Protective and therapeutic role for αB-crystallin in autoimmune demyelination

Nature

Volumn 448, Issue 7152, 2007, Pages 474-479

  Ousman, Shalina S ^a   Tomooka, Beren H ^b,c   Van Noort, Johannes M ^d   Wawrousek, Eric F ^e   O'Conner, Kevin ^f   Hafler, David A ^f   Sobel, Raymond A ^g   Robinson, William H ^b,c   Steinman, Lawrence ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^d TNO   (Netherlands)

^e NATIONAL EYE INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 2; RECOMBINANT ALPHAB CRYSTALLIN; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIBODY; BRAIN; GENE; IMMUNE RESPONSE; IMMUNE SYSTEM; NERVOUS SYSTEM DISORDER; RODENT;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CONTROLLED STUDY; CYTOKINE RELEASE; DEMYELINATION; FEMALE; GENE FUNCTION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; MACROPHAGE; MOUSE; MULTIPLE SCLEROSIS; MYELIN SHEATH; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; WILD TYPE;

MUS;

EID: 34547152612     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05935     Document Type: Article

References (30)

1. Chabas, D. et al. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 294, 1731-1735 (2001).
2. Aoyama, A., Frohli, E., Schafer, R. & Klemenz, R. αB-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection. Mol. Cell. Biol. 13, 1824-1835 (1993).
3. 2-induced apoptosis through down-regulation of the alpha B-crystallin gene. J. Biol. Chem. 276, 43435-43445 (2001).
4. Dasgupta, S., Hohman, T. C. & Carper, D. Hypertonic stress induces alpha B-crystallin expression. Exp. Eye Res. 54, 461-470 (1992).
5. Mehlen, P., Kretz-Remy, C., Preville, X. & Arrigo, A. P. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J. 15, 2695-2706 (1996).
6. Andley, U. P., Song, Z., Wawrousek, E. F., Fleming, T. P. & Bassnett, S. Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells. J. Biol. Chem. 275, 36823-36831 (2000).
7. Li, D. W. et al. Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis. Exp. Cell Res. 266, 279-291 (2001).
8. Masilamoni, J. G. et al. Molecular chaperone alpha-crystallin prevents detrimental effects of neuroinflammation. Biochim. Biophys. Acta 1762, 284-293 (2006).
9. van Noort, J. M. et al. The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis. Nature 375, 798-801 (1995).
10. Bajramovic, J. J. et al. Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: an early event following inflammatory demyelination. J. Immunol. 164, 4359-4366 (2000).
11. Kamradt, M. C., Chen, F., Sam, S. & Cryns, V. L. The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. J. Biol. Chem. 277, 38731-38736 (2002).
12. Morrison, L. E., Hoover, H. E., Thuerauf, D. J. & Glembotski, C. C. Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circ. Res. 92, 203-211 (2003).
13. Webster, K. A. Serine phosphorylation and suppression of apoptosis by the small heat shock protein alphaB-crystallin. Circ. Res. 92, 130-132 (2003).
14. Liu, J. P. et al. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Exp. Eye Res. 79, 393-403 (2004).
15. van Loo, G. et al. Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nature Immunol. 7, 954-961 (2006).
16. Youssef, S. & Steinman, L. At once harmful and beneficial: the dual properties of NF-κB. Nature Immunol. 7, 901-902 (2006).
17. Robinson, W. H. et al. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nature Biotechnol. 21, 1033-1039 (2003).
18. Ellmerich, S. et al. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur. J. Immunol. 34, 1839-1848 (2004).
19. van Noort, J. M., Verbeek, R., Meilof, J. F., Polman, C. H. & Amor, S. Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire. Mult. Scler. 12, 287-293 (2006).
20. Cobb, B. A. & Petrash, J. M. Characterization of alpha-crystallin- plasma membrane binding. J. Biol. Chem. 275, 6664-6672 (2000).
21. Matsuoka, Y. et al. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to β-amyloid. J. Neurosci. 23, 29-33 (2003).
22. Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916-919 (2000).
23. Korlimbinis, A., Hains, P. G., Truscott, R. J. & Aquilina, J. A. 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. Biochemistry 45, 1852-1860 (2006).
24. Finley, E. L., Dillon, J., Crouch, R. K. & Schey, K. L. Identification of tryptophan oxidation products in bovine alpha-crystallin. Protein Sci. 7, 2391-2397 (1998).
25. Tusher, V. G., Tibshirani, R. & Chu, G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA 98, 5116-5121 (2001).
26. Brady, J. P. et al. αB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest. Ophthalmol. Vis. Sci. 42, 2924-2934 (2001).
27. Suzuki, A. et al. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. J. Cell Biol. 140, 1113-1124 (1998).
28. Doerwald, L. et al. Sequence and functional conservation of the intergenic region between the head-to-head genes encoding the small heat shock proteins αB-crystallin and HspB2 in the mammalian lineage. J. Mol. Evol. 59, 674-686 (2004).
29. Huang, D. R., Wang, J., Kivisakk, P., Rollins, B. J. & Ransohoff, R. M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193, 713-726 (2001).
30. Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA 95, 14863-14868 (1998).