Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

Journal of Experimental Medicine

Volumn 183, Issue 6, 1996, Pages 2459-2469

  Kaliyaperumal, Arunan ^a   Mohan, Chandra ^a,b   Wu, Wei ^a   Datta, Syamal K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; DNA DETERMINATION; HELPER CELL; IMMUNOGLOBULIN BLOOD LEVEL; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; CROSSES, GENETIC; CYTOKINES; DNA; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTONES; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; NUCLEOSOMES; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0029953857     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.6.2459     Document Type: Article

References (36)

1. Datta, S.K., H. Patel, and D. Berry. 1987. Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J. Exp. Med. 165:1252-1268.
2. Ando, D.G., E.E. Sercarz, and B.H. Hahn. 1987. Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 murine SLE model. J. Immunol. 138:3185-3190.
3. - T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB × SWR model of lupus nephritis. J. Immunol. 140:2215-2224.
4. Adams, S., P. Leblanc, and S.K. Datta. 1991. Junctional region sequences of T-cell receptor β chain genes expressed by pathogenic anti-DNA autoantibody-inducing T helper cells from lupus mice: possible selection by cationic autoantigens. Proc. Natl. Acad. Sci. USA. 88:11271-11275.
5. Mohan, C., S. Adams, V. Stanik, and S.K. Datta. 1993. Nucleosome: a major immunogen for the pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177:1367-1381.
6. Mohan, C., Y. Shi, J.D. Laman, and S.K. Datta. 1995. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J. Immunol. 154:1470-1480.
7. + T helper cell lines that express the γ/δ T-cell receptor. Proc. Natl. Acad. Sci. USA. 87:7020-7024.
8. Desai-Mehta, A., C. Mao, S. Rajagopalan, T. Robinson, and S.K. Datta. 1995. Structure and specificity of T-cell receptors expressed by pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J. Clin. Invest. 95:531-541.
9. Mao, C., G.E. Osman, S. Adams, and S.K. Datta. 1994. T cell receptor alpha-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice. J. Immunol. 152:1462-1470.
10. Burlingame, R.W., R.L. Rubin, R.S. Balderas, and A.N. Theofilopoulos. 1993. Genesis and evolution of anti-chromatin autoantibodies in murine lupus implicates immunization with self antigen. J. Clin. Invest. 91:1687-1696.
11. Di Valerio, R., K.A. Bernstein, E. Varghese, and J.B. Lefkowith. 1995. Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism. J. Immunol. 155:2258-2268.
12. Chabre, H., Z. Amoura, J.-C. Piette, P. Godeau, J.-F. Bach, and S. Koutouzov. 1995. Presence of nucleosome-restricted antibodies in patients with systemic lupus erythematosus. Arthritis. Rheum. 38:1485-1491.
13. Bavykin, S.G., S.I. Usachenko, A.O. Zalensky, and A.D. Mirzabekov. 1990. Structure of nucleosomes and organization of internucleosomal DNA in chromatin. J. Mol. Biol. 212:495-511.
14. d binding peptides derived from unrelated protein antigens share a common structural motif. J. Immunol. 141: 45-48.
15. Margalit, H., J.L. Spouge, J.L. Cornette, K.B. Cease, C. Delisi, and J.A. Berzofsky. 1987. Prediction of immunodominant helper T cell antigenic sites from the primary sequence. J. Immunol. 138:2213-2229.
16. Rothbard, J.B., and W.R., Taylor. 1988. A sequence pattern common to T cell epitopes. EMBO (Eur. Mol. Biol. Organ.) J. 7:93-100.
17. d molecules in the activation of MHC class II-restricted T cells. J. Immunol. 147:198-204.
18. Portanova, J.P., J.C. Cheronis, J.K. Blodgett, and B.L. Kotzin. 1990. Histone autoantigens in murine lupus: definition of a major epitope within an accessible region of chromatin J. Immunol. 144:4633-4640.
19. Meziere, C., F. Stockl, S. Batsford, A. Vogt, and S. Muller. 1994. Antibodies to DNA, chromatin core particles and histones in mice with graft-versus-host disease and their involvement in glomerular injury. Clin. Exp. Immunol. 98:287-294.
20. Hefeneider, S.H., K.A. Cornell, L.E. Brown, A.C. Bakke, S.L. McCoy, and R.M. Bennett. 1992. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin. Immunol. Immunopathol. 63:245-251.
21. Nanda, N.K., K.K. Arzoo, H.M. Geysen, A. Sette, and E.E. Sercarz. 1995. Recognition of multiple peptide cores by a single T cell receptor. J. Exp. Med. 182:531-539.
22. Hagerty, D.T., and P.M. Allen. 1995. Intramolecular mimicry: identification and analysis of two cross-reactive T cell epitopes within a single protein. J. Immunol. 155:2993-3001.
23. Jorgensen, J.L., U. Esser, P.A. Reay, B. Fazekas de St. Groth, and M.M. Davis. 1992. Mapping T cell receptor/peptide contacts by variant peptide immunization of single-chain transgenics. Nature (Lond). 355:224-230.
24. Snapper, C.M., T.M. McIntyre, K. Mandler, L.M. Pecanha, F.D. Finkelman, A. Lees, and J.J. Mond. 1992. Induction of IgG3 secretion by interferon-γ: a model of T cell-dependent class switching in response to T cell-independent type 2 antigens. J. Exp. Med. 175:1367-1371.
25. Mamula, M.J., S. Fatenejad, and J. Craft. 1994. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. J. Immunol. 152:1453-1461.
26. Lanzavecchia, A. 1995. How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181:1945-1948.
27. Lehmann, P.V., T. Forsthuber, A. Miller, and E.E. Sercarz. 1992. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature (Lond.). 358:155-157.
28. James, J.A., T. Gross, R.H. Scofield, and J.D. Harley. 1995. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J. Exp. Med. 181:453-461.
29. Lou, Y., and K.S.K. Tung. 1993. T cell peptide of a self-protein elicits autoantibody to the protein antigen. J. Immunol. 151:5790-5799.
30. Singh, R.R., V. Kumar, F.M. Ebling, S. Southwood, A. Sette, E.E. Sercarz, and H.H. Hahn. 1995. T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine SLE. J. Exp. Med. 181:2017-2027.
31. Casciola-Rosen, L.A., G. Anhalt, and A. Rosen. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179:1317-1330.
32. Gilkeson, G.S., A.M.M. Pippen, and D.S. Pisetsky. 1995. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J. Clin. Invest. 95:1398-1402.
33. Dong, X., K.J. Hamilton, M. Satoh, J. Wang, and W.H. Reeves. 1994. Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J. Exp. Med. 179:1243-1252.
34. Desai, D.D., M.R. Krishnan, J.T. Swindle, and T.N. Marion. 1993. Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice. J. Immunol. 151: 1614-1626.
35. Desai-Mehta, A., L. Liangjun, R. Ramsey-Goldman, and S.K. Datta. 1996. Hyperexpression of CD40 ligand in human lupus and its role in pathogenic autoantibody production. J. Clin. Invest. 97:2063-2073.
36. Rammensee, H.G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics. 41:178-228.