Microcirculatory Exchange Function

Microcirculation

Volumn , Issue , 2008, Pages 81-124

  Durán, Walter N ^a   Sánchez, Fabiola A ^a   Breslin, Jerome W ^b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79952955107     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374530-9.00004-8     Document Type: Chapter

References (466)

1. B.S. Daniels (1993) Regional versus systemic modulation of the microcirculation in diabetes mellitus. J Lab Clin Med 121 375-376.
2. A.J. Jaap and J.E. Tooke (1995) Pathophysiology of microvascular disease in non-insulin-dependent diabetes. Clin Sci (Lond) 89 3-12.
3. M.C. Mazzoni and G.W. Schmid-Schonbein (1996) Mechanisms and consequences of cell activation in the microcirculation. Cardiovasc Res 32 709-719.
4. P.F. McDonagh and J.Y. Hokama (2000) Microvascular perfusion and transport in the diabetic heart. Microcirculation 7 163-181.
5. C.C. Michel and F.E. Curry (1999) Microvascular permeability. Physiol Rev 79 703-761.
6. T. Yamaji, T. Fukuhara and M. Kinoshita (1993) Increased capillary permeability to albumin in diabetic rat myocardium. Circ Res 72 947-957.
7. S.Y. Yuan, J.W. Breslin, R. Perrin, N. Gaudreault, M. Guo, H. Kargozaran and M.H. Wu (2007) Microvascular permeability in diabetes and insulin resistance. Microcirculation 14 363-373.
8. S.Y. Yuan, E.E. Ustinova, M.H. Wu, J.H. Tinsley, W. Xu, F.L. Korompai and A.C. Taulman (2000) Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes. Circ Res 87 412-417.
9. A.B. Groeneveld (2002) Vascular pharmacology of acute lung injury and acute respiratory distress syndrome. Vascul Pharmacol 39 247-256.
10. A.B. Groeneveld, T.A. van Lambalgen and L.G. Thijs (1986) Microvascular permeability in endotoxin and bacterial shock. Acute Care 12 195-218.
11. C.W. Lush and P.R. Kvietys (2000) Microvascular dysfunction in sepsis. Microcirculation 7 83-101.
12. G. Arturson (2000) Forty years in burns research-the postburn inflammatory response. Burns 26 599-604.
13. W.G. Cioffi (2001) What's new in burns and metabolism. J Am Coll Surg 192 241-254.
14. N.S. Gibran and D.M. Heimbach (2000) Current status of burn wound pathophysiology. Clin Plast Surg 27 11-22.
15. T. Lund, H. Onarheim and R.K. Reed (1992) Pathogenesis of edema formation in burn injuries. World J Surg 16 2-9.
16. E.M. Renkin (1985) Capillary transport of macromolecules: pores and other endothelial pathways. J Appl Physiol 58 315-325.
17. D.O. Bates and S.J. Harper (2003) Regulation of vascular permeability by vascular endothelial growth factors. Vascul Pharmacol 39 225-237.
18. F.E. Curry (1984) Mechanics and thermodynamics of transcapillary exchange. E.M. Renkin, C.C. Michel (Eds) Handbook of Physiology: The Cardiovascular System. Microcirculation Bethesda, MD: American Physiological Society 411-466.
19. C. Crone and D.G. Levitt (1984) Capillary permeability to small solutes. Handbook of Physiology: The Cardiovascular System. Microcirculation Bethesda, MD: American Physiological Society 411-466.
20. C.C. Michel (1984) Fluid movements through capillary walls. Handbook of Physiology: The Cardiovascular System. Microcirculation Bethesda, MD: American Physiological Society 375-409.
21. A.E. Taylor and D.N. Granger (1984) Exchange of macrfomolecules across the microcirculation. E.M. Renkin, C.C. Michel (Eds) Handbook of Physiology: The Cardiovascular System. Microcirculation Bethesda, MD: American Physiological Society 467-520.
22. E.H. Starling (1896) On the absorption of fluids from the connective tissue spaces. J Physiol 19 312-326.
23. E.M. Landis (1927) Microinjection studies of capillary permeability. II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries. Am J Physiol 82 217-238.
24. O. Kedem and A. Katchalsky (1958) Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochim Biophys Acta 27 229-246.
25. C.S. Patlak, D.A. Goldstein and J.F. Hoffman (1963) The flow of solute and solvent across a two-membrane system. J Theor Biol 5 426-442.
26. R.H. Adamson, J.F. Lenz, X. Zhang, G.N. Adamson, S. Weinbaum and F.E. Curry (2004) Oncotic pressures opposing filtration across non-fenestrated rat microvessels. J Physiol 557 889-907.
27. V.H. Huxley and D.A. Williams (1996) Basal and adenosine-mediated protein flux from isolated coronary arterioles. Am J Physiol 271 H1099-H1108.
28. S. Bingaman, V.H. Huxley and R.E. Rumbaut (2003) Fluorescent dyes modify properties of proteins used in microvascular research. Microcirculation 10 221-231.
29. Q. Huang and Y. Yuan (1997) Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability. Am J Physiol 273 H2442-hH2451.
30. H.M. Wu, Q. Huang, Y. Yuan and H.J. Granger (1996) VEGF induces NO-dependent hyperpermeability in coronary venules. Am J Physiol 271 H2735-hH2739.
31. H.M. Wu, Y. Yuan, D.C. Zawieja, J. Tinsley and H.J. Granger (1999) Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. Am J Physiol 276 H535-hH542.
32. S.Y. Yuan, M.H. Wu, E.E. Ustinova, M. Guo, J.H. Tinsley, P. De Lanerolle and W. Xu (2002) Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage. Circ Res 90 1214-1221.
33. Y. Yuan, W.M. Chilian, H.J. Granger and D.C. Zawieja (1993) Permeability to albumin in isolated coronary venules. Am J Physiol 265 H543-hH552.
34. Y. Yuan, H.J. Granger, D.C. Zawieja and W.M. Chilian (1992) Flow modulates coronary venular permeability by a nitric oxide-related mechanism. Am J Physiol 263 H641-hH646.
35. Y. Yuan, H.J. Granger, D.C. Zawieja, D.V. DeFily and W.M. Chilian (1993) Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade. Am J Physiol 264 H1734-hH1739.
36. Y. Yuan, Q. Huang and H.M. Wu (1997) Myosin light chain phosphorylation: modulation of basal and agonist-stimulated venular permeability. Am J Physiol 272 H1437-hH1443.
37. Y. Yuan, F.Y. Meng, Q. Huang, J. Hawker and H.M. Wu (1998) Tyrosine phosphorylation of paxillin/pp125FAK and microvascular endothelial barrier function. Am J Physiol 275 H84-hH93.
38. Y. Yuan, R.A. Mier, W.M. Chilian, D.C. Zawieja and H.J. Granger (1995) Interaction of neutrophils and endothelium in isolated coronary venules and arterioles. Am J Physiol 268 H490-hH498.
39. C. Crone and O. Christensen (1981) Electrical resistance of a capillary endothelium. J Gen Physiol 77 349-371.
40. S.P. Olesen, M.L. de Saint-Aubain and M. Bundgaard (1984) Permeabilities of single arterioles and venules in the frog skin: a functional and morphological study. Microvasc Res 28 1-22.
41. G. Majno, G.E. Palade and G.I. Schoefl (1961) Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: a topographic study. J Biophys Biochem Cytol 11 607-626.
42. R.S. Cotran and G. Majno (1964) The delayed and prolonged vascular leakage in inflammation. I. topography of the leaking vessels after thermal injury. Am J Pathol 45 261-281.
43. M.P. Boric, J.S. Roblero and W.N. Durán (1987) Quantitation of bradykinin-induced microvascular leakage of FITC-dextran in rat cremaster muscle. Microvasc Res 33 397-412.
44. P.K. Dillon and W.N. Durán (1988) Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. Circ Res 62 732-740.
45. J. Fox, F. Galey and H. Wayland (1980) Action of histamine on the mesenteric microvasculature. Microvasc Res 19 108-126.
46. D.M. Gawlowski and W.N. Durán (1986) Dose-related effects of adenosine and bradykinin on microvascular permselectivity to macromolecules in the hamster cheek pouch. Circ Res 58 348-355.
47. D.M. Gawlowski, A.B. Ritter and W.N. Durán (1982) Reproducibility of microvascular permeability responses to successive topical applications of bradykinin in the hamster cheek pouch. Microvasc Res 24 354-363.
48. K.L. Horan, S.W. Adamski, W. Ayele, J.J. Langone and G.J. Grega (1986) Evidence that prolonged histamine suffusions produce transient increases in vascular permeability subsequent to the formation of venular macromolecular leakage sites. Proof of the Majno-Palade hypothesis. Am J Pathol 123 570-576.
49. L. Lindbom (2003) Regulation of vascular permeability by neutrophils in acute inflammation. Chem Immunol Allergy 83 146-166.
50. E. Svensjo (1990) The hamster cheek pouch as a model in microcirculation research. Eur Respir J Suppl 12 595s-s600s. discussion, 600s-601s
51. E. Svensjo and W.L. Joyner (1984) The effects of intermittent and continuous stimulation of microvessels in the cheek pouch of hamsters with histamine and bradykinin on the development of venular leaky sites. Microcirc Endothelium Lymphatics 1 381-396.
52. N.Z. Wu and A.L. Baldwin (1992) Transient venular permeability increase and endothelial gap formation induced by histamine. Am J Physiol 262 H1238-hH1247.
53. T.H. Allen and P.D. Dralpvats (1948) Spectrophotometric measurement of traces of the dye T-1824 by extraction with cellophane from both blood serum and urine of normal dogs. Am J Physiol 154 27-38.
54. R.A. Rawson (1943) The binding of T-1824 and structurally related diazo dyes by plasma proteins. Am J Physiol 138 708-717.
55. A.A. Miles and E.M. Miles (1952) Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs. J Physiol 118 228-257.
56. A. Saria and J.M. Lundberg (1983) Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues. J Neurosci Methods 8 41-49.
57. K. Udaka, Y. Takeuchi and H.Z. Movat (1970) Simple method for quantitation of enhanced vascular permeability. Proc Soc Exp Biol Med 133 1384-1387.
58. T.W. Evans, K.F. Chung, D.F. Rogers and P.J. Barnes (1987) Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. J Appl Physiol 63 479-484.
59. D. Sheppard, L. Scypinski, J. Horn, T. Gordon and J.E. Thompson (1986) Granulocyte-mediated airway edema in guinea pigs. J Appl Physiol 60 1213-1220.
60. M.G. Sirois and E.R. Edelman (1997) VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. Am J Physiol 272 H2746-hH2756.
61. H.F. Dvorak, J.A. Nagy, D. Feng, L.F. Brown and A.M. Dvorak (1999) Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol 237 97-132.
62. D.O. Bates and F.E. Curry (1996) Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels. Am J Physiol 271 H2520-hH2528.
63. D.O. Bates, D. Lodwick and B. Williams (1999) Vascular endothelial growth factor and microvascular permeability. Microcirculation 6 83-96.
64. A. Taylor, M.I. Townsley and R.J. Korthuis (1985) Macromolecule transport across the pulmonary microvessel walls. Exp Lung Res 8 97-123.
65. J.R. Levick and C.C. Michel (1973) The permeability of individually perfused frog mesenteric capillaries to T1824 and T1824-albumin as evidence for a large pore system. Q J Exp Physiol Cogn Med Sci 58 67-85.
66. W.N. Durán and P.K. Dillon (1990) Acute microcirculatory effects of platelet-activating factor. J Lipid Mediat 2(Suppl), S215-sS227.
67. W.G. Mayhan and W.L. Joyner (1984) The effect of altering the external calcium concentration and a calcium channel blocker, verapamil, on microvascular leaky sites and dextran clearance in the hamster cheek pouch. Microvasc Res 28 159-179.
68. B.R. Duling (1973) The preparation and use of the hamster cheek pouch for studies of the microcirculation. Microvasc Res 5 423-429.
69. D. Kim, P.M. Armenante and W.N. Durán (1993) Transient analysis of macromolecular transport across microvascular wall and into interstitium. Am J Physiol 265 H993-hH999.
70. M.M. Ramirez, S.M. Quardt, D. Kim, H. Oshiro, M. Minnicozzi and W.N. Durán (1995) Platelet activating factor modulates microvascular permeability through nitric oxide synthesis. Microvasc Res 50 223-234.
71. E. Svensjo, K.E. Arfors, G. Arturson and G. Rutili (1978) The hamster cheek pouch preparation as a model for studies of macromolecular permeability of the microvasculature. Ups J Med Sci 83 71-79.
72. A.Y. Bekker, A.B. Ritter and W.N. Durán (1989) Analysis of microvascular permeability to macromolecules by video-image digital processing. Microvasc Res 38 200-216.
73. P.M. Armenante, D. Kim and W.N. Durán (1991) Experimental determination of the linear correlation between in vivo TV fluorescence intensity and vascular and tissue FITC-DX concentrations. Microvasc Res 42 198-208.
74. T. Hatakeyama, P.J. Pappas, R.W. Hobson II, M.P. Boric, W.C. Sessa and W.N. Durán (2006) Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. J Physiol 574 275-281.
75. A.Y. Bekker, A.B. Ritter and W.N. Durán (1986) Reduction of pressure in postcapillary venules induced by EPI-fluorescent illumination of FITC-dextrans. Microcirc Endothelium Lymphatics 3 411-423.
76. A.Y. Bekker, P.K. Dillon, J. Paul, A.B. Ritter and W.N. Durán (1988) Dose-response relationships between platelet activating factor and permeability–surface area product of FITC-dextran 150 in the hamster cheek pouch. Microcirc Endothelium Lymphatics 4 433-446.
77. E. Svensjo, S.W. Adamski, K. Su and G.J. Grega (1982) Quantitative physiological and morphological aspects of microvascular permeability changes induced by histamine and inhibited by terbutaline. Acta Physiol Scand 116 265-273.
78. L.E. Gerlowski and R.K. Jain (1986) Microvascular permeability of normal and neoplastic tissues. Microvasc Res 31 288-305.
79. V.H. Huxley, F.E. Curry and R.H. Adamson (1987) Quantitative fluorescence microscopy on single capillaries: alpha-lactalbumin transport. Am J Physiol 252 H188-hH197.
80. K. Ley and K.E. Arfors (1982) Changes in macromolecular permeability by intravascular generation of oxygen-derived free radicals. Microvasc Res 24 25-33.
81. K. Ley and K.E. Arfors (1986) Segmental differences of microvascular permeability for FITC-dextrans measured in the hamster cheek pouch. Microvasc Res 31 84-99.
82. A.B. Ritter, W. Braun, A. Stein and W. Durán (1985) Visualization of the coronary microcirculation using digital image processing. Comput Biol Med 15 361-374.
83. L.J. Nugent and R.K. Jain (1984) Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed. Am J Physiol 246 H129-hH137.
84. J.R. Fox and H. Wayland (1979) Interstitial diffusion of macromolecules in the rat mesentery. Microvasc Res 18 255-276.
85. D. Kim, P.M. Armenante and W.N. Durán (1990) Mathematical modeling of mass transfer in microvascular wall and interstitial space. Microvasc Res 40 358-378.
86. A.A. Noel, S.R. Fallek, R.W. Hobson II and W.N. Durán (1995) Inhibition of nitric oxide synthase attenuates primed microvascular permeability in the in vivo microcirculation. J Vasc Surg 22 661-669. discussion 669–670, 1995
87. W.D. Suval, W.N. Durán, M.P. Boric, R.W. Hobson III, P.B. Berendsen and A.B. Ritter (1987) Microvascular transport and endothelial cell alterations preceding skeletal muscle damage in ischemia and reperfusion injury. Am J Surg 154 211-218.
88. W.D. Suval, R.W. Hobson II, M.P. Boric, A.B. Ritter and W.N. Durán (1987) Assessment of ischemia reperfusion injury in skeletal muscle by macromolecular clearance. J Surg Res 42 550-559.
89. H. Yasuhara, R.W. Hobson II, P.K. Dillon and W.N. Durán (1991) A new model for studying ischemia-reperfusion injury in hamster cheek pouch. Am J Physiol 261 H1626-hH1629.
90. Y. Suzuki, E.A. Deitch, S. Mishima, W.N. Durán and D.Z. Xu (2000) Endotoxin-induced mesenteric microvascular changes involve iNOS-derived nitric oxide: results from a study using iNOS knock out mice. Shock 13 397-403.
91. S.Y. Yuan (2000) Signal transduction pathways in enhanced microvascular permeability. Microcirculation 7 395-403.
92. J.H. Tinsley, E.E. Ustinova, W. Xu and S.Y. Yuan (2002) Src-dependent, neutrophil-mediated vascular hyperpermeability and beta -catenin modification. Am J Physiol Cell Physiol 283 C1745-cC1751.
93. J.H. Tinsley, D.C. Zawieja, M.H. Wu, E.E. Ustinova, W. Xu and S.Y. Yuan (2001) Protein transfection of intact microvessels specifically modulates vasoreactivity and permeability. J Vasc Res 38 444-452.
94. E.A. Jaffe, R.L. Nachman, C.G. Becker and C.R. Minick (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52 2745-2756.
95. M. Gumbleton and K.L. Audus (2001) Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier. J Pharm Sci 90 1681-1698.
96. S.M. Albelda, P.M. Sampson, F.R. Haselton, J.M. McNiff, S.N. Mueller, S.K. Williams, A.P. Fishman and E.M. Levine (1988) Permeability characteristics of cultured endothelial cell monolayers. J Appl Physiol 64 308-322.
97. M.E. Schelling, C.J. Meininger, J.R. Hawker Jr. and H.J. Granger (1988) Venular endothelial cells from bovine heart. Am J Physiol 254 H1211-hH1217.
98. J.W. Breslin and S.Y. Yuan (2004) Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability. Am J Physiol Heart Circ Physiol 286 H1057-hH1062.
99. J.H. Tinsley, M.H. Wu, W. Ma, A.C. Taulman and S.Y. Yuan (1999) Activated neutrophils induce hyperpermeability and phosphorylation of adherens junction proteins in coronary venular endothelial cells. J Biol Chem 274 24930-24934.
100. T. Tilling, D. Korte, D. Hoheisel and H.J. Galla (1998) Basement membrane proteins influence brain capillary endothelial barrier function in vitro. J Neurochem 71 1151-1157.
101. M.B. Furie, E.B. Cramer, B.L. Naprstek and S.C. Silverstein (1984) Cultured endothelial cell monolayers that restrict the transendothelial passage of macromolecules and electrical current. J Cell Biol 98 1033-1041.
102. M. Navab, G.P. Hough, J.A. Berliner, J.A. Frank, A.M. Fogelman, M.E. Haberland and P.A. Edwards (1986) Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance. J Clin Invest 78 389-397.
103. D.M. Shasby and S.S. Shasby (1986) Effects of calcium on transendothelial albumin transfer and electrical resistance. J Appl Physiol 60 71-79.
104. M. Territo, J.A. Berliner and A.M. Fogelman (1984) Effect of monocyte migration on low density lipoprotein transport across aortic endothelial cell monolayers. J Clin Invest 74 2279-2284.
105. T.J. Abbruscato and T.P. Davis (1999) Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity. J Pharmacol Exp Ther 289 668-675.
106. T.J. Raub, S.L. Kuentzel and G.A. Sawada (1992) Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells. Exp Cell Res 199 330-340.
107. S.P. Olesen and C. Crone (1983) Electrical resistance of muscle capillary endothelium. Biophys J 42 31-41.
108. C. Crone and S.P. Olesen (1982) Electrical resistance of brain microvascular endothelium. Brain Res 241 49-55.
109. I. Giaever and C.R. Keese (1991) Micromotion of mammalian cells measured electrically. Proc Natl Acad Sci USA 88 7896-7900.
110. I. Giaever and C.R. Keese (1993) A morphological biosensor for mammalian cells. Nature 366 591-592.
111. A.B. Moy, K. Blackwell and A. Kamath (2002) Differential effects of histamine and thrombin on endothelial barrier function through actin-myosin tension. Am J Physiol Heart Circ Physiol 282 H21-hH29.
112. A.B. Moy, K. Blackwell, N. Wang, K. Haxhinasto, M.K. Kasiske, J. Bodmer, G. Reyes and A. English (2004) Phorbol ester-mediated pulmonary artery endothelial barrier dysfunction through regulation of actin cytoskeletal mechanics. Am J Physiol Lung Cell Mol Physiol 287 L153-lL167.
113. A.B. Moy, J. Van Engelenhoven, J. Bodmer, J. Kamath, C. Keese, I. Giaever, S. Shasby and D.M. Shasby (1996) Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces. J Clin Invest 97 1020-1027.
114. A.B. Moy, M. Winter, A. Kamath, K. Blackwell, G. Reyes, I. Giaever, C. Keese and D.M. Shasby (2000) Histamine alters endothelial barrier function at cell-cell and cell-matrix sites. Am J Physiol Lung Cell Mol Physiol 278 L888-lL898.
115. C. Tiruppathi, A.B. Malik, P.J. Del Vecchio, C.R. Keese and I. Giaever (1992) Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci USA 89 7919-7923.
116. H. Lum and A.B. Malik (1994) Regulation of vascular endothelial barrier function. Am J Physiol 267 L223-lL241.
117. P.F. McDonagh and S.K. Williams (1984) The preparation and use of fluorescent-protein conjugates for microvascular research. Microvasc Res 27 14-27.
118. J.P. Martin and N. Logsdon (1987) Oxygen radicals mediate cell inactivation by acridine dyes, fluorescein, and lucifer yellow CH. Photochem Photobiol 46 45-53.
119. D.M. Gawlowski, N.R. Harding and H.J. Granger (1989) Leukocyte phagocytosis and alterations in microvascular integrity elicited by FITC-dextran 150 and epi-illumination in the microcirculation of the hamster cheek pouch. Microvasc Res 37 1-15.
120. M.W. Reed and F.N. Miller (1988) Importance of light dose in fluorescent microscopy. Microvasc Res 36 104-107.
121. H. Vink and B.R. Duling (1996) Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries. Circ Res 79 581-589.
122. J.L. Zhang, S. Yokoyama and T. Ohhashi (1997) Inhibitory effects of fluorescein isothiocyanate photoactivation on lymphatic pump activity. Microvasc Res 54 99-107.
123. R.E. Rumbaut, N.R. Harris, A.J. Sial, V.H. Huxley and D.N. Granger (1999) Leakage responses to L-NAME differ with the fluorescent dye used to label albumin. Am J Physiol 276 H333-hH339.
124. R.E. Rumbaut and A.J. Sial (1999) Differential phototoxicity of fluorescent dye-labeled albumin conjugates. Microcirculation 6 205-213.
125. J.R. Pappenheimer, E.M. Renkin and L.M. Borrero (1951) Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability. Am J Physiol 167 13-46.
126. E.M. Renkin (1994) Cellular aspects of transvascular exchange: a 40-year perspective. Microcirculation 1 157-167.
127. B. Rippe and B. Haraldsson (1994) Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev 74 163-219.
128. E.M. Renkin, M. Gustafson Sgro and L. Sibley (1998) Coupling of albumin flux to volume flow in skin and muscles of anesthetized rats. Am J Physiol 255 H458-hH466.
129. F.E. Curry and C.C. Michel (1980) A fiber matrix model of capillary permeability. Microvasc Res 20 96-99.
130. G.E. Palade (1960) Transport in quanta across the endothelium of blood capillaries. Anat Rec 116 254. (Abstract)
131. R.R. Bruns and G.E. Palade (1968) Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries. J Cell Biol 37 277-299.
132. G. Clough and C.C. Michel (1981) The role of vesicles in the transport of ferritin through frog endothelium. J Physiol 315 127-142.
133. M.A. Jennings and L. Florey (1967) An investigation of some properties of endothelium related to capillary permeability. Proc R Soc Lond B Biol Sci 167 39-63.
134. B.R. Johansson (1979) Size and distribution of endothelial plasmalemmal vesicles in consecutive segments of the microvasculature in cat skeletal muscle. Microvasc Res 17 107-117.
135. N. Simionescu, M. Siminoescu and G.E. Palade (1975) Permeability of muscle capillaries to small heme-peptides. Evidence for the existence of patent transendothelial channels. J Cell Biol 64 586-607.
136. D. Predescu, R. Horvat, S. Predescu and G.E. Palade (1994) Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide. Proc Natl Acad Sci USA 91 3014-3018.
137. J.E. Schnitzer, P. Oh, E. Pinney and J. Allard (1994) Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J Cell Biol 127 1217-1232.
138. M. Simionescu and N. Simionescu (1984) Ultrastructure of the microvascular wall: functional correlations. E.M. Renkin, C.C. Michel (Eds) Handbook of Physiology: The Cardiovascular System. Microcirculation 2nd Ed. Bethesda, MD: American Physiological Society 41-101.
139. M. Bundgaard, J. Frokjaer-Jensen and C. Crone (1979) Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface. Proc Natl Acad Sci USA 76 6439-6442.
140. J. Frokjaer-Jensen (1980) Three-dimensional organization of plasmalemmal vesicles in endothelial cells. An analysis by serial sectioning of frog mesenteric capillaries. J Ultrastruct Res 73 9-20.
141. C. Crone (1984) Recent Advances in Physiology. London: Chruchill Livingstone
142. R.K. Reed (1988) Transcapillary albumin extravasation in rat skin and skeletal muscle: effect of increased venous pressure. Acta Physiol Scand 134 375-382.
143. O. Carlsson, B.I. Rosengren and B. Rippe (2001) Transcytosis inhibitor N-ethylmaleimide increases microvascular permeability in rat muscle. Am J Physiol Heart Circ Physiol 281 H1728-hH1733.
144. B. Rippe and A. Taylor (2001) NEM and filipin increase albumin transport in lung microvessels. Am J Physiol Heart Circ Physiol 280 H34-hH41.
145. B. Haraldsson and B.R. Johansson (1985) Changes in transcapillary exchange induced by perfusion fixation with glutaraldehyde, followed by measurements of capillary filtration coefficient, diffusion capacity and albumin clearance. Acta Physiol Scand 124 99-106.
146. G. Clough (1991) Relationship between microvascular permeability and ultrastructure. Prog Biophys Mol Biol 55 47-69.
147. A.M. Dvorak and D. Feng (2001) The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle. J Histochem Cytochem 49 419-432.
148. D. Feng, J.A. Nagy, R.A. Brekken, A. Pettersson, E.J. Manseau, K. Pyne, R. Mulligan, P.E. Thorpe, H.F. Dvorak and A.M. Dvorak (2000) Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors. J Histochem Cytochem 48 545-556.
149. E. Vasile, H. Qu, H.F. Dvorak and A.M. Dvorak (1999) Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels. J Histochem Cytochem 47 159-167.
150. R.D. Minshall, C. Tiruppathi, S.M. Vogel, W.D. Niles, A. Gilchrist, H.E. Hamm and A.B. Malik (2000) Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway. J Cell Biol 150 1057-1070.
151. S.M. Vogel, R.D. Minshall, M. Pilipovic, C. Tiruppathi and A.B. Malik (2001) Albumin uptake and transcytosis in endothelial cells in vivo induced by albumin-binding protein. Am J Physiol Lung Cell Mol Physiol 281 L1512-lL1522.
152. A. Holmang, P. Bjorntorp and B. Rippe (1992) Tissue uptake of insulin and inulin in red and white skeletal muscle in vivo. Am J Physiol 263 H1170-hH1176.
153. E. Vasile, M. Simionescu and N. Simionescu (1983) Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ. J Cell Biol 96 1677-1689.
154. J.C. Rutledge (1992) Temperature and hydrostatic pressure-dependent pathways of low-density lipoprotein transport across microvascular barrier. Am J Physiol 262 H234-hH245.
155. R. Chambers and B.W. Zweifach (1947) Intercellular cement and capillary permeability. Physiol Rev 27 436-463.
156. G. Majno and G. Palade (1961) Studies on inflammation I. The effect of histamine and serotonin on vascular permeability: An electron microscopic study. J Biophys Cytol 11 597-605.
157. S.M. Dudek and J.G. Garcia (2001) Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91 1487-1500.
158. J.G. Garcia, H.W. Davis and C.E. Patterson (1995) Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J Cell Physiol 163 510-522.
159. A.B. Moy, R. Sheldon, K. Lindsley, S. Shasby and D.M. Shasby (1994) Centripetal tension and endothelial retraction. Chest 105 107S-sS108S.
160. S.Y. Yuan (2003) Protein kinase signaling in the modulation of microvascular permeability. Vascul Pharmacol 39 213-223.
161. E.A. Hixenbaugh, Z.M. Goeckeler, N.N. Papaiya, R.B. Wysolmerski, S.C. Silverstein and A.J. Huang (1997) Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells. Am J Physiol 273 H981-hH988.
162. M.S. Kolodney and R.B. Wysolmerski (1992) Isometric contraction by fibroblasts and endothelial cells in tissue culture: A quantitative study. J Cell Biol 117 73-82.
163. N.S. Harhaj and D.A. Antonetti (2004) Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 36 1206-1237.
164. G. Bazzoni and E. Dejana (2004) Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 84 869-901.
165. E.C. Beyer, J. Gemel, K.H. Seul, D.M. Larson, K. Banach and P.R. Brink (2000) Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins. Braz J Med Biol Res 33 391-397.
166. C.G. Kevil, N. Okayama, S.D. Trocha, T.J. Kalogeris, L.L. Coe, R.D. Specian, C.P. Davis and J.S. Alexander (1998) Expression of zonula occludens and adherens junctional proteins in human venous and arterial endothelial cells: role of occludin in endothelial solute barriers. Microcirculation 5 197-210.
167. T. Hirase, J.M. Staddon, M. Saitou, Y. Ando-Akatsuka, M. Itoh, M. Furuse, K. Fujimoto, S. Tsukita and L.L. Rubin (1997) Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 110(Pt 14), 1603-1613.
168. L. DeMaio, Y.S. Chang, T.W. Gardner, J.M. Tarbell and D.A. Antonetti (2001) Shear stress regulates occludin content and phosphorylation. Am J Physiol Heart Circ Physiol 281 H105-hH113.
169. D.A. Antonetti, A.J. Barber, S. Khin, E. Lieth, J.M. Tarbell and T.W. Gardner (1998) Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes 47 1953-1959.
170. Z. Muresan, D.L. Paul and D.A. Goodenough (2000) Occludin 1B, a variant of the tight junction protein occludin. Mol Biol Cell 11 627-634.
171. D.A. Antonetti, A.J. Barber, L.A. Hollinger, E.B. Wolpert and T.W. Gardner (1999) Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 274 23463-23467.
172. T. Nitta, M. Hata, S. Gotoh, Y. Seo, H. Sasaki, N. Hashimoto, M. Furuse and S. Tsukita (2003) Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161 653-660.
173. M. Corada, F. Liao, M. Lindgren, M.G. Lampugnani, F. Breviario, R. Frank, W.A. Muller, D.J. Hicklin, P. Bohlen and E. Dejana (2001) Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood 97 1679-1684.
174. M. Corada, M. Mariotti, G. Thurston, K. Smith, R. Kunkel, M. Brockhaus, M.G. Lampugnani, I. Martin-Padura, A. Stoppacciaro, L. Ruco, D.M. McDonald, P.A. Ward and E. Dejana (1999) Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci USA 96 9815-9820.
175. M. Guo, M.H. Wu, H.J. Granger and S.Y. Yuan (2004) Transference of recombinant VE-cadherin cytoplasmic domain alters endothelial junctional integrity and porcine microvascular permeability. J Physiol 554 78-88.
176. A.M. Simon and A.R. McWhorter (2003) Role of connexin37 and connexin40 in vascular development. Cell Commun Adhes 10 379-385.
177. A.M. Simon and A.R. McWhorter (2002) Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40. Dev Biol 251 206-220.
178. S. Suarez and K. Ballmer-Hofer (2001) VEGF transiently disrupts gap junctional communication in endothelial cells. J Cell Sci 114 1229-1235.
179. D. Thuringer (2004) The vascular endothelial growth factor-induced disruption of gap junctions is relayed by an autocrine communication via ATP release in coronary capillary endothelium. Ann N Y Acad Sci 1030 14-27.
180. P. Agre and W. Homer (2000) Smith award lecture. Aquaporin water channels in kidney. J Am Soc Nephrol 11 764-777.
181. L.S. King, S. Nielsen, P. Agre and R.H. Brown (2002) Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc Natl Acad Sci USA 99 1059-1063.
182. A.S. Verkman (2002) Aquaporin water channels and endothelial cell function. J Anat 200 617-627.
183. W.F. de Weerd and L.M. Leeb-Lundberg (1997) Bradykinin sequesters B2 bradykinin receptors and the receptor-coupled Galpha subunits Galphaq and Galphai in caveolae in DDT1 MF-2 smooth muscle cells. J Biol Chem 272 17858-17866.
184. F. Snyder (1990) Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol 259 C697-cC708.
185. B. Millauer, S. Wizigmann-Voos, H. Schnurch, R. Martinez, N.P. Moller, W. Risau and A. Ullrich (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72 835-846.
186. T.P. Quinn, K.G. Peters, C. De Vries, N. Ferrara and L.T. Williams (1993) Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 90 7533-7537.
187. T. Izumi and T. Shimizu (1995) Platelet-activating factor receptor: gene expression and signal transduction. Biochim Biophys Acta 1259 317-333.
188. A. Kuruvilla, C. Pielop and W.T. Shearer (1994) Platelet-activating factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and phosphatidylinositol 3-kinase in a human B cell line. J Immunol 153 5433-5442.
189. J. Kroll and J. Waltenberger (1997) The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem 272 32521-32527.
190. D. Guo, Q. Jia, H.Y. Song, R.S. Warren and D.B. Donner (1995) Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J Biol Chem 270 6729-6733.
191. D. Mukhopadhyay, J.A. Nagy, E.J. Manseau and H.F. Dvorak (1998) Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium. Cancer Res 58 1278-1284.
192. J.W. Breslin, N. Gaudreault, K.D. Watson, R. Reynoso, S.Y. Yuan and M.H. Wu (2007) Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism. Am J Physiol Heart Circ Physiol 293 H709-hH718.
193. J.W. Breslin, S.Y. Yuan and M.H. Wu (2007) VEGF-C alters barrier function of cultured lymphatic endothelial cells through a vEGFR-3 dependent mechanism. Lymphat Res Biol 5 105-113.
194. N.J. Hillman, C.E. Whittles, T.M. Pocock, B. Williams and D.O. Bates (2001) Differential effects of vascular endothelial growth factor-C and placental growth factor-1 on the hydraulic conductivity of frog mesenteric capillaries. J Vasc Res 38 176-186.
195. A.C. Tomeo and W.N. Durán (1991) Resistance and exchange microvessels are modulated by different PAF receptors. Am J Physiol 261 H1648-hH1652.
196. R.L. McLeod, G.G. Mingo, C. Herczku, F. DeGennaro-Culver, W. Kreutner, R.W. Egan and J.A. Hey (1999) Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol 13 391-399.
197. R.L. McLeod, G.G. Mingo, W. Kreutner and J.A. Hey (2005) Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80. Life Sci 76 1787-1794.
198. M.G. Lampugnani, A. Zanetti, F. Breviario, G. Balconi, F. Orsenigo, M. Corada, R. Spagnuolo, M. Betson, V. Braga and E. Dejana (2002) VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell 13 1175-1189.
199. D. Kim and W.N. Durán (1995) Platelet-activating factor stimulates protein tyrosine kinase in hamster cheek pouch microcirculation. Am J Physiol 268 H399-hH403.
200. A.C. Newton (1997) Regulation of protein kinase C. Curr Opin Cell Biol 9 161-167.
201. J.H. Tinsley, N.R. Teasdale and S.Y. Yuan (2004) Involvement of PKCdelta and PKD in pulmonary microvascular endothelial cell hyperpermeability. Am J Physiol Cell Physiol 286 C105-cC111.
202. A. Johnson, D.C. Hocking and T.J. Ferro (1990) Mechanisms of pulmonary edema induced by a diacylglycerol second messenger. Am J Physiol 258 H85-hH91.
203. I. Kobayashi, D. Kim, R.W. Hobson II and W.N. Durán (1994) Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C. Am J Physiol 266 H1214-hH1220.
204. J.J. Lynch, T.J. Ferro, F.A. Blumenstock, A.M. Brockenauer and A.B. Malik (1998) Increased endothelial albumin permeability mediated by protein kinase C activation. J Clin Invest 85 1991-1998.
205. T.M. Pocock, R.R. Foster and D.O. Bates (2004) Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol 286 H1015-hH1026.
206. M.M. Ramirez, D.D. Kim and W.N. Durán (1996) Protein kinase C modulates microvascular permeability through nitric oxide synthase. Am J Physiol 271 H1702-hH1705.
207. H. Aramoto, J.W. Breslin, P.J. Pappas, R.W. Hobson II and W.N. Durán (2004) Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation. Am J Physiol Heart Circ Physiol 287 H1590-hH1598.
208. M.A. Murray, D.D. Heistad and W.G. Mayhan (1991) Role of protein kinase C in bradykinin-induced increases in microvascular permeability. Circ Res 68 1340-1348.
209. A. Johnson, P. Phillips, D. Hocking, M.F. Tsan and T. Ferro (1989) Protein kinase inhibitor prevents pulmonary edema in response to H2O2. Am J Physiol 256 H1012-hH1022.
210. T. Tanita, C. Song, H. Kubo, S. Ono and S. Fujimura (2000) Endothelial signal transduction system enhances neutrophil-induced pulmonary vascular permeability. Eur Respir J 15 452-458.
211. J.W. Breslin, P.J. Pappas, J.J. Cerveira, R.W. Hobson II and W.N. Durán (2003) VEGF Increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol Heart Circ Physiol 284 H92-hH100.
212. A. Siflinger-Birnboim, M.S. Goligorsky, P.J. Del Vecchio and A.B. Malik (1992) Activation of protein kinase C pathway contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab Invest 67 24-30.
213. J.H. Tinsley, J.W. Breslin, N.R. Teasdale and S.Y. Yuan (2005) PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells. Am J Physiol ePub ahead of print, PMID: 15821015, 2005
214. P. Xia, L.P. Aiello, H. Ishii, Z.Y. Jiang, D.J. Park, G.S. Robinson, H. Takagi, W.P. Newsome, M.R. Jirousek and G.L. King (1996) Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98 2018-2026.
215. D.D. Kim, M.M. Ramirez and W.N. Durán (2000) Platelet-activating factor modulates microvascular dynamics through phospholipase C in the hamster cheek pouch. Microvasc Res 59 7-13.
216. D.O. Bates and F.E. Curry (1997) Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am J Physiol 273 H687-hH694.
217. R. Sandoval, A.B. Malik, R.D. Minshall, P. Kouklis, C.A. Ellis and C. Tiruppathi (2001) Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions. J Physiol 533 433-445.
218. R. Sandoval, A.B. Malik, T. Naqvi, D. Mehta and C. Tiruppathi (2001) Requirement for Ca2+ signaling in the mechanism of thrombin-induced increase in endothelial permeability. Am J Physiol Lung Cell Mol Physiol 280 L239-lL247.
219. P. He, S.N. Pagakis and F.E. Curry (1990) Measurement of cytoplasmic calcium in single microvessels with increased permeability. Am J Physiol 258 H1366-hH1374.
220. C.A. Glass, T.M. Pocock, F.E. Curry and D.O. Bates (2005) Cytosolic Ca2+ concentration and the rate of increase of the cytosolic Ca2+ concentration in the regulation of vascular permeability in Rana in vivo. J Physiol
221. T.M. Pocock, B. Williams, F.E. Curry and D.O. Bates (2000) VEGF and ATP act by different mechanisms to increase microvascular permeability and endothelial [Ca(2+)](i). Am J Physiol Heart Circ Physiol 279 H1625-hH1634.
222. T. Ferro, P. Neumann and N. Gertzberg (2000) Clements R and Johnson A. Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha. Am J Physiol Lung Cell Mol Physiol 278 L1107-lL1117.
223. D. Mehta, A. Rahman and A.B. Malik (2001) Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 276 22614-22620.
224. P.G. Nagpala, A.B. Malik, P.T. Vuong and H. Lum (1996) Protein kinase C beta 1 overexpression augments phorbol ester-induced increase in endothelial permeability. J Cell Physiol 166 249-255.
225. M.R. Jirousek, J.R. Gillig, C.M. Gonzalez, W.F. Heath, J.H. McDonald III, D.A. Neel, C.J. Rito, U. Singh, L.E. Stramm, A. Melikian-Badalian, M. Baevsky, L.M. Ballas, S.E. Hall, L.L. Winneroski and M.M. Faul (1979) (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J Med Chem 39 2664-2671.
226. L.P. Aiello, S.E. Bursell, A. Clermont, E. Duh, H. Ishii, C. Takagi, F. Mori, T.A. Ciulla, K. Ways, M. Jirousek, L.E. Smith and G.L. King (1997) Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 46 1473-1480.
227. H. Ishii, M.R. Jirousek, D. Koya, C. Takagi, P. Xia, A. Clermont, S.E. Bursell, T.S. Kern, L.M. Ballas, W.F. Heath, L.E. Stramm, E.P. Feener and G.L. King (1996) Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272 728-731.
228. D. Koya, M. Haneda, H. Nakagawa, K. Isshiki, H. Sato, S. Maeda, T. Sugimoto, H. Yasuda, A. Kashiwagi, D.K. Ways, G.L. King and R. Kikkawa (2000) Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 14 439-447.
229. M. Guo, M.H. Wu, F. Korompai and S.Y. Yuan (2003) Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes. Physiol Genomics 12 139-146.
230. G.M. Comer and T.A. Ciulla (2004) Pharmacotherapy for diabetic retinopathy. Curr Opin Ophthalmol 15 508-518.
231. K.R. Tuttle and P.W. Anderson (2003) A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition. Am J Kidney Dis 42 456-465.
232. H. Kim, T. Sasaki, K. Maeda, D. Koya, A. Kashiwagi and H. Yasuda (2003) Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. Diabetes 52 2102-2109.
233. J.E. Stasek Jr., C.E. Patterson and J.G. Garcia (1992) Protein kinase C phosphorylates caldesmon77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers. J Cell Physiol 153 62-75.
234. H. Abedi and I. Zachary (1997) Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272 15442-15451.
235. J.S. Alexander, S.A. Jackson, E. Chaney, C.G. Kevil and F.R. Haselton (1998) The role of cadherin endocytosis in endothelial barrier regulation: involvement of protein kinase C and actin-cadherin interactions. Inflammation 22 419-433.
236. T.M. Moore, P.M. Chetham, J.J. Kelly and T. Stevens (1998) Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP. Am J Physiol 275 L203-lL222.
237. P. He, M. Zeng and F.E. Curry (2000) Dominant role of cAMP in regulation of microvessel permeability. Am J Physiol Heart Circ Physiol 278 H1124-hH1133.
238. R.H. Adamson, B. Liu, G.N. Fry, L.L. Rubin and F.E. Curry (1998) Microvascular permeability and number of tight junctions are modulated by cAMP. Am J Physiol 274 H1885-hH1894.
239. M.H. Cobb (1999) MAP kinase pathways. Prog Biophys Mol Biol 71 479-500.
240. J. Hood and H.J. Granger (1998) Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells. J Biol Chem 273 23504-23508.
241. A. Parenti, L. Morbidelli, X.L. Cui, J.G. Douglas, J.D. Hood, H.J. Granger, F. Ledda and M. Ziche (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase 1/2 activation in postcapillary endothelium. J Biol Chem 273 4220-4226.
242. M.R. Kooistra, M. Corada, E. Dejana and J.L. Bos (2005) Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 579 4966-4972.
243. L.M. DeFouw and D.O. DeFouw (2001) Differential phosphodiesterase activity contributes to restrictive endothelial barrier function during angiogenesis. Microvasc Res 62 263-270.
244. M.H. Sarker and P.A. Fraser (2002) The role of guanylyl cyclases in the permeability response to inflammatory mediators in pial venular capillaries in the rat. J Physiol 540 209-218.
245. W.G. Mayhan (1994) Nitric oxide accounts for histamine-induced increases in macromolecular extravasation. Am J Physiol 266 H2369-hH2373.
246. D.J. Meyer Jr. and V.H. Huxley (1992) Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators. Circ Res 70 382-391.
247. P. He, M. Zeng and F.E. Curry (1998) cGMP modulates basal and activated microvessel permeability independently of [Ca2+]i. Am J Physiol 274 H1865-hH1874.
248. S. Varma, J.W. Breslin, B.K. Lal, P.J. Pappas, R.W. Hobson II and W.N. Durán (2002) p42/44MAPK regulates baseline permeability and cGMP-induced hyperpermeability in endothelial cells. Microvasc Res 63 172-178.
249. G.D. Thakker, D.P. Hajjar, W.A. Muller and T.K. Rosengart (1999) The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling. J Biol Chem 274 10002-10007.
250. N.M. Conus, K.M. Hannan, B.E. Cristiano, B.A. Hemmings and R.B. Pearson (2002) Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. J Biol Chem 277 38021-38028.
251. J. Downward (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10 262-267.
252. B.A. Hemmings (1997) Akt signaling: linking membrane events to life and death decisions. Science 275 628-630.
253. J. Schlessinger (2000) Cell signaling by receptor tyrosine kinases. Cell 103 211-225.
254. B.K. Lal, S. Varma, P.J. Pappas, R.W. Hobson II and W.N. Durán (2001) VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc Res 62 252-262.
255. P.M. Bauer, J. Yu, Y. Chen, R. Hickey, P.N. Bernatchez, R. Looft-Wilson, Y. Huang, F. Giordano, R.V. Stan and W.C. Sessa (2005) Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci USA 102 204-209.
256. L. Chang and M. Karin (2001) Mammalian MAP kinase signalling cascades. Nature 410 37-40.
257. E. Chuang, D. Barnard, L. Hettich, X.F. Zhang, J. Avruch and M.S. Marshall (1994) Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. Mol Cell Biol 14 5318-5325.
258. J. English, G. Pearson, J. Wilsbacher, Swantek, M. Karandikar, S. Xu and M.H. Cobb (1999) New insights into the control of MAP kinase pathways. Exp Cell Res 253 255-270.
259. T.P. Garrington and G.L. Johnson (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11 211-218.
260. H. Mischak, T. Seitz, P. Janosch, M. Eulitz, H. Steen, M. Schellerer, A. Philipp and W. Kolch (1996) Negative regulation of Raf-1 by phosphorylation of serine 621. Mol Cell Biol 16 5409-5418.
261. J. Wu, P. Dent, T. Jelinek, A. Wolfman, M.J. Weber and T.W. Sturgill (1993) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3’,5’-monophosphate. Science 262 1065-1069.
262. C. Hagemann and U.R. Rapp (1999) Isotype-specific functions of Raf kinases. Exp Cell Res 253 34-46.
263. P.M. Becker, A.D. Verin, M.A. Booth, F. Liu, A. Birukova and J.G. Garcia (2001) Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 281 L1500-l1511.
264. C.G. Kevil, T. Oshima, B. Alexander, L.L. Coe and J.S. Alexander (2000) H(2)O(2)-mediated permeability: role of MAPK and occludin. Am J Physiol Cell Physiol 279 C21-c30.
265. C.G. Kevil, D.K. Payne, E. Mire and J.S. Alexander (1998) Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. J Biol Chem 273 15099-15103.
266. P. Yu, T. Hatakeyama, H. Aramoto, T. Miyata, H. Shigematsu, H. Nagawa, R.W. Hobson and W.N. Durán (2005) Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability. Microcirculation 12 637-643.
267. A.D. Verin, F. Liu, N. Bogatcheva, T. Borbiev, M.B. Hershenson, P. Wang and J.G. Garcia (2000) Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 279 L360-l370.
268. M.H. Wu, S.Y. Yuan and H.J. Granger (2005) The protein kinase MEK1/2 mediate vascular endothelial growth factor- and histamine-induced hyperpermeability in porcine coronary venules. J Physiol 563 95-104.
269. J.G. Garcia, P. Wang, K.L. Schaphorst, P.M. Becker, T. Borbiev, F. Liu, A. Birukova, K. Jacobs, N. Bogatcheva and A.D. Verin (2002) Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. FASEB J 16 1064-1076.
270. K. Issbrucker, H.H. Marti, S. Hippenstiel, G. Springmann, R. Voswinckel, A. Gaumann, G. Breier, H.C. Drexler, N. Suttorp and M. Clauss (2003) p38 MAP kinase – a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. FASEB J 17 262-264.
271. K. Niwa, O. Inanami, T. Ohta, S. Ito, T. Karino and M. Kuwabara (2001) p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not. Free Radic Res 35 519-527.
272. F.E. Nwariaku, J. Chang, X. Zhu, Z. Liu, S.L. Duffy, N.H. Halaihel, L. Terada and R.H. Turnage (2002) The role of p38 map kinase in tumor necrosis factor-induced redistribution of vascular endothelial cadherin and increased endothelial permeability. Shock 8 82-85.
273. A.K. Kiemer, N.C. Weber, R. Furst, N. Bildner, S. Kulhanek-Heinze and A.M. Vollmar (2002) Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability. Circ Res 90 874-881.
274. S. Shi, J.G. Garcia, S. Roy, N.L. Parinandi and V. Natarajan (2000) Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 279 L441-l451.
275. S.M. Thomas and J.S. Brugge (1997) Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13 513-609.
276. C.G. Kevil, N. Okayama and J.S. Alexander (2001) H(2)O(2)-mediated permeability II: importance of tyrosine phosphatase and kinase activity. Am J Physiol Cell Physiol 281 C1940-c1947.
277. F.E. Nwariaku, Z. Liu, X. Zhu, R.H. Turnage, G.A. Sarosi and L.S. Terada (2002) Tyrosine phosphorylation of vascular endothelial cadherin and the regulation of microvascular permeability. Surgery 132 180-185.
278. B.P. Eliceiri, R. Paul, P.L. Schwartzberg, J.D. Hood, J. Leng and D.A. Cheresh (1999) Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 4 915-924.
279. R. Paul, Z.G. Zhang, B.P. Eliceiri, Q. Jiang, A.D. Boccia, R.L. Zhang, M. Chopp and D.A. Cheresh (2001) Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med 7 222-227.
280. C. Tiruppathi, W. Song, M. Bergenfeldt, P. Sass and A.B. Malik (1997) Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway. J Biol Chem 272 25968-25975.
281. A.N. Shajahan, B.K. Timblin, R. Sandoval, C. Tiruppathi, A.B. Malik and R.D. Minshall (2004) Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. J Biol Chem 279 20392-20400.
282. K.G. Birukov, C. Csortos, L. Marzilli, S. Dudek, S.F. Ma, A.R. Bresnick, A.D. Verin, R.J. Cotter and J.G. Garcia (2001) Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). J Biol Chem 276 8567-8573.
283. S.M. Dudek, K.G. Birukov, X. Zhan and J.G. Garcia (2002) Novel interaction of cortactin with endothelial cell myosin light chain kinase. Biochem Biophys Res Commun 298 511-519.
284. J.G. Garcia, A.D. Verin, K. Schaphorst, R. Siddiqui, C.E. Patterson, C. Csortos and V. Natarajan (1999) Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src). Am J Physiol 276 L989-l998.
285. D.R. Mucha, C.L. Myers and R.C. Schaeffer Jr. (2003) Endothelial contraction and monolayer hyperpermeability are regulated by Src kinase. Am J Physiol Heart Circ Physiol 284 H994-hH1002.
286. B.M. Gumbiner (1995) Signal transduction of beta-catenin. Curr Opin Cell Biol 7 634-640.
287. B.P. Eliceiri, X.S. Puente, J.D. Hood, D.G. Stupack, D.D. Schlaepfer, X.Z. Huang, D. Sheppard and D.A. Cheresh (2002) Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol 157 149-160.
288. J.G. Garcia, K.L. Schaphorst, A.D. Verin, S. Vepa, C.E. Patterson and V. Natarajan (2000) Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation. J Appl Physiol 89 2333-2343.
289. P. Wang, A.D. Verin, A. Birukova, L.I. Gilbert-McClain, K. Jacobs and J.G. Garcia (2001) Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol Physiol 281 L1472-l1483.
290. A. Cruz, L.M. DeFouw and D.O. DeFouw (2000) Restrictive endothelial barrier function during normal angiogenesis in vivo: partial dependence on tyrosine dephosphorylation of beta-catenin. Microvasc Res 59 195-203.
291. A.A. Birukova, K. Smurova, K.G. Birukov, K. Kaibuchi, J.G. Garcia and A.D. Verin (2004) Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 67 64-77.
292. A.D. Verin, C.E. Patterson, M.A. Day and J.G. Garcia (1995) Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities. Am J Physiol 269 L99-l108.
293. K. Tar, A.A. Birukova, C. Csortos, E. Bako, J.G. Garcia and A.D. Verin (2004) Phosphatase 2A is involved in endothelial cell microtubule remodeling and barrier regulation. J Cell Biochem 92 534-546.
294. H. Lum, J.L. Podolski, M.E. Gurnack, I.T. Schulz, F. Huang and O. Holian (2001) Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 281 L546-l555.
295. S. Abbi and J.L. Guan (2002) Focal adhesion kinase: protein interactions and cellular functions. Histol Histopathol 17 1163-1171.
296. B. Wojciak-Stothard and A.J. Ridley (2002) Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol 39 187-199.
297. B. Wojciak-Stothard, S. Potempa, T. Eichholtz and A.J. Ridley (2001) Rho and Rac but not Cdc42 regulate endothelial cell permeability. J Cell Sci 114 1343-1355.
298. P. Kouklis, M. Konstantoulaki, S. Vogel, M. Broman and A.B. Malik (2004) Cdc42 regulates the restoration of endothelial barrier function. Circ Res 94 159-166.
299. M. Amano, K. Chihara, K. Kimura, Y. Fukata, N. Nakamura, Y. Matsuura and K. Kaibuchi (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275 1308-1311.
300. H.M. Flinn and A.J. Ridley (1996) Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J Cell Sci 109(Pt 5), 1133-1141.
301. A. Hall (1998) Rho GTPases and the actin cytoskeleton. Science 279 509-514.
302. L.K. Needham and E. Rozengurt (1998) Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate. J Biol Chem 273 14626-14632.
303. J. Sinnett-Smith, J.A. Lunn, D. Leopoldt and E. Rozengurt (2001) Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS). Exp Cell Res 266 292-302.
304. J.M. Carbajal and R.C. Schaeffer Jr. (1999) RhoA inactivation enhances endothelial barrier function. Am J Physiol 277 C955-c964.
305. R.T. Clements, F.L. Minnear, H.A. Singer, R.S. Keller and P.A. Vincent (2005) RhoA and Rho-kinase dependent and independent signals mediate TGF-β-induced pulmonary endothelial cytoskeletal reorganization and permeability. Am J Physiol Lung Cell Mol Physiol 288 L-294-l-L-306.
306. F.E. Nwariaku, P. Rothenbach, Z. Liu, X. Zhu, R.H. Turnage and L.S. Terada (2002) Rho inhibition decreases TNF-induced endothelial MAPK activation and monolayer permeability. J Appl Physiol 95 1889-1895.
307. J.W. Breslin, H. Sun, W. Xu, C. Rodarte, A.B. Moy, M.H. Wu and S.Y. Yuan (2006) Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage. Am J Physiol Heart Circ Physiol 290 H741-h750.
308. J.M. Carbajal, M.L. Gratrix, C.H. Yu and R.C. Schaeffer Jr. (2000) ROCK mediates thrombin's endothelial barrier dysfunction. Am J Physiol Cell Physiol 279 C195-c204.
309. G.P. van Nieuw Amerongen, S. van Delft, M.A. Vermeer, J.G. Collard and V.W. van Hinsbergh (2000) Activation of RhoA by thrombin in endothelial hyperpermeability: Role of Rho kinase and protein tyrosine kinases. Circ Res 87 335-340.
310. R.H. Adamson, F.E. Curry, G. Adamson, B. Liu, Y. Jiang, K. Aktories, H. Barth, A. Daigeler, N. Golenhofen, W. Ness and D. Drenckhahn (2002) Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice. J Physiol 539 295-308.
311. K. Tokuyama, H. Nishimura, K. Iizuka, M. Kato, H. Arakawa, R. Saga, H. Mochizuki and A. Morikawa (2002) Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. Pharmacology 64 189-195.
312. H. Sun, J.W. Breslin, J. Zhu, S.Y. Yuan and M.H. Wu (2006) Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability. Microcirculation 13 237-247.
313. J.H. Tinsley, N.R. Teasdale and S.Y. Yuan (2004) Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns. Am J Physiol Lung Cell Mol Physiol 286 L841-l847.
314. H.Z. Zheng, K.S. Zhao, B.Y. Zhou and Q.B. Huang (2003) Role of Rho kinase and actin filament in the increased vascular permeability of skin venules in rats after scalding. Burns 29 820-827.
315. T. Hirase, S. Kawashima, E.Y. Wong, T. Ueyama, Y. Rikitake, S. Tsukita, M. Yokoyama and J.M. Staddon (2001) Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms. J Biol Chem 276 10423-10431.
316. I. Petrache, A.D. Verin, M.T. Crow, A. Birukova, F. Liu and J.G. Garcia (2001) Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 280 L1168-l1178.
317. B. Wojciak-Stothard, A. Entwistle, R. Garg and A.J. Ridley (1998) Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J Cell Physiol 176 150-165.
318. J.G. Garcia, F. Liu, A.D. Verin, A. Birukova, M.A. Dechert, W.T. Gerthoffer, J.R. Bamberg and D. English (2001) Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest 108 689-701.
319. S. Hippenstiel, S. Tannert-Otto, N. Vollrath, M. Krull, I. Just, K. Aktories, C. von Eichel-Streiber and N. Suttorp (1997) Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function. Am J Physiol 272 L38-l43.
320. J. Waschke, W. Baumgartner, R.H. Adamson, M. Zeng, K. Aktories, H. Barth, C. Wilde, F.E. Curry and D. Drenckhahn (2004) Requirement of Rac activity for maintenance of capillary endothelial barrier properties. Am J Physiol Heart Circ Physiol 286 H394-h401.
321. G. Thurston and A.L. Baldwin (1994) Endothelial actin cytoskeleton in rat mesentery microvasculature. Am J Physiol 266 H1896-h1909.
322. A.L. Baldwin and G. Thurston (1995) Changes in endothelial actin cytoskeleton in venules with time after histamine treatment. Am J Physiol 269 H1528-h1537.
323. G. Thurston, A.L. Baldwin and L.M. Wilson (1995) Changes in endothelial actin cytoskeleton at leakage sites in the rat mesenteric microvasculature. Am J Physiol 268 H316-h329.
324. R.J. Korthuis, D.L. Carden, P.R. Kvietys, D. Shepro and J. Fuseler (1991) Phalloidin attenuates postischemic neutrophil infiltration and increased microvascular permeability. J Appl Physiol 71 1261-1269.
325. A.L. Baldwin and G. Thurston (2001) Mechanics of endothelial cell architecture and vascular permeability. Crit Rev Biomed Eng 29 247-278.
326. D.M. McDonald, G. Thurston and P. Baluk (1999) Endothelial gaps as sites for plasma leakage in inflammation. Microcirculation 6 7-22.
327. H.J. Schnittler, A. Wilke, T. Gress, N. Suttorp and D. Drenckhahn (1990) Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium. J Physiol 431 379-401.
328. A.B. Moy, S.S. Shasby, B.D. Scott and D.M. Shasby (1993) The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells. J Clin Invest 92 1198-1206.
329. R. Sheldon, A. Moy, K. Lindsley, S. Shasby and D.M. Shasby (1993) Role of myosin light-chain phosphorylation in endothelial cell retraction. Am J Physiol 265 L606-l612.
330. S. Shi, A.D. Verin, K.L. Schaphorst, L.I. Gilbert-McClain, C.E. Patterson, R.P. Irwin, V. Natarajan and J.G. Garcia (1998) Role of tyrosine phosphorylation in thrombin-induced endothelial cell contraction and barrier function. Endothelium 6 153-171.
331. R. Reynoso, R.M. Perrin, J.W. Breslin, D.A. Daines, K.D. Watson, D.M. Watterson, M.H. Wu and S. Yuan (2007) A Role for Long Chain Myosin Light Chain Kinase (Mlck-210) in Microvascular Hyperpermeability During Severe Burns. Shock 28 589-595.
332. J.H. Tinsley, P. De Lanerolle, E. Wilson, W. Ma and S.Y. Yuan (2000) Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability. Am J Physiol Cell Physiol 279 C1285-c1289.
333. M. Amano, Y. Fukata and K. Kaibuchi (2000) Regulation and functions of Rho-associated kinase. Exp Cell Res 261 44-51.
334. R.K. Wong, A.L. Baldwin and R.L. Heimark (1999) Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma-induced permeability in mesenteric venules. Am J Physiol 276 H736-h748.
335. D.M. Shasby, D.R. Ries, S.S. Shasby and M.C. Winter (2002) Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. Am J Physiol Lung Cell Mol Physiol 282 L1330-l1338.
336. A.A. Birukova, K. Smurova, K.G. Birukov, P. Usatyuk, F. Liu, K. Kaibuchi, A. Ricks-Cord, V. Natarajan, I. Alieva, J.G. Garcia and A.D. Verin (2004) Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol 201 55-70.
337. C.E. Cattan and K.C. Oberg (1999) Vinorelbine tartrate-induced pulmonary edema confirmed on rechallenge. Pharmacotherapy 19 992-994.
338. A.A. Birukova, K.G. Birukov, K. Smurova, D. Adyshev, K. Kaibuchi, I. Alieva, J.G. Garcia and A.D. Verin (2004) Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J 18 1879-1890.
339. A.A. Birukova, D. Adyshev, B. Gorshkov, G.M. Bokoch, K.G. Birukov and A.D. Verin (2006) GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 290 L540-l548.
340. E. Dejana, M.G. Lampugnani, O. Martinez-Estrada and G. Bazzoni (2000) The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability. Int J Dev Biol 44 743-748.
341. D. Vittet, T. Buchou, A. Schweitzer, E. Dejana and P. Huber (1997) Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci USA 94 6273-6278.
342. L. Caveda, I. Martin-Padura, P. Navarro, F. Breviario, M. Corada, D. Gulino, M.G. Lampugnani and E. Dejana (1996) Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin). J Clin Invest 98 886-893.
343. A. Shay-Salit, M. Shushy, E. Wolfovitz, H. Yahav, F. Breviario, E. Dejana and N. Resnick (2002) VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc Natl Acad Sci USA 99 9462-9467.
344. M.G. Lampugnani, M. Corada, L. Caveda, F. Breviario, O. Ayalon, B. Geiger and E. Dejana (1995) The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 129 203-217.
345. M.G. Lampugnani, M. Corada, P. Andriopoulou, S. Esser, W. Risau and E. Dejana (1997) Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sci 110(Pt 17), 2065-2077.
346. P. Andriopoulou, P. Navarro, A. Zanetti, M.G. Lampugnani and E. Dejana (1999) Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions. Arterioscler Thromb Vasc Biol 19 2286-2297.
347. A.W. Cohen, J.M. Carbajal and R.C. Schaeffer Jr. (1999) VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction. Am J Physiol 277 H2038-h2049.
348. S. Esser, M.G. Lampugnani, M. Corada, E. Dejana and W. Risau (1998) Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 111(Pt 13), 1853-1865.
349. J.S. Alexander, B.C. Alexander, L.A. Eppihimer, N. Goodyear, R. Haque, C.P. Davis, T.J. Kalogeris, D.L. Carden, Y.N. Zhu and C.G. Kevil (2000) Inflammatory mediators induce sequestration of VE-cadherin in cultured human endothelial cells. Inflammation 24 99-113.
350. J.H. Tinsley, J. Hawker and Y. Yuan (1998) Efficient protein transfection of cultured coronary venular endothelial cells. Am J Physiol 275 H1873-h1878.
351. S.M. Brady-Kalnay, T. Mourton, J.P. Nixon, G.E. Pietz, M. Kinch, H. Chen, R. Brackenbury, D.L. Rimm, R.L. Del Vecchio and N.K. Tonks (1998) Dynamic interaction of PTPmu with multiple cadherins in vivo. J Cell Biol 141 287-296.
352. J.R. Downing and A.B. Reynolds (1991) PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate. Oncogene 6 607-613.
353. H. Hoschuetzky, H. Aberle and R. Kemler (1994) Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Bjiol 127 1375-1380.
354. S. Tsukita, K. Oishi, T. Akiyama, Y. Yamanashi and T. Yamamoto (1991) Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J Cell Biol 113 867-879.
355. J.A. Ukropec, M.K. Hollinger, S.M. Salva and M.J. Woolkalis (2000) SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. J Biol Chem 275 5983-5986.
356. P. Carmeliet, M.G. Lampugnani, L. Moons, F. Breviario, V. Compernolle, F. Bono, G. Balconi, R. Spagnuolo, B. Oostuyse, M. Dewerchin, A. Zanetti, A. Angellilo, V. Mattot, D. Nuyens, E. Lutgens, F. Clotman, M.C. de Ruiter, A. Gittenberger-de Groot, R. Poelmann, F. Lupu, J.M. Herbert, D. Collen and E. Dejana (1999) Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98 147-157.
357. A. Zanetti, M.G. Lampugnani, G. Balconi, F. Breviario, M. Corada, L. Lanfrancone and E. Dejana (2002) Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling. Arterioscler Thromb Vasc Biol 22 617-622.
358. P.Z. Anastasiadis and A.B. Reynolds (2001) Regulation of Rho GTPases by p120-catenin. Curr Opin Cell Biol 13 604-610.
359. E.E. Sander, J.P. ten Klooster, S. van Delft, R.A. van der Kammen and J.G. Collard (1999) Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol 147 1009-1022.
360. G.C. Zondag, E.E. Evers, J.P. ten Klooster, L. Janssen, R.A. van der Kammen and J.G. Collard (2000) Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol 149 775-782.
361. V.M. Braga, M. Betson, X. Li and N. Lamarche-Vane (2000) Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. Mol Biol Cell 11 3703-3721.
362. V.M. Braga, L.M. Machesky, A. Hall and N.A. Hotchin (1997) The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol 137 1421-1431.
363. K. Kaibuchi, S. Kuroda, M. Fukata and M. Nakagawa (1999) Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases. Curr Opin Cell Biol 11 591-596.
364. K. Takaishi, T. Sasaki, H. Kotani, H. Nishioka and Y. Takai (1997) Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol 139 1047-1059.
365. D.J. Mariner, P. Anastasiadis, H. Keilhack, F.D. Bohmer, J. Wang and A.B. Reynolds (2001) Identification of Src phosphorylation sites in the catenin p120ctn. J Biol Chem 276 28006-28013.
366. J.T. Murphy and S. Duffy (2003) ZO-1 redistribution and F-actin stress fiber formation in pulmonary endothelial cells after thermal injury. J Trauma 54 81-89. discussion 89–90
367. L.M. Leeb-Lundberg, X.H. Song and S.A. Mathis (1994) Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells. J Biol Chem 269 24328-24334.
368. M. Guo, M.H. Wu, H.J. Granger and S.Y. Yuan (2005) Focal adhesion kinase in neutrophil-induced microvascular hyperpermeability. Microcirculation 12 223-232.
369. M.H. Wu, M. Guo, S.Y. Yuan and H.J. Granger (2003) Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor. J Physiol 552 691-699.
370. J.L. Guan and D. Shalloway (1992) Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358 690-692.
371. S.K. Hanks, M.B. Calalb, M.C. Harper and S.K. Patel (1992) Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA 89 8487-8491.
372. M.M. Huang, L. Lipfert, M. Cunningham, J.S. Brugge, M.H. Ginsberg and S.J. Shattil (1993) Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol 122 473-483.
373. S.M. Frisch, K. Vuori, E. Ruoslahti and P.Y. Chan-Hui (1996) Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134 793-799.
374. G.P. van Nieuw Amerongen, K. Natarajan, G. Yin, R.J. Hoefen, M. Osawa, J. Haendeler, A.J. Ridley, K. Fujiwara, V.W. van Hinsbergh and B.C. Berk (2004) GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. Circ Res 94 1041-1049.
375. R. Govers and T.J. Rabelink (2001) Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 280 F193-f206.
376. J. Liu, T.E. Hughes and W.C. Sessa (1997) The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. J Cell Biol 137 1525-1535.
377. W.C. Sessa, G. Garcia-Cardena, J. Liu, A. Keh, J.S. Pollock, J. Bradley, S. Thiru, I.M. Braverman and K.M. Desai (1995) The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J Biol Chem 270 17641-17644.
378. P.W. Shaul, E.J. Smart, L.J. Robinson, Z. German, I.S. Yuhanna, Y. Ying, R.G. Anderson and T. Michel (1996) Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 271 6518-6522.
379. Q. Zhang, J.E. Church, D. Jagnandan, J.D. Catravas, W.C. Sessa and D. Fulton (2006) Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol 26 1015-1021.
380. J. Liu, G. Garcia-Cardena and W.C. Sessa (1996) Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization. Biochemistry 35 13277-13281.
381. T. Sakoda, K. Hirata, R. Kuroda, N. Miki, M. Suematsu, S. Kawashima and M. Yokoyama (1995) Myristoylation of endothelial cell nitric oxide synthase is important for extracellular release of nitric oxide. Mol Cell Biochem 152 143-148.
382. G. Garcia-Cardena, P. Oh, J. Liu, J.E. Schnitzer and W.C. Sessa (1996) Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci USA 93 6448-6453.
383. B.F. Pobiner, J.K. Northup, P.H. Bauer, E.D. Fraser and J.C. Garrison (1991) Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes. Mol Pharmacol 40 156-167.
384. I. Fleming and R. Busse (1999) Signal transduction of eNOS activation. Cardiovasc Res 43 532-541.
385. O. Feron, F. Saldana, J.B. Michel and T. Michel (1998) The endothelial nitric-oxide synthase-caveolin regulatory cycle. J Biol Chem 273 3125-3128.
386. G. Garcia-Cardena, P. Martasek, B.S. Masters, P.M. Skidd, J. Couet, S. Li, M.P. Lisanti and W.C. Sessa (1997) Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem 272 25437-25440.
387. J.B. Michel, O. Feron, D. Sacks and T. Michel (1997) Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. J Biol Chem 272 15583-15586.
388. J.B. Michel, O. Feron, K. Sase, P. Prabhakar and T. Michel (1997) Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase. J Biol Chem 272 25907-25912.
389. L.A. Blatter, Z. Taha, S. Mesaros, P.S. Shacklock, W.G. Wier and T. Malinski (1995) Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells. Circ Res 76 922-924.
390. A.J. Kanai, H.C. Strauss, G.A. Truskey, A.L. Crews, S. Grunfeld and T. Malinski (1995) Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. Circ Res 77 284-293.
391. Y. Feng, V.J. Venema, R.C. Venema, N. Tsai and R.B. Caldwell (1999) VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase, and caveolin-1 in vascular endothelial cells. Biochem Biophys Res Commun 256 192-197.
392. R.M. Goetz, H.S. Thatte, P. Prabhakar, M.R. Cho, T. Michel and D.E. Golan (1999) Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 96 2788-2793.
393. P. Prabhakar, H.S. Thatte, R.M. Goetz, M.R. Cho, D.E. Golan and T. Michel (1998) Receptor-regulated translocation of endothelial nitric-oxide synthase. J Biol Chem 273 27383-27388.
394. V.J. Venema, M.B. Marrero and R.C. Venema (1996) Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton. Biochem Biophys Res Commun 226 703-710.
395. Q. Wang, W.F. Patton, H.B. Hechtman and D. Shepro (1997) A novel anti-inflammatory peptide inhibits endothelial cell cytoskeletal rearrangement, nitric oxide synthase translocation, and paracellular permeability increases. J Cell Physiol 172 171-182.
396. D.C. Yeh, J.A. Duncan, S. Yamashita and T. Michel (1999) Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin. J Biol Chem 274 33148-33154.
397. J. Dedio, P. Konig, P. Wohlfart, C. Schroeder, W. Kummer and W. Muller-Esterl (2001) NOSIP, a novel modulator of endothelial nitric oxide synthase activity. FASEB J 15 79-89.
398. K. Zimmermann, N. Opitz, J. Dedio, C. Renne, W. Muller-Esterl and S. Oess (2002) NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 99 17167-17172.
399. R.F. Furchgott (1984) The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol 24 175-197.
400. R.F. Furchgott and J.V. Zawadzki (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 373-376.
401. L.J. Ignarro (1990) Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol 30 535-560.
402. C. Crone (1987) The Malpighi lecture. From “Porositates carnis” to cellular microcirculation. Int J Microcirc Clin Exp 6 101-122.
403. A. Ialenti, A. Ianaro, S. Moncada and M. Di Rosa (1992) Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 211 177-182.
404. I. Kurose, P. Kubes, R. Wolf, D.C. Anderson, J. Paulson, M. Miyasaka and D.N. Granger (1993) Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage. Circ Res 73 164-171.
405. I. Kurose, R. Wolf, M.B. Grisham, T.Y. Aw, R.D. Specian and D.N. Granger (1995) Microvascular responses to inhibition of nitric oxide production. Role of active oxidants. Circ Res 76 30-39.
406. I. Kurose, R. Wolf, M.B. Grisham and D.N. Granger (1994) Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide. Circ Res 74 376-382.
407. W.N. Durán, A. Seyama, K. Yoshimura, D.R. Gonzalez, P.I. Jara, X.F. Figueroa and M.P. Boric (2000) Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo. Microvasc Res 60 104-111.
408. L. Zhu, V. Castranova and P. He (2005) fMLP-stimulated neutrophils increase endothelial [Ca2+]i and microvessel permeability in the absence of adhesion: role of reactive oxygen species. Am J Physiol Heart Circ Physiol 288 H1331-h1338.
409. D. Fukumura, T. Gohongi, A. Kadambi, Y. Izumi, J. Ang, C.O. Yun, D.G. Buerk, P.L. Huang and R.K. Jain (2001) Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA 98 2604-2609.
410. W.N. Durán, T. Hatakeyama and F.A. Sanchez (2006) Endothelial nitric oxide synthase-derived NO signals regulate microvascular permeability. Physiol News 65 21-23.
411. J.F. Arnal, A.T. Dinh-Xuan, M. Pueyo, B. Darblade and J. Rami (1999) Endothelium-derived nitric oxide and vascular physiology and pathology. Cell Mol Life Sci 55 1078-1087.
412. G. Garcia-Cardena, R. Fan, V. Shah, R. Sorrentino, G. Cirino, A. Papapetropoulos and W.C. Sessa (1998) Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 392 821-824.
413. H. He, V.J. Venema, X. Gu, R.C. Venema, M.B. Marrero and R.B. Caldwell (1999) Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. J Biol Chem 274 25130-25135.
414. J.D. Hood, C.J. Meininger, M. Ziche and H.J. Granger (1998) VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 274 H1054-h1058.
415. H. Ju, V.J. Venema, M.B. Marrero and R.C. Venema (1998) Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase. J Biol Chem 273 24025-24029.
416. S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse and A.M. Zeiher (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 601-605.
417. I. Fleming, B. Fisslthaler, S. Dimmeler, B.E. Kemp and R. Busse (2001) Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependentendothelial nitric oxide synthase activity. Circ Res 88 E68-e75.
418. D. Fulton, J.P. Gratton, T.J. McCabe, J. Fontana, Y. Fujio, K. Walsh, T.F. Franke, A. Papapetropoulos and W.C. Sessa (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399 597-601.
419. G. Garcia-Cardena, R. Fan, D.F. Stern, J. Liu and W.C. Sessa (1996) Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem 271 27237-27240.
420. J.P. Gratton, J. Fontana, D.S. O'Connor, G. Garcia-Cardena, T.J. McCabe and W.C. Sessa (2000) Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem 275 22268-22272.
421. Z. Luo, Y. Fujio, Y. Kureishi, R.D. Rudic, G. Daumerie, D. Fulton, W.C. Sessa and K. Walsh (2000) Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest 106 493-499.
422. B.J. Michell, J.E. Griffiths, K.I. Mitchelhill, I. Rodriguez-Crespo, T. Tiganis, S. Bozinovski, P.R. de Montellano, B.E. Kemp and R.B. Pearson (1999) The Akt kinase signals directly to endothelial nitric oxide synthase. Curr Biol 9 845-848.
423. B.J. Michell, Z. Chen, T. Tiganis, D. Stapleton, F. Katsis, D.A. Power, A.T. Sim and B.E. Kemp (2001) Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 276 17625-17628.
424. T.A. Marsen, G. Egink, G. Suckau and C.A. Baldamus (1999) Tyrosine-kinase-dependent regulation of the nitric oxide synthase gene by endothelin-1 in human endothelial cells. Pflugers Arch 438 538-544.
425. Y. Ohara, H.S. Sayegh, J.J. Yamin and D.G. Harrison (1995) Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension 25 415-420.
426. B.Q. Shen, D.Y. Lee and T.F. Zioncheck (1999) Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J Biol Chem 274 33057-33063.
427. S. Wedgwood, J.M. Bekker and S.M. Black (2001) Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC. Am J Physiol Lung Cell Mol Physiol 281 L490-l498.
428. L.J. Ignarro, G. Cirino, A. Casini and C. Napoli (1999) Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol 34 879-886.
429. M. Yonemaru, K. Ishii, F. Murad and T.A. Raffin (1992) Atriopeptin-induced increases in endothelial cell permeability are associated with elevated cGMP levels. Am J Physiol 263 L363-l369.
430. W.G. Mayhan (1999) VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway. Am J Physiol 276 C1148-c1153.
431. M.A. Corson, N.L. James, S.E. Latta, R.M. Nerem, B.C. Berk and D.G. Harrison (1996) Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res 79 984-991.
432. T. Michel and O. Feron (1997) Nitric oxide synthases: which, where, how, and why? J Clin Invest 100 2146-2152.
433. T. Michel, G.K. Li and L. Busconi (1993) Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 90 6252-6256.
434. F.A. Sanchez, N.B. Savalia, R.G. Durán, B.K. Lal, M.P. Boric and W.N. Durán (2006) Functional significance of differential eNOS translocation. Am J Physiol Heart Circ Physiol 291 H1058-h1064.
435. P.A. Erwin, A.J. Lin, D.E. Golan and T. Michel (2005) Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 280 19888-19894.
436. X.F. Figueroa, D.R. Gonzalez, A.D. Martinez, W.N. Durán and M.P. Boric (2002) ACh-induced endothelial NO synthase translocation, NO release and vasodilatation in the hamster microcirculation in vivo. J Physiol 544 883-896.
437. J.S. Pober, M.S. Kluger and J.S. Schechner (2001) Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin. Ann N Y Acad Sci 941 12-25.
438. H.L. Beynon, K.A. Davies, D.O. Haskard and M.J. Walport (1994) Erythrocyte complement receptor type 1 and interactions between immune complexes, neutrophils, and endothelium. J Immunol 153 3160-3167.
439. A.R. Burns, D.C. Walker, E.S. Brown, L.T. Thurmon, R.A. Bowden, C.R. Keese, S.I. Simon, M.L. Entman and C.W. Smith (1997) Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners. J Immunol 159 2893-2903.
440. P. Kubes, M.B. Grisham, J.A. Barrowman, T. Gaginella and D.N. Granger (1991) Leukocyte-induced vascular protein leakage in cat mesentery. Am J Physiol 261 H1872-h1879.
441. M. Minnicozzi, W.N. Durán, G.J. Gleich and R.W. Egan (1994) Eosinophil granule proteins increase microvascular macromolecular transport in the hamster cheek pouch. J Immunol 153 2664-2670.
442. M. Minnicozzi, M.M. Ramirez, R.W. Egan, G.J. Gleich, I. Kobayashi, D. Kim and W.N. Durán (1995) Polyarginine and eosinophil-derived major basic protein increase microvascular permeability independently of histamine or nitric oxide release. Microvasc Res 50 56-70.
443. J.G. Garcia, A.D. Verin, M. Herenyiova and D. English (1998) Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration. J Appl Physiol 84 1817-1821.
444. A.C. Tomeo, R.W. Egan and W.N. Durán (1991) Priming interactions between platelet activating factor and histamine in the in vivo microcirculation. FASEB J 5 2850-2855.
445. F.E. Curry, M. Zeng and R.H. Adamson (2003) Thrombin increases permeability only in venules exposed to inflammatory conditions. Am J Physiol Heart Circ Physiol 285 H2446-hH2453.
446. J. Fan and A.B. Malik (2003) Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat Med 9 315-321.
447. K.P. Mollen, R.J. Anand, A. Tsung, J.M. Prince, R.M. Levy and T.R. Billiar (2006) Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock 26 430-437.
448. J.W. Breslin, M.H. Wu, M. Guo, R. Reynoso and S.Y. Yuan (2008) Toll-like receptor-4 contributes to microvascular inflammation and barrier dysfunction in thermal injury. Shock 29 349-355.
449. D.M. Dudzinski, J. Igarashi, D. Greif and T. Michel (2006) The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol 46 235-276.
450. J. de Rooij, F.J. Zwartkruis, M.H. Verheijen, R.H. Cool, S.M. Nijman, A. Wittinghofer and J.L. Bos (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396 474-477.
451. A.E. Christensen, F. Selheim, J. de Rooij, S. Dremier, F. Schwede, K.K. Dao, A. Martinez, C. Maenhaut, J.L. Bos, H.G. Genieser and S.O. Doskeland (2003) cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem 278 35394-35402.
452. L.M. DiPilato, X. Cheng and J. Zhang (2004) Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci USA 101 16513-16518.
453. J.M. Enserink, A.E. Christensen, J. de Rooij, M. van Triest, F. Schwede, H.G. Genieser, S.O. Doskeland, J.L. Blank and J.L. Bos (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 4 901-906.
454. G.C. Kramer, B.A. Harms, B.I. Bodai, R.H. Demling and E.M. Renkin (1982) Mechanisms for redistribution of plasma protein following acute protein depletion. Am J Physiol 243 H803-h809.
455. X. Cullere, S.K. Shaw, L. Andersson, J. Hirahashi, F.W. Luscinskas and T.N. Mayadas (2005) Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 105 1950-1955.
456. S. Fukuhara, A. Sakurai, H. Sano, A. Yamagishi, S. Somekawa, N. Takakura, Y. Saito, K. Kangawa and N. Mochizuki (2005) Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 25 136-146.
457. F.J. Zwartkruis and J.L. Bos (1999) Ras and Rap1: two highly related small GTPases with distinct function. Exp Cell Res 253 157-165.
458. F.L. Minnear, L. Zhu and P. He (2005) Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. Am J Physiol Heart Circ Physiol 289 H840-h844.
459. D.D. Kim, A.M. Pica, R.G. Durán and W.N. Durán (2006) Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases. Microcirculation 13 577-585.
460. D.D. Kim, F.A. Sanchez, R.G. Durán, T. Kanetaka and W.N. Durán (2007) Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension. Am J Physiol Heart Circ Physiol 292 H2131-h2137.
461. Q. Huang, M. Wu, C. Meininger, K. Kelly and Y. Yuan (1998) Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. Am J Physiol 275 H1138-h1147.
462. V.H. Huxley and D.A. Williams (2000) Role of a glycocalyx on coronary arteriole permeability to proteins: evidence from enzyme treatments. Am J Physiol Heart Circ Physiol 278 H1177-h1185.
463. M.H. Wu, E. Ustinova and H.J. Granger (2001) Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules. J Physiol 532 785-791.
464. R.E. Rumbaut and V.H. Huxley (2002) Similar permeability responses to nitric oxide synthase inhibitors of venules from three animal species. Microvasc Res 64 21-31.
465. D.G. Garlick and E.M. Renkin (1970) Transport of large molecules from plasma to interstitial fluid and lymph in dogs. Am J Physiol 219 1595-1605.
466. L.T. Baxter, R.K. Jain and E. Svensjö (1987) Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs. Microvasc Res 34 336-348.