Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

Journal of Cell Biology

Volumn 157, Issue 1, 2002, Pages 149-159

  Eliceiri, Brian P ^a   Puente, Xose S ^a   Hood, John D ^a   Stupack, Dwayne G ^a   Schlaepfer, David D ^a   Huang, Xiaozhu Z ^a   Sheppard, Dean ^b   Cheresh, David A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Integrin; Src; Tyrosine kinase; Vascular permeability; VEGF

Indexed keywords

ALPHAVBETA5 INTEGRIN; BASIC FIBROBLAST GROWTH FACTOR; BETA1 INTEGRIN; BETA3 INTEGRIN; EPIDERMAL GROWTH FACTOR; FOCAL ADHESION KINASE; INTEGRIN; PROTEIN KINASE P60; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; BLOOD VESSEL; CHICK EMBRYO; COMPLEX FORMATION; EMBRYO; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CHICK EMBRYO; CHORION; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTEGRINS; KIDNEY; LYMPHOKINES; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RABBITS; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TYROSINE; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 0036544562     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200109079     Document Type: Article

References (56)

1. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
2. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells
3. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
4. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that α3β1 complexes with EMMPRIN/basigin/OX47/M6
5. Platelet-derived growth factor receptor beta and VEGFR 2 bind to the β3 integrin through its extracellular domain
6. Requirement of vascular integrin αvβ3 for angiogenesis
7. Insulin-like growth factor receptor cooperates with integrin αvβ5 to promote tumor cell dissemination in vivo
8. A mechanism for modulation of cellular responses to VEGF: Activation of the integrins
9. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
10. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase
11. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK
12. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
13. The Src family of protein tyrosine kinases: Regulation and functions
14. The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells
15. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
16. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
17. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
18. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
19. The biology of vascular endothelial growth factor
20. Definition of two angiogenic pathways by distinct αv integrins
21. Integrin signaling
22. Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity
23. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
24. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
25. Normal development, wound healing, and adenovirus susceptibility in β5-deficient mice
26. Receptor tyrosine kinase signaling required for integrin αvβ5-directed cell motility but not adhesion on vitronectin
27. Regulation of cell motility by mitogen-activated protein kinase
28. Targeting Pyk2 to β1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells
29. Association between the PDGF receptor and members of the src family of tyrosine kinases
30. Mapping in vivo associations of cytoplasmic proteins with integrin β1 cytoplasmic domain mutants
31. Protein kinase C αvβ5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation
32. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
33. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
34. TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice
35. Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways
36. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke
37. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
38. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate pl30Cas
39. The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor
40. Cloning, primary structure and properties of a novel human integrin beta subunit
41. Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK
42. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
43. Integrin signalling and tyrosine phosphorylation: Just the FAKs?
44. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
45. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
46. Integrin-mediated signaling events in human endothelial cells
47. FAK integrates growth-factor and integrin signals to promote cell migration
48. Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells
49. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
50. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
51. Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes
52. Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: Identification of a vinculin and pp125Fak-binding region
53. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain
54. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
55. The cytoplasmic tyrosines ofintegrin subunit β1 are involved in focal adhesion kinase activation
56. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis