 41, 603-612 (1998). (Pubitemid 28214978)
    • (1998) Arthritis and Rheumatism , vol.41 , Issue.4 , pp. 603-612
    • Fatenejad, S.1    Bennett, M.2    Moslehi, J.3    Craft, J.4


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