메뉴 건너뛰기




Volumn 129, Issue 2, 2010, Pages 170-177

Molecular immunology lessons from therapeutic T-cell receptor gene transfer

Author keywords

Lessons; Molecular immunology; T cell receptor (TCR) gene transfer

Indexed keywords

CD3 ANTIGEN; LENTIVIRUS VECTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; RETROVIRUS VECTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 73949100822     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03227.x     Document Type: Review
Times cited : (43)

References (48)
  • 1
    • 0033168142 scopus 로고    scopus 로고
    • Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity
    • Clay TM, Custer MC, Sachs J et al. Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity. J Immunol 1999 163 : 507 513.
    • (1999) J Immunol , vol.163 , pp. 507-513
    • Clay, T.M.1    Custer, M.C.2    Sachs, J.3
  • 2
    • 0033887418 scopus 로고    scopus 로고
    • Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes
    • Cooper LJ, Kalos M, Lewinsohn DA, Riddell SR, Greenberg PD. Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes. J Virol 2000 74 : 8207 8212.
    • (2000) J Virol , vol.74 , pp. 8207-8212
    • Cooper, L.J.1    Kalos, M.2    Lewinsohn, D.A.3    Riddell, S.R.4    Greenberg, P.D.5
  • 3
    • 0034234527 scopus 로고    scopus 로고
    • Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex
    • Fujio K, Misaki Y, Setoguchi K et al. Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex. J Immunol 2000 165 : 528 532.
    • (2000) J Immunol , vol.165 , pp. 528-532
    • Fujio, K.1    Misaki, Y.2    Setoguchi, K.3
  • 4
    • 0037442013 scopus 로고    scopus 로고
    • Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes
    • Schaft N, Willemsen RA, de Vries J et al. Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes. J Immunol 2003 170 : 2186 2194.
    • (2003) J Immunol , vol.170 , pp. 2186-2194
    • Schaft, N.1    Willemsen, R.A.2    De Vries, J.3
  • 6
    • 0034780027 scopus 로고    scopus 로고
    • Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer
    • Stanislawski T, Voss RH, Lotz C et al. Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. Nat Immunol 2001 2 : 962 970.
    • (2001) Nat Immunol , vol.2 , pp. 962-970
    • Stanislawski, T.1    Voss, R.H.2    Lotz, C.3
  • 7
    • 20344400625 scopus 로고    scopus 로고
    • A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection
    • Morris EC, Tsallios A, Bendle GM, Xue SA, Stauss HJ. A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection. Proc Natl Acad Sci USA 2005 102 : 7934 7939.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7934-7939
    • Morris, E.C.1    Tsallios, A.2    Bendle, G.M.3    Xue, S.A.4    Stauss, H.J.5
  • 8
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan RA, Dudley ME, Wunderlich JR et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006 314 : 126 129.
    • (2006) Science , vol.314 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 9
    • 33846294781 scopus 로고    scopus 로고
    • Lentiviral vectors for T-cell suicide gene therapy: Preservation of effector function after cytokine-mediated transduction
    • Qasim W, Mackey T, Sinclair J et al. Lentiviral vectors for T-cell suicide gene therapy: preservation of effector function after cytokine-mediated transduction. Mol Ther 2007 15 : 355 360.
    • (2007) Mol Ther , vol.15 , pp. 355-360
    • Qasim, W.1    MacKey, T.2    Sinclair, J.3
  • 10
    • 0037481021 scopus 로고    scopus 로고
    • Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence
    • Cavalieri S, Cazzaniga S, Geuna M et al. Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence. Blood 2003 102 : 497 505.
    • (2003) Blood , vol.102 , pp. 497-505
    • Cavalieri, S.1    Cazzaniga, S.2    Geuna, M.3
  • 11
    • 17644395663 scopus 로고    scopus 로고
    • The T cell receptor: Critical role of the membrane environment in receptor assembly and function
    • Call ME, Wucherpfenning KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol 2005 23 : 101 125.
    • (2005) Annu Rev Immunol , vol.23 , pp. 101-125
    • Call, M.E.1    Wucherpfenning, K.W.2
  • 12
    • 33749005425 scopus 로고    scopus 로고
    • Enhanced antitumor activity of murine-human hybrid t-cell receptor (tcr) in human lymphocytes is associated with improved pairing and TCR/CD3 stability
    • Cohen CJ, Zhao Y, Zheng Z, Rosenberg SA, Morgan RA. Enhanced antitumor activity of murine-human hybrid t-cell receptor (tcr) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res 2006 66 : 8878 8886.
    • (2006) Cancer Res , vol.66 , pp. 8878-8886
    • Cohen, C.J.1    Zhao, Y.2    Zheng, Z.3    Rosenberg, S.A.4    Morgan, R.A.5
  • 14
    • 33645997354 scopus 로고    scopus 로고
    • Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells
    • Scholten KB, Kramer D, Kueter EW et al. Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells. Clin Immunol 2006 119 : 135 145.
    • (2006) Clin Immunol , vol.119 , pp. 135-145
    • Scholten, K.B.1    Kramer, D.2    Kueter, E.W.3
  • 15
    • 58149296551 scopus 로고    scopus 로고
    • Requirements for effective antitumor responses of TCR transduced T cells
    • de Witte MA, Jorritsma A, Kaiser A et al. Requirements for effective antitumor responses of TCR transduced T cells. J Immunol 2008 181 : 5128 5136.
    • (2008) J Immunol , vol.181 , pp. 5128-5136
    • De Witte, M.A.1    Jorritsma, A.2    Kaiser, A.3
  • 16
    • 36349004799 scopus 로고    scopus 로고
    • Selecting highly affine and well-expressed TCRs for gene therapy of melanoma
    • Jorritsma A, Gomez-Eerland R, Dokter M et al. Selecting highly affine and well-expressed TCRs for gene therapy of melanoma. Blood 2007 110 : 3564 3572.
    • (2007) Blood , vol.110 , pp. 3564-3572
    • Jorritsma, A.1    Gomez-Eerland, R.2    Dokter, M.3
  • 17
    • 0025997947 scopus 로고
    • The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos
    • Ghattas IR, Sanes JR, Majors JE. The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos. Mol Cell Biol 1991 11 : 5848 5859.
    • (1991) Mol Cell Biol , vol.11 , pp. 5848-5859
    • Ghattas, I.R.1    Sanes, J.R.2    Majors, J.E.3
  • 18
    • 54549106702 scopus 로고    scopus 로고
    • Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition
    • Yang S, Cohen CJ, Peng PD et al. Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition. Gene Ther 2008 15 : 1411 1423.
    • (2008) Gene Ther , vol.15 , pp. 1411-1423
    • Yang, S.1    Cohen, C.J.2    Peng, P.D.3
  • 19
    • 43049101949 scopus 로고    scopus 로고
    • Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette
    • Leisegang M, Engels B, Meyerhuber P et al. Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette. J Mol Med 2008 86 : 573 583.
    • (2008) J Mol Med , vol.86 , pp. 573-583
    • Leisegang, M.1    Engels, B.2    Meyerhuber, P.3
  • 20
    • 33845985925 scopus 로고    scopus 로고
    • Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex
    • Heemskerk MH, Hagedoorn RS, van der Hoorn MA et al. Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex. Blood 2007 109 : 235 243.
    • (2007) Blood , vol.109 , pp. 235-243
    • Heemskerk, M.H.1    Hagedoorn, R.S.2    Van Der Hoorn, M.A.3
  • 21
    • 33751217134 scopus 로고    scopus 로고
    • Designer T cells by T cell receptor replacement
    • Sommermeyer D, Neudorfer J, Weinhold M et al. Designer T cells by T cell receptor replacement. Eur J Immunol 2006 36 : 3052 3059.
    • (2006) Eur J Immunol , vol.36 , pp. 3052-3059
    • Sommermeyer, D.1    Neudorfer, J.2    Weinhold, M.3
  • 22
    • 38449094082 scopus 로고    scopus 로고
    • Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells
    • Thomas S, Xue SA, Cesco-Gaspere M et al. Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells. J Immunol 2007 179 : 5803 5810.
    • (2007) J Immunol , vol.179 , pp. 5803-5810
    • Thomas, S.1    Xue, S.A.2    Cesco-Gaspere, M.3
  • 23
    • 73949111896 scopus 로고    scopus 로고
    • Allogeneic HLA-A2-restricted WT1-specific T cells from mismatched donors are highly reactive but show potentially hazardous promiscuity
    • Falkenburg WJJ, Melenhorst JJ, Kester MGD et al. Allogeneic HLA-A2-restricted WT1-specific T cells from mismatched donors are highly reactive but show potentially hazardous promiscuity. Blood (ASH Annual Meeting Abstracts) 2009 114 : 4081.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 4081
    • Falkenburg, W.J.J.1    Melenhorst, J.J.2    Kester, M.G.D.3
  • 24
    • 33947217494 scopus 로고    scopus 로고
    • Facilitating matched pairing and expression of TCR chains introduced into human T cells
    • Kuball J, Dossett ML, Wolfl M et al. Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood 2007 109 : 2331 2338.
    • (2007) Blood , vol.109 , pp. 2331-2338
    • Kuball, J.1    Dossett, M.L.2    Wolfl, M.3
  • 25
    • 34248595961 scopus 로고    scopus 로고
    • Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond
    • Cohen CJ, Li YF, El-Gamil M, Robbins PF, Rosenberg SA, Morgan RA. Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond. Cancer Res 2007 67 : 3898 3903.
    • (2007) Cancer Res , vol.67 , pp. 3898-3903
    • Cohen, C.J.1    Li, Y.F.2    El-Gamil, M.3    Robbins, P.F.4    Rosenberg, S.A.5    Morgan, R.A.6
  • 26
    • 40449129554 scopus 로고    scopus 로고
    • Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells
    • Voss RH, Willemsen RA, Kuball J et al. Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells. J Immunol 2008 180 : 391 401.
    • (2008) J Immunol , vol.180 , pp. 391-401
    • Voss, R.H.1    Willemsen, R.A.2    Kuball, J.3
  • 27
    • 3142576998 scopus 로고    scopus 로고
    • Transgenic TCR expression: Comparison of single chain with full-length receptor constructs for T-cell function
    • Zhang T, He X, Tsang TC, Harris DT. Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther 2004 11 : 487 496.
    • (2004) Cancer Gene Ther , vol.11 , pp. 487-496
    • Zhang, T.1    He, X.2    Tsang, T.C.3    Harris, D.T.4
  • 28
    • 47249100641 scopus 로고    scopus 로고
    • Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer
    • Sebestyen Z, Schooten E, Sals T et al. Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer. J Immunol 2008 180 : 7736 7746.
    • (2008) J Immunol , vol.180 , pp. 7736-7746
    • Sebestyen, Z.1    Schooten, E.2    Sals, T.3
  • 30
    • 59849094300 scopus 로고    scopus 로고
    • Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo
    • van der Veken LT, Coccoris M, Swart E, Falkenburg JH, Schumacher TN, Heemskerk MH. Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo. J Immunol 2009 182 : 164 170.
    • (2009) J Immunol , vol.182 , pp. 164-170
    • Van Der Veken, L.T.1    Coccoris, M.2    Swart, E.3    Falkenburg, J.H.4    Schumacher, T.N.5    Heemskerk, M.H.6
  • 31
    • 67349199658 scopus 로고    scopus 로고
    • Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes
    • Hiasa A, Nishikawa H, Hirayama M et al. Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes. Gene Ther 2009 16 : 620 628.
    • (2009) Gene Ther , vol.16 , pp. 620-628
    • Hiasa, A.1    Nishikawa, H.2    Hirayama, M.3
  • 32
    • 0034176750 scopus 로고    scopus 로고
    • Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1
    • Gao L, Bellantuono I, Elsasser A et al. Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood 2000 95 : 2198 2203.
    • (2000) Blood , vol.95 , pp. 2198-2203
    • Gao, L.1    Bellantuono, I.2    Elsasser, A.3
  • 33
    • 27644566777 scopus 로고    scopus 로고
    • Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells
    • Xue SA, Gao L, Hart D et al. Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells. Blood 2005 106 : 3062 3067.
    • (2005) Blood , vol.106 , pp. 3062-3067
    • Xue, S.A.1    Gao, L.2    Hart, D.3
  • 34
    • 19944434233 scopus 로고    scopus 로고
    • Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
    • Kuball J, Schmitz FW, Voss RH et al. Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity 2005 22 : 117 129.
    • (2005) Immunity , vol.22 , pp. 117-129
    • Kuball, J.1    Schmitz, F.W.2    Voss, R.H.3
  • 35
    • 12344322695 scopus 로고    scopus 로고
    • High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3
    • Chlewicki LK, Holler PD, Monti BC, Clutter MR, Kranz DM. High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3. J Mol Biol 2005 346 : 223 239.
    • (2005) J Mol Biol , vol.346 , pp. 223-239
    • Chlewicki, L.K.1    Holler, P.D.2    Monti, B.C.3    Clutter, M.R.4    Kranz, D.M.5
  • 37
    • 12344322695 scopus 로고    scopus 로고
    • High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3
    • Holler PD, Monti BC, Clutter MR, Kranz DM. High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3. J Mol Biol 2005 346 : 223 239.
    • (2005) J Mol Biol , vol.346 , pp. 223-239
    • Holler, P.D.1    Monti, B.C.2    Clutter, M.R.3    Kranz, D.M.4
  • 38
    • 21444445173 scopus 로고    scopus 로고
    • Directed evolution of human T-cell receptors with picomolar affinities by phage display
    • Li Y, Moysey R, Molloy PE et al. Directed evolution of human T-cell receptors with picomolar affinities by phage display. Nat Biotechnol 2005 23 : 349 354.
    • (2005) Nat Biotechnol , vol.23 , pp. 349-354
    • Li, Y.1    Moysey, R.2    Molloy, P.E.3
  • 39
    • 30044449525 scopus 로고    scopus 로고
    • Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function
    • Weber KS, Donermeyer DL, Allen PM, Kranz DM. Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci USA 2005 102 : 19033 19038.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19033-19038
    • Weber, K.S.1    Donermeyer, D.L.2    Allen, P.M.3    Kranz, D.M.4
  • 40
    • 57349118383 scopus 로고    scopus 로고
    • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
    • Varela-Rohena A, Molloy PE, Dunn SM et al. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nat Med 2008 14 : 1390 1395.
    • (2008) Nat Med , vol.14 , pp. 1390-1395
    • Varela-Rohena, A.1    Molloy, P.E.2    Dunn, S.M.3
  • 41
    • 0029037210 scopus 로고
    • Serial triggering of many T cell receptors by a few peptide-MHC complexes
    • Valtutti S, Muller S, Cella M, Padovan E, Lanzavecchia A. Serial triggering of many T cell receptors by a few peptide-MHC complexes. Nature 1995 375 : 148 151.
    • (1995) Nature , vol.375 , pp. 148-151
    • Valtutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 42
    • 0037234768 scopus 로고    scopus 로고
    • TCRs with high affinity for foreign pMHC show self-reactivity
    • Holler PD, Chlewicki LK, Kranz DM. TCRs with high affinity for foreign pMHC show self-reactivity. Nat Immunol 2003 4 : 55 62.
    • (2003) Nat Immunol , vol.4 , pp. 55-62
    • Holler, P.D.1    Chlewicki, L.K.2    Kranz, D.M.3
  • 43
    • 33750795840 scopus 로고    scopus 로고
    • The study of high-affinity TCRs reveals duality in T cell recognition of antigen: Specificity and degeneracy
    • Donermeyer DL, Weber KS, Kranz DM, Allen PM. The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy. J Immunol 2006 177 : 6911 6919.
    • (2006) J Immunol , vol.177 , pp. 6911-6919
    • Donermeyer, D.L.1    Weber, K.S.2    Kranz, D.M.3    Allen, P.M.4
  • 44
    • 38449104431 scopus 로고    scopus 로고
    • High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines
    • Zhao Y, Bennett AD, Zheng Z et al. High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. J Immunol 2007 179 : 5845 5854.
    • (2007) J Immunol , vol.179 , pp. 5845-5854
    • Zhao, Y.1    Bennett, A.D.2    Zheng, Z.3
  • 45
    • 44449128698 scopus 로고    scopus 로고
    • Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions
    • Robbins PF, Li YF, El-Gamil M et al. Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions. J Immunol 2008 180 : 6116 6131.
    • (2008) J Immunol , vol.180 , pp. 6116-6131
    • Robbins, P.F.1    Li, Y.F.2    El-Gamil, M.3
  • 46
    • 63049108160 scopus 로고    scopus 로고
    • Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
    • Kuball J, Hauptrock B, Malina V et al. Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain. J Exp Med 2009 206 : 463 475.
    • (2009) J Exp Med , vol.206 , pp. 463-475
    • Kuball, J.1    Hauptrock, B.2    Malina, V.3
  • 47
    • 55849142632 scopus 로고    scopus 로고
    • Conferring indirect allospecificity on CD4+ CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice
    • Tsang JY, Tanriver Y, Jiang S et al. Conferring indirect allospecificity on CD4+ CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest 2008 118 : 3619 3628.
    • (2008) J Clin Invest , vol.118 , pp. 3619-3628
    • Tsang, J.Y.1    Tanriver, Y.2    Jiang, S.3
  • 48
    • 73149093194 scopus 로고    scopus 로고
    • Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
    • Wright GP, Notley CA, Xue SA et al. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proc Natl Acad Sci USA 2009 106 : 19078 19083.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19078-19083
    • Wright, G.P.1    Notley, C.A.2    Xue, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.